8/16/2019

The International Association for the Advancement

of High Performance Thin Layer Chromatography
Marcel Hug, PR HPTLC Association

© HPTLC Association 2019 www.hptlc-association.org

The International Association for the Advancement of HPTLC

 Incorporated on January 27, 2012 in Basel,

Switzerland

 Private, non-profit organization

 According to Swiss Law

 Since 2018 office in Rheinfelden,

Switzerland

1
 8/16/2019

Founding members (2012)

Prof. Beat Meier ZHAW, Zurich University of Applied Science Switzerland

Prof. Matthias Hamburger Dept. of Pharmaceutical Biology, University Basel Switzerland

Prof. Wang Zheng Tao Shanghai University of TCM, Shanghai China

Dr. Eike Reich CAMAG Laboratory, Muttenz Switzerland

Prof. Ikhlas Khan National Center for Natural Products Research, University of  USA

Mississippi
Mr. Roy Upton American Herbal Pharmacopoeia, Soquel, CA USA

Prof. Vila Dept. of Pharmacology and Pharmacognosy, University of  Spain

Barcelona
Prof. Alberto Cardoso Arruda Universidade Federal do Pará Brazil

Founding members (cont.)

Prof. Salvador Cañigueral Dept. of Pharmacology and Pharmacognosy, University of  Spain

Barcelona
Dr. Francis Hadji‐Minaglou Botanicert, Montauroux France

Prof. Annie Bligh Dept. of Complimentary Medicine, University of Westminster,  UK
London
Dr. Olumuyiwa L. Ogegbo London Metropolitan University, London UK

Dr. Gu Lihua Institute of Chinese Materia Medica, Shanghai University of  China

TCM, Shanghai
Dr. Maged H.M. Sharaf United States Pharmacopeial Convention (USP), Rockville, MD USA

Dr. Thomas Lehmann Swissmedic, Swiss Agency for Therapeutic Products, Bern Switzerland

2
 8/16/2019

Board of Directors (2019)

President Dr. Eike Reich, CAMAG Laboratory, Muttenz, Switzerland

Chairperson Advisory Board Prof. Salvador Cañigueral, Unit of Pharmacology, Pharmacognosy and 

Therapeutics, Faculty of Pharmacy and Food Sciences, University of Barcelona, 
Spain

Chairperson Method Review Committee Dr. Maged H.M. Sharaf, CSI, Wilmington, NC, USA

Chairperson Scientific Communication Prof. Bernd Spangenberg, Offenburg University of Applied Sciences, Germany

PR, Treasurer Marcel Hug, CAMAG, Muttenz, Switzerland

Honorary President Prof. Beat Meier, ZHAW, Zurich University of Applied Science, Switzerland

Chair of the Australian Chapter Tom Sostaric, Adjunct Research Fellow, Faculty of Health and Medical Sciences, 
University of Western Australia, Perth; Chromatech Scientific P/L, Yangebup, 
Australia

Members and Chapters

(as per August 2019)

UK Chapter
President:
Dr. Anthony 
Booker
China Chapter
North America
Secretary
Chapter President:
General:
Mrs. Nicolas  Prof. Wang Zengtao
Chair:
Dr. Maged H.M.  Robinson
Sharaf Secretary General:
Ms. Candy Tang
International
HPTLC Association
(08.2019)

Total members 103 India Chapter

Thailand Chapter
Europe 34 Secretary:
President: Australia Chapter
Dr. Amit 
Asia 33 Prof. Wanchai De‐
Agarwal Chair:
Eknamkul
Mr. Tom Sostaric
Australia 7
Secretary General:
N America 24 Mrs. Aninthaya 
Singhasut
S America2

Africa 3
6

3
 8/16/2019

Goals of the HPTLC Association

 Promote the use of HPTLC in plant analysis and other analytical fields.

 Through collaborations, the Association aims to:

 Develop and validate common standards and methods for analysis of plants and their adulterants.

 Serve as the worldwide leading resource for information and training.

 Supports pharmacopoeias and similar organizations of individual countries or regions with expertise,
guidance, methods and validation data.

 Establish and maintain a “Global Atlas of HPTLC Methods for Identification of Herbal Drugs (Atlas)” as
a recognized reference tool for quality control.

 The Association publishes educational materials, issues guidelines, and contributes to

journals and organizes scientific meetings, educational and training events.
7

www.hptlc-association.org

4
 8/16/2019

Accomplishments of the HPTLC Association:

Method Collection on medicinal plants

• 274 validated HPTLC methods for ID (as per 08.2019)

• Continuing expansion of the collection
• Free download as pdf‐documents (public domain)

www.hptlc‐association.org

HPTLC Association: Download methods as pdf-document (example)

page 1 page 2 page 3

10

5
 8/16/2019

Accomplishments: collaboration with USP

 Chapter <1064> - Identification of Articles of Botanical Origin by High-Performance Thin-

Layer Chromatography Procedure.

 Chapter <203> - High-Performance Thin-Layer Chromatography - Procedure for

Identification of Articles of Botanical Origin.

https://hmc.usp.org/about/general-chapters

 Illustration of HPTLC/TLC methods in the USP Dietary Supplements Compendium (2012,

2015 and 2019). https://www.usp.org/products/dietary-supplements-compendium

11

USP Herbal Medicines Compendium & Dietary Supplements Compendium

12

6
 8/16/2019

Accomplishments: collaboration with Ph. Eur.

 Chapter 2.8.25 - HPTLC of Herbal Drugs and Herbal Drug Preparations.

 Proposal of numerous HPTLC methods for identification in EP monographs on plant drugs,

plant drug extracts, and essential oils.

 Harmonization of methods for identification of flavonoid containing drugs

 Harmonization of methods for identification of essential oils

 Pilot study: development of alternative HPTLC assays for TCM drugs

13

Accomplishments: education and training

Collaboration with American Herbal Products Association

 HPTLC-Workshops HPTLC for quality control of

herbals in the USA (2015―2017)

 All lectures are freely available for members

Collaboration with UNPA

 Memorandum of Understanding (Sep 2013) targeting education

14

7
 8/16/2019

Goals for the next years

 Grow membership and create additional chapters

 South-East Asia, South America, Middle East
 We invite individuals who like to help us achieve our goals!

 Grow and strengthen the advisory board

 Invite regulators, individuals from standard setting organizations, members of trade / industry associations
and other professionals to help challenge and refine our concepts.

 Focus on education of analysts and decision makers of various industries in HPTLC

 Broaden the scope our training materials and invite qualified individuals who provide training in local
languages

 Collaborate globally on the “Atlas project”

15

HPTLC Association @ EAS2019

HPTLC Conference:
High Performance Thin-Layer Chromatography ─
Planar Chromatography Beyond the Ordinary!
At Eastern Analytical Symposium and Exhibition
Princeton, NJ, USA - Nov. 18-20, 2019

Nov 17, 2019: One-day HPTLC short course

Nov 18, 2019: Scientific program on HPTLC

HPTLC Today and in the Future.

• Recent contributions of HPTLC to the analysis of complex samples
covering wide ranges of polarity (biofuels, petroleum, lipidomic
analysis).
• Comprehensive HPTLC Fingerprinting - a new approach to quality.

Nov 19, 2019: HPTLC Poster session

16

8
 8/16/2019

The Global HPTLC Atlas

For identification of herbal drugs

© HPTLC Association 2019 www.hptlc-association.org

Scope

The Global HPTLC ATLAS:

 Illustrates chemical profiles and natural/regional variability of herbal drugs

 Is based on standardized HPTLC methods

 Provides harmonized data for setting acceptance criteria for different regulatory
categories of herbal materials

 Links local pharmacopeial and other compendial standards

 Is created through international collaboration

 Current collaborations:
 USP, Thailand, FHH, China, Malaysia, India, …
18

9
 8/16/2019

The ATLAS on www.hptlc-association.org

19

39 ATLAS entries completed

94 ATLAS entries in progress

One ATLAS entry for

each herbal drug

20

10
 8/16/2019

Accepted Latin name

Plant part

Link to other related

herbal drug

21

Selected ATLAS method

Undesirable solvents
marked in red

Description of the
method
Evaluated methods

Results using HPTLC

standard conditions

22

11
 8/16/2019

Description of the
selected method

Natural / regional
variability of herbal
drugs

Related herbal drugs

ATLAS documents to
download

23

How can HPTLC users benefit from the HPTLC Association?

 Get validated methods for ID of medicinal plants (free download)

 Have access to the Global Atlas for ID of Herbal Drugs (ATLAS) as a reference tool

 Become a member, join your local chapter to collaborate and network, exchange HPTLC
knowledge and get more know-how on the method

 Get educational material prepared by HPTLC Association members

 Participate at events such as HPTLC conferences

24

12
 8/16/2019

THANK YOU !

info@hptlc-association.org

© HPTLC Association 2019 www.hptlc-association.org

13