Charcot Marie Tooth

Charcot Marie Tooth is a peripheral nerves disease that control muscles. It is a group of genetically
heterogeneous disorders which affect the motor and peripheral sensory nerves, resulting in muscle
weakness and atrophy in addition to sensory loss. Distal legs followed by hands are some of the
first locations which exhibit such manifestations. The nerve cells in these individuals are unable
to send electrical signals accurately because of abnormalities in the nerve axon or the insulation
(myelin) around the axon.

Charcot Marie Tooth Market Outlook

The therapeutic Charcot Marie Tooth market in the seven major markets is expected to change for
the forecast period 2019-2028. It has been approximated, the United States had the largest Charcot
Marie Tooth market size in 2017, which accounts for approximately 47% of the total market,
whereas, Spain accounted for the least Charcot Marie Tooth market share (8.62%) among the
7MM countries.

Charcot Marie Tooth treatment

Due to the dearth of approved therapeutic regimens for Charcot Marie Tooth management involves
a multidisciplinary approach consisting of supportive management such as occupational therapies,
physiotherapy, ankle-foot orthoses (AFO), and shoe inserts. Foot surgery for correction of foot
deformities remains an option of last resort in approximately 30% of the total number of diagnosed
cases.

Pharmacotherapies mainly comprise of pain killers which help reduce either joint or muscle pain
or neuropathic pain (caused by damage to the nerves).
The great efforts and investments on the studies of Charcot Marie Tooth have made the
development of new therapies an achievable goal shortly. To add to that, the implementation of
treatment protocols combining different approaches will form a more significant challenge to face
to improve patient management further.
Orthopaedic surgery is frequently required for Charcot Marie Tooth patients to correct severe foot
deformities. The goals of surgical intervention for Charcot Marie Tooth patients are to obtain a
plantigrade foot and to correct the bony deformities and muscle imbalance. The indication for
surgery is usually determined by the failure of conservative measures, such as physical therapy
and the use of orthoses, which are first‐line treatments for foot deformities.

Charcot Marie Tooth Market size

The Charcot Marie Tooth market size of the currently available off-label therapies for the Charcot
Marie Tooth treatment is expected to experience steady growth throughout the study period [2017-
2028], owing to the lack of any significant curative Charcot Marie Tooth treatment options.
However, the Charcot Marie Tooth emerging therapies targeted to reduce the symptoms are
expected to fuel the growth of the Charcot Marie Tooth market.
Currently, some promising research is ongoing that may provide new ways of treating people with
Charcot Marie Tooth.
Some of the key players in the therapeutic Charcot Marie Tooth market are Pharnext, Acceleron,
MedDay Pharmaceuticals, and others.