6/29/2019 The Best Binders To Use In The Production Of Your Pills

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Binder Types and Properties Used in Tablet Manufacturing

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Binder Types and Properties Used in Tablet Manufacturing

A binder (https://www.lfatabletpresses.com/products/binding- lling- owing-agents)is a chemical compounds that

has an adhesive property, and is one of the more important excipients that are included in tablet formulations. In
simple terms, binders or adhesives are the substances that promotes cohesiveness. A binder is therefore used for
transforming powder into granules through a process known as granulation. In tablet making, granulation is the
process by which small powdery particles are agglomerated into larger entities called granules. In the
agglomeration, the active ingredient and excipients are bound together by the binder which gives the granule
strength. Binders can also form intergranular bonds that fuse the granules together, forming bridges between
adjacent granules. The bridges may result from the melting or softening of the binder during the compression
process. Rather than add the binder to the powder before the granulation process, a relatively recent innovation is
to mix a dry binder directly with the powder before the tablet compression step. This approach is known as direct
compression. The types of binder used for granulation and direct compression are described below.

Binders for Granulation

Flow or uidity and compressibility are the essential characteristics required for powders/granules that are
intended for tablet compression. Fluidity is necessary for the production of tablets of consistent weight and uniform
strength. Compressibility is required to form a stable, intact and compact mass when pressure is applied.
Traditionally granulation has been the means to achieve both uidity and compressibility of the tablet material.
Granulation has also been used to improve the appearance, mixing properties, to avoid dustiness, to densify
material, to reduce segregation, and in general to either eliminate undesirable properties or to improve the physical
characteristics of ne powders.

Granulation techniques include wet granulation in which the binder is added in the form of a solution or
suspension, and dry granulation/slugging in which the binder is added as a dry powder.

For both solution and dry binders, the compounds are added in low concentrations - typically about 2-10% by

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weight. Common traditional binders include sucrose, gelatin and starch. More recently introduced binders include
polymers such as cellulose derivatives and polyvinylpyrrolidone, which have improved adhesive properties.  - Terms
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6/29/2019 The Best Binders To Use In The Production Of Your Pills

Examples of dry binders include cross-linked polyvinylpyrrolidone and microcrystalline cellulose

(https://www.lfatabletpresses.com/microcrystalline-cellulose).

The most common and means of adding binder to powder that is to be granulated, is as a solution. Although the
solution method is considered the most e ective way of adding binder, an important issue is the compatibility of
binder with the API & other tablet components. This is traditionally found by choosing an appropriate stability study
design.

Drug characteristics such as compressibility, particle size, surface area, porosity, hydrophobicity and solubility in
binder are all important when assessing granulation. A poorly compressible drug formulation will requires a strong
binder such as liquid glucose, sucrose, etc., whereas drugs that exhibit good compressibility can be successfully
handled using a weak binder (starch paste etc.). Fine and porous powder particles require higher amounts of liquid
binder in contrast to coarse particles which require lsee. Hydrophilic drug/excipients also require a higher volume
of binder compared to hydrophobic drug/excipients. The granule quality (size, friability) is governed by the solubility
of the drug in the granulation solution.

The uniformity of the particle size, hardness, disintegration and compressibility of the granules depends on the type
and quantity of binder added to formulation. For example hard granulations that require excessive force during
tabletting may be the result of using a stronger binder or a highly concentrated binder solution. On the other hand,
fragile granulations may be due to an insu cient quantity of binder in which particles segregate easily. Larger
quantities of granulating liquid tend to produce a narrower particle size range of coarse and hard granules, i.e. the
proportion of ne granulates is less. Therefore the optimum quantity of liquid needed to obtain a given particle size
should be determined before setting up the granulation process so as to keep batch to batch variations to a
minimum.

Binder Concentration Recommendation:

Preservative Concentration for Liquid Oral Preparation

Sr. Recommended
No. Binder %

1 Acacia gum with water for hydro alcohol 2 to 5%

2 Gum tragacanth with water 1 to 3%

3 Gelatin with water 1 to 4%

4 Sucrose with water 2 to 20%

5 Starch paste in water 1 to 4%

6 Sodium alginate with water 3 to 5%

7 Methyl cellulose with water 2 to 6%

8 Sodium carboxymethyl cellulose with water 6%

9 Ethyl cellulose with alcohol 0.5 to 2%

10 Hydroxy propyl methyl cellulose with water, hydro alcohol, methylene chloride 2 to 5%
etc.

11 Polyvinyl pyrrolidone with water, alcohol and hydro alcohol 0.5 to 5%

12 Magnesium aluminium silicates with water 2 to 10%

Binders for Direct Compression

Direct compression o ers a simpler route to tablet manufacture, product stability and high e ciency, and the
method has therefore increased in popularity in recent years. Direct compression is suited to moisture- or heat-
sensitive ingredients that are contraindicated in wet granulation. It is also well suited to powders which can be
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mixed well and do not require further granulation steps prior to introduction to the tablet press. For Direct
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6/29/2019 The Best Binders To Use In The Production Of Your Pills

Compression, directly compressible binders are required which should exhibit adequate powder compressibility
and owability. Direct compression binders should therefore be selected on the basis of compression behaviour,
volume reduction under applied pressure and ow behaviour in order to have optimum binding performance. The
choice and selection of binders is extremely critical for Direct Compression tablets. It is possible to use pre
formulated pill powder mix like Firmapress (https://www.lfatabletpresses.com/ready-mix- rmapress).

Commonly Used Direct Compression Binders

LFA stocks a large range of binders as well as other excipients (https://www.lfatabletpresses.com/ready-mix-
rmapress). If you are having trouble formulating your mix why not get in contact and see if we are able to help. We
have a lot of experience in developing custom formulas.

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