7/22/2019

ARTICHOKE LEAF EXTRACT FOR HYPER CHOLESTEROLEMIA

Presented By :V.Rekha*, M.Ramya,N.Harikrishnan
ABSTRACT:
Background: Hypercholesterolemia (High cholesterol) is global health problem and the incidence Hypercholesterolemia is
increasing at alarming rate all over the world. Hypercholesterolaemia is directly associated with an increased risk for coronary
heart disease and other sequelae of atherosclerosis. Artichoke leaf extract has been implicated in lowering cholesterol levels.
Objective: The present study aimed to cure hypercholesterolemia by using Artichoke leaf extract .
INTRODUCTION:
Hypercholesterolemia still remain a major cause of mortality in the world. It also called high cholesterol, is the presence of high levels
of cholesterol in the blood. According to WHO high cholesterol is estimated to cause 2.6 million deaths and 29.7 million disabilities. To over
come this I have chosen an herbal plant Artichoke(Cynara cardunculus).
Signs and Symptoms:

Adverse Effects
ARTICHOKE Mechanism Of Action Of Artichoke Leaf Extract:
Artichoke leaf extract inhibit HMG Co A Reductase
enzyme because of that cholesterol level decreases.

Conclusion: A relative study between globe artichoke standard extracts(root, bract, receptacle and leaf) was revealed that the edible parts(receptacle
and bracts) contain the highest amount poly phenols especially the potent anti-oxidant, chlorogenic acid.. Where,the medicinally used leaves exhibited lower
proportion of it followed by roots. Bract and leaf extract approximately exert the antihypercholestemia action, as well as more than root extract. However, higher
dose of artichoke (900mg/kg/day) is unadvised since signs of fatty degenerations and necrosis of liver cells are noticed. So, our recommendation is use of the
edible parts of artichoke as commercial leaf preparation designed for liver protection.

ACKNOWLEDGEMENT :
We are grateful to thank our principal Dr.N.Harikrishnan and VELS university for providing this oppurtunity.