2019/3/13 Recombinant Human Hyaluronidase PH20

www.creative-enzymes.com

Description

Recombinant Human Hyaluronidase PH20 belongs to a family of

enzymes that catalyze the degradation of hyaluronic acid (HA). The
enzyme is effective to hyaluronic acid in the extracellular matrix
(ECM) and promote the diffusion of extracellular substances.

Product Information

Cat No. NATE-1923 Endotoxin: ≤10 EU/ml

EC No. EC 3.2.1.35 Storage: -20 °C

CAS No. 37326-33-3 Control Tests: Laboratory of QC
Species: Human Appearance: Sterile lyophilized powder,
Source: CHO dissolved in pure water to form a clear,
colorless to pale yellow solution. Must not
Purity: ≥99%
contain visible insoluble matter.
Activity: ≥12,000 IU/vial

Highlights

Creative Enzymes® Hyaluronidase PH20 shows several advantages over similar products on the
market:

Creative Enzymes® HAase PH20 Similar Products on the Market

Species Human Animal

Source CHO cell Testis

Technology Recombinant DNA Extraction

Purity ≥99% Low

Applications

Oncology Pharmacokinetics

PH20 degrades HA in tumor cells PH20 hydrolyzes hyaluronic acid and

coating, which may result in the increases diffusion of injected drugs, thus
inhibition of tumor cell growth. facilitating their absorption.

Enzymatic degradation of ECM HA with PH20 can be used as an adjunct in

PH20 is associated with remodeling of subcutaneous urography to improve
the tumor stroma, reduction of tumor resorption of radiopaque agents.
interstitial fluid pressure, and expansion
of tumor blood vessels, resulting in
facilitated delivery of anti-cancer Scientific Research
agents.
ELISA; SDS-PAGE; Western blot.

Note: Our products are not intended for private therapeutic use!

Tel: 1-631-562-8517

Fax: 1-631-938-8127 Contact Information

E-mail: info@creative-enzymes.com

Address: 45-1 Ramsey Road, Shirley, NY 11967, USA

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