Low Temperature Sterilization Agenda

• Low Temperature Sterilization Types

• Plumbing Schematic and Graph

• Hydrogen Peroxide vs “Plasma Sterilization”

• Instrument Application Dos and Don’t’s

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Low Temp Sterilization Types
• Ethylene Oxide (EtO) – C2H4O
• Hydrogen Peroxide – H2O2
• Ozone - O3
• Gamma ,etc

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 Ethylene Oxyde
Pros :
• Kills Everything
• Boils @ 250C
• Form in small molecule (have excellent penetration)
• Perform well in instrument with lumens
• Compatible with almost every packaging
• Use Alkylation method to do sterilization
• Use Bacillus Athropaeus for BI

Cons :
• Kills Everyone (can develop Carcinogen), handle with care
• Toxic residue (need to dispose with certain procedure)
• Requires extensive time for sterilization (8-12 hours for aeration, 6-7 hours for sterilization)

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 Hydrogen Peroxide
Pros :
• Kills Everything
• No Toxic Residue
• Fast Processing time (28 minutes for non lumen)
• Use Oxydation method to do sterilization
• Use Geobacillus Sterothermophilus for BI

Cons :
• Need Sterilant to do sterilization
• Compatible only with Tyvex material
• Rely on Deep Vacuum Draw
• Don’t work well on linen,paper,cotton

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Plumbing Schematic

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Graph

Vacuum

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Hydrogen Peroxide VS Plasma Gas
• Similiarity :
• Use the same Sterilant = 59% H2O2
• Use Oxidation for sterilization process
• Only Compatible with Tyvek material
• Use Geobacillus Sterothermophilus for BI
• Use Catalytic Converter to convert to H2O and O2
• Differentiate :
• Plasma use generator to excite vaporized H2O2
• Plasma tend to have longer time to process
• Plasma tend to increase H2O2 concentration to 90%
http://www.chemdaq.com/we-dont-use-hydrogen-peroxide-we-have-a-sterrad-plasma-sterilizer/

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Plumbing Schematic

Plasma
Generator

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Graph

Introduce RF from
Plasma Generator
To convert H2O2 to
H2O and O2

Vacuum

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 Increase concentration to 90%
Graph

Introduce RF from
Plasma Generator
To convert H2O2 to
H2O and O2

Vacuum

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Instrument Application Dos & Dont’s
• Dos :
• Sterilize almost everything
• See FAQ each instrument to meet the requirements
http://www.hungaronotes.hu/minden/notes2014/Sonicision.pdf
• Wash first before sterilize
• Choose correct mode for sterilization
• Use CI & BI for monitoring
• Dont’s :
• Don’t use cotton,paper,linen
(everything that have celluse material)
• Don’t forget to change oil for vacuum pump
• Don’t forget to change filter in PM kit
• Don’t turn off the machine

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