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2
2 The Physics of Small Fields
2.1 Under which conditions can you 2.2 The dose volume effect
consider a field as small?
When the dose changes noticeably across the
} If the field is smaller than approximately detector, the signal is subject to the volume
4 cm x 4 cm. effect. As a consequence of the volume effect,
} If the focus is partially hidden by the the dose in the field is underestimated and the
collimators. width of the penumbra is overestimated.
} If lateral electron equilibrium is not given
In Figure 1 you can see a size comparison of
in the center of the field.
some small field detectors against a Gaussian
shaped field of FWHM1 1.4 cm x 1.4 cm.
From the figure it is apparent that a diode is
probably small enough to characterize such a
field but a Semiflex 0.125 cm³ chamber is not.
In Figure 2 the effect of a too large detector is
described in more detail, experimental results
are shown in Figure 3.
1
Full width at half maximum, this is the same as the
width of the 50 % isodose
Dose [%]
Figure 1 Size comparison of a 1.4 cm x 1.4 cm FWHM Gaussian shaped field with some small field detectors.
3
a
4
c
Figure 2
Viewgraph showing the origin of the volume effect.
In part a) you can see the size of a Semiflex 0.125 cm³ chamber against a FWHM 1.4 cm x 1.4 cm
Gaussian field. Clearly, the chamber seems to be too big to characterize that field.
In part b) you can see what that chamber will actually do: it will average the dose across its
sensitive volume, depicted as a blue box. When you move the chamber through the field, it
will always average across its volume at every measurement position.
The result is shown in part c). The blue curve shows the signal after averaging. The CAX²
value of the dose is underestimated, and the penumbra is broadened.
2
CAX stands for central axis.
5
6
a
b
Dose normalized to Diamond CAX [%] Output factor
c
100
Semiflex T31010
80
Signal [mm]
microDiamond T60019
60
40
20
0
0 10 20 30 40 50 60 70 80 90
Position [mm]
Figure 3
Experimental verification of the volume effect.
In part a) the output factors3 for small square fields are shown. For the 1 cm x 1 cm field, the
reduction of the measured dose for the Semiflex and the PinPoint chamber is clearly visible.
Part b) shows a profile measurement in an 1 cm x 1 cm field. Again, the dose reduction
of the Semiflex chamber in the field center is apparent.
In part c) the penumbra broadening of the Semiflex chamber in a 10 cm x 10 cm field can
be seen. Note that the field width (50 % isodose) is measured correctly. This is always the
case when there is no volume effect in the field center.
3
Synonyms for output factor: relative dose factor and total scatter factor.
7
Additional effects due to CAX is taken from Figure 3 b) and normalized to
normalization the respective CAX values of the curves. The
increase of the penumbra data leads to an
Usually, profiles are evaluated after performing
increase of the apparent field width (i.e. the
a CAX4 normalization, i.e. all profiles are nor-
FWHM is broadened).
malized such that their CAX-value corresponds
A similar effect can happen with percentage
to 100 %. For the example in Figure 3 b, this
depth dose curves (PDDs) if there is a strong
corresponds to multiplying the entire blue curve
volume effect present. As the volume effect
by 1.20. This includes the penumbra of the
depends on field size and the field size
measurement and the out-of-field part. Hence
depends on depth, the volume effect at the
if you combine the volume effect with a CAX
normalization point (at maximum dose) is dif-
normalization, the out-of-field dose and the
ferent compared to positions deep in the
penumbra dose will be slightly overestimated.
water. A PDD subject to this effect will overes-
This can be seen in Figure 4 where the data
timate the dose deep in the water.
Figure 4
Profiles of a 6 MV 1 cm x 1 cm field measured with a Diode E (similar to Diode SRS), a TM60003 Diamond
and a Semiflex 0.125 chamber after CAX normalization. The data is the same as in Figure 3 b). In addition
to penumbra broadening two more effects are visible, indicated by arrows. (i) The FWHM of the Semiflex
measurement seems larger than that of the other detectors. This is in contrast to the original measurement
without CAX normalization shown in Figure 3 b). (ii) The dose in the out-of-field region is overestimated.
4
CAX stands for central axis.
8
2.3 Low energy response 2.4 Other effects in small fields
Low energy scattered radiation hardly }
The alignment of beam and detector is
plays any role in small fields. much more important compared to large
In large fields (roughly above 10 cm x 10 cm) field sizes.
there is a large dose contribution due to low- }
Often, an irradiation is composed of many
energy scattered radiation. In small fields, the small fields. To correctly add these up, the
dose contribution by this radiation is compara penumbras of the fields must be determined
tively small. Consequently, the low-energy res very accurately.
ponse (response to photons in the keV range) }
For small fields the field size must not equal
does not play a large role in small fields. the set collimator value due to partial occlu-
What about the out-of-field region? In the sion of the focus by the collimators and
out-of-field region, the radiation consists penumbra overlap.
only of scattered photons. For small fields this }
In field sizes below roughly 2 cm x 2 cm,
radiation contains a low-energy part but it is lack of lateral electron equilibrium leads
less important than for large fields. to the density perturbation effect, see e.g.
Hence, for small fields: [Fenwick2013]. We recommend to
} Silicon diode detectors can be used. thoroughly study small field literature
before working in such small fields.
} Shielding of the silicon diode is not necessary.
}
Some small field systems are flattening filter
} In very small fields, shielding will lead to an
free linacs.
overestimated dose due to the density per-
turbation effect.
Summary:
} If your detector is larger than roughly 1/4th of the lateral field dimension, you should
watch out for a volume effect of several percent.
} keV scattered photon radiation is less important in small fields. Unshielded
silicon diodes can be used.
} If the volume effect is present,
• The dose in the field center will be underestimated;
• The penumbra appears wider than it is.
} If in addition to the volume effect you perform a CAX normalization in a small field,
• The field (50 % isodose) will appear wider than it is;
• The dose in the out-of-field region will be overestimated;
• The dose of PDDs at large depths can be overestimated.
} [IPEM 103] recommends to use more than one detector to perform a high quality
characterization.
} For a thorough introduction see, e.g., [Wuerfel2013]
9
3 Detector Types
The following section presents a quick introduction into the various types of single detectors
used for dose measurements in a water phantom.
10
4 Detector Selection Guide
Which detector
is best suited for
my application?
11
Detector Selection Tree
Minimum field size required 1 cm x 1 cm
MAXIMUM
field size (cm)
required: 10 x 10 20 x 20
Type of
measurement: Absolute dose 1 & Profiles & Absolute dose & Profiles &
output factors PDDs output factors PDDs
Remarks 1
In small fields absolute dose measurement
often requires cross calibration, see chapter 5.
12
30 x 30 40 x 40
Absolute dose & Profiles & Absolute dose & Profiles &
output factors PDDs output factors PDDs
13
Detector Selection Tree
Minimum field size required 2 cm x 2 cm
MAXIMUM
field size (cm)
required: 10 x 10 20 x 20
Type of
measurement: Absolute dose 1 & Profiles & Absolute dose & Profiles &
output factors PDDs output factors PDDs
Remarks 1
In small fields absolute dose measurement The microDiamond detector is suitable for
often requires cross calibration, see chapter 5. absolute dose and output factor measurements.
However, whereas the microDiamond must be
cross-calibrated, the PinPoint 3D (new, T31022)
chamber can be directly applied according to
IAEA 398 and DIN 6800-2.
14
30 x 30 40 x 40
Absolute dose & Profiles & Absolute dose & Profiles &
output factors PDDs output factors PDDs
15
Detector Selection Tree
Minimum field size required 3 cm x 3 cm
MAXIMUM
field size (cm)
required: 10 x 10 20 x 20
Type of
measurement: Absolute dose 1 & Profiles & Absolute dose & Profiles &
output factors PDDs output factors PDDs
Remarks The Semiflex 3D is best suited for absolute The microDiamond detector is suitable for
dose measurements as it does not need to be absolute dose and output factor measurements.
cross-calibrated. However, whereas the microDiamond must be
cross-calibrated, the Semiflex 3D chamber can
1
In small fields absolute dose measurement be directly applied according to IAEA 398 and
often requires cross calibration, see chapter 5. DIN 6800-2.
16
30 x 30 40 x 40
Absolute dose & Profiles & Absolute dose & Profiles &
output factors PDDs output factors PDDs
Though the PinPoint chambers, the Both microDiamond and Diode P are well suited
microDiamond and the Diode P are well for the entire field size range from 1 cm x 1 cm
suited for measurements over the entire range up to 40 cm x 40 cm. But if you are aiming for
from 3 cm x 3 cm to 30 cm x 30 cm, we utmost accuracy in large fields, a medium sized
recommend using a combination of two air-filled ionization chamber will be better than
detectors for the most accurate profile and any solid state detector. If you can choose
PDD measurements. between Diode P and microDiamond, take the
microDiamond.
For accurate penumbra measurements in fields
smaller or equal than 20 cm x 20 cm, a detector
smaller than the Semiflex 0.125 should be used. 17
Overview: Field Size Range
Field size range of PTW small field detectors. Data is taken from [DETECTORS] and valid for output factor measurements.
18
Overview: Additional Selection Criteria
Diode E,
unshielded
++++ ++ ++ +++ +++ – +
Diode SRS,
unshielded ++++ ++ ++ 2 ++++ +++ – +++
Diode P,
shielded ++++ +++ ++ +++ ++ ++ +
microDiamond
Detector ++++ ++++ ++++ ++++ ++++ +++ +
PinPoint Chamber,
0.015 cm³, axial +++ ++++ ++++ ++++ 3 ++++ 4 +++ +++
orientation
PinPoint Chamber,
0.015 cm³, radial ++ ++++ ++++ ++++ 3 ++++ 4 +++ +++
orientation
PinPoint Chamber,
0.03 cm³, radial ++ ++++ ++++ ++++ 3 ++++ 5 +++ ++++
orientation
Semiflex 3D Chamber,
0.07 cm³, radial or ++ ++++ ++++ ++++ 3 ++++ 5 +++ ++++
axial orientation
Semiflex Chamber,
0.125 cm³, radial + ++++ ++++ ++++ 3 ++++ 4 ++++ ++++
orientation
19
Why is it relevant?
20
5 Absolute Dose Measurements with
PTW Small Field Detectors
} Fields < 2 cm × 2 cm 5.1 How to perform the cross-
Cross-calibrate your small field detector calibration
for each radiation quality in a 4 cm x 4 cm For absolute dose measurements, all small field
or 5 cm x 5 cm field against a Semiflex 3D detectors except air-filled ionization chambers
or Semiflex 0.125 cm³ ionization chamber. must be cross-calibrated against a medium-
size ionization chamber such as a Semiflex 3D
or Semiflex 0.125.
} Fields 2 cm × 2 cm … 4 cm x 4 cm
Use a PinPoint ionization chamber directly The cross-calibration is done in a phantom
or cross-calibrate your small field detector for each radiation quality. It should be per-
for each radiation quality in a 4 cm x 4 cm formed in two steps in a field of 4 cm x 4 cm
or 5 cm x 5 cm field against a Semiflex 3D or 5 cm x 5 cm:
or Semiflex 0.125 cm³ ionization chamber.
1. Use a medium-size vented ionization
} Fields >
_ 4 cm x 4 cm chamber, e.g. a Semiflex 3D or a Semiflex
0.125 chamber, to determine the dose Dref
Use a Semiflex 3D or Semiflex 0.125 cm³
for the radiation quality and depth of interest.
ionization chamber.
Use one of the international or national dosi
metry protocols, e.g. [IAEA 398, AAPM TG51,
} Detector orientation DIN 6800-2].
Perform a new cross-calibration if you
change the detector orientation. 2. Replace the medium-size ionization chamber
by the small-size detector to be cross-calibrat-
ed. Make sure the effective points of measure-
Note: when you use an ionization chamber ment are located at the same depth. Apply the
directly, follow one of the international or same number of monitor units as before and
national dosimetry protocols, e.g. [IAEA 398, determine the reading Msmall of the small-size
AAPM TG51, DIN 6800 2]. Additional kQ detector. The cross-calibration factor for the
correction factors for the PinPoint chambers small-size detector is the ratio Dref/Msmall.
are given in [Muir2011], [DETECTORS], or can
be obtained from PTW technical support. After cross-calibration, the small-size detector
can be used in fields smaller than the cross-cali-
bration field and at different depths, but always
at the same radiation quality and detector
orientation. In literature, this approach is
sometimes addressed as “daisy chaining”.
21
6 Frequently Asked Questions
22
My field is smaller than 1 cm x 1 cm. What is the advantage of silicon diodes
Which detector can I use? over air-filled ionization chambers?
If you need to measure smaller field sizes, we Due to the higher density of atoms in silicon
recommend to use non-shielded detectors with compared to air, a diode detector can be
a small cross-section perpendicular to the beam. constructed very small and still have a good
These are the Diode E (T60017) for all photon response. Hence in high-gradient regions,
energies and the Diode SRS (T60018) for pho- such as the penumbra, a diode detector will
ton energies of 6 MV and below. You can also be more accurate. The microDiamond detector
consider the microDiamond T60019 for such combines the advantages of silicon diodes and
measurements. air-filled ionization chambers, but its cross-
For any detector we recomend to look up section in the beam is slightly larger than for
correction factors for very small fields in the PTW silicon diode detectors.
scientific literature.
What is the advantage of air-filled
My field is not square. Which detector ionization chambers over silicon diodes?
is suitable? In contrast to silicon diodes the response of
There are formulas to calculate an equivalent air-filled ionization chambers to low-energy
square field size for non-square field shapes. scattered radiation is excellent, except if they
The aim of these calculations is to predict the have a steel central electrode. For this reason,
output factor of an irregular field. To estimate they are suited to precisely deduce the dose
whether a detector will be prone to the volume in large fields and in the out-of-field region.
effect, these formulas cannot be used. Instead, In addition, air-filled ionization chambers are
the smallest dimension of the field plays the perfectly suited to deduce the absolute dose
central role. For rectangular fields, this is the according to international dosimetry protocols.
small edge. For example, if your field size is Air-filled ionization chambers do not suffer any
2 cm x 10 cm, take a detector that is suited for response degradation due to irradiation.
a 2 cm x 2 cm field.
For circular fields, the vendor of your irra- When do I use a shielded diode?
diation unit will in most cases recommend In shielded diodes, the over-response to
a detector for the measurements. As rule of keV-energy scattered radiation – which is
thumb: to measure output factors, i.e. when mainly present in fields >
_ 10 cm x 10 cm – is
measuring in the center of the field, take the compensated by a metal shield absorbing that
diameter of the field as smallest dimension. type of radiation. Due to this combination,
For example, to measure the output factor in a shielded diodes can be used in the entire field size
3 cm diameter field, take a detector that is suited range from 1 cm x 1 cm up to 40 cm x 40 cm.
for a 3 cm x 3 cm field. For profile measurements, Nevertheless one must keep in mind that this
it is difficult to give a precise recommendation. large field size range does not come free of
If you are unsure which detector to use, take costs. Shielded diodes are a compromise.
the smaller one. They can be used for small and large fields,
but if you want to increase the accuracy, we
23
recommend to use a microDiamond instead of Where do I place the reference detector
a Diode P. For highest accuracy use a small field in a small field?
detector for small fields (e.g. an unshielded sili- Placing a reference detector in a very small
con diode or a microDiamond) and an air-filled field without disturbing the main detector
ionization chamber for large fields. is not feasible. Simply placing the reference
detector outside the field border is not a very
How can I check if my detector is good solution either, because the signal of the
accurately positioned in the field? reference will then be very noisy and will lead
The option CenterCheck of the MEPHYSTO to a noisy measurement (i.e. the curves will not
package allows you to check the positioning be flat). There are several options what you
and alignment of your detector in the beam. could do:
In addition, you can improve reproducibility }
ou can use the PTW T-REF chamber. This is
Y
and ease of use by mounting your detectors a very thin transmission chamber providing a
using the TRUFIX system. strong and very low noise reference signal
It is important to check the positioning at
I
} f you are very sure that your linac is very sta-
shallow and large depths in the water. Use the
ble, measure without reference
PTW technical note D811.200.01 to optimize
CenterCheck for small fields. ou can use a very large ionization chamber,
}
Y
e.g. a Bragg-Peak chamber or a 100 mm
How can I tell the effective point of CT-chamber as reference right next to the
measurement and water equivalent beam. The larger the chamber the better,
window thickness of PTW solid state a Farmer chamber is still better than a semi-
detectors? flex chamber. Note, that this technique will
increase the noise of your measurement.
Each PTW solid state detector has a colored
Do not use a diode as reference as diodes
ring which is situated at the water equivalent
exhibit strong quantum noise
depth of the effective point of measurement of
the detector. To find the “zero” water position, }
ou can increase your integration time. Four
Y
make the ring level with the water surface times longer integration time leads to half
and define this as zero water level. The detec- the noise
tor should be used in axial orientation for this ou can measure the PDD, profile, etc.
}
Y
procedure. several times. If several curves coincide, the
If you are using TRUFIX and the stop thimble linac was stable
corresponding to your detector, the detector ou can measure step by step irradiating a
}
Y
will directly be positioned in the correct depth. fixed number of MUs for each data point
This, of course, requires that you first have
If you use a reference chamber outside of the
correctly set the zero position with TRUFIX.
beam, remember to pre-irradiate it if it has not
been in the beam before. A more thorough
description including measured data can be
found in [Wuerfel2013].
24
7 Detector Overview
T31010 0.125 cm³ radius of sensitive 66 kV … 50 MV photons
Semiflex Chamber volume 2.75 mm, (10 … 45) MeV electrons
length 6.5 mm (50 … 270) MeV protons
T31014 0.015 cm³ radius of sensitive 60
Co … 50 MV photons
PinPoint Chamber volume 1 mm,
length 5 mm
26
0.125 cm3 Semiflex
Chamber
Type 31010
Standard therapy chamber for
scanning systems and for absolute
dosimetry
27
PinPoint Chambers
Type 31014, 31015
28
PinPoint 3D Chamber
Type 31022
29
microDiamond
Type 60019
Long-term stability ≤ 0.5 % per year [2] C. Di Venanzio, M. Marinelli, E. Milani, G. Prestopino, C. Verona,
G. Verona-Rinati, M. D. Falco, P. Bagalà, R. Santoni and M. Pimpinella,
Dose stability < 0.25 % / kGy at 18 MV Characterization of a synthetic single crystal diamond Schottky diode for
radiotherapy electron beam dosimetry, Med. Phys. 40 (2013), 021712
Temperature ≤ 0.08 % / K
response
Energy response ± 13 % (100 keV ... 60Co)
Bias voltage 0V
Signal polarity positive 1 At the high end of the temperature range, higher leakage currents may
Directional ≤ 1 % for tilting ≤ ± 40° occur.
response in water
2 This detector is well suited for measurements in field sizes smaller than
Leakage current1 ≤ 20 fA 1 cm x 1 cm. Depending on the accuracy required by the user, correction
factors may be necessary as described in international scientific publications.
Cable leakage ≤ 200 fC / (Gy·cm) This applies to any detector used in very small fields.
30
Dosimetry Diode P
Type 60016
31
Dosimetry Diode E
Type 60017
32
Dosimetry Diode SRS
Type 60018
33
8 References and Further Reading
[AAPM TG51] AAPM’s TG-51 protocol for clinical reference dosimetry of high-energy
photon and electron beams. Med. Phys. 26 (9), September 1999, 1847-1870
[Alfonso2008] A new formalism for reference dosimetry of small and nonstandard fields,
Med. Phys. 35 (2008), 5179-5186
[Crop2009] F. Crop et al., The influence of small field sizes, penumbra, spot size and
measurement depth on perturbation factors for microionization chambers,
Phys. Med. Biol. 54 (2009) 2951
[Cyarnecki2013] D. Cyarnecki and K. Zink, Monte Carlo calculated correction factors for diodes
and ion chambers in small photon fields, Phys. Med. Biol. 58 (2013) 2431–2444
[DIN 6800-2] Dosismessverfahren nach der Sondenmethode für Photonen- und Elektronen-
strahlung. Teil 2: Dosimetrie hochenergetischer Photonen- und Elektronen-
strahlung mit Ionisationskammern, März 2008
[Fenwick2013] J.D. Fenwick et al., Using cavity theory to describe the dependence on detector
density of dosimeter response in non-equilibrium small fields, Phys. Med. Biol.
58 (2013), 2901
[Francescon2012] P. Francescon et al., Monte Carlo simulated correction factors for machine spe-
cific reference field dose calibration and output factor measurement using fixed
and iris collimators on the CyberKnife system, Phys. Med. Biol. 57 (2012), 3741
[IPEM 103] Report Number 103, Small Field MV Photon Dosimetry, Institute of Physics and
Engineering in Medicine, 2010, ISBN 978 1 903613 45 0
[Looe2015] H.K. Looe et al, Understanding the lateral dose response functions of high-res-
olution photon detectors by reverse Monte Carlos and deconvolution analysis,
Phys. Med. Biol. 60 (2015), 6585
[Muir2011] Muir et al., Measured and Monte Carlo calculated kQ factors: Accuracy and
comparison, Med. Phys. 38 (2011), 4600
34
[PTW D560.210.03] Absorbed Dose Determination in Small Fields of High Energy Photon Beams
based on the German Standard DIN 6809-9
[PTW D811.200.01] How to Center a Detector in Small Fields with the TBA System, Technical Note
[Scott2012] A.J.D. Scott et al., Characterizing the influence of detector density on dosi
meter response in non-equilibrium small photon fields, Phys. Med. Biol. 57
(2012) 4461–4476
[Sterpin2012] E. Sterpin et al., Monte Carlo computed machine-specific correction factors
for reference dosimetry of TomoTherapy static beam for several ion cham-
bers, Med. Phys. 39 (2012), 4066
[Pantelis 2012] E. Pantelis et al., On the output factor measurements of the CyberKnife iris
collimator small fields: Experimental determination of the k[..] correction
factors for microchamber and diode detectors, Med. Phys. 39 (2012), 4875
[Wuerfel2013] J.U. Wuerfel, Dose measurements in small fields, Medical Physics International
1 (2013), 81. You can download this article from the PTW website:
http://www.ptw.de/. Go to Literature > small field
[Gago-Arias2013] A. Gago-Arias et al., Correction factors for ionization chamber dosimetry in
CyberKnife: Machine-specific, plan-class, and clinical fields, Med. Phys. 40
(2013) 011721
35
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