Safety Data Sheet Isoxamine

1. Product and Company Identification

Product name Isoxamine

Product code 04 4186 4

Company information Manufacturer: Local representation:

F. Hoffmann-La Roche AG
Postfach
CH-4070 Basel
Switzerland

Phone *41-61/688 54 80
Fax *41-61/681 72 76

2. Composition/Information on ingredients

Chemical name - 5-Methyl-3-isoxazolamine

Synonyms - 3-Amino-5-methylisoxazole

CAS number 1072-67-9

EINECS number 214 013 6

Roche number Ro 05-3095/000

Empirical formula C4H6N2O

Molecular mass 98.11 g/mol

NH 2

O N

3. Hazards identification

Most important hazards - No particular hazards known.

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4. First-aid measures

Eye contact - rinse immediately with tap water for 10 minutes - open eyelids
forcibly

Skin contact - remove immediately contaminated clothes, wash affected skin with
water and soap - do not use any solvents

Inhalation - remove the casualty to fresh air and keep him/her calm

Note to physician - treat symptomatically

5. Fire-fighting measures

Suitable extinguishing media - water spray jet, dry powder, foam, carbon dioxide, adapt
extinguishing media to surrounding fire conditions

Unsuitable extinguishing media - full water jet

Specific hazards - formation of toxic and corrosive combustion gases (ammonia

(NH3), nitrogen oxides (NOx)) possible

Protection of fire-fighters - chemical incident emergency response unit with full protective
equipment

Special method of fire-fighting - cool endangered containers with water spray

6. Accidental release measures

Personal precautions - keep people away and stay on the upwind side

Environmental protection - do not allow to enter drains or waterways

Methods for cleaning up - take up mechanically and dispose of

7. Handling and storage

Handling

Technical measures - processing in closed systems, superposed by inert gas (e.g.

nitrogen)
- local exhaust ventilation necessary
- take precautionary measures against electrostatic charging
- avoid dust formation; very high dust explosion hazard

Suitable materials - plastic

Unsuitable materials - steel, stainless steel

Storage

Storage conditions - below 40 °C

- dry, cool and ventilated place

Packaging materials - tightly closing; material: coated steel (lined with polyethylene bag)

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Note - when plastics are used, possible electrostatic charges must be

considered

8. Exposure controls/Personal protection

Engineering Measures - see 7.

Personal protective equipment

Respiratory protection - in case of open handling or accidental release:

particle mask or respirator with independent air supply

Hand protection - protective gloves

Eye protection - safety glasses

9. Physical and chemical properties

Colour yellow

Form flakes

Odour amine-like

Solubility soluble, water (20 °C)

soluble, ethanol (20 °C)
soluble, dichloromethane (20 °C)

pH value (20 °C) 6.0 to 7.5 (10 g/l)

Melting temperature 58 to 61 °C

10. Stability and reactivity

Stability - stable under the conditions mentioned in chapter 7

Conditions to avoid - temperatures above 140 °C

- humidity
- air

Materials to avoid - iron (III) salts

- risk of a thermal runaway reaction

Hazardous decomposition - ammonia

products - nitrous oxides

Note - contamination with traces of iron (III) salts causes a noticeable

lowering of the decomposition temperature

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11. Toxicological information

Acute toxicity - LD50 2’410 mg/kg (oral, mouse)

- LD50 3’250 mg/kg (i.p., mouse)

Subacute toxicity - LD50 840 mg/kg (i.p., mouse, 5 days)

Local effects - skin: slightly irritant

12. Ecological information

Inherent biodegradability - not inherently biodegradable

0 %, 28 days
(Zahn-Wellens test, OECD No. 302 B)

Ecotoxicity - barely toxic for fish (rainbow trout)

LC0 > 2000 mg/l
(OECD No. 203)

13. Disposal considerations

Waste from residues - observe local/national regulations regarding waste disposal

- incinerate in qualified installation with flue gas scrubbing

14. Transport information

Note - not classified by transport regulations

15. Regulatory information

Note - no classification and labelling according to EU

Water hazard class (Germany) 2: hazardous for water (own classification according to directive
VwVwS of 17.05.1999)

16. Other information

Use - intermediate

Safety-lab number - BS-2671

- BS-2094

Edition documentation - first edition

The information in this safety data sheet is based on current scientific knowledge. It should not be
taken as expressing or implying any warranty concerning product characteristics.

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