Brand Name Generic Indication and Nursing Consideration Action of the Dose and Side Effects

Name Contraindication Drug Administration

Eprex Epoetin alfa Anemia caused by -Monitor renal studies, urinalysis, Erythropoietin is SC/ IV 50- 100 CNS: Seizures,
reduction endogenous protein, blood,BUN, creatinine, one factor U/kg 3x/wk, coldness,
erythropoietin I&O; report drop in output < 50 controlling rate then adjust dose sweating
production primarily ml/hr of red cell by 25
end stage renal disease; production; drug U/kg/dose to CV:
to correct hemostatic -monitor blood studies; reticulocyte is developed by maintain Hypertension,
defect in uremia. count weekly; check for symptoms recombinant appropriate Hct. hypertensive
of anemia, fatigue, pallor, dyspnea DNA encephalopathy
Contraindications: technology. Available
hypersensitivity to -Assess CNS symptoms; coldness, forms: 2000, MS: bone pain
albumin, hypertension, sweating 3000, 4000,
erythropoietin levels of 10,000 U/ml
>200 mU/ml -Assess CV status: BP before and
during Tx; Htn may occur rapidly
Precautions: leading to Htn encephalopathy
pregnancy class C
-Assess patient during hemodialysis
for bruits, thrills of shunts; drug
prevents severe anemia in chronic
renal failure; clotting may need to be
treated with increased anticoagulant.

-Monitor serum iron levels, ferritin,

transferring levels; iron therapy may
be needed to prevent recurring
anemia.

-Monitor blood studies; BUN, WBC,

phosphorus, potassium, bleeding
time. Hct should be checked in
chronic renal failure.