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IMPLEMENTATION
Unconjugated
hyperbilirubinaemia
impacts on clearance
necessitating a dose
reduction (Palmer 2008).
Drug of choice for
overdose is regimen of N-
acetylcysteine IV infusion.
DRUG NAME ACTION INDICATIONS CONTRAINDICATI ADVERSE REACTION INTERACTIONS NURSING
ON IMPLEMENTATI
ON
Generic . Blocks Hypertensi Contraindicated CNS: dizziness, fatigue, weakness, General anesthetics, IV Monitor BP
Name: in: anxiety, depression, drowsiness,
stimulation on. phenytoin, diltiazem, and pulse
History of insomnia, memory loss, mental
Carvedilol of HF status changes, nervousness, and verapamil may cause ↑ frequently
serious
beta1(myoc (ischemic nightmares myocardial depression. during dose
Brand Name: hypersensitivity
ardial) and or EENT: blurred vision, dry eyes, ↑ risk of bradycardia adjustment
reaction intraoperative floppy iris syndrome,
Coreg beta2 (pulm cardiomyo with digoxin. period and
(Stevens- nasal stuffiness
Coreg CR onary, pathic) with Resp: bronchospasm, wheezing Amiodarone or fluconazole periodically
Johnson
vascular, digoxin, CV: BRADYCARDIA, HF, PULMON may ↑ levels. during
syndrome,
Class: and diuretics, ARY EDEMA ↑ hypotension may occur therapy. Asses
angioedema, GI: diarrhea, constipation, nausea
uterine)- and ACE with s for
antihypertensiv anaphylaxis); GU: erectile dysfunction, ↓ libido
adrenergic inhibitors. Derm: STEVENS-JOHNSON other antihypertensives, orthostatic
es Pulmonary
beta blockers receptor Left SYNDROME, TOXIC EPIDERMAL acute ingestion of alcohol, hypotension
edema; NECROLYSIS, itching, rashes,
sites. ventricular or nitrates. when assisting
Cardiogenic urticaria
Also has dysfunction Concurrent use patient up
shock; Endo: hyperglycemia,
alpha1 bloc after with clonidine ↑ hypotension from supine
Bradycardia, hypoglycemia
king myocardial MS: arthralgia, back pain, muscle and bradycardia. position.
heart block or
activity, infarction. cramps May ↑ withdrawal Monitor intake
sick sinus Neuro: paresthesia
which may phenomenon and output
syndrome Misc: ANAPHYLAXIS, ANGIOEDE
result in from clonidine (discontinue ratios and
(unless a MA, drug-induced lupus syndrome
orthostatic carvedilol first). daily weight.
pacemaker is in
hypotensio Concurrent administration Assess patient
place);
n. of thyroid routinely for
Therapeutic Uncompensated preparations may ↓ evidence of
Effect(s):
HF requiring IV effectiveness. fluid overload
Decreased
inotropic agents May alter the effectiveness (peripheral
heart rate
(wean before of insulins or oral edema,
and BP.
starting hypoglycemic dyspnea,
Improved
carvedilol); agents (dose adjustments rales/crackles,
cardiac
Severe hepatic may be necessary). fatigue, weight
output,
impairment; May ↓ effectiveness gain, jugular
slowing of
Asthma or other of theophylline. venous
the
bronchospastic May ↓ beneficial beta1- distention).
progression
disorders. cardiovascular effects Patients may
of HF and
of dopamine or dobutamin experience
decreased
e. worsening of
risk of
Use cautiously within 14 symptoms
death.
days of MAO during
inhibitor therapy (may result initiation of
in hypotension/bradycardia). therapy for
Cimetidine may ↑ toxicity HF.
from carvedilol. Do not confuse
Concurrent NSAIDs may ↓ carvedilol with
captopril
antihypertensive action.
Effectiveness may be ↓ PO: Take apical
by rifampin. pulse before
May ↑ serum digoxin levels. administering. If
<50 bpm or if
May ↑ blood levels
arrhythmia
of cyclosporine (monitor occurs, withhold
blood levels). medication and
notify health care
professional.
Instruct patient to
take medication
as directed, at the
same time each
day, even if
feeling well. Do
not skip or double
up on missed
doses. Take
missed doses as
soon as possible
up to 4 hr before
next dose. Abrupt
withdrawal may
precipitate life-
threatening
arrhythmias,
hypertension, or
myocardial
ischemia.
Advise patient to
notify health care
professional if
slow pulse,
difficulty
breathing,
wheezing, cold
hands and feet,
dizziness,
confusion,
depression, rash,
fever, sore throat,
unusual bleeding,
or bruising
occurs.
Generic Name: Contains treat and prevent symptoms Hypersensitivity to Lung . Avoid MAOIs, Not for primary
2 medications: ipratropium and albuter (wheezing and shortness of albuterol, disorders, tricyclics within treatment of
Salbutamol(albuter ol (also known as salbutamol). Both breath) caused by ipratropium, pharyngitis, 14 days acute attack.
ol)+ Ipratropium drugs work by relaxing the muscles ongoing lung disease (chronic atropine and chest pain, (increased Avoid excessive
inhalation around the airways so that they open obstructive pulmonary derivatives, soy, or GI cardiovascular use. Discontinue
up and you can breathe more easily. disease-COPD which peanut disturbances effects). if paradoxical
Brand Name: Controlling symptoms of breathing
includes bronchitis and emphy , bronchitis, Caution with bronchospasm
Duoneb problems can decrease time lost from
sema) UTI, leg other or cardiovascular
work or school.
Class: cramps, anticholinergics, effects occur.
pain, voice sympathomimet
Anticholinergic Nursing mothers:
changes, ics, drugs that
not
anticholinerg lower
Beta- agonist recommended
ic effects, potassium.
nervousness Monitor digoxin.
, headache, Antagonized by
dizziness, β-blockers.
insomnia,
tachycardia,
hypokalemia
, paradoxical
bronchospas
m.
Generic Severe Contraindicated . Use with extreme caution in patients Assess level of
Name: . Binds to opiate in: consciousness,
receptors in the pain (the CNS: confusion, sedat receiving MAO inhibitors within 14 days prior
Hypersensitivity; BP, pulse, and
Morphine CNS. Alters the 20 ion, dizziness, (may result in unpredictable, severe
Some products respirations before
perception of mg/mL dysphoria, euphoria, reactions–↓ initial dose of morphine to 25% of
Brand and response to contain floating feeling, and periodically
Name: oral usual dose). during
painful stimuli tartrazine, hallucinations,
while producing solution headache, unusual Use with benzodiazepines or other CNS administration. If
Arymo bisulfites, or respiratory rate is
generalized concentr dreams depressants including otheropioids, non-
ER CNS alcohol and EENT: blurred vision, <10/min, assess
ation benzodiazepine
Astramor depression. should be diplopia, miosis level of sedation.
should sedative/hypnotics, anxiolytics, general
Therapeutic avoided in Resp: RESPIRATOR Physical
ph only be anesthetics, muscle
Effect(s): patients with Y DEPRESSION stimulation may be
Decrease in used in CV: hypotension, relaxants, antipsychotics, and alcohol may sufficient to
severity of pain. known bradycardia
opioid- cause profound sedation, respiratory prevent significant
Addition of hypersensitivity; Endo: adrenal
tolerant depression, coma, and death; reserve hypoventilation.
Class: naltrexone Acute, mild, insufficiency
Subsequent doses
in Embeda prod patients). GI: constipation, concurrent use for when alternative treatment
intermittent, or may need to be
opioid uct is designed Pain nausea, vomiting options are inadequate.
analgesics postoperative GU: urinary retention decreased by 25–
to prevent severe Drugs that affect serotonergic
abuse or pain Derm: flushing, 50%. Initial
enough neurotransmitter systems, including tricyclic
misuse by (extended/sustai itching, sweating drowsiness will
to require antidepressants, SSRIs, SNRIs, MAO
altering the daily, ned-release); Misc: physical inhibitors, TCAs, tramadol, trazodone, mirt diminish with
formulation. dependence, continued use.
around- Significant azapine, 5–HT3 receptor
Naltrexone has psychological
no effect unless the-clock respiratory dependence, antagonists, linezolid, methylene blue, Assess risk for
the capsule is long-term depression tolerance and triptans ↑ risk of serotonin syndrome. opioid addiction,
crushed or opioid (extended- Administration of partial-antagonist opioid abuse, or misuse
chewed. treatment release); analgesics may precipitate opioid withdrawal prior to
administration.
and for Acute or severe in physically dependent patients.
Abuse or misuse
which bronchial Buprenorphine, nalbuphine, butorphanol, of extended-
alternativ asthma or pentazocine may ↓ analgesia. release
e (extended- May ↑ the anticoagulant effect of warfarin. preparations by
treatment release); Cimetidine ↓ metabolism and may ↑ effects. crushing, chewing,
options Paralytic ileus snorting, or
are (extended- injecting dissolved
product will result
inadequa release).
in uncontrolled
te delivery of
(extende morphine and can
d- result in overdose
release). and death.
Pulmona
Do not confuse
ry
MS Contin
edema.
(morphine
Pain
sulfate) with
associate
Oxycontin
d with
(oxycodone).
MI.
Do not confuse
morphine (non-
concentrated
oral liquid) with
morphine
(concentrated
oral liquid).
High Alert: Do
not confuse
morphine with
hydromorphone
–errors have
resulted in
death.
Administer 2.5–15
mg over 5 min.
Rapid
administration
may lead to
increased
respiratory
depression,
hypotension, and
circulatory
collapse.
Explain to patient
and family how
and when to
administer
morphine and how
to care for infusion
equipment
properly. Pedi: Te
ach parents or
caregivers how to
accurately
measure liquid
medication and to
use only the
measuring device
dispensed with the
medication
Generic Name: . .
Brand Name:
Class:
Generic Name: Alone or Contraindicated in: CNS: dizziness, fatigue, . Concurrent use Assess patient for
. Angiotensin- headache, insomnia
with other Hypersensitivity with sacubitril ↑ risk of signs of
Captopril converting Resp: cough angioedema
Brand Name: enzyme (ACE) agents in History of CV: hypotension, chest pain, angioedema; concurrent (swelling of face,
inhibitors block palpitations, tachycardia extremities, eyes,
Capoten the angioedema with use contraindicated; do
the conversion GI: taste disturbances, lips, tongue,
of angiotensin manageme previous use of ACE abdominal pain, anorexia, not administer within 36
Class: difficulty in
I to the nt of inhibitors constipation, diarrhea, hr of switching swallowing or
antihypertensive vasoconstricto hypertensio Concurrent use with nausea, vomiting to/from sacubitril/valsart breathing); may
s r angiotensin n. aliskiren in patients GU: proteinuria, impaired an. occur at any time
II. ACE renal function
inhibitors also
Manageme with diabetes or Derm: ANGIOEDEMA, rash, Excessive hypotension during therapy.
ace inhibitors
prevent the nt of heart moderate-to-severe pruritis may occur with Discontinue
degradation of failure. renal impairment F and E: hyperkalemia concurrent use medication and
bradykinin and Hemat: AGRANULOCYTOSI provide supportive
Reduction (CCr <60 mL/min); of diuretics.
other S, neutropenia care.
of risk of Concurrent use with Additive hypotension with
vasodilatory Misc: fever
prostaglandins death, heart sacubitril/valsartan; other antihypertensives. Monitor CBC with
. ACE failure- must be a 36–hr ↑ risk of hyperkalemia differential prior to
inhibitors also initiation of therapy,
related washout period after with concurrent use
↑ plasma renin every 2 wk for the
hospitalizati switching to/from ofpotassium
levels and ↓ first 3 mo, and
aldosterone ons, and sacubitril/valsartan; supplements, potassiu periodically for up
levels. Net developme OB: Can cause injury m-sparing diuretics, to 1 yr in patients at
result is nt of overt or death of fetus – if or potassium-containing risk for neutropenia
systemic heart failure pregnancy occurs, salt substitutes. (patients with renal
vasodilation. impairment, or
Therapeutic following discontinue ↑ risk of hyperkalemia,
collagen-vascular
Effect(s): myocardial immediately renal dysfunction,
disease) or at first
Lowering of infarction. Lactation: Discontinu hypotension, and sign of infection.
BP in Treatment e drug or use syncope with concurrent Discontinue
patients of diabetic formula. use of angiotensin II therapy if
with nephropath receptor neutrophil count is
hypertensio y in patients blockers or aliskiren; <1000/mm3.
n. with Type 1 avoid concurrent use with Do not confuse
Improved diabetes aliskiren in patients with captopril with
survival mellitus and diabetes or CCr <60 carvedilol.
and retinopathy. mL/min; avoid concurrent Instruct patient to
reduced use with angiotensin II notify health care
professional if
symptoms receptor blockers.
immediately rash;
in patients NSAIDs and mouth sores; sore
with heart selective COX-2 throat; fever;
failure. inhibitors may blunt the swelling of hands
Improved antihypertensive effect or feet; irregular
survival and ↑ the risk of renal heart beat; chest
and dysfunction. pain; dry cough;
hoarseness;
reduced ↑ levels and may ↑ the
swelling of face,
developme risk of lithium toxicity. eyes, lips, or
nt of overt ↑ risk of angioedema tongue; difficulty
heart with temsirolimus, siroli swallowing or
failure after mus, or everolimus. breathing occurs;
myocardial Drug-Natural Products: or if taste
infarction. impairment or skin
Avoid natural licorice
rash persists
Decreased (causes sodium and water
progression retention and increases
potassium loss).
of diabetic
Drug-Food:
nephropath
y with Food significantly ↓
absorption. Administer
decreased
captopril 1 hr before meals.
need for
transplantat
ion or
dialysis.
DRUG NAME ACTION INDICATIONS CONTRAINDICATION ADVERSE INTERACTIONS NURSING
REACTION IMPLEMENTATION
Generic Name: Maintain acid- low potassium Contraindicated in: CNS: confusion, Drug-Drug: Use with asess for signs and
base balance, (hypokalemia) Hyperkalemia; Severe restlessness, potassium-sparing symptoms of
Potassium Chloride Increase effect
isotonicity, and renal impairment; weakness. CV: diuretics or hypokalemia
Brand Name: electrophysiologic of another Untreated Addison’s ARRHYTHMIAS, ACEinhibitors or (weakness, fatigue, U
balance of the treatment disease; Some ECG changes. GI: angiotensin II wave on ECG,
Neo-K cell. Activator in General health products may contain abdominal pain, receptor antagonists arrhythmias, polyuria,
Potassium Sandoz many enzymatic
stiffness/spasticity
tartrazine (FDC yellow diarrhea, flatulence, may lead to polydipsia) and
reactions; dye #5) or alcohol; nausea, hyperkalemia. hyperkalemia
Treat side
essential to vomitingtablets, Anticholinergics
Class: effects of another avoid using in patients Administer with or after
transmission of capsules only, GI mayqGI mucosal
treatment with known meals to decrease GI
mineral and electrolyte nerve impulses; ulceration, stenotic lesions in patients
hypersensitivity or irritation.
replacements/supplements contraction of intolerance;
lesions.Neuro: taking wax-matrix
cardiac, skeletal, paralysis, potassium chloride Explain to patient
Hyperkalemic familial
and smooth paresthesia. preparations. purpose of the
periodic paralysis. Use
muscle; gastric Interactions Drug- medication and the
Cautiously in: Cardiac
secretion; renal Drug: Use with need to take as
disease; Renal
function; tissue potassium-sparing directed, especially
impairment; Diabetes
synthesis; and diuretics or when concurrent
mellitus (liquids may
carbohydrate ACEinhibitors or digoxin or diuretics are
contain sugar);
metabolism. angiotensin II taken. A missed dose
Hypomagnesemia
Therapeutic receptor antagonists should be taken as
(may make correction
Effects: may lead to soon as remembered
of hypokalemia more
Replacement. hyperkalemia. within 2 hr; if not,
difficult); GI
Prevention of Anticholinergics return to regular dose
hypomotility including
deficiency mayqGI mucosal schedule. Do not
dysphagia or
lesions in patients double dose.
esophageal
taking wax-matrix
compression from left Emphasize the
potassium chloride
atrial enlargement importance of regular
preparations.
(tablets, capsules); follow-up exams to
Route/Dosage
Patients receiving monitor serum levels
Expressed as mEq
potassium-sparing
drugs. of potassium. and progress.
Potassium
bicarbonate contains
10 mEq potassium/
g; potassium chloride
contains 13.4 mEq
potassium/g. Normal
Daily Requirements
PO (Adults): 40– 80
mEq/day. PO
(Children): 2– 3
mEq/kg/day. PO
(Neonates): 2– 6
mEq/kg/day.
Prevention of
hypokalemia during
Diuretic Therapy PO
(Adults): 20– 40
mEq/day in 1– 2
divided doses; single
dose should not
exceed 20 mEq. PO
(Neonates , Infants
and Children): 1– 2
mEq/kg/day in 1– 2
divided doses.
Treatment of
Hypokalemia PO
(Adults): 40– 100
mEq/day in divided
doses. PO
(Neonates , Infants
and Children): 2– 5
mEq/kg/day in
divided doses
Generic Name: . Trimetazidine Trimetazidine Parkinson's disease, Dizziness, headache, Use with extreme Instruct patient to take
inhibits β- is used in parkinsonian symptoms, abdominal pain, caution in patients Trimetazidine with food
Trimetazidine
oxidation of combination tremors, restless leg dyspepsia, diarrhoea, and do not take in larger
receiving MAO
fatty acids with other syndrome and other nausea, vomiting, amounts than
through drugs for the movement related pruritus, rash, urticaria, inhibitors within 14 advised/prescribed.
Brand Name: inhibition of symptomatic disorders. Severe renal asthenia. Rarely, days prior (may result in Advised patient to report
long-chain 3- treatment of impairment (CrCl <30 tachycardia, palpitations, unpredictable, severe any undesirable side
Metacart
ketoacyl-CoA stable angina mL/min). Lactation. extrasystoles, orthostatic reactions–↓ initial dose effects.
Trimet thiolase, which pectoris, chest hypotension, arterial of morphine to 25% of Ensure that the treatment
enhances pain caused by hypotension, flushing. usual dose).
Class: course is completed.
glucose decreased
Anti-Anginal Drugs oxidation. It oxygen supply Instruct patient to not stop
ensures proper due to reduced the use of this medicine
functioning of blood flow to without consulting her
ionic pumps the heart. This doctor.
and medicine is
transmembrane used when
Na-K flow by patients do not
preventing respond
decrease in adequately to
intracellular other agents or
ATP levels. are intolerant
to first line anti-
anginal agents.
DRUG ACTION INDICATI CONTRAINDICA ADVERSE REACTION INTERACTIONS NURSING
NAME ONS TION IMPLEMENTATION
Generic Inhibit Edema Contraindicated CNS: blurred vision, dizziness, . ↑ risk of hypotension Assess patient for skin
Name: in: headache, vertigo
s the due to with antihypertensives, nitrates, or rash frequently during
Hypersensitivit EENT: hearing loss, tinnitus therapy. Discontinue
Furosem reabs heart CV: hypotension acute ingestion of alcohol.
y; furosemide at first sign of
ide orptio failure, GI: anorexia, constipation, diarrhea, ↑ risk of hypokalemia with rash; may be life-
Cross- dry mouth, dyspepsia, ↑ liver
Brand n of hepatic other diuretics, amphotericin threatening. Stevens-
sensitivity with enzymes, nausea, pancreatitis,
Name: sodiu impairm B, stimulant laxatives, Johnson syndrome, toxic
thiazides and vomiting
m ent, or GU: ↑ BUN, excessive urination, and corticosteroids. epidermal necrolysis, or
Lasix sulfonamides erythema multiforme may
and renal nephrocalcinosis Hypokalemia may ↑ risk
may occur; develop. Treat
Class: chlori disease. Derm: ERYTHEMA of digoxin toxicity and ↑ risk of
Hepatic coma MULTIFORME, STEVENS- symptomatically; may
de Hyperte arrhythmia in patients taking drugs
Loop or anuria; JOHNSON SYNDROME, TOXIC recur once treatment is
diuretics from nsion. EPIDERMAL NECROLYSIS, that prolong the QT interval. stopped.
Some liquid
the photosensitivity, pruritis, rash, ↓ lithium excretion, may
products may urticaria Do not confuse Lasix
loop cause lithium toxicity.
contain Endo: hypercholesterolemia,
of ↑ risk of ototoxicity with Luvox.
alcohol, avoid hyperglycemia, hypertriglyceridemia, o If administering
Henle with aminoglycosides or cisplatin.
in patients hyperuricemia
and F and ↑ risk of nephrotoxicity twice daily, give last
with alcohol dose no later than
distal E: dehydration, hypocalcemia, hypoc with cisplatin.
intolerance. hloremia, hypokalemia, hypomagnes
renal NSAIDS ↓ effects of furosemide. 5 PM to minimize
Use Cautiously emia, hyponatremia, hypovolemia, m
tubule in: May ↑ risk of methotrexate toxicity. disruption of sleep
etabolic alkalosis
. Severe liver Hemat: APLASTIC ↓ effects of furosemide when given cycle.
Incre ANEMIA, AGRANULOCYTOSIS, at same time o IV route is preferred
disease (may
ases hemolytic anemia, leukopenia, as sucralfate, cholestyramine, over IM route for
precipitate
renal thrombocytopenia or colestipol. parenteral
hepatic coma; MS: muscle cramps
excret concurrent ↑ risk of salicylate toxicity (with use administration.
Neuro: paresthesia
ion of Misc: fever of high-dose salicylate therapy). PO: May be taken with
use with
water, potassium- Concurrent use food or milk to
sodiu sparing with cyclosporine may ↑ risk of minimize gastric
m, diuretics may gouty arthritis. irritation. Tablets may
chlori be necessary); be crushed if patient
de, Electrolyte has difficulty
magn depletion; swallowing
esium Diabetes Advise patient to contact
, mellitus; health care professional
immediately if rash,
potas Hypoproteine
muscle weakness,
sium, mia (↑ risk of cramps, nausea,
and ototoxicity); dizziness, numbness, or
calciu Severe renal tingling of extremities
m. impairment (↑ occurs.
Effect risk of
ivene ototoxicity);
ss
persis
ts in
impair
ed
renal
functi
on.
Therape
utic
Effect(s)
:
Diure
sis
and
subse
quent
mobili
zation
of
exces
s fluid
(ede
ma,
pleur
al
effusi
ons).
Decre
ased
BP.
Generic Name: . It suppresses Treatment in Known hypersensitivity Adults: Most common . Atazanavir and Give medication before
stomach acid adults of to any component of adverse reactions in nelfinavir: PRILOSEC meals, preferably in the
omeprazole
secretion by specific duodenal ulcer the formulation or adults (incidence ≥ reduces plasma levels morning for once-daily
Brand Name: inhibition of the H+/K+- (1.1) and gastric substituted 2%) are • Headache, of atazanavir and dosing. If necessary,
ATPase system found ulcer (1.2) • benzimidazoles abdominal pain, nelfinavir. also give an antacid, as
PRILOSEC
at the secretory Treatment in (angioedema and nausea, diarrhea, Concomitant use is prescribed.
Class: surface of gastric adults and anaphylaxis have vomiting, and not recommended
If needed, open capsule
parietal cells. ... The children of occurred) flatulence (6) Pediatric (7.1) • Saquinavir:
proton pump and sprinkle the
inhibitory effect gastroesophageal patients (1 to 16 years PRILOSEC increases
inhibitor of omeprazole occurs granules on applesauce
reflux disease of age): Safety profile plasma levels of
or yogurt or mix with
within 1 hour after oral (GERD) (1.3) and similar to that in saquinavir. Monitor for
water or acidic fruit
administration. maintenance of adults, except that toxicity and consider
juice, such as apple or
healing of erosive respiratory system dose reduction of
cranberry juice. Give
esophagitis events and fever were saquinavir (7.1) • May
immediately.
the most frequently interfere with drugs for
•To give drug via NG
reported reactions in which gastric pH
tube, mix granules in
pediatric studies affects bioavailability
acidic juice because
(e.g., ketoconazole,
enteric coating dissolves
iron salts, ampicillin
in alkaline pH.
esters, and digoxin).
•Because drug can
Patients treated with
interfere with
PRILOSEC and
absorption of vitamin
digoxin may need to
B12, monitor for anemia.
be monitored for
•Be aware that long-
increases in digoxin
term use of medication
toxicity (7.2) • Co-
may increase the risk of
administration of
gastric carcinoma.
clopidogrel with 80 mg
omeprazole may
reduce the
pharmacological
activity of clopidogrel if
given concomitantly or
if given 12 hours apart
(7) • Cilostazol:
PRILOSEC increases
systemic exposure of
cilostazol and one of
its active metabolites.
Consider dose
reduction of
cilostazol.(7.3) • Drugs
metabolized by
cytochrome P450
(e.g., diazepam,
warfarin, phenytoin,
cyclosporine,
disulfiram,
benzodiazepines):
PRILOSEC can
prolong their
elimination. Monitor
and determine need
for dose adjustments
(7.3) • Patients treated
with proton pump
inhibitors and warfarin
may need to be
monitored for
increases in INR and
prothrombin time (7.3)
• Combined inhibitor of
CYP 2C19 and 3A4
(e.g. voriconazole)
may raise omeprazole
levels (7.3) •
Tacrolimus:
PRILOSEC may
increase serum levels
of tacrolimus (7.4) •
Methotrexate:
PRILOSEC may
increase serum levels
of methotrexate
Ge . Manag Contraindicated in: Hypersensitivity; Anuria; Acute renal insufficiency; Significant renal impairment (CCr CNS: . Drug- Asses
neri Caus ement dizzin Drug: Use s
c es of 30 mL/min); SCr 2.5 m g/dL (for patients with heart failure); Hyperkalemia; Addison’s disease; Concurrent use ess, with patient
Na loss primar of eplerenone. clumsi eplerenon for
me: of y ness, eqrisk of skin
sodiu hypera heada hyperkale rash
Spir
m ldoster che, mia; freque
olac
bicar onism. sedati concurren ntly
ton
bona Manag on. t use during
e
te ement CV: contraindi therap
Bra and of arrhyt cated. q y.
nd calci edema hmias. hypotensi Discon
Na um associ GI: GI on with tinue
me: while ated irritatio acute diureti
savin with n. GU: ingestion c at
Ald g HF, erectil of alcohol, first
acto potas cirrhos e other sign of
ne sium is and dysfun antihypert rash;
Cla and nephr ction, ensive may
hydr otic dysuri agents, or be life-
ss: ogen syndro a. nitrates. threat
ions me. Endo: Use with ening.
diur
by Manag ameno ACE Steve
etic
anta ement rrhea, inhibitors, ns-
s,
goniz of gynec NSAIDs, Johns
pot
ing essent omasti potassium on
assi
aldos ial a (in suppleme syndro
um-
teron hypert males) nts, me or
spa
e. ension , angiotensi toxic
ring
Ther . breast n II epider
diur
apeu Treat tender receptor mal
etic
tic ment ness, antagonist necrol
s
Effec of deepe s, ysis
ts: hypok ning of potassium may
Incre alemia voice, -sparing develo
ased (count qhair diuretics, p.
survi eracts growth angiotensi Treat
val in potass (in n sympt
patie ium female converting omatic
nts loss s), enzyme ally;
with cause sexual inhibitors, may
sever d by dysfun or recur
e other ction. cyclospori once
heart diureti F and neqrisk of treatm
failur cs). E: hyperkale ent is
e hyperk mia.plithiu stoppe
(New alemia m d.
York , excretion.
PO:
Heart hypon Antihypert
Admini
Asso atremi ensive
ster in
ciatio a, and
AMto
n hyperc diuretic
avoid
class hlorem effectiven
interru
II-IV). ic ess may
Wea metab bepby pting
k olic NSAIDs. sleep
diure acidos Mayqthe patter
tic is. effects of n. ●
and Hemat digoxin.ph Admini
antih : ypoprothr ster
ypert agran ombinemi with
ensiv ulocyt c effect food
e osis, oforal or milk
resp throm anticoagul to
onse bocyto ants. minimi
when penia. Cholestyr ze
comp Derm: aminemay gastric
ared DRUG qrisk of irritatio
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Generic Name: . Increases Treatment of Contraindicated in: . Drug-Drug: Should not be Assess patient for
water content chronic Patients on low- used with other laxatives in abdominal distention,
Lactulose GI: belching, cramps,
and softens constipation. galactose diets. Use the treatment of hepatic presence of bowel
distention, flatulence,
Brand Name: the stool. Adjunct in the Cautiously in: Diabetes encephalopathy (leads to sounds, and normal
diarrhea. Endo:
Lowers the pH management of mellitus; Excessive or inability to determine pattern of bowel function.
Cholac, Constilac, hyperglycemia (diabetic
of the colon, portal-systemic prolonged use (may optimal dose of lactulose). ● Assess color,
Constulose, patients).
which inhibits (hepatic) lead to Anti- consistency, and amount
Enulose, the diffusion of encephalopathy dependence);OB, infectivesmaypeffectiveness of stool produced
Generlac, ammonia from (PSE). Lactation:Safety not in treatment of hepatic
Kristalose PO:Mix with fruit juice,
the colon into established. encephalopathy.
water, milk, or
Class: the blood,
carbonated citrus
thereby
: laxatives beverage to improve
reducing blood
Pharmacologic: flavor. Administer with a
ammonia
osmotics full glass (240 mL) of
levels.
water or juice. May be
Therapeutic
administered on an
Effects: Relief
empty stomach for more
of
rapid results.
constipation.
Decreased Encourage patients to
blood use other forms of bowel
ammonia regulation, such as
levels with increasing bulk in the
improved diet, increasing fluid
mental status intake, and increasing
in PSE. mobility. Normal bowel
habits are individualized
and may vary from 3
times/day to 3 times/wk.
● Caution patients that
this medication may
cause belching,
flatulence, or abdominal
cramping. Health care
professional should be
notified if this becomes
bothersome or if diarrhea
occurs
Generic Name: . .
Brand Name:
Class:
DRUG NAME ACTION INDICATIONS CONTRAINDICATION ADVERSE REACTION INTERACTIONS NURSING
IMPLEMENTATION
Generic Name: . .
Brand Name:
Class:
DRUG NAME ACTION INDICATIONS CONTRAINDICATION ADVERSE REACTION INTERACTIONS NURSING
IMPLEMENTATION
Generic Name: . .
Brand Name:
Class:
DRUG NAME ACTION INDICATIONS CONTRAINDICATION ADVERSE REACTION INTERACTIONS NURSING
IMPLEMENTATION
Generic Name: . .
Brand Name:
Class:
DRUG NAME ACTION INDICATIONS CONTRAINDICATION ADVERSE REACTION INTERACTIONS NURSING
IMPLEMENTATION
Generic Name: . .
Brand Name:
Class: