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Trends in Food Science & Technology 91 (2019) 634–639

Contents lists available at ScienceDirect

Trends in Food Science & Technology


journal homepage: www.elsevier.com/locate/tifs

Commentary

eNutrition - The next dimension for eHealth? T


a,⁎ a,b
Mike Boland , John Bronlund
a
Riddet Institute, Massey University, Palmerston North, 4442, New Zealand
b
School of Food and Advanced Technology, Massey University, Palmerston North, 4442, New Zealand

A B S T R A C T

Rapid communication technology, inexpensive sensing devices and big data enable “eNutrition” – the use of ICT to develop and support personalized healthy
nutrition. eNutrition combines personal health records, monitoring of body functions and activity by smart wearables, monitoring food consumption, and datasets of
food composition. An AI system, a personal virtual dietitian, can use this information to provide nutritional advice and alerts at the time of purchase and consumption
of foods. eNutrition has the potential to significantly lessen the public heath burden of non-communicable diseases such as hypertension, type 2 diabetes and allergic
reactions to foods.

1. Introduction systems, including eHealth repositories, and by the use of sensing de-
vices that use either the native capability of a mobile phone (such as an
The presence of digital technologies in almost all aspects of life accelerometer or built-in camera) or by a range of connected sensing
together with rapid worldwide electronic communications, often re- devices that currently include smart watches and fitness bands, but also
ferred to as the 4th Industrial Revolution, or I4, is in the process of blood glucose monitors, blood pressure monitors, electrocardiographs
changing the world and how we live. eNutrition is a term for the and even pocket-sized cardiac ultrasound units.
emergence of digital technologies that can guide our nutrition and lead Online health records are an essential part of an eHealth system,
to better health at both personal and (by implication) national and primarily aimed at patient management and making personal health
global health and lifestyle. data immediately available to a medical professional as the need arises.
Development and alignment of these systems has been the main focus of
2. Emergence of eHealth and mHealth eHealth. Another new focus has been TeleHealth: the remote mon-
itoring of patients, in some cases leading to “hospitals without beds”,
Today's Information and Communications Technology (ICT) gives whereby patients are remotely monitored while living at home instead
the possibility of widespread management of health through the in- of having to live in a hospital. eHealth systems can provide a platform
ternet and smart devices. “eHealth” is defined by the World Health that will support a smart personalized nutrition system, providing di-
Organization as “the use of information and communication technologies agnosis information to guide diet, information on allergies to avoid
(ICT) for health”. The scope of eHealth was acknowledged by the World foods that may contain undesired ingredients and information about
Health Assembly in resolution WHA58.28 (2005): “eHealth is the cost- drugs to avoid adverse drug reactions (for example patients taking
effective and secure use of ICT in support of health and health-related fields, statins must avoid grapefruit in the diet). This sets the stage for
including health-care services, health surveillance, health literature, and eNutrition. We have deliberately used the term eNutrition in this con-
health education, knowledge and research.” text because it adds the dimension of nutrition to the eHealth system.
mHealth is a component of eHealth. The WHO Global Observatory We believe this is the proper use of this term.
for eHealth (GOe) has defined mHealth or mobile health as “medical and
public health practice supported by mobile devices, such as mobile phones, 3. Importance of nutrition and NCDs
patient monitoring devices, personal digital assistants (PDAs), and other
wireless devices”. mHealth usually involves the use of a mobile phone's Non-communicable diseases (NCDs) are estimated to be responsible
communication functionality by voice, short messaging service (SMS) for 71% of all deaths (41 million people per annum) globally (World
and internet connectivity as well as more diverse applications including Health Organization). These diseases include cardiovascular and re-
the use of global positioning system (GPS), and Bluetooth technology. spiratory disease, cancers and diabetes which are collectively re-
This can be further enhanced by interaction with large cloud-based data sponsible for 80% of all premature NCD deaths. There is a strong


Corresponding author.
E-mail address: m.boland@massey.ac.nz (M. Boland).

https://doi.org/10.1016/j.tifs.2019.08.001
Received 8 April 2019; Received in revised form 24 June 2019; Accepted 2 August 2019
Available online 09 August 2019
0924-2244/ © 2019 Elsevier Ltd. All rights reserved.
M. Boland and J. Bronlund Trends in Food Science & Technology 91 (2019) 634–639

linkage between many NCDs and diet, and the World Health become more reliable, and that nutritionist-supported apps will emerge
Organization is leading a campaign to decrease the risk of NCDs. The that can be reliably used for diet advice and management (Chen,
importance of diet and the burden of disease has recently been high- Gemming, Hanning, & Allman-Farinelli, 2018). However, few of these
lighted in a major international study that found that in 2017, 11 yet relate specifically to what food is actually eaten or should be eaten,
million deaths and 255 million disability-adjusted life-years were at- and fewer still are personalized to any degree.
tributable to dietary risk factors (GBD 2017 Diet Collaborators, 2019). One of the strengths of smartphones is internet connectivity. This
In terms of deaths attributable to NCDs, the leading metabolic risk potentially enables immediate access to two important datasets. The
factor is elevated blood pressure (to which 19% of global deaths are first is the person's health data: Most countries now have patients'
attributed), followed by overweight and obesity and raised blood glu- health information available online (eHealth systems) and this can be
cose. All of these factors can, be managed or mitigated by diet, espe- used to inform diet, based on general health data, diagnosed conditions
cially when coupled with appropriate exercise. that require dietary management (such as blood pressure, blood cho-
Properly designed nutrition has the potential to significantly reduce lesterol), any medications that require avoidance of certain foods (e.g.
the effects and occurrence of NCDs, and eNutrition could play a sig- statins) and known allergies. The second dataset is the composition of
nificant role towards achieving this reduction. foodstuffs, and again many large databases, usually government-run,
contain independently-obtained nutritional and compositional data on
4. Issues with current methods for nutrition management most available foodstuffs, both natural and packaged (for example the
USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/,
Management of nutrition has generally been left up to the in- soon to be changed to the USDA Food and Nutrient Data System). These
dividual. Most people don't keep any record of what they have eaten datasets are coordinated internationally by INFOODS, an instrument of
over any time, and even those with a diagnosed condition and are under the United Nations Food and Agriculture Organization. These datasets
nutritional management are generally not good at keeping accurate are an important resource for providing advice on what food a con-
records (Cade, 2017). Moreover, there is no current system that can sumer should purchase and consume.
monitor what you are about to eat and advise on portion size, what else The other important role of the smartphone is through its Bluetooth
should be consumed, or what should be avoided. connectivity, which allows communication with wearable and con-
In addition to this, advice on nutrition is not generally linked to a nected devices such as fitness bands and smart scales.
measurement of recent physical activity. Such activity will affect the
caloric intake needed and can be measured by many devices available
today (even if only on a crude basis). Nor is nutritional advice usually 6. Enablement through wearable and connected devices
personalized: we are all different and have different nutritional re-
quirements, based on body parameters, lifestyle, genetic and epigenetic One of the big trends in the past few years has been the emergence
makeup (nutritional phenotype), dentition and oral health, and any of smart watches and fitness bands. Through the inbuilt accelerometer,
history of disease or allergies. All of these factors, in principle, are these devices “measure” the number of steps that have been taken
available to feed into a nutritional model and provide timely nutritional during a day and estimate the expenditure of calories. While the idea is
advice. right, caution must be observed. It is well recognized that these devices
are prone to errors such as under-measurement of steps if worn on the
5. Enablement through mobile communications and smartphone wrist, and over-measurement if the wearer uses tools or other devices
apps that cause vibration (such as an orbital sander, for example).
In addition to fitness bands and smart watches, there is a wide range
A critical enabler of e-Nutrition is the Smartphone. These devices of wearable devices that can report on a range of activities and body
can communicate widely through a variety of protocols (typically voice, functions. Some of these are listed in Table 1.
SMS, Bluetooth and internet), connecting personal devices to the wider Bathroom scales are important non-wearable but Internet of Things
world. Smartphones also have native computing ability that allows the (IoT) connected devices. In addition to reporting and tracking weight,
use of programs (apps) that can carry out a wide range of useful many of these devices measure body fat, using body conductance from
functions. one foot to the other. While this form of measurement is subject to
There is a wide range of apps for Smartphones that can advise on systematic error, trends and changes over time are useful metrics.
diet, some even linking to the level of physical activity (as measured by
accelerometers native to smartphones, smartwatches and fitness
bands). However, a recent review identified more than 165,000 mobile 7. Monitoring of diet and food intake
health apps and stated: “These apps have the potential to provide low-cost,
around-the-clock access to high-quality, evidence-based health information An important aspect of eNutrition is monitoring what food is actu-
to end users on a global scale. However, they have not yet lived up to their ally consumed by an individual, to provide a direct measure of the
potential due to multiple barriers, including lack of regulatory oversight, intake of energy, nutrients and bioactives. In the past, individuals on
limited evidence-based literature, and concerns of privacy and security. The strict diets, have kept food diaries. This has often resulted in erratic and
future directions may consist of improving data integration into the health inaccurate records, as these are usually filled in from memory.
care system, an interoperable app platform allowing access to electronic Moreover, there is tendency for people to underestimate portion sizes
health record data, cloud-based personal health record across health care (Cade, 2017; Hassannejad et al., 2017) and to forget between-meal
networks, and increasing app prescription by health care providers. For snacks. New app-supported record-keeping may improve this (Maria
consumer mobile health apps to fully contribute value to health care delivery Bejar, Adrian Reyes, & Dolores Garcia-Perea, 2018). Automated re-
and chronic disease management, all stakeholders within the ecosystem must cording, that requires no effort from the consumer would be a better
collaborate to overcome the significant barriers.” (Kao & Liebovitz, 2017). option but does not yet fully exist. New technologies can enable the
There are concerns about the accuracy of nutrition and diet apps. A automatic monitoring of food intake. This can be done two ways: one is
recent survey in Germany of three apps selected from a random sample by inference from use of recipes, changes in food inventory in the home
of 100 nutrition apps from Google Play, identified significant variances and food purchases and disposals; the other is from a range of direct
in the caloric values ascribed to different foods, with errors of as much measurements including food image capture and analysis and the use of
as 50% (Holzmann, Proell, Hauner, & Holzapfel, 2017). It can be ex- various on-body sensing systems to monitor eating behaviors.
pected that, as the use of diet apps becomes more mainstream, they will

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M. Boland and J. Bronlund Trends in Food Science & Technology 91 (2019) 634–639

Table 1
Some wearable e-health devices.
Name of device What it does Where to find out more
(web sites accessed March 2019)

Fitness band Activity trackers and smart watches that provide health and fitness https://www.fitbit.com/
monitoring:
• Heart rate
• Steps taken (km walked)

Other fitness bands and


• Sleep time
A variety of functions as above that may also include: http://www.cronovo.com/
smartwatches • Blood pressure (by either wrist cuff or photoplethysmography) https://omronhealthcare.com/products/heartguide-wearable-
• Body composition (conductance) blood-pressure-monitor-bp8000m/
• Blood glucose (prototype) https://www.tomtom.com/en_nz/sports/fitness-trackers/fitness-
• Pulse oximetry tracker-touch/black-large/
• ECG https://www.pkvitality.com/ktrack-glucose/
https://www.garmin.com.sg/garmin-technology/pulse-ox/
https://www.engadget.com/2019/01/06/withings-move-ecg/
Blood glucose monitor Continuously measures blood glucose levels and reports via local Rodbard (2016)
station or smartphone https://www.dexcom.com/continuous-glucose-monitoring
https://freestylediabetes.co.uk/our-products/freestyle-libre
http://www.medtronicdiabetes.com/products/guardian-connect-
continuous-glucose-monitoring
VitalPatch Monitors vital signs: https://vitalconnect.com/solutions/vitalpatch/
•ECG
•Heart rate
•Respiration
•Temperature
•Posture
•Activity

Polar H10
•Falls
Wearable (chest strap) heart rate sensor https://www.polar.com/au-en/products/accessories/h10_heart_
rate_sensor
QardioCore Wearable (chest strap) continuous ECG monitor. https://store.getqardio.com/products/qardiocore

7.1. Inferential approaches 7.2. Direct approaches

A smart kitchen has the potential to track whole food and ingredient Direct approaches to monitoring diet include image analysis and
use in the home through changes in inventory, for example in a smart wearable devices (Hassannejad et al., 2017). There are smartphone
refrigerator; and an assistive kitchen (such as the Miele “Invisible apps that can identify, sometimes with surprising accuracy, what is on a
Kitchen”) will be able to track food use through recipes and cooking plate, and wearable cameras (e-buttons) can take a photo of a plate of
activities. This will give an overview of food consumption in the home, food and identify the components of a serving. These methods are not
but not how it is divided between cohabiting individuals or how much always accurate, and improvements may be possible when coupled with
is consumed or disposed of. Plating and serving sizes can be managed other contextual information that may be available, such as location
by tracking weights on scales or weight-sensitive surfaces. (from smartphone GPS, for example for specific types of restaurant) or
Snacking is an important component of food intake that is often known preferences (Herranz, Jiang, & Xu, 2017).
missed. This could be tracked through purchasing events for out of Smartphones are the most convenient device for diet monitoring.
home snacks and from inventory changes in the home. The use of so- The image processing-based methods currently in use are too resource-
called “loyalty cards” with food retailers enables the purchaser's de- demanding for smartphone capability. Weaknesses of image analysis
tailed purchasing records to be linked to their personal details. At systems are that they give only a two-dimensional image of the food,
present this is used to estimate demographics of purchasing for mar- and so they are not good at estimating serving size, and that they
keting purposes, but there is no technical reason why these data could analyze only the surface of the food, which, in the case of a non-
not be used as part of the food record for that person. homogeneous food, means they are of little use. The recent develop-
It has been estimated that nearly half the world's population eats out ment of cameras that take 3-dimensional images, such as the Intel de-
at least once a week (Nielsen, 2016). Understanding of the nutritional vice called RealSense (https://www.intel.com/content/www/us/en/
values for restaurant and other food service dishes is therefore im- architecture-and-technology/realsense-overview.html), a little camera
portant. The nutritional composition of food from the major chains of that gives 3D surface scans with mm scale accuracy, may go some way
restaurants in the United States is available through the website to better estimation of portion size. Another weakness is that condi-
Menustat.org, and these values are likely to be valid for those chains ments that may be sprinkled on food, most importantly salt (blood
where they extend outside the United States, although this would need pressure) and sugar (blood glucose) are not able to be seen and mea-
to be verified. A difficulty in using the nutritional values from many of sured. A recent review concluded: “We believe that food image analysis is
these restaurants is that while the composition of their dishes is known, not likely to provide a general fully automated mobile stand-alone solution in
serving sizes can vary, thus altering intake values (Niederman, Leonard, the near future. Nevertheless, it can be integrated with other technologies to
& Clapp, 2017). Small independent restaurants cannot provide reliable form comprehensive solutions and improve the monitoring system's effec-
nutritional data: being able to report and manage meal composition is tiveness and accuracy.” (Hassannejad et al., 2017).
beyond the means of most, both technically and in terms of compliance Smart Plate Top View appears to be a partial solution – it is a system
costs (Brown et al., 2017). that combines a segmented, weighed plate with smartphone photo-
graphy, image recognition software and artificial intelligence to
monitor what is on your plate, interpret food intake and make re-
commendations. This system has the same limitation concerning foods

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Table 2
Smart devices that could be used to track food consumption.
Name of device What it does Where to find out more (web sites accessed March 2019)

Diet eyeglasses Recognizes chewing Zhang, Bernhart, Amft, and Ieee (2016)
Electromyography Recognizes swallowing Nederkoorn, Smulders, and Jansen (1999)
Autodietary Acoustic recognition of eating Bi et al. (2016)
Chefling Smartphone or tablet app - records inventory and suggests recipes http://www.chefling.net/
Neo Smart Jar Jar that is programmed for what it will contain, nutritional values, monitors contents and https://innovationessence.com/understand-pantries-accordily/
reports/reorders via Bluetooth and an app.
SmartPlate Intelligent nutrition platform that uses advanced photo recognition, inbuilt scales and AI https://www.indiegogo.com/projects/smart-plate-topview-
technology to identify, analyze, and track what is eaten. your-personal-nutritionist#/
GeniCan Barcode scanning attachment for garbage can – reorder when you use something. https://www.genican.com/
HapiFork Monitors eating rate and eating habits https://www.hapi.com/product/hapifork
SCio Scanner Near Infrared scanner smartphone attachment – gives surface composition of food https://www.consumerphysics.com/
https://www.dietsensor.com/product/scio-scanner/
KogniChef Prototype assistive kitchen – provides instruction and controls kitchen devices for meal Neumann et al. (2017)
preparation

that are non-homogeneous as other image recognition apps, but does warnings or reminders about aspects of food purchasing and con-
allow identification between suggested options, and does manage por- sumption to support the health of the client. Whether the App can be
tion size better. It does not link to health and other biological data (such based solely on a smartwatch, on a smartphone or needs to be based in
as nutritional phenotype) and it appears to be designed only for non- the cloud is not clear and it is possible that a mixture of the three will be
animal foods. An earlier version of this device has been withdrawn, and used. The functionality and data flows of the system are shown sche-
a new improved version is projected to become available in July 2019. matically in Fig. 2.
Another device that has potential but is not currently being widely The Artificial Intelligence Engine (AI) must offer dietary advice
used for nutrition purposes is the smartphone linked pocket-size near from inputs such as food intake, physical exercise and medical history.
infrared scanner (SCiO - www.consumerphysics.com). This device has The model itself will be based around balances, carried out to predict
been shown to be useful for measuring the ripeness (sugar content) of energy, macro and micro nutrient intake vs consumption based on food
fruit (Kaur, Kunnemeyer, & Mcglone, 2017) and may have wider ap- composition databases and recommended daily allowances. Machine
plication, as near infrared spectroscopy can be used for measuring the learning allows improvement of the AI engine advice based on the in-
composition of food items. dividual's health response resulting from adoption of past advice, en-
The use of on-body sensors is another possibility. A wide range of abling personalization of the system. These ‘personalization's’ will ac-
different wearable sensors have been developed, with many available count for differences between people such as those due to metabolic
commercially; some are listed in Table 2. These devices are still in their phenotype diversity (Holmes et al., 2008) and microbiome. Training of
infancy, especially when applied to food and eating, but more accurate the AI to an individual could be done by applying the AI to their current
and more sophisticated ways to determine what and when we eat are to diet for some initial period prior to offering advice to achieve nutrition
be expected. and health goals.
A recent comprehensive review of technology-based tools for Metabolomic researchers are developing sophisticated models of
dietary intake assessment concluded: “Dietary assessment methods that human metabolism, where key metabolites, networks of metabolism
utilize technology offer many advantages for research and are often pre- pathways and reaction and transport fluxes are mathematically mod-
ferable to consumers over more traditional methods. In order to meet general elled. One such model is the community-developed Recon 2.2
quality standards, new technology tools require detailed publications de- (Swainston et al., 2016), which includes 5324 metabolites, 7785 reac-
scribing tool development, food identification and quantification, customi- tions and 1675 genes and can predict ATP production on different
zation, outputs, food composition tables used, and usability/validity testing.” carbon sources and in different conditions. While these models are
(Eldridge et al. (2019). developed for disease study, identification of new biomarkers, under-
standing host-microbe interactions (Thiele et al., 2013) and drug dis-
covery (Kell & Goodacre, 2014), they could be used to develop sim-
8. Putting it all together plified metabolic models to extend the accuracy of AI predictions. A
potential outcome of this approach could be characterization of an in-
The full eNutrition solution will be a virtual personal dietitian, and dividual's “Biochemical Profile” that links dietary intake and exercise to
assistive system that monitors what food is consumed, provides alerts physiological status. This information could assist medical profes-
about foods that should be consumed or avoided, or inappropriate sionals, nutritionists and the AI itself to advise on changes towards
portion sizes, at the same time monitoring health and body functions on health aspirations (e.g. prescription of metformin to change carbohy-
a semi-continuous basis. It should also be able to advise on recipes and drate metabolism and storage).
menu choices for food. Most of the necessary components exist in some A personalized nutrition AI must not only be personalized with re-
form at present, although many are quite rudimentary and not espe- spect to the response of the individual to dietary uptake, it must also
cially accurate. consider preference when proposing dietary suggestions. The food
A schematic of how a fully functional assistive Personalized market place is driven by personal choice and to be accepted by con-
eNutrition management system might work is shown in Fig. 1. We note sumers, a personalized nutrition app must facilitate choice as well as
that similar systems have been proposed by Bashiardes, Godneva, tailoring suggestions that will be readily accepted by its user. As well as
Elinav, and Segal (2018) with a particular focus on metabolic syndrome avoiding foods that have drug or allergic responses, foods that a con-
and by Boland, Alam, and Bronlund (2019) with a focus on personali- sumer dislikes should also be avoided. Foods or recipes aligned with
zation. cultural or favorite cuisines should be prioritized while still maintaining
The heart of the system is what we have here designated an “App”. choice or variety. Behavioral cues may be derived from wearable device
This App is, in fact, an artificial intelligence system that uses the various data to aid in providing appropriate dietary advice. For example, signs
data streams – about aspects of health, activity, preferences, body data, of ongoing stress from elevated blood pressure or heart rate could
food purchasing and food consumption – and provides timely advice,

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M. Boland and J. Bronlund Trends in Food Science & Technology 91 (2019) 634–639

Fig. 1. Overview of the hardware of theeNutrition system and its interactions.

promote the suggestion of comfort food or something that can be pre- The smartwatch component has two main functions, one providing
pared rapidly. The flexibility and adaptive nature of AI and machine timely physical and physiological data about the client to the App,
learning can facilitate development of these outcomes. while also being the primary carrier of alerts. Most smartwatches today
The smartphone is an essential component for implementation of an produce a reasonable estimate of energy expenditure based on the
AI engine, enabling access to the internet and datasets in the cloud, and number of steps taken (for a review of this function see (Xie et al.,
the camera function allows photography of food items and menu list- 2018)) and also pulse rate, based on an interpretation of blood vessel
ings. The code-reading function of the camera will allow conversion of expansion and contraction, from reflectance of the skin (photo-
barcodes and QR codes on packaging to nutritional data about food plethysmography) (Kao, Chao, & Wey, 2018). While this is a reasonably
products by using the online datasets. good measure for pulse rate, further extension to measure blood

Fig. 2. Schematic of the data linkages and flows in the eNutrition system.

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