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AQA TRILOGY
INFECTION AND
RESPONSE
Q1-6 FOUNDATON
Q3-9 HIGHER
Page 1 of 30
Q1.
Figure 1 shows one type of white blood cell.
Figure 1
Cell membrane
Cell wall
Cytoplasm
Nucleus
(1)
(b) White blood cells help to defend the body against pathogens.
Clone pathogens
Engulf pathogens
Produce antibiotics
Produce antibodies
Produce antitoxins
Page 2 of 30
Produce toxins
(3)
Figure 2 shows the number of cases of measles in England and Wales between 2012 and
2015
Figure 2
(c) Use Figure 2 to calculate the decrease in the number of cases of measles between
2012 and 2015
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(d) Suggest one reason for the decrease in the number of cases of measles between
2012 and 2015
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(1)
Page 3 of 30
(e) Antibiotics cannot be used to treat measles.
Suggest why.
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(1)
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(1)
A clear area around the disc means the antibiotic has killed the bacteria.
Figure 3
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Page 4 of 30
(1)
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(1)
Antibiotic ___________________________________________________________
Reason ____________________________________________________________
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(2)
(Total 13 marks)
Q2.
Antibiotics are used to kill some types of pathogen.
AIDS
Measles
Salmonella
Type 2 diabetes
(1)
He noticed that one of his Petri dishes containing bacteria had become contaminated with
a fungus.
Page 5 of 30
(b) Read the information about the discovery of penicillin.
Information Description
Conclusion
Hypothesis
Investigation
Observation
Result
(4)
The greater the distance from the fungus the more bacteria grew.
Page 6 of 30
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(1)
1. _________________________________________________________________
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2. _________________________________________________________________
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(2)
(Total 8 marks)
Q3.
Pathogens are microorganisms that cause infectious disease.
(a) Draw one line from each disease to the way the disease is spread.
Drinking contaminated
Cholera
water
(b) One way the human body protects itself against the entry of pathogens is by
producing antimicrobial chemicals.
Give two other ways the human body protects itself against the entry of pathogens.
1. _________________________________________________________________
Page 7 of 30
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2. _________________________________________________________________
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(2)
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(1)
In 2013, 92% of children in the UK had two vaccination injections against measles.
The figure below shows how the concentration of antibodies in the blood changes
after each measles vaccination.
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(1)
(e) What is the highest concentration of antibodies produced by the first vaccination?
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(1)
(f) How will the number of children getting measles change as more children are
vaccinated against measles?
Page 8 of 30
Change ___________________________________________________________
Reason ____________________________________________________________
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(2)
(Total 10 marks)
Q4.
There are several methods of contraception.
(a) Draw one line from each method of contraception to how the method works.
Method of
How the method works
contraception
(b) When a new oral contraceptive is tested on volunteers, the contraceptive is first
given at a low dose. Later, the dose is increased.
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(1)
(c) The table below shows information about three methods of contraception.
Percentage (%)
98.0 99.7 99.8
effectiveness
Headaches, Headaches,
Possible side No serious
nausea, high nausea, blood
effects side effects
blood pressure clots
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Page 9 of 30
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(6)
(Total 9 marks)
Q5.
Food poisoning can be caused by eating food that is contaminated with Salmonella
bacteria.
(a) Give one difference between a bacterial cell and an animal cell.
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(1)
The table shows the number of confirmed cases of salmonella food poisoning in the UK.
2006 23.82
2007 22.24
2008 18.82
2009 17.17
2010 15.39
2011 15.12
2012 14.00
2013 13.16
2014 12.63
Page 10 of 30
2015 14.50
It is estimated that in the UK, for every confirmed case of salmonella poisoning there are
another 3 unconfirmed cases.
(b) Estimate the total probability of suffering from salmonella food poisoning in 2015.
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(3)
(c) Describe the trend in the number of confirmed cases of salmonella food poisoning
between 2006 and 2014.
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(1)
(d) Suggest two reasons for the trend in the data between 2006 and 2014.
1. _________________________________________________________________
___________________________________________________________________
2. _________________________________________________________________
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(2)
(e) The graph shows the number of confirmed cases of salmonella food poisoning in
the UK during one year.
Page 11 of 30
Suggest one reason for the high number of cases of salmonella food poisoning in
the summer.
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___________________________________________________________________
(1)
(Total 8 marks)
Q6.
Scientists at a drug company developed a new pain-killing drug, drug X.
Why?
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(1)
(b) The scientists compared drug X with two other pain-killing drugs, drug A and drug
B.
In their investigation the scientists:
• chose 600 volunteers. The volunteers were all in pain
• gave 200 of the volunteers a standard dose of drug A
• gave 200 of the volunteers a standard dose of drug B
• gave 200 of the volunteers a standard dose of drug X.
Over the next seven hours the volunteers recorded how much pain they felt.
To get valid results the three groups of volunteers should be matched for as many
factors as possible.
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Page 12 of 30
(2)
(i) How much pain did the volunteers still feel, four hours after taking drug A?
______________________________ percent
(1)
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(1)
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(2)
(d) Drug X is much more expensive than both drug A and drug B.
A pharmacist advised a customer that it would be just as good to take drug A and
drug B together instead of drug X.
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Page 13 of 30
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(3)
(Total 10 marks)
Q7.
White blood cells protect the body against pathogens such as bacteria and viruses.
______________________________________________________________
______________________________________________________________
(1)
(ii) White blood cells produce antibodies. This is one way white blood cells protect
us against pathogens.
Give two other ways that white blood cells protect us against pathogens.
1. ____________________________________________________________
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2. ____________________________________________________________
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(2)
What does the doctor inject into the child to make the child immune to
measles?
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Page 14 of 30
(2)
(ii) A few weeks after the vaccination, the child becomes infected with measles
viruses from another person.
The graph shows the number of measles antibodies in the child’s blood from
before the vaccination until after the infection.
More measles antibodies are produced after the infection than after the
vaccination.
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(3)
(iii) Vaccination against the measles virus will not protect the child against the
rubella virus.
Why?
______________________________________________________________
(1)
Page 15 of 30
(c) What is the advantage of vaccinating a large proportion of the population against
measles?
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(1)
(Total 10 marks)
Q8.
Malaria is a disease caused by a microorganism carried by mosquitoes.
© watcharapon/iStock
The World Health Organisation estimates that 3 × 108 people are infected with malaria
every year.
The people who are infected with malaria but do not die, may be seriously ill and need
health care for the rest of their lives.
(a) Based on the estimated figures, what percentage of people infected with malaria die
from the disease?
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Page 16 of 30
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(2)
Explain why.
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(2)
Do you think scientists should release millions of male GM mosquitoes into the
wild?
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(4)
Page 17 of 30
(iii) Describe the process for creating a GM mosquito.
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(3)
(Total 11 marks)
Q9.
In 2014 there was an outbreak of Ebola virus disease (EVD) in Africa.
(a) By March 2015 there were an estimated 9 850 deaths worldwide from EVD.
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(1)
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(1)
(c) After the outbreak began, drug companies started to develop drugs and vaccines for
EVD.
A drug has to be thoroughly tested and trialled before it is licensed for use.
Testing, trialling and licensing new drugs usually takes several years.
Draw one line from each word about drug testing to the definition of the word.
Page 18 of 30
Dose Side effects making the person ill
(d) The results of drug testing and drug trials are studied in detail by other scientists.
Suggest one reason why the results are studied by other scientists.
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(1)
The World Health Organization (WHO) decided it was ethical to use unlicensed
drugs.
The WHO said unlicensed drugs could only be given to people who gave their
permission.
Also, any results had to be shared with other researchers and drug companies.
Some vaccines had shown positive results in animal testing, but the vaccines had
not been tested and trialled in humans.
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(2)
(f) Evaluate the use of unlicensed drugs and vaccines during the EVD outbreak.
Give a conclusion.
Page 19 of 30
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(6)
(Total 13 marks)
Page 20 of 30
Mark schemes
Q1.
(a) cell membrane
extra ticks negates marks
1
produce antibodies
1
produce antitoxins
1
extra ticks negates marks
= 1950
allow 1 mark for a correct subtraction of incorrect
values
1
an answer of 1950 scores 2 marks
Page 21 of 30
• vaccination / immunisation
• avoid sexual intercourse / contact
do not accept less sexual intercourse / contact
1
(h) to check that the disc / water did not have an effect
or
to make sure it was the antibiotic that had an effect
allow for comparison with the antibiotics
allow as a (experimental) control
do not accept as a control variable
1
(i) (antibiotic) A
no marks if wrong antibiotic given
1
Q2.
(a) salmonella
1
(b)
1
1
1
1
Page 22 of 30
(c) lower concentration of antibiotic / chemical further from the fungus
allow less antibiotic / chemical further from the fungus
1
Q3.
(a) Disease Way the disease is spread
(e) 2.5
1
less likely to come into contact with someone with measles / the disease
1
[10]
Page 23 of 30
Q4.
(a)
2
2 marks for all 3 correct
allow 1 mark for 1 or 2 correct
Level 2: Some logically linked reasons are given. There may also be a simple
judgement.
3−4
Level 1: Relevant points are made. They are not logically linked.
1−2
No relevant content
0
Indicative content
ignore costs
ignore how the contraceptive works
[9]
Q5.
(a) any one from (bacterial cell):
Page 24 of 30
• has a cell wall
• has plasmids
allow converse
• has a single DNA loop
• has no nucleus
• is much smaller
1
43.5 + 14.50 = 58
or
14.50 × 4 = 58
allow 58 for 2 marks
1
(58 / 100000 =)
0.00058 or 0.058%
an answer of 0.00058 or 0.058% scores 3 marks
1
vaccination of poultry
1
Q6.
(a) don’t kill pathogens / bacteria / viruses / microbes / microorganisms
allow don’t contain antibiotics
ignore antibodies / attack / fight
allow only treat symptoms / pain
ignore kill disease / germs
1
• age
• gender
Page 25 of 30
• type of pain / illness / site of pain
accept ‘the pain’ for 1 mark, if neither extent or type given
ignore pain threshold
• ethnicity
2
(c) (i) 75
ignore calculations / %
1
(Yes because)
(No because)
Page 26 of 30
3
[10]
Q7.
(a) (i) any one from:
Page 27 of 30
Q8.
(a) 0.67(%)
allow
allow 1 mark for evidence of (2 × 106) ÷ (3 × 108)
or
allow 1 mark for 0.0067 or 0.6
2
(b) (i) idea that food chains start with plants / producers
allow food chains do not start with animals or larvae are
consumers
1
idea that these make food (for other organisms in the chain)
allow idea that plants / producers photosynthesise or plants /
producers get energy from the sun
allow mosquito larvae do not make food / photosynthesise or
mosquito larvae do not get energy from the sun
1
advantages:
• fewer mosquitos biting or spreading malaria
• fewer people get / die from malaria
allow people won’t get / die from malaria
• lower medical costs (for those infected or for treatment) or less
healthcare needed
• better economically for developing / tropical countries.
disadvantages:
• fewer crops reproduce
allow fewer crops pollinated
• poorer crop yield
• possible starvation (of people)
• high cost of GM production / mosquito release
• less food for bats / birds or bats / birds die
allow disruption to food chain / ecosystem or reduction of
biodiversity
• gene could ‘escape’ into other wildlife / species
ignore into plants
4
Page 28 of 30
3
[11]
Q9.
(a) any one from:
(c)
if less people (in a population) have EVD less chance of it being passed on
1
Page 29 of 30
Discrete relevant points made. The logic may be unclear and the conclusion, if
present,
may not be consistent with the reasoning.
0 marks:
No relevant content
Indicative content
pros
• might save some lives
• vaccine could reduce chance of future outbreaks
• patient made aware of risk and agreed to use of drug
• sharing of results could speed up development of effective vaccines / drugs
• used mainly for health workers who were risking their lives to help
cons
• could be dangerous
or
vaccine could harm a healthy person
• goes against legislation / laws governing drug development
• might set a precedent for other drugs not to be fully tested
• unfair as not available to the African people
a justified conclusion
6
[13]
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