Clinical Practice

Scientific Basis of Medicine

MBBS 1 Case Based Learning Medical Professional and Personal Development

Year 1 Semester 1 / Case: 6

Emily & Kieran Curran
Age: 13 and 16 Occupation: Holiday in Phuket

LEARNING OUTCOMES
On completion of this case students should be able to:

SCIENCE & SCHOLARSHIP

Anatomy and Physiology
Explain how the tubular gut is divided into its 3 main divisions (fore-, mid-, hindgut) based on its embryological
development
Describe the corresponding blood supply / nervous innervation of the fore-, mid- and hindgut
Describe the parts of the GI tract that make up the fore-, mid- and hindgut
Explain the organisation of the 4 layers of the gut, including the differences between circular / longitudinal muscle
Describe the histology and absorptive function of the small intestine
Describe the histology and absorptive function of the large intestine
Describe the function of the normal small intestinal enterocyte, including transporters on the apical and basolateral
membranes
Account for the daily volumes of fluids ingested, secreted and absorbed and excreted from the GI tract

Pathology and Pathophysiology

Explain the mechanisms behind the different types of diarrhoea (secretory, osmotic, inflammatory and altered motility)
Describe the mechanism of colicky pain in patients with diarrhoea
Describe the key features that differentiate intestinal diseases associated with diarrhoea including infections, Post-
Infectious Inflammatory Bowel Syndrome (PI-IBS), Inflammatory Bowel Disease (IBD; Ulcerative Colitis and Crohn’s
Disease) and Coeliac Disease

Microbiology and Immunology

Describe the role of the normal intestinal flora and its role in intestinal function
Explain the defence mechanisms against infection in the GIT
List the common and important pathogens responsible for Travellers’ diarrhoea and how this varies across different
regions of the world
For common and important pathogens responsible for Traveller’s Diarrhoea, describe the:
• routes of infection
• timelines from infection to symptoms/signs
• symptoms and /or signs which can distinguish types of pathogens

HEALTH & SOCIETY

Social, Cultural and Behavioural Science
Identify the significant difficulties experienced by people with chronic GIT diseases and its effect on quality of life.

Population Health and Epidemiology

Describe the incidence and prevalence of Travellers’ Diarrhoea and the locations where risk is highest
Identify the risk factors for contracting Travellers’ Diarrhoea
Explain the measures advised for prophylaxis (prevention) of Travellers’ Diarrhoea and how they can break down in
practice
Describe the incidence, prevalence, and risk factors associated with Inflammatory Bowel Disease

The University of Adelaide 1 of 2 © Adelaide Medical School

 Clinical Practice
Scientific Basis of Medicine
MBBS 1 Case Based Learning Medical Professional and Personal Development

Year 1 Semester 1 / Case: 6

Emily & Kieran Curran
Age: 13 and 16 Occupation: Holiday in Phuket

PROFESSIONALISM & LEADERSHIP

No new objectives

CLINICAL PRACTICE
Describe symptoms and signs related to diarrhoea and fluid loss in patients
Describe an appropriate physical examination in a patient with chronic diarrhoea due to gastrointestinal causes
Describe appropriate initial and follow-up investigations in a patient with chronic diarrhoea due to gastrointestinal causes

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