Ciprofloxacin 2 mg/ml solution for infusion , Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage

ge & Rx Info | Ciprofloxacin Uses, Side Effects – Antifungal/ Antibacterial, Ciprofloxacin 2 mg/ml solution for infusion : Indications, Side Effects, Warnings, Ciprofloxacin - Drug Information - Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin , Taj Pharma Ciprofloxacin 2 mg/ml solution for infusion , - Taj Pharma . Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.

1. What Ciprofloxacin Infusion is and infections:

CIPROFLOXACIN • lung and bronchial infections in children and
what it is used for
SOLUTION FOR INFUSION Ciprofloxacin contains the active substance adolescents suffering from cystic fibrosis
ciprofloxacin. Ciprofloxacin is an antibiotic • complicated urinary tract infections,
2MG/ML belonging to the fluoroquinolone family. including infections that have reached the
Ciprofloxacin works by killing bacteria that kidneys (pyelonephritis)
Package leaflet: Information for the patient • anthrax inhalation exposure
cause infections. It only works with specific
Ciprofloxacin 2mg/ml Solution for
strains of bacteria.
Infusion. Ciprofloxacin may also be used to treat other
Adults specific severe infections in children and
Read all of this leaflet carefully before you adolescents when your doctor considered this
start taking this medicine because it Ciprofloxacin is used in adults to treat the necessary.
contains important information for you. following bacterial infections:
- Keep this leaflet. You may need to read it • respiratory tract infections 2. Before you are given Ciprofloxacin
again. • long lasting or recurring ear or sinus Infusion
- If you have any further questions, ask your infections You must not be given Ciprofloxacin:
doctor or pharmacist. • urinary tract infections • if you are allergic to the active substance, to
- This medicine has been prescribed for you • genital tract infections in men and women other quinolone drugs or to any of the other
only. Do not pass it on to others. It may harm • gastro-intestinal tract infections and intra- ingredients of this medicine (listed in Section
them, even if their signs of illness are the same abdominal infections 6)
as yours. • skin and soft tissue infections • if you are taking tizanidine (see section 2:
- If any of the side effects gets serious, or if • bone and joint infections Other medicines and Ciprofloxacin)
you notice any side effects not listed in this • anthrax inhalation exposure
leaflet, please tell your doctor. Warnings and precautions:
Ciprofloxacin may be used in the management
of patients with low white blood cell counts Talk to your doctor before you are given
What is in this leaflet Ciprofloxacin:
(neutropenia) who have a fever that is
suspected to be due to a bacterial infection. • if you have ever had kidney problems
1. What Ciprofloxacin Infusion is and what it is because your treatment may need to be
used for If you have a severe infection or one that is adjusted.
2. Before you are given Ciprofloxacin Infusion caused by more than one type of bacterium, • if you suffer from epilepsy or other
3. How you will be given Ciprofloxacin you may be given additional antibiotic neurological conditions.
Infusion treatment in addition to Ciprofloxacin. • if you have a history of tendon problems
4. Possible side effects during previous treatment with antibiotics
5. How Ciprofloxacin Infusion is stored Children and adolescents such as Ciprofloxacin.
6. Further Information • if you are diabetic because you may
Ciprofloxacin is used in children and experience a risk of hypoglycaemia with
adolescents, under specialist medical ciprofloxacin.
supervision, to treat the following bacterial
Ciprofloxacin 2 mg/ml solution for infusion , Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects – Antifungal/ Antibacterial, Ciprofloxacin 2 mg/ml solution for infusion : Indications, Side Effects, Warnings, Ciprofloxacin - Drug Information - Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin , Taj Pharma Ciprofloxacin 2 mg/ml solution for infusion , - Taj Pharma . Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.

• if you have myasthenia gravis (a type of For the treatment of some genital tract • If you suffer from epilepsy or other
muscle weakness) because symptoms can be infections, your doctor can prescribe another neurological conditions such as cerebral
exacerbated. antibiotic in addition to ciprofloxacin. If there ischemia or stroke, you may experience side
• if you have heart problems. Caution should is no improvement in symptoms after 3 days effects associated with the central nervous
be taken when using Ciprofloxacin, if you were of treatment, please consult your doctor. system. If seizure happens, stop taking
born with or have family history of prolonged Ciprofloxacin and contact your doctor
QT interval (seen on ECG, electrical recording While under treatment with Ciprofloxacin immediately.
of the heart), have salt imbalance in the blood • You may experience symptoms of
(especially low level of potassium or Tell your doctor immediately, if any of the neuropathy such as pain, burning, tingling,
magnesium in the blood), have a very slow following occurs during treatment with numbness and/or muscle weakness. If this
heart rhythm (called ‘bradycardia’), have a Ciprofloxacin. Your doctor will decide happens, stop taking Ciprofloxacin and
weak heart (heart failure), have a history of whether treatment with Ciprofloxacin needs contact your doctor immediately.
heart attack (myocardial infarction), you are to be stopped. • You may experience psychiatric reactions
female or elderly or you are taking other • If you feel sudden, severe pain in your after first administration of ciprofloxacin. If
medicines that result in abnormal ECG abdomen, chest or back, go immediately to an you suffer from depression or psychosis, your
changes (see section 2: Other medicines and emergency room. symptoms may become worse under
Ciprofloxacin). • Severe, sudden allergic reaction (an treatment with Ciprofloxacin. In rare cases,
• if you have been diagnosed with an anaphylactic reaction/shock, angiooedema). depression or psychosis can progress to
enlargement or "bulge" of a large blood vessel Even with the first dose, there is a rare chance thoughts of suicide, suicide attempts, or
(aortic aneurysm or large vessel peripheral that you may experience a severe allergic completed suicide. If this happens, contact
aneurysm). reaction with the following symptoms: your doctor immediately.
• if you have experienced a previous episode tightness in the chest, feeling dizzy, feeling • Hypoglycaemia has been reported most
of aortic dissection (a tear in the aorta wall). sick or faint, or experience dizziness on often in diabetic patients, predominantly in
• if you have a family history of aortic standing. If this happens, tell your doctor elderly population. If this happens, contact
aneurysm or aortic dissection or other risk immediately since the administration of your doctor immediately.
factors or predisposing conditions (e.g. Ciprofloxacin will have to be stopped. • Diarrhoea may develop while you are on
connective tissue disorders such as Marfan • Pain and swelling in the joints, and antibiotics, including Ciprofloxacin, or even
syndrome, or vascular Ehlers-Danlos tendinitis may occur occasionally, particularly several weeks after you have stopped using
syndrome, or vascular disorders such as if you are elderly and are also being treated them. If it becomes severe or persistent or you
Takayasu arteritis, giant cell arteritis, Behcet’s with corticosteroids. Inflammation and notice that your stool contains blood or
disease, high blood pressure, or known ruptures of tendons may occur even within the mucus, stop taking Ciprofloxacin and contact
atherosclerosis). first 48 hours of treatment or up to several your doctor immediately, as this can be life-
• if you or a member of your family is known months after discontinuation of Ciprofloxacin threatening. Do not take medicines that stop
to have a deficiency in glucose-6- phosphate therapy. At the first sign of any pain or or slow down bowel movements.
dehydrogenase (G6PD), since you may inflammation stop taking Ciprofloxacin, • If your eyesight becomes impaired or if your
experience a risk of anaemia with contact your doctor and rest the painful area. eyes seem to be otherwise affected, consult
ciprofloxacin. Avoid any unnecessary exercise as this might an eye specialist immediately.
increase the risk of a tendon rupture. • Your skin becomes more sensitive to
Ciprofloxacin 2 mg/ml solution for infusion , Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects – Antifungal/ Antibacterial, Ciprofloxacin 2 mg/ml solution for infusion : Indications, Side Effects, Warnings, Ciprofloxacin - Drug Information - Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin , Taj Pharma Ciprofloxacin 2 mg/ml solution for infusion , - Taj Pharma . Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.

sunlight or ultraviolet (UV) light under given Ciprofloxacin). • caffeine

treatment with Ciprofloxacin. Avoid exposure The following medicines are known to interact • duloxetine (for depression, diabetic nerve
to strong sunlight or artificial UV light such as with Ciprofloxacin in your body. Using damage or incontinence)
sunbeds. Ciprofloxacin together with these medicines • lidocaine (for heart conditions or anaesthetic
• Tell the doctor or laboratory staff that you can influence the therapeutic effect of these use)
are taking Ciprofloxacin if you have to provide medicines. It can also increase the probability • sildenafil (e.g. for erectile dysfunction)
a blood or urine sample. of experiencing side effects. • agomelatine (for depression)
• If you suffer from kidney problems, tell the
doctor because your dose may need to be Tell your doctor if you are taking: Ciprofloxacin with food and drink
adjusted. • Vitamin K antagonists (e.g. warfarin, Food and drink does not affect your treatment
• Ciprofloxacin may cause liver damage. If you acenocoumarol, phenprocoumon or with Ciprofloxacin.
notice any symptoms such as loss of appetite, fluindione) or other oral anti-coagulants (to
jaundice (yellowing of the skin), dark urine, thin the blood) Pregnancy and breast-feeding
itching, or tenderness of the stomach, • probenecid (for gout) If you are pregnant or breast-feeding, think
Ciprofloxacin must be stopped immediately. • methotrexate (for certain types of cancer, you may be pregnant or are planning to have a
• Ciprofloxacin may cause a reduction in the psoriasis, rheumatoid arthritis) baby, ask your doctor or pharmacist for advice
number of white blood cells and your • theophylline (for breathing problems) before taking this medicine.
resistance to infection may be decreased. If • tizanidine (for muscle spasticity in multiple It is preferable to avoid the use of
you experience an infection with symptoms sclerosis) Ciprofloxacin during pregnancy.
such as fever and serious deterioration of your • olanzapine (an antipsychotic) Do not take Ciprofloxacin during breast-
general condition, or fever with local infection • clozapine (an antipsychotic) feeding because ciprofloxacin is excreted in
symptoms such as sore throat/pharynx/mouth • ropinirole (for Parkinson’s disease) breast milk and can be harmful for your child.
or urinary problems you should see your • phenytoin (for epilepsy)
• cyclosporin (for skin conditions, rheumatoid Driving and using machines
doctor immediately. A blood test will be taken
arthritis and in organ transplantation) Ciprofloxacin may make you feel less alert.
to check possible reduction of white blood
• other medicines that can alter your heart Some neurological adverse events can occur.
cells (agranulocytosis). It is important to
rhythm: medicines that belong to the group of Therefore, make sure you know how you react
inform your doctor about your medicine.
antiarrhythmics (e.g. quinidine, to Ciprofloxacin before driving a vehicle or
Other medicines and Ciprofloxacin hydroquinidine, disopyramide, amiodarone, operating machinery. If in doubt, talk to your
sotalol, dofetilide, ibutilide), tricyclic doctor.
Tell your doctor or pharmacist if you are antidepressants, some antimicrobials (that
taking, have recently taken or might take any Ciprofloxacin contains glucose
belong to the group of macrolides), some
other medicines. Contains 9 g glucose in 200 ml solution for
antipsychotics
infusion. This should be taken into account in
• zolpidem (for sleep disorders)
Do not use Ciprofloxacin together with patients with diabetes mellitus.
tizanidine, because this may cause side Ciprofloxacin may increase the levels of the
effects such as low blood pressure and 3. How you will be given Ciprofloxacin
following medicines in your blood:
sleepiness (see section 2: You must not be • pentoxifylline (for circulatory disorders) Infusion
Your doctor will explain to you exactly how
Ciprofloxacin 2 mg/ml solution for infusion , Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects – Antifungal/ Antibacterial, Ciprofloxacin 2 mg/ml solution for infusion : Indications, Side Effects, Warnings, Ciprofloxacin - Drug Information - Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin , Taj Pharma Ciprofloxacin 2 mg/ml solution for infusion , - Taj Pharma . Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.

much Ciprofloxacin you will be given as well as side effects, although not everybody gets section 2: Warnings and precautions)
how often and for how long. This will depend them. • a serious life-threatening skin rash, usually in
on the type of infection you have and how bad the form of blisters or ulcers in the mouth,
it is. The following section contains the most throat, nose, eyes and other mucous
serious side effects that you can recognise membranes such as genitals which may
Tell your doctor if you suffer from kidney yourself: progress to widespread blistering or peeling of
problems because your dose may need to be the skin (Stevens-Johnson syndrome, toxic
adjusted. Stop taking Ciprofloxacin and contact your epidermal necrolysis).
doctor immediately in order to consider
Treatment usually lasts between 5 and 21 another antibiotic treatment if you notice any Not known (frequency cannot be estimated
days, but may be longer for severe infections. of the following serious side effects: from the available data)
• unusual feelings of pain, burning tingling,
Your doctor will give you each dose by slow Uncommon (may affect up to 1 in 100 people) numbness or muscle weakness in the
infusion through a vein into your bloodstream. • seizure (see section 2: Warnings and extremities (neuropathy) (see section 2:
For children, the infusion duration is 60 precautions) Warnings and precautions)
minutes. In adult patients, infusion time is 60 • a drug reaction that causes rash, fever,
minutes for 400 mg Ciprofloxacin and 30 Rare (may affect up to 1 in 1,000 people)
inflammation of internal organs, hematologic
minutes for 200 mg Ciprofloxacin. • severe, sudden allergic reaction with
abnormalities and systemic illness (DRESS
Administering the infusion slowly helps symptoms such as tightness in the chest,
Drug Reaction with Eosinophilia and Systemic
prevent immediate side effects occurring. feeling dizzy, sick or faint, or experience
Symptoms, AGEP Acute Generalised
dizziness when standing up (anaphylactic
Exanthematous Pustulosis).
Remember to drink plenty of fluids while you shock) (see section 2: Warnings and
are taking this medicine. precautions) Other side effects which have been observed
• tendon rupture, particularly affecting the during treatment with Ciprofloxacin are listed
If you stop your course of Ciprofloxacin, it is large tendon at the back of the ankle (Achilles below by how likely they are:
important that you finish the course of tendon) (see section 2: Warnings and
treatment even if you begin to feel better precautions) Common (may affect up to 1 in 10 people)
after a few days. If you stop using this • nausea, diarrhoea, vomiting
medicine too soon your infection may not be Very rare (may affect up to 1 in 10,000 people) • joint pain and joint inflammation in children
completely cured and the symptoms of the • severe, sudden allergic reaction with • local reaction at the injection site, rash
infection may return or get worse. You might symptoms such as tightness in the chest, • temporary increased amounts of substances
also develop resistance to the antibiotic. feeling dizzy, sick or faint, or experience in the blood (transaminases)
dizziness when standing up (anaphylactic
If you have any further questions about the reaction) (see section 2: Warnings and Uncommon (may affect up to 1 in 100 people)
use of this medicine, ask your doctor or precautions) • joint pain in adults
pharmacist. • muscle weakness, inflammation of the • fungal superinfections
tendons which could lead to rupture of the • a high concentration of eosinophils, a type of
4. Possible Side Effects tendon, particularly affecting the large tendon white blood cell,
Like all medicines, this medicine can cause at the back of the ankle (Achilles tendon) (see • increased or decreased amounts of a blood
Ciprofloxacin 2 mg/ml solution for infusion , Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects – Antifungal/ Antibacterial, Ciprofloxacin 2 mg/ml solution for infusion : Indications, Side Effects, Warnings, Ciprofloxacin - Drug Information - Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin , Taj Pharma Ciprofloxacin 2 mg/ml solution for infusion , - Taj Pharma . Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.

clotting factor (thrombocytes) membranes (angiooedema) (see section 2: reaction (see section 2: Warnings and
• decreased appetite Warnings and precautions) precautions)
• hyperactivity, agitation, confusion, • increased blood sugar (hyperglycemia) • disturbed coordination, unsteady walk (gait
disorientation, hallucinations • decreased blood sugar (hypoglycaemia) (see disturbance), pressure on the brain
• headache, dizziness, sleeping problems, section 2: Warnings and precautions) (intracranial pressure and pseudotumor
taste disorders, pins and needles, unusual • anxiety reaction, strange dreams, depression cerebri)
sensitivity to stimuli of the senses, giddiness (potentially leading to thoughts of suicide, • visual colour distortions
• eyesight problems including double vision suicide attempts, or completed suicide), • various skin eruptions or rashes
• loss of hearing mental disturbances (psychotic reactions • worsening of the symptoms of myasthenia
• rapid heartbeat (tachycardia) potentially leading to thoughts of suicide, gravis (see section 2: Warnings and
• expansion of the blood vessels suicide attempts, or completed suicide) (see precautions)
(vasodilation), low blood pressure section 2: Warnings and precautions)
• abdominal pain, digestive problems such as • decreased skin sensitivity, tremor, migraine, Not known (frequency cannot be estimated
stomach upset (indigestion/heartburn), wind disorder of sense of smell (olfactory disorders) from the available data)
• liver disorders, increased amounts of one • tinnitus, impaired hearing • feeling highly excited (mania) or feeling
substance in the blood (bilirubin), jaundice • fainting, inflammation of the blood vessel great optimism and overactivity (hypomania)
(cholestatic icterus) (vasculitis) • abnormal fast heart rhythm, life-threatening
• itching, hives • shortness of breath including asthmatic irregular heart rhythm, alteration of the heart
• poor kidney function, kidney failure symptoms rhythm (called ‘prolongation of QT interval’,
• pains in your muscles and bones, feeling • pancreatitis seen on ECG, electrical activity of the heart)
unwell (asthenia), fever, fluid retention • hepatitis, death of liver cells (liver necrosis) • influence on blood clotting (in patients
• increase in blood alkaline phosphatase (a very rarely leading to life-threatening liver treated with Vitamin K antagonists)
certain substance in the blood) failure (see section 2: Warnings and
precautions) Reporting of side effects
Rare (may affect up to 1 in 1,000 people) • sensitivity to light (see section 2: Warnings If you get any side effects, talk to your doctor
• muscle pain, inflammation of the joints, and precautions), small, pin-point bleeding or pharmacist. This includes any possible side
increased muscle tone and cramping under the skin (petechiae) effects not listed in this leaflet. By reporting
• inflammation of the bowel (colitis) linked to • blood or crystals in the urine, urinary tract side effects you can help provide more
antibiotic use (can be fatal in very rare cases) inflammation information on the safety of this medicine.
(see section 2: Warnings and precautions) • excessive sweating
• changes to the blood count (leukopenia, 5. How Ciprofloxacin Infusion is stored
• increased levels of the enzyme amylase
leukocytosis, neutropenia, anaemia), a drop in Your medicine will be stored and administered
the number of red and white blood cells and Very rare (may affect up to 1 in 10,000 people) by healthcare professionals, who will follow
platelets (pancytopenia), which may be fatal, • a special type of reduced red blood cell count this guidance:
bone-marrow depression which may also be (haemolytic anaemia); a dangerous drop in a
Keep this medicine out of the sight and reach
fatal type of white blood cells (agranulocytosis) (see
of children.
• allergic reaction, allergic swelling (oedema), section 2: Warnings and precautions)
rapid swelling of the skin and mucous • allergic reaction called serum sickness-like
Ciprofloxacin 2 mg/ml solution for infusion , Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects – Antifungal/ Antibacterial, Ciprofloxacin 2 mg/ml solution for infusion : Indications, Side Effects, Warnings, Ciprofloxacin - Drug Information - Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin , Taj Pharma Ciprofloxacin 2 mg/ml solution for infusion , - Taj Pharma . Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.

Do not use this medicine after the expiry date 1 ml solution contains: 2 mg ciprofloxacin (as This leaflet was last revised in July 2019
which is stated on the label after “EXP”. The ciprofloxacin lactate).
expiry date refers to the last day of that
month. The other ingredients are:
• glucose monohydrate
Keep the infusion bag within the sealed outer • 50% lactic acid
foil wrap before use, in order to protect from • hydrochloric acid
light and evaporation. • water for injections.

For single use only. Use immediately after first What Ciprofloxacin Infusion looks like
opening the infusion bag. and contents of the pack
Solution for infusion.
Do not store above 25C. Do not refrigerate or
freeze. Clear, nearly colourless to slightly yellowish
solution.
At cool storage temperatures precipitation
may occur, which will re-dissolve at room It is available in transparent infusion (PVC or
temperature (15°C – 25°C). polyolefin) bags that contain 50 ml, 100 ml or
200 ml sterile solution of ciprofloxacin 2
From a microbiological point of view, unless mg/ml. The bags are sealed in an outer
the method of opening and mixing with packaging of a double sheet of metallised
coinfusion solutions precludes the risk of polyethylene terephthalate.
microbial contamination, the product should
be used immediately. If not used immediately, Pack sizes:
in-use storage times and conditions are the 5 x 50 ml, 10 x 50 ml, 50 x 50 ml
responsibility of the user. 5 x 100 ml, 10 x 100 ml, 50 x 100 ml
5 x 200 ml, 10 x 200 ml, 20 x 200 ml
Do not throw away any medicines via Not all pack sizes may be marketed.
wastewater or household waste. Ask your
pharmacist how to throw away medicines you
no longer use. These measures will help
protect the environment.

6. Further information Manufactured in India by:

TAJ PHARMACEUTICALS LTD.
What Ciprofloxacin Infusion contains Mumbai, India
The active substance is ciprofloxacin. At: 615, GIDC, Kerala, Bavla, Dist. Ahmedabad
438225, Gujarat, INDIA