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Abstract
Surprisingly, there does not appear to be a comprehensive source of information relating to
methamphetamine. While no list is ever complete, this one attempts to answer technical
questions related to the chemical methamphetamine. Unfortunately, there tends to be a great deal
of street lore that is blatantly wrong about methamphetamine and similar compounds. This
document also attempts to point out some of the more common myths, and provide rational
explanations.
Disclaimer
Do not use this information. I am not a chemist. This is for informational purposes only. Use of this
information for illegal purposes is not condoned. The author makes no warranty, expressed or implied, of the
suitability of this information for any particular purpose. The author does not endorse the abuse of any drugs,
legal or otherwise.
This is a preliminary document and should be considered fictitious until proven otherwise.
Overview
Methamphetamine (also known as speed, meth, crystal, crank, and sometimes confusingly called ice) is a
chemical widely known for its stimulant properties on the human body. It is frequently confused with other
drugs that share similar symptoms, including amphetamine, 4-methyl-aminorex, ephedrine, caffeine, and
other chemicals, both legal and illegal.
Terminology
In this document, we shall refer to the drugs by their common chemical names, rather than by "street names",
since the street names do not have a one-to-one correspondence to actual chemicals. For example, the term
"speed" can mean methamphetamine or amphetamine. The term "ice" is generally considered to apply to
4-methyl-aminorex, but is often used to refer to relatively pure (and in some cases, not so pure) forms of
methamphetamine.
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We shall use the term "methamphetamine" to refer to the substance in either its free base (i.e. simple,
unadorned) or salt (usually hydrochloride) form. When precision is needed, we shall explicitly state one form
or the other.
Pharmacology
This is one of the most difficult sections to write, partially because there is very little "science" involved. The
literature gives conflicting reports, due to the fact that many criterion are subjective, and probably also due to
confusion over terminology.
The pharmacological effects of methamphetamine are very similar to those of similarly structured molecules.
Administration
Methamphetamine can be taken orally, snorted, smoked or injected, in approximately increasing order of
immediacy of onset.
Onset
Onset can be immediate (in the case of injection), or can take as long as 30-40 minutes if ingested orally.
Duration
Duration is subjective, but is probably on the order of 4 - 8 hours. Delayed absorption (for example, due to
oral ingestion) can prolong the effects relative to time of administration. Of course, larger doses last longer
due to the fact that it is removed from the blood at a finite rate.
Plasma Life
The length of time that methamphetamine will stay in the plasma (blood) is between 4 to 6 hours. It can be
detected in the urine one hour after use and up to 48 hours after use.
Dosage
A toxic reaction (or overdose) can occur at relatively low levels, 50 milligrams of pure drug for a
non-tolerant user. Different peoples' metabolisms work at different rates, and drug strengths vary, so there is
no way of stating a "safe" or "unsafe" level of use.
Effects
These include euphoria, hyperexcitability, extreme nervousness, accelerated heartbeat, sweating, dizziness,
restlessness, insomnia, tooth grinding, incessant talking, and other effects.
Methamphetamine and other CNS stimulants have strong bronchodilation effects. Vasoconstriction
(tightening of blood vessels) and pupil dilation are also common. Elevated blood pressure, heart rate, and
other general symptoms of increased sympathetic nervous activity.
The physical effects are almost assuredly due to interactions between the amphetamine structure and human
physiology, probably due to the similarity to adrenaline (epinephrine).
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Mental capacity is not diminished directly by the drug. In fact, some studies have shown slight increases in
mental capacity on simple tasks. It has been prescribed for attention deficit disorder, among other things.
Confusing reports here tend to center around the effects of fatigue on mental capacity.
Emotional responses may range from euphoria to anger and paranoia. Preliminary doses tend to produce the
former, while continued use (e.g. for three or more days) tends to produce the latter.
It appears that these feelings may be linked to the neurotransmitters dopamine and/or serotonin, although I
have not seen a good reference on this yet.
Chemistry
This is the easiest section to write, and the most fun, since I can be relatively sure of the facts.
Molecular Information
Naming
Previous name:
d-N,alpha-dimethylphenethylamine
Alternate Names:
d-N-methylamphetamine
d-deoxyephedrine (e.g. right-handed ephedrine, minus an oxygen)
d-desoxyephedrine
1-phenyl-2-methylaminopropane
d-phenylisopropylmethane
methyl-beta-phenylisopropylamine
Trademarks:
Norodin
Methamphetamine Hydrochloride:
What we mean by hydrochloride is that it has formed a "salt". The basic structure is unchanged, but an HCl
molecule has become attracted to the free base. In this case, the hydrogen from the HCl has become attracted
to the nitrogen in the free base.
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You will notice that the salt form is much more common. This is for physiological reasons. The same
reaction which attracts the free base to HCl could also attract it to other molecules, causing irritation and
other symptoms.
Trademarks:
Amphedroxyn
Desfedrin
Methedrine
(many others)
Structure
Formula
Hill Convention:
C10H15N
Molecular Weight
149.24
Percent Composition
Melting Point
170-175 degrees C
Chirality
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Discuss other opinions (some say chirality does not matter, etc.)
Synthesis
Industrial Methods
(add references)
Field Methods
General
Assuming you don't have amphetamine lying around, an easy synthesis with a very high yield is
to reduce the condensation product of phenylacetone and methylamine. The benefit of this
method is that different amines can be used to produce novel N-alkyl amphetamines
(ethamphetamine, tert-butylamphetamine, etc.)
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metal as a catalyst. The product of this step is N-methylamphetamine and HCl. Evaporate off the
water and you have methamphetamine hydrochloride.
Hydrogenation starting with (-) ephedrine, whether direct or via the halide, will give d-meth. If
you start with dl-ephedrine, you get dl-meth.
In some reductions, the need for HI is dispensed with just by mixing red phosphorus and iodine
crystals in a water solution. The red phosphorus then goes on to make HI by the above
mentioned process. With a small amount of due care, this is an excellent alternative to either
purchasing, stealing, or making your own pure hydroiodic acid.
This method has the advantage of being easy to do. It was formerly the most popular method of
making meth from ephedrine. Now red phosphorus is on the California list of less restricted
chemicals, so an increased level of subterfuge is called for to obtain significant amounts. One
might think that this is easily gotten around by making your own red phosphorus, but this is a
process I would not want to undertake. Ever hear of phosphorus shells? I would much rather face
the danger of exploding champagne bottles. Those who insist on finding out for themselves, will
see Journal of the American Chemical Society, volume 68, page 2305. As I recall, the Poor
Man's James Bond also has a formula for making red phosphorus. Those with a knack for
scrounging from industrial sources will profit from knowing that red phosphorus is used in large
quantities in the fireworks and matchmaking industries. The striking pad on books of matches is
about 50% red phosphorus.
The determined experimenter could obtain a pile of red phosphorus by scraping off the striking
pads of matchbooks with a sharp knife. A typical composition of the striking pad is about 40%
red phosphorus, along with about 30% antimony sulfide, and lesser amounts of glue, iron oxide,
MnO2, and glass powder. I don't think these contaminants will seriously interfere with the
reaction. Naturally, it is a tedious process to get large amounts of red phosphorus by scraping the
striking pads off matchbooks.
Another problem with this method is that it can produce a pretty crude product if some simple
precautions are not followed. From checking out typical samples of street meth, it seems basic
precautions are routinely ignored. I believe that the by-products in the garbage meth are
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iodoephedrine, and the previously mentioned azirine. If a careful fractional distillation is done,
these products can be removed. They can be avoided in the first place if, when making
hydroiodic acid from iodine and red phosphorus, the acid is prepared first, and allowed to come
to complete reaction for 20 minutes before adding the ephedrine to it. This will be a hassle for
some, because the obvious procedure to follow is to use the water extract of the ephedrine pills
to make the HI in. The way around the roadblock here is to just boil off some more of the water
from the ephedrine pill extract, and make the acid mixture in fresh pure water. Since the
production of HI from iodine and red phosphorus gives off a good deal of heat, it is wise to chill
the mixture in ice, and slowly add the iodine crystals to the red phosphorus-water mixture.
To do the reaction, a 1000 ml round bottom flask is filled with 150 grams of ephedrine
hydrochloride (or PPA-HCl). The use of the sulfate salt is unacceptable because HI reduces the
sulfate ion, so this interferes with the reaction. Also added to the flask are 40 grams of red
phosphorus and 340 ml of 47% hydroiodic acid. This same acid and red phosphorus mixture can
be prepared from adding 150 grams of iodine crystals to 150 grams of red phosphorus in 300 ml
of water. This should produce the strong hydroiodic acid solution needed. Exactly how strong
the acid needs to be, I can't say . I can tell you that experiments have shown that one molar HI is
ineffective at reducing ephedrine to meth. The 47% acid mentioned above is a little over 3.5
molar. I would think that so long as one is over 3 molar acid, the reaction will work.
With the ingredients mixed together in the flask, a condenser is attached to the flask, and the
mixture is boiled for one day. This length of time is needed for best yields and highest octane
numbers on the product. While it is cooking, the mixture is quite red and messy looking from the
red phosphorus floating around in it.
When one day of boiling under reflux is up, the flask is allowed to cool, then it is diluted with an
equal volume of water. Next, the red phosphorus is filtered out. A series of doubled up coffee
filters will work to get out all the red phosphorus, but real filter paper is better. The filtered
solution should look a golden color. A red color may indicate that all the phosphorus is not yet
out. If so, it is filtered again. The filtered-out phosphorus can be saved for use in the next batch.
If filtering does not remove the red color, there may be iodine floating around the solution. It can
be removed by adding a few dashes of sodium bisulfate or sodium thiosulfate.
The next step in processing the batch is to neutralize the acid. A strong lye solution is mixed up
and added to the batch with shaking until the batch is strongly basic. This brings the meth out as
liquid free base floating on top of the water. The strongly basic solution is shaken vigorously to
ensure that all the meth has been converted to the free base.
With free base meth now obtained, the next step, as usual, is to form the crystalline
hydrochloride salt of meth. To do this, a few hundred mls of toluene is added to the batch, and
the meth free base extracted out as usual. If the chemist's cooking has been careful, the color of
the toluene extract will be clear to pale yellow. If this is the case, the product is sufficiently pure
to make nice white crystals just by bubbling dry HCl gas through the toluene extract as described
in Chapter 5. If the toluene extract is darker colored, a distillation is called for to get pure meth
free base. The procedure for that is also described in Chapter 5. The yield of pure
methamphetamine hydrochloride should be from 100 to 110 grams.
Lithium-Ammonia Reduction
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Procedure:
All the chemicals were reagent grade, with no special treatment of the tetrahydrofuran (THF),
and the atmosphere above the condensed ammonia was not flushed with nitrogen gas.
A three-neck flask was cooled in a dry ice/acetone bath. A condenser was fitted in the center
neck, an additional funnel containing l-ephedrine base in THF was fitted into one side neck, and
a rubber stopper fitted with a glass tube extending to the bottom of the flask was fitted in the
third neck. Anhydrous ammonia gas was condensed and collected in the flask. Small pieces of
lithium metal were rinsed in petroleum ether, patted dry, and added to the condensed ammonia.
A deep royal blue color was noted as the lithium metal dissolved in the condensed ammonia.
The l-ephedrine was added drop wise to the lithium ammonia solution over a period of
approximately 10 minutes with stirring. When all of the l-ephedrine had been added, ammonium
chloride was added slowly to the solution. The flask was removed from the cooling bath, and the
condensed ammonia was allowed to warm to room temperature and evaporate from the flask
through the side necks.
When most of the ammonia had evaporated, water was added to the remaining solution until it
cleared and any remaining lithium metal was decomposed. The remaining solution was removed
from the flask to a separatory funnel, where the aqueous layer was discarded. The THF layer was
dried with magnesium sulfate, and the hydrochloride salt of the methamphetamine was made by
bubbling hydrogen chloride through the THF.
The same procedure was used, substituting phenylproponolamine and methylephedrine as the
starting materials. A second synthesis was conducted with l-ephedrine, using the same procedure
except that the reaction was not quenched with ammonium chloride.
Results:
The reaction was found to reduce l-ephedrine to d-methamphetamine quickly and easily .
Furthermore, it was found that the reaction converted phenylpropanolamine to amphetamine and
methylephedrine to dimethylamphetamine. The time required for the reaction to proceed from
the condensing of the ammonia gas in the reaction flask until the excess lithium was decomposed
was approximately one hour. The majority of this time was spent waiting for the condensed
ammonia to evaporate from the reaction flask.
It was also found that the ephedrine would reduce to methamphetamine without the addition of
ammonium chloride as a quenching agent.
This may be so (in fact I read the same article), but typically a water quench leads to the alcohol,
which is what we were trying to get rid of to start with. Also, if one were using Na rather than Li
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(Na is the Birch, I too forget the Li named reduction), adding water to quench will *definitely*
be exciting, particularly considering the flammability of THF or ether.
Apparently they were following the guys handwritten notes. It would have been even more
interesting had they used the real Birch method, using Na, especially when they tried the water
quench ;>)
Yep - apparently that would be the case. As well, any extra Li (or Na if doing the straight Birch
method) would convert to the Hydroxide, which might fuck the product up a bit.
I bet you they *did* do that the first time, and then, after they replaced that wing of the lab, they
decided not to "publish" those results ;-).
From Phenylalanine
A surprisingly simple synthesis is possible from the amino acid phenylalanine, which is available
at health food stores for about $14 for 100 tablets. Phenylalanine is 2-amino-3-phenylpropanoic
acid, which is more or less amphetamine with a COOH where the CH3 should be at the end of
the chain. Thionyl chloride will replace the OH with a Cl, which falls off and is replaced by H
when you give it lithium aluminum hydride, sodium borohydride, or hydrogen gas and
nickel/platinum. If you use hydrogen and metal for that step, you'll ha v e to reduce the carbonyl
group with one of the hydrides, so best save time + effort and use them and do both reductions at
once. When that carbonyl is reduced, you now have amphetamine. Go back up to that first one I
mentioned for upgrading amphetamine into methamphetamine.
Incomplete Syntheses
These are methods that are subjectively evaluated to be less useful, but still may serve as interesting lessons
in applied chemistry.
One of the easiest ways to make methamphetamine is from amphetamine. Of course, this
assumes you have amphetamine in the first place, but let's just pretend you have some and you
want to spice it up a bit. The difference between amphetamine and methamphetamine is the
addition of a single methyl group (CH3) to the amino group sticking off the middle carbon atom
in the chain. Fortunately, substituting amines is really simple. Vaporize your amine (your
amphetamine) with a bunch of vaporized chloromethane (CH3Cl, a solvent) and some gaseous
pyridine... voila, the amino group takes the methyl from the chloromethane and lets a hydrogen
go. The hydrogen joins the liberated chlorine, and the resulting HCl is soaked up by the pyridine.
The pyridine is optional. Adding it drives the reaction a bit by pulling the excess HCl out of the
equation, but it's not necessary.
Methylamine
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This last question is solved be reference to a principle called the law of mass action. An excess
of methylamine will inhibit the secondary reactions.
Typically, a reductive amination done in a parr bomb or using sodium cyanoborohydride is done
with a five times molar excess of methylamine (or methylamine hydrochloride.)
Phenylacetone
Let me know how bromobenzene + acetone + NaOH turns out. I'm interested in this since I
haven't seen it anywhere else (unlike some people, I don't have the Abstracts in my closet :)
Make sure to use an EXCESS of acetone, because 1 its more readily available and 2 it will
prevent any diphenyl/triphenyl/xphenyl acetone from forming.
Hell, if your making straight amphetamine, you could even just go with acetone as the solvent
too, if you could come up with a good way to separate the 2-aminopropane you'd make with the
amphetamine. Given that this gunk has a bp of 33 or 34 degrees at standard pressure, it shouldn't
be too hard. Smells like ammonia though... maybe you should "catch" it in HCl water when you
distill.
As with any distillation there will be some left over. Never fear, 2aminopropane (or
"isopropylamine") is water MISCIBLE. Yes, the BASE form is miscible w/ H2O! Amphetamine
BASE is only "slightly" soluble in water, so if your really a purist you can dissolve your "mostly
amphetamine some 2aminopropane" in ether and backwash with water maybe ONCE. Then
precipitate the crystals with dry HCl or H2SO4?
Question is, how much ammonia and reducing agent are you willing to waste on making
2aminopropane?
Purification by Crystallization
For a purification by crystallization of any of the HCL salts of ephedrine and related illegals, I'd
suggest a two solvent system with methanol and methylethylketone. This tends to occlude a
slight amount of solvent so keep your crystal size small and grind and dry the result. Both these
solvents are easily available if you know where to look.
I wouldn't suggest ethanol or acetone as they tend to easily collect H2O; this can happen
unexpectedly and when it does, their solvency power will greatly increase, redissolving your
crystals. Be careful as methanol is toxic; don't get it on you or breathe the fumes.
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Related Chemistry
amphetamine
ephedrine
pseudoephedrine
phenylalanine
Street Knowledge
Very scientifically unsound, but interesting nonetheless.
Street Doses
An average wrap of speed contains less than 10% Amphetamines, (often as low as 2%) and over 90% of
adulterants.
Coloration
Methamphetamine in its pure hydrochloride salt form is colorless. However, products on the
market today are often not colorless. The following is a table of some common impurities and
the colors associated with them. Note: There is no doubt a segment of the dealers who will add
food coloring or some other such color to their drug to make it more appealing, with the
philosophy that a brightly-colored product may sell better than an off color product. This is
relatively uncommon however.
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RED: The product was made from pseudoephedrine, and the red coloring of the tablet was
not adequately washed away (it is difficult)
ORANGE: Ephedrine sulfate was used, and some of the sulfate was reduced to sulfur.
PURPLE: Iodine from a phosphorus-iodine reaction was not washed out.
GREEN: Copper (or other metallic) salts somehow made their way in to the mixture,
probably due to the reaction vessel used in the manufacture.
BROWN: Oxidized red coloring (see above), or tablating agent was present in the
reduction.
Sometimes "speed" is present as waxy rocks that almost seem wet, but do not dry out properly. I
am not sure what the cause of this is, but its most likely some form of oil, either formed in the
reaction or left over from a very poor solvent. It may or may not be harmless depending upon
what it is. This oil is often removed with acetone, but ethyl-ether would be better suited for this
as it dries faster.
Pure methamphetamine HCl melts at around 170c (338f ). The crystals can be carefully chopped
and mixed with sodium carbonate, and when the resulting powder is heated (and the
methamphetamine HCl melts) CO2 and methamphetamine base vapor is given off. This is
probably one of the more effective ways of smoking meth if you are careful, however the
hydrochloride salt is often the form smoked as the base form is often an oil and is difficult to
store, transport, and work with. Smoking the HCl form is OK if you don't mind a small quantity
of pyrolysed drug.
RESULT:
Same as water: DL-methamphetamine (or other inactive) Most likely made from P2P
(methamphetamine) or DLPA (phenylalanine). The DLPA-crank may in fact only be
dl-amphetamine. Might be 100% cut [read: nothing] also...
Same as Vicks: You've been ripped off ! -or- there's so much unchanged ephedrine as to
cancel the dextrorotary effects of the meth (l-ephedrine, when reduced, is dextrorotary (see
explanation elsewhere)
Worth Noting: Cathinone and Methcathinone, when dissolved in methanol, will become
racemic due to the nature of the molecule (keytone). I'm not sure what other conditions
cause this but I am aware that it happens easily, so methcathinone from the black market is
almost definitely racemic...
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It is advisable to become familiar with the many ways of synthesizing methcathinone from
(pseudo)ephedrine, as just such a procedure can be used on freshly produced methamphetamine
to verify that the (pseudo)ephedrine was in fact reduced.
The smell of basic methcathinone has been reported to resemble that of "pistachio ice cream".
Suffice to say that it is sweet, pleasant, and to a cat-head, nirvana. You should become familiar
with this as well, in order to be able to know if suspected methamphetamine is in fact actually
methcathinone.
Sometimes 'speed' is present as waxy rocks that almost seem wet, but do not dry out
properly. I am not sure what the cause of this is, but its most likely some form of oil,
either formed in the reaction or left over from a very poor solvent. It may or may not
be harmless depending upon what it is.
It is more than likely the "didesoxyephedrine" referred to by Emde, a product of the coupling of
two radicals of the reduced ephedrine or pseudoephedrine. It appears to some extent in almost all
syntheses relying on reduction and typically appears at the very end of the process of forming the
HCl salt by bubbling HCl through the mixture. And no, I haven't forgotten my promise to post
this paper. The scans just sucked when I tried to scan as text (5 pages magically became 10-15 of
scrambled text). I am currently trying gif type scans. The *oil* may be removed, as you stated,
by washing with ether. However, it will never dry out as completely one might suspect. Even
drying under heavy vacuum leads to only a temporary solution. Once it is exposed to air it
quickly becomes an oil again. Often this is a brown color as you stated for other by-products. As
far as the rest of the post, I find it very useful and agree with it completely.
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"Meth Oil" ??
"Speed Bumps"
Incorrect Syntheses
Phrack Magazine
Take a ball about the size of a lead pellet, and wrap it in tissue, and swallow, or you can put it in
capsules and use it. You can smoke it, mix it with vitamin B-12, and snort it like cocaine. You
can also sell it, for about $65-70.00 a gram, and don't forget to cut it. Remember, this is pure
stuff!!
Dilute Hydrochloric acid--> This may be purchased at the hardware store. It sold as a brick
and driveway cleaner. They call it muriatic acid.
Sodium Hydroxide--> This, you probably already have. It's called "lye" at most places; it's
drain cleaner.
Ethyl Ether--> You'll probably have to make this. Don't worry, it's a breez Just go to your
local K-mart or Auto parts store, and get a can of that "STARTING FLUID" it comes in a
spray can. It's used for cold weather starting of gasoline engines.
"VICKS" nasal inhalers--> USE ONLY VICKS!! No other kind will work that I know of.
These are at any drug store or grocery, etc.. You need 12 of em, but don't buy em' by the
dozen, unless its winter time, then you can just say yer from some nursing home, and
you're stockin up for the patients. Otherwise buy em' 2 at a time, if possible. Get a friend
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to help you. The druggists at the drug store usually will know what's goin on if you buy
quantity.
LIST OF EQUIPMENT
-==*(> N O T I C E <)*==-
PLEASE! DON'T SMOKE IN THE SAME ROOM WHEN YOU DO THIS. OPEN A
WINDOW IN THE ROOM IF POSSIBLE. FOLLOW THESE INSTRUCTIONS EXACTLY.
THIS RECIPE HAS BEEN TESTED AND THIS IS T BEST WAY TO DO IT. DON'T TAKE
SHORTCUTS, AND DON'T EVEN START TO DO THIS UNLESS YOU HAVE ABOUT 3
HOURS SPARE.
PREPARING ETHER!
Take one of the small bottles and spray starter fluid in it till it looks half-full. Then fill the rest of
the way with water, cap the bottle and shake for 5 minutes. Then, draw off the top layer with the
eyedropper, and throw away the water layer. Repeat this until you have about 3 oz. of ether. Put
the cap on it, and put it in the refrigerator if you can. (If you can't, don worry about it) You'll use
this in the procedure below.
1. Break open the inhalers, a pair of real sharp scissors does this good. Place the cottons that
were inside in a jar and close the lid. (Remember you use all 12 cottons.)
2. In the bowl, combine 1- 1/3 oz. water and 2/3 oz. muriatic acid. Shred cottons in this
solution, and knead for 5 minutes with hands. (ALWAYS BE SURE THERE'S CLEAN
RUBBER GLOVES on your hands.) You can do it bare-handed if you' got tough skin.
Squeeze all juice out of filters after you knead, and throw em away.
3. Filter the remaining liquid into the quart jar. It will be necessary to this several times to get
that awful smelling oil out. The chemicals in the inhalers have been bonded to the HCl,
and the oils have been filtered off. Throw the filters away.
4. Pour enough of the solution into a small bottle to fill it 1/3 full. Save any leftover juice for
the second batch.
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5. Pour 1/4 teaspoon of the lye crystals into the bottle and agitate. Do this carefully, as the
mixture will become hot, and give off a gas. Repeat this step until the mixture remains
cloudy.
6. Fill the bottle from step (5) up the rest of the way with ether. Cap the bottle, and agitate for
about 8 minutes. It is very important to expose ever molecule of the free-base to the ether
for as long as possible.
7. Let the mixture settle. There will be a middle layer that is very thick. Tap the side of the
bottle to get this layer as thin as possible.
8. Remove the top layer with the eyedropper, being careful not to get any of the middle layer
in it. Save the top layer, and throw the rest away.
9. Fill a bottle half-way with water, and about 10 drops of acid. Pour the top layer from step
(8) into the bottle, and cap it. Shake the bottle for 2 minutes. When it settles, remove the
top layer and throw it away. The free base has now been bonded to the HCl/water mixture.
10. If there is anything left from step (3), repeat the procedure with it.
11. Evaporate the solution in the Pyrex dish on low heat. You can do this o the stove, but I
have found that if you leave it on top of a hot-water heater (like the one that supplies hot
water to your house) for about 2-3 days, the remaining crystals will be Methamphetamine.
Some notes:
It is very easy to become delirious off the ether fumes, so be sure you are well ventilated, I mean
it!!!
Small, aspirin, or experiment bottles seem to work the best for smaller batches. The
measurements are not exact, so you don't have to be either.
In step 9, be sure you don't use too much water. Remember, this is the water you have to use to
evaporate.
==Phrack Inc.==
(WARNING!) This recipe is bogus! YOU WILL NOT HAVE METHAMPHETAMINE! You
have simple extracted pseudoephedrine! All this stuff will give you is engziety(sp?)...
There are better recipes out there but if you cant get your hands on sodium borohydride and a
reflux condenser then don't even mess with this recipe!
One, from Phrack magazine, is the "tried and true method" for prepping meth from Vick's nasal
inhalers. Vick's nasal inhalers contain "l-desoxyephedrine," another name for
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The procedure described would extract the l-meth from the inhalers and collect it and that's it.
I'm sorry, but the Isomer Fairy can't wave her magick wand and reverse the chirality of the
molecule. The only way to change between the two isomers is to oxidize the l-meth into
phenylacetone, condense it with methylamine, then reduce it. Sorry, but soaking inhalers in HCl
then separating the "juice" with Et2OH just won't do it. You'll get l-meth and that's that.
Dilute HCl - also called Muriatic acid - can be obtained from hardware stores, in the pool
section.
NaOH - also called lye - can be obtained from supermarkets in the "drain cleaner" section.
"Red Devil Lye" recommended.
Ethyl Ether - aka Diethyl Ether - Et-0-Et - can be obtained from engine starting fluid,
usually from a large supermarket. Look for one that says "high ethyl ether content", such
as Prestone.
Desoxyephedrine - can be obtained from "VICKS" nasal inhalers. These are found at any
drug store or grocery, etc. They contain 50mg of l-desoxyephedrin e per container. Also
known as methamphetamine. 6 containers will give 300mg of l-desoxyephedrine.
Distilled water - it's really cheap, so you have no reason to use the nasty stuff from the tap.
Do things right.
List of equipment
a glass eyedropper
three small glass bottles with lids (approx. 3 oz., but not important)
one should be marked at 1.5oz, use tape on the outside to mark it (you might want to
label it as ether)
one should be clear (and it can't be the marked one)
a Pyrex dish (the meatloaf one is suggested)
a glass quart jar
sharp scissors
clean rubber gloves
coffee filters
a measuring cup
measuring spoons
WARNINGS: Ethyl Ether is very flammable and is heavier than air. Do not use ethyl ether near
flame or non-sparkless motors. It is also an anaesthetic and can cause respiratory collapse if you
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Take the unmarked small bottle and spray starter fluid in it until it looks half-full. Then fill the
rest of the way with water, cap the bottle and shake for 5 minutes. Let it sit for a minute or two,
and tap the side to try and separate the clear upper layer. Then, draw off the top (ether) layer
with the eyedropper, and throw away the lower (water) and cloudy layer. Place the ether in the
marked container. Repeat this until you have about 1.5 oz. of ether. Put the cap on it, and put it
in the freezer if you can. Rinse the other bottle and let it stand.
Ethyl ether is very pungent. Even a small evaporated amount is quite noticeable.
Extracting l-desoxyephedrine
1. Break open the inhalers, a pair of real sharp scissors does this well. Place the cottons that
were inside in a bottle (the unmarked one) and close the lid. I use 6 cottons.
2. In the Pyrex dish, combine 2/3 oz. water and 1/3 oz. muriatic acid. Shred cottons in this
solution, and knead for 5 minutes with your gloves on. Squeeze all juice out of filters after
you knead, and discard them. This step bonds the HCl to the meth, forming the HCl salt
(what you want). The salt is soluble in water, and thus dissolves.
3. Filter the remaining liquid into the quart jar. It will be necessary to this several times to get
the awful smelling oils (check the packaging if you are interested in which ones). The
chemicals in the inhalers have been bonded to the HCl, and the oils have been filtered off.
Discard the filters and clean the Pyrex dish. Remember to wet the filters with distilled
water before you pour, otherwise you'll lose some product.
4. Pour enough of the solution into the clear bottle to fill it 1/3 full. Save any leftover juice
for the second batch.
5. Pour 1/8 teaspoon of the lye crystals into the bottle and agitate. Do this carefully, as the
mixture will become hot, and give off hydrogen gas and/or steam. H2 gas is explosive and
lighter than air; avoid any flames as usual. Repeat this step until the mixture remains
cloudy. This step neutralizes the HCl in the salt, leaving the insoluble free base
(l-desoxyephedrin e) again. Why do we do this? So that we can get rid of any
water-soluble impurities. For 3 oz. bottles, this should take only 3 repetitions or so.
6. Fill the bottle from step 5 up the rest of the way with ethyl ether. Cap the bottle, and
agitate for about 8 minutes. It is very important to expose every molecule of the free-base
to the ether for as long as possible. This will cause the free base to dissolve into the ether
(it -is- soluble in ether).
7. Let the mixture settle. There will be a middle layer that is very thick. Tap the side of the
bottle to get this layer as thin as possible. This is why this bottle should be clear.
8. Remove the top (ether) layer with the eyedropper, being careful not to get any of the
middle layer in it. Place the removed ether layer into a third bottle.
9. Add to the third bottle enough water to fill it half-way. and about 5 drops of muriatic acid.
Cap it. Shake the bottle for 2 minutes. When it settles, remove the top layer and throw it
away. The free base has now been bonded to the HCl again, forming a water soluble salt.
This time, we're getting rid of ether-soluble impurities. Make sure to get rid of all the ether
before going to step 11!
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10. If there is anything left from step 3, repeat the procedure with it.
11. Evaporate the solution in the Pyrex dish on low heat. You can do this on the stove or nuke
it in the microwave (be careful of splashing), but I have found that if you leave it on top of
a hot-water heater (like the one that supplies hot water to your house) for about 2-3 days,
the remaining crystals will be Methamphetamine HCl.
If you microwave it, I suggest no more than 5-10s at one time. If it starts "popping", that
means you have too little liquid left to microwave. You can put it under a bright (100W)
lamp instead. Microwaving can result in uneven heating, anyway.
Inhalers: $19.73
Eyedroppers: $ 1.09
Lye: $ 2.79
Catalytic Reduction
A more credible sounding one mentions that "methamphetamine is prepared by the calalytic
reduction of pseudoephedrine in acetic acid" blahblahblah and then goes on to describe, not
catalytic reduction via acetic acid, but reduction with sodium borohydride. I'm sorry to say that
no method attempting to directly reduce (pseudo)ephedrine's hydroxyl group is going to work.
You can't expose it to a strong acid, or a weak acid, or sodium borohydride, or even lithium
aluminum hydride and expect it to reduce at all. As with the Vick's Inhalers "recipe," you get a
lot of SOMETHING, but it ain't d-meth. All you'll be left with is your (pseudo)ephedrine and a
bunch of acid, lithium, and/or sodium and lotsa hydrogen gas. This is because the hydroxyl
group (the OH in ephedrine) is on a very acidic carbon (the first carbon away from the ring) and
a hydroxyl group is very basic. If the hydroxyl were on the second carbon from the ring (the
carbon with the amine group, the NH2 or NHCH3), there might be some chance, but it's not and
there's not. You're not getting a basic group off an acidic carbon without a fight, and acids,
borohydride, and LiAlhydride aren't gonna fight that hard.
I'm sorry to say that no method attempting to directly reduce (pseudo)ephedrine's hydroxyl group
is going to work.
Your post was interesting, but this is not quite true. Direct hydrogenation over Pd or Pd on a
carrier is well known and facile. You add a little perchloric, phosphoric or sulphuric acid, which
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Thus making the intermediate halide via SOCl2, like you mentioned, is unnecessary.
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