SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 27.04.2010

1. Identification of the substance/mixture and of the company/undertaking

Product Information
Catalogue No.: 108681
Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur
Use of the Reagent for analysis, Chemical production, Pharmaceutical production
Substance/Mixture and analysis

Regional representation: Merck Chemicals Ltd * Boulevard Industrial Park * Padge Road *
Beeston * Nottingham * NG9 2JR * Tel. 01159 430840 *
information@merckchem.co.uk.
Emergency telephone: +49 (0) 6151 722440

Responsible/issuing person: EQ-EPS * e-mail: prodsafe@merck.de

2. Hazards identification
GHS Classification
Flammable liquid, Category 3 H226: Flammable liquid and vapour.
Acute toxicity, Category 4, Dermal H312: Harmful in contact with skin.
Acute toxicity, Category 4, Inhalation H332: Harmful if inhaled.
Skin irritation, Category 2 H315: Causes skin irritation.
EC Classification
R10
Xn; R20/21
Xi; R38
For the full text of the R-phrases mentioned in this Section, see Section 16.

3. Composition/information on ingredients
Formula C₆H₄(CH₃)₂ C₈H₁₀ (Hill)
CAS-No. 1330-20-7
Index-No. 601-022-00-9
EC-No. 215-535-7
Molar mass 106,17 g/mol

4. First aid measures

After inhalation: fresh air. If breathing stops: mouth-to-mouth respiration or mechanical

ventilation. Oxygen mask if necessary! Immediately call in physician.
After skin contact: wash off with plenty of water. Remove contaminated clothing. Get medical
attention.
After eye contact: rinse out with plenty of water with the eyelid held wide open. Call in
ophthalmologist if necessary.

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Page 1 of 8
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108681

Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur

If swallowed Caution Aspiration hazard Keep respiratory tract clear. Call a physician
immediately. Subsequently administer: activated charcoal (20 - 40 g in 10% slurry). More severe
effects if alcohol is consumed.

5. Fire-fighting measures

Suitable extinguishing media

Carbon dioxide (CO2), Foam, Dry powder
Specific hazards during fire fighting
Combustible material, Vapours are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at elevated temperatures.
Special protective equipment for fire-fighters
Do not stay in dangerous zone without self-contained breathing apparatus. In order to
avoid contact with skin, keep a safety distance and wear suitable protective clothing.
Further information
Prevent fire extinguishing water from contaminating surface water or the ground water system.

6. Accidental release measures

Personal precautions
Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation.
Environmental precautions
Do not empty into drains. Explosive properties
Methods for cleaning up
Take up with liquid-absorbent material (e.g. Chemizorb® ). Forward for disposal. Clean up
affected area.

7. Handling and storage

Handling
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition. Take precautionary
measures against static discharge.

Storage
Further information on storage conditions
Keep away from heat and sources of ignition. Keep container tightly closed in a dry and well-
ventilated place.
Without limitations.

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
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Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108681

Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur

8. Exposure controls/personal protection

Components with workplace control parameters
Components
Basis Value Control Ceiling Limit Value, Remarks
parameters
Xylene (mixture of isomers) (1330-20-7)
ECTLV Short Term Exposure 100 ppm
Limit (STEL): 442 mg/m3

Skin designation: Can be absorbed through the skin.

Time Weighted Average 50 ppm

(TWA): 221 mg/m3

EH40 WEL Short Term Exposure 100 ppm

Limit (STEL): 441 mg/m3

Time Weighted Average 50 ppm

(TWA): 220 mg/m3

Skin designation: Can be absorbed through the skin.

Personal protective equipment

Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds
Hand protection
full contact:
Glove material: Viton (R)
Glove thickness: 0,70 mm
Break through time: > 480 min
splash contact:
Glove material: Nitrile rubber
Glove thickness: 0,40 mm
Break through time: > 30 min
The protective gloves to be used must comply with the specifications of EC irective 89/686/EEC
and he resultant standard EN374, for example. KCL 890 Vitoject® (full contact), KCL 730
Camatril® -Velours (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to
EN374 with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet and supplied by
us as well as to the purpose specified by us. When dissolving in or mixing with other substances
and under conditions deviating from those stated in EN374 please contact the supplier of CE-
approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Eye protection
Tightly fitting safety goggles
Protective measures
Flame retardant antistatic protective clothing

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 3 of 8
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108681

Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur

Hygiene measures
Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands
and face after working with substance.

9. Physical and chemical properties

Form liquid

Colour colourless

Odour aromatic

pH not applicable

Viscosity, dynamic ca.0,6 mPa.s

at 20 °C

Melting point > -34 °C

Boiling point/boiling range 137 - 143 °C

Ignition temperature ca. 465 °C

Method: DIN 51794

Flash point 25 °C
Method: c.c.

Oxidizing properties no data available

Flammability no data available

Lower explosion limit 1,0 %(V)

Upper explosion limit 7,0 %(V)

Vapour pressure 10 hPa

at 20 °C

Relative vapour density 3,7

Density 0,86 g/cm3

at 20 °C

Solubility/qualitative no data available

Water solubility 0,2 g/l

at 20 °C

Partition coefficient: n- log Pow: 3,12

octanol/water Method: (experimental)
(Lit.) An appreciable bioaccumulation potential is to be
expected (log Po/w >3).
Evaporation rate no data available

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 4 of 8
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108681

Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur

10. Stability and reactivity

Conditions to avoid
Heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical.
Materials to avoid
Violent reactions possible with:
Strong oxidizing agents, conc. sulfuric acid, sulfur
Risk of explosion with:
Nitric acid, uranium hexafluoride
Hazardous decomposition products
no information available
Further information
incompatible with:
Light metals, rubber, various plastics
Vapour/air-mixtures are explosive at intense warming.

11. Toxicological information

Acute oral toxicity
LD50 rat
Dose: 2.840 mg/kg
(External MSDS)
Symptoms: Gastrointestinal disturbance, Risk of aspiration upon vomiting.
Acute inhalation toxicity
LC50 rat
Dose: 28 mg/l, 4 h
(IUCLID)
Symptoms: absorption, Inhalation may lead to the formation of oedemas in the respiratory tract.
Acute dermal toxicity
LD50 rabbit
Dose: > 4.350 mg/kg
(IUCLID)
Symptoms: absorption, Drying-out effect resulting in rough and chapped skin.
Skin irritation
rabbit
Result: Irritations
(IUCLID)
Eye irritation
rabbit
Result: slight irritation
(IUCLID)
Genotoxicity in vitro
Mutagenicity (mammal cell test): chromosome aberration.
Result: negative
(National Toxicology Program)
Mutagenicity (mammal cell test): micronucleus.
Result: negative
(IUCLID)
The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
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Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108681

Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur

Ames test
Result: negative
(IUCLID)
Carcinogenicity
No indication of carcinogenic activity. (IUCLID)
Further information
After long-term exposure to the chemical:
Dermatitis
After absorption of toxic quantities:
Systemic effects:
Headache, drowziness, Dizziness, euphoria, agitation, spasms, narcosis
Effect potentiated by:
ethanol
Damage of:
Kidney, Central nervous system, Liver
Further data:
Handle in accordance with good industrial hygiene and safety practice.

12. Ecological information

Ecotoxicity
Toxicity to fish
LC50
Species: Oncorhynchus mykiss (rainbow trout)
Dose: 8,2 mg/l
Exposure time: 96 h
(ECOTOX Database)
Toxicity to daphnia and other aquatic invertebrates.
EC50
Species: Daphnia magna (Water flea)
Dose: 75,5 mg/l
Exposure time: 24 h
(ECOTOX Database)
Mobility
Henry constant
772Pa*m3/mol
Method: (experimental)
(Lit.) Passage from aqueous solution into the atmosphere is not to be expected.

Partition coefficient: n-octanol/water

log Pow: 3,12
Method: (experimental)
(Lit.) An appreciable bioaccumulation potential is to be expected (log Po/w >3).
Additional ecological information
Do not allow to enter waters, waste water, or soil!

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 6 of 8
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108681

Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur

13. Disposal considerations

Product
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.de you will find country- and substance-specific information as well as contact
partners.
Packaging
Merck product packaging must be disposed of in compliance with the country-specific
regulations or must be passed to a packaging return system. Under www.retrologistik.de you will
find special information on the respective national conditions as well as contact partners.

14. Transport information

ADR/RID
UN 1307 XYLENES, 3, III
IATA
UN 1307 XYLENES, 3, III
IMDG
UN 1307 XYLENES, 3, III
EmS F-E S-D
The transport regulations re cited according to international regulations and in the form applicable
in Germany. Possible national deviations in other countries are not considered.

15. Regulatory information

GHS-Labelling
Hazard pictograms

Signal word
Warning

Hazard statements
H226: Flammable liquid and vapour.
H332: Harmful if inhaled.
H312: Harmful in contact with skin.
H315: Causes skin irritation.

Precautionary statements
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.

Reduced labelling (≤125 ml)

Hazard pictograms

Signal word
The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 7 of 8
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 108681

Product name: Xylene for analysis EMSURE® ACS,ISO,Reag. Ph Eur

Warning

Index-No. 601-022-00-9
Labelling according to EC Directives
Symbol(s): Xn Harmful

R-phrase(s): 10-20/21-38 Flammable. Harmful by inhalation and in contact with

skin. Irritating to skin.
S-phrase(s): 25 Avoid contact with eyes.
EC-No. 215-535-7 EC Label
Reduced labelling (≤125 ml)
Symbol(s): Xn Harmful

R-phrase(s): 10-20/21 Flammable. Harmful by inhalation and in contact with skin.

National legislation
Storage class VCI: 3 Flammable Liquids
Major Accident Hazard 96/82/EC Update: 2003
Legislation: Flammable.
6
Quantity 1: 5.000 t
Quantity 2: 50.000 t
Other regulations: Take note of Dir 94/33/EC on the protection of young people at
work. Take note of Dir 92/85/EEC on the safety and health at work
of pregnant workers.

16. Other information

Full text of R-phrases referred to under sections 2 and 3
R10 Flammable.
R20/21 Harmful by inhalation and in contact with skin.
R38 Irritating to skin.

The information contained herein is based on the present state of our knowledge. It characterizes the product with
regard to the appropriate safety precautions. It does not represent a guarantee of the properties of the product.

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
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