THE CORRELATION BETWEEN SERUM LIPID PROFILE

WITH CAROTID PLAQUE

Enggar S. Kesumawardani, Bagus Prasetyo, Wibisono Firmanda
Cardiology Unit, Sekayu Hospital, Musi Banyuasin, South Sumatera

Table 1. Clinical characteristics (n=38)

Variables Mean ± SD or %
Gender, male (%) 35 (98.10)

BACKGROUND
?

? Age (years) 48.42 ± 7.47

Blood pressure, hypertension (%) 8 (15.80)
Fasting blood glucose (mg/dL) 97.11 ± 29.70
Atherosclerosis is the primary cause of mortality TC 223.74 ± 45.45
and morbidity in cardiovascular disease (CVD), and TG 103.16 ± 38.77
1
dyslipidemia is the most important risk factor HDL-C 49.53 ± 8.01
2,3
Previous studies on global population: LDL-C 136.26 ± 35.80
LDL-C is the primary atherogenic lipoprotein TC/HDL-C ratio 4.60 ± 1.02

HDL-C is the predominant anti-sclerotic lipoprotein LDL-C/HDL-C ratio 2.80 ± 0.80

TG/HDL-C ratio 2.16 ± 0.92
Lipid ratios are better predictive value Presence of carotid plaque (%) 7 (18.42)
No data for Indonesian population
Abbreviations: TC serum total cholesterol, TG serum triglycerides, HDL-C serum high-density lipoprotein cholesterol, LDL-C

OBJECTIVE
To evaluate the association between conventional lipid
profile with carotid plaque

METHOD 1 2
Consecutive cross-sectional study from general popu-
lation performed MCU Picture 1 and 2. Mixed plaque at left bifurcation carotid artery (arrow) examined by
38 subjects (mean age 48.42 years; 92.1% male) B mode (1) and doppler ultrasonography (2)
Demographics, vital sign, and laboratory data were
collected
The Presence of carotid plaque was evaluated by B- Table 2. Association between carotid plaque with serum lipid profile and other variables
mode ultrasonography Independent T-test & Chi-square Linear regression
VARIABELE
Plaque (+) (n=7 ) Plaque (-) (n=31 ) p-value OR p-value

RESULT & DISCUSSION Gender (male)* 7 (100) 22 (70.98) 0.533 2.22 0.034
Age (years) 51.57 ± 4.76 47.71 ± 7.83 0.112 1.38 0.179
T-test: carotid plaque associated with TG serum (p=0.041) Hypertension* 2 (28.57) 4 (12.90) 0.302 1.06 0.296
and TG/C-HDL ratio (p=0.037) Fasting blood glucose 105.86 ± 54.97 95.13 ± 21.47 0.629 0.85 0.929
Logistic regression: Male gender, LDL-C/HDL-C & TG/HDL-C TC 244.29 ± 48.17 219.10 ± 45.57 0.119 2.54 0.999
TG 130.00 ± 25.96 97.10 ± 38.90 0.041 1.59 0.652
Similar studies:
• LDL-C/HDL-C ratio combined with HDL-C may predict the presence of HDL-C 46.57 ± 7.85 50.19 ± 8.02 0.286 1.66 0.108
1
carotid plaque (402 subjects, Chinese) LDL-C 141.86 ± 36.03 135 ± 36.22 0.653 -0.06 0.948
• TG level , rate of newly identified carotid plaque  (1949 subjects, TC/HDL-C ratio 5.24 ± 0.84 4.45 ± 1.01 0.063 -0.316 0.754
2
5-year-cohort, Beijing) LDL-C/HDL-C ratio 3.04 ± 0.68 2.74 ± 0.82 0.371 2.24 0.033
• TG/HDL-C was independently associated to a greater probability of TG/HDL-C ratio 2.00 ± 0.88 2.88 ± 0.86 0.037 2.44 0.047
5
carotid plaque (332 women, Argentina) Use Chi-square*
Abbreviations: TC serum total cholesterol, TG serum triglycerides, HDL-C serum high-density lipoprotein cholesterol, LDL-C

CONCLUSION
 Serum TG and TG/HDL-C ratio was associated with carotid
plaque.
 Male gender, LDL-C/HDL-C and TG/HDL-C ratio may predict
the presence of carotid plaque.
References:
1. Yang et al.: The correlation between serum lipid profile with carotid intima-media thickness and plaque. BMC Cardiovascular Disorders 2014 14:181
2. 2016 ESC/EAS Guidelines for the Management of Dyslipidemias. European Heart Journal 2016 37: 2999-3058
3. 2014 NICE Clinical Guideline Lipid Modification: Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention od cardiovascular disease. National Clinical Guideline Center
2014