Rajiv Gandhi University of Health Sciences, Karnataka

4th T Block Jayanagar, Bengaluru

Curriculum design, continuous and formative assessment evaluation of B.
Pharm. course of Semester 1 & 2 w.e.f Academic year 2017-18
SEMESTER-IV
BP 403 T: physical pharmaceutics-II

1. Departmental objectives (what the learners will be able to perform after

completing the subject):
A. Learning Objectives:

Upon completion of this course the student should be able to

1. Understand various physicochemical properties of drug molecules in the designing the dosage
form

2. Know the principles of chemical kinetics & to use them in assigning expiry date for
Formulation

3. Demonstrate use of physicochemical properties in evaluation of dosage forms.

4. Appreciate physicochemical properties of drug molecules in formulation research and

Development

2. Content distribution as per the list of topics, time allotted for each topic,
distribution for ‘Must know’, ‘Desirable to know’ and ‘Nice to know’ and the
probable weightage.

The following table can also be a reference frame for continuous and formative
assessment of learning. If the curriculum management is scheduled as per the
tabulation, there can be clarity for both learners and teachers to take stock of the
mastery achieved in each objective. This will also help for professional excellence
that goes beyond the examination process.

UNIT-I Hours:10 Weightage: 24 Marks

Learning Topics
content
Colloidal dispersions
distribution
Must know General characteristics, size & shapes of colloidal particles, classification of
colloids & comparative account of their general properties. Optical, kinetic
& electrical properties. Effect of electrolytes, coacervation, peptization &
protective action.
Desirable to Classification of dispersed systems
know
Nice to know Preparation and purification of colloids.

UNIT-II Hours: 10 Weightage: 19 Marks

1
Learning Topics
content
Rheology
distribution
Must know Newtonian systems, law of flow, kinematic viscosity, effect of temperature,
non-Newtonian systems, pseudoplastic, dilatants, plastic, thixotropy,
thixotropy in formulation, determination of viscosity, capillary and
rotational viscometers
Deformation of solids: Plastic and elastic deformation, Heckel equation,
Stress, Strain, Elastic Modulus
Desirable to Determination of viscosity falling Sphere,
know
Nice to know Brookfield Viscometer

UNIT-III Hours: 10 Weightage: 19 Marks

Learning Topics
content
Coarse dispersion
distribution
Must know Suspension, interfacial properties of suspended particles, settling in
suspensions, formulation of suspensions. Emulsions and theories of
emulsification,; Physical stability of emulsions, rheological properties of
emulsions, phase equilibria and emulsion formulation by HLB method.
Desirable to Microemulsion and multiple emulsions, preservation of emulsions,
know
Nice to know Nano suspension and emulsion.

UNIT-IV Hours: 08 Weightage: 19 Marks

Learning Topics
content
Micromeretics
distribution
Must know Int Particle size and distribution, , methods for determining particle size by
Introduction,
(different methods), counting and separation method, particle shape, specific surface, methods
for determining surface area, permeability, adsorption, derived properties of powders,
porosity, packing arrangement, densities, bulkiness & flow properties.
Desirable to Average particle size, number and weight distribution, particle number
know
Nice to know Applications of derived properties of powders in designing solid
dosage forms

UNIT-V Hours: 7 Weightage: 14 Marks

Learning Topics
content
Drug stability
distribution
Must know Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate
constants, determination of reaction order. Physical and chemical factors
influencing the chemical degradation of pharmaceutical product:

2
 temperature, solvent, ionic strength, dielectric constant, specific & general
acid base catalysis,. Stabilization of medicinal agents against common
reactions like hydrolysis & oxidation. Accelerated stability testing in
expiration dating of pharmaceutical dosage forms.
Desirable to Simple numerical problems, Photolytic degradation and its prevention
know
Nice to know Applications of kinetics in bioavailability

Blueprint of question paper, for each QP. This shows the weightage given to each
chapter in the summative assessment. This improves the content validity by
distributing the assessment of learners in the competencies that are represented by
learning objectives under each chapter.

BLUE PRINT OF MODEL QUESTION PAPER

BP403T: Physical Pharmaceutics-II
TIME: 3 HOURS MAX. MARKS: 75

Unit No Must know Desirable to know Weightag

Hours

LE SE SA LE SE SA e of
(10X3) (5X8) (2X5) (10X0) (5X1) (2X5) marks
Unit-I 10 1 2 1 _ 1 24
Unit-II 10 1 1 1 _ 1 19
Unit-III 10 1 1 1 _ 1 19
Unit-IV 08 2 1 _ 1 1 19
Unit-V 07 2 1 _ 1 14
Total 45 30 40 10 - 5 10 95
80 15 95

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