10/4/2019 Evaluating Dysphagia - American Family Physician

Evaluating Dysphagia

MICHAEL R. SPIEKER, CAPT, MC, USN, Naval Hospital, Jacksonville, Florida

Am Fam Physician. 2000 Jun 15;61(12):3639-3648.

Dysphagia is a problem that commonly affects patients cared for by family physicians in the office, as hospital inpatients and as nursing home residents.
Familiar medical problems, including cerebrovascular accidents, gastroesophageal reflux disease and medication-related side effects, often lead to
complaints of dysphagia. Stroke patients are at particular risk of aspiration because of dysphagia. Classifying dysphagia as oropharyngeal, esophageal
and obstructive, or neuromuscular symptom complexes leads to a successful diagnosis in 80 to 85 percent of patients. Based on the patient history and
physical examination, barium esophagram and/or gastroesophageal endoscopy can confirm the diagnosis. Special studies and consultation with
subspecialists can confirm difficult diagnoses and help guide treatment strategies.

Complaints of dysphagia (difficult swallowing) are common, especially in aging persons. Approximately 7 to 10 percent of adults older than 50 years have dysphagia,
although this number may be artificially low because many patients with this problem may never seek medical care.1,2 Up to 25 percent of hospitalized patients and 30
to 40 percent of patients in nursing homes experience swallowing problems.3,4

Epidemiology
Diseases of the esophagus are among the top 50 reasons that patients seek medical care and, in frequency, rank alongside problems such as pneumonia, bronchitis
and otitis media.5 Conditions that cause dysphagia can produce esophageal rupture, nutritional deficits and aspiration pneumonia. Elderly patients are at the highest
risk of dysphagia and its subsequent complications, especially silent aspiration.

Although the two conditions are often associated, dysphagia should be distinguished from odynophagia (painful swallowing). In addition, care should also be taken not
to confuse globus with dysphagia. Globus is the constant sensation of a lump in the throat, although no organic defect or true difficulty in swallowing is apparent.

Anatomy and Physiology of Deglutition

Deglutition is the act of swallowing in which a food or liquid bolus is transported from the mouth through the pharynx and esophagus into the stomach. Normal
deglutition involves a complex series of voluntary and involuntary neuromuscular contractions proceeding from the mouth to the stomach and is commonly divided into
oropharyngeal and esophageal stages.

OROPHARYNGEAL STAGE
The oropharyngeal stage of deglutition begins with contractions of the tongue and striated muscles of mastication. The muscles work in a coordinated fashion to mix
the food bolus with saliva and propel it from the anterior oral cavity into the oropharynyx, where the involuntary swallowing reflex is triggered6 (Figure 1a). The
cerebellum controls output for the motor nuclei of cranial nerves V, VII and XII. The entire sequence lasts about one second.

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FIGURE 1A.

The tongue initially forms the food bolus (green) with compression against the hard palate.

In the posterior oropharynx, a complex and precisely coordinated succession of muscular contractions and relaxations occurs. The soft palate elevates to close the
nasopharynx, and the suprahyoid muscles pull the larynx up and forward6 (Figure 1b). The epiglottis moves downward to cover the airway while striated pharyngeal
muscles contract to move the food bolus past the cricopharyngeus muscle (the physiologic upper esophageal sphincter and into the proximal esophagus6 (Figure 1c).
This swallowing reflex lasts approximately one second and involves the motor and sensory tracts from cranial nerves IX and X.

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FIGURE 1B.

Displacement of the food bolus into the pharynx by the tongue initiates deglutition.

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FIGURE 1C.

Relaxation of the cricopharyngeal muscle (the physiological upper esophageal sphincter) permits movement of the food bolus into the proximal esophagus.

ESOPHAGEAL STAGE
As food is propelled from the pharynx into the esophagus, involuntary contractions of the skeletal muscles of the upper esophagus force the bolus through the mid and
distal esophagus. The medulla controls this involuntary swallowing reflex, although voluntary swallowing may be initiated by the cerebral cortex. The lower esophageal
sphincter relaxes at the initiation of the swallow, and this relaxation persists until the food bolus is propelled into the stomach. It may take eight to 20 seconds for the
contractions to drive the bolus into the stomach.7

Pathophysiology
Organic abnormalities of deglutition may be related to initiation of the swallowing reflex in the oropharynx or to propulsion of the food bolus through the esophagus
(Table 1).8

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TABLE 1.
Differential Diagnoses of Dysphagia
OROPHARYNGEAL DYSPHAGIA ESOPHAGEAL DYSPHAGIA

Neuromuscular disease Neuromuscular disorders

Diseases of the central nervous system Achalasia

Cerebrovascular accident Spastic motor disorders

Parkinson's disease Diffuse esophageal spasm

Brain stem tumors Hypertensive lower esophageal sphincter

Degenerative diseases Nutcracker esophagus

Amyotrophic lateral sclerosis Scleroderma

Multiple sclerosis Obstructive lesions

Huntington's disease Intrinsic structural lesions

Postinfectious Tumors

Poliomyelitis Strictures

Syphilis Peptic

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OROPHARYNGEAL DYSPHAGIA ESOPHAGEAL DYSPHAGIA

Peripheral nervous system Radiation-induced

Peripheral neuropathy Chemical-induced

Motor end-plate dysfunction Medication-induced

Myasthenia gravis Lower esophageal rings (Schatzki's ring)

Skeletal muscle disease (myopathies) Esophageal webs

Polymyositis Foreign bodies

Dermatomyositis Extrinsic structural lesions

Muscular dystrophy (myotonic dystrophy, oculopharyngeal dystrophy) Vascular compression

Cricopharyngeal (upper esophageal sphincter), achalasia Enlarged aorta or left atrium

Obstructive lesions Aberrant vessels

Tumors Mediastinal masses

Inflammatory masses Lymphadenopathy

Trauma/surgical resection Substernal thyroid

Zenker's diverticulum

Esophageal webs

Extrinsic structural lesions

Anterior mediastinal masses

Cervical spondylosis

Reproduced with permission from Castell DO. Approach to the patient with dysphagia. In: Yamada T, ed. Textbook of gastroenterology. 2d ed. Philadephia: Lippincott Williams & Wilkins,
1995.

In oropharyngeal dysphagia, symptoms arise from the dysfunctional transfer of a food bolus in the pharynx past the upper esophageal sphincter into the esophagus.
Oropharyngeal dysphagia is most common in elderly patients and frequently presents as part of a broader complex of signs and symptoms that lead the physician to a
correct primary diagnosis. Stroke is the leading cause of oropharyngeal dysphagia.8

Esophageal dysphagia is caused by disordered peristaltic motility or conditions that obstruct the flow of a food bolus through the esophagus into the stomach.
Achalasia and scleroderma are the leading motility disorders, while carcinomas, strictures and Schatzki's rings are the most common obstructive lesions.

History
Patients who have dysphagia may present with a variety of complaints, but they usually report coughing or choking, or the abnormal sensation of food sticking in the
back of the throat or upper chest when they are trying to swallow. A carefully conducted patient history will enable the physician to identify 80 to 85 percent of the
causes of dysphagia. Specific questions about the onset, duration and severity of the dysphagia, and a variety of associated symptoms (Table 2)9 may help narrow the
differential diagnoses to a specific diagnosis or to an anatomic or pathophysiologic-related diagnosis.

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TABLE 2.
Associated Symptoms and Possible Etiologies of Dysphagia
CONDITION DIAGNOSES TO CONSIDER

Progressive dysphagia Neuromuscular dysphagia

Sudden dysphagia Obstructive dysphagia, esophagitis

Difficulty initiating swallow Oropharyngeal dysphagia

Food “sticks” after swallow Esophageal dysphagia

Cough

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CONDITION DIAGNOSES TO CONSIDER

Early in swallow Neuromuscular dysphagia

Late in swallow Obstructive dysphagia

Weight loss

In the elderly Carcinoma

With regurgitation Achalasia

Progressive symptoms

Heartburn Peptic stricture, scleroderma

Intermittent symptoms Rings and webs, diffuse esophageal spasm, nutcracker esophagus

Pain with dysphagia Esophagitis

Postradiation

Infectious: herpes simplex virus, monilia

Pill-induced

Pain made worse by:

Solid food only Obstructive dysphagia

Solids and liquids Neuromuscular dysphagias

Regurgitation of old food Zenker's diverticulum

Weakness and dysphagia Cerebrovascular accidents, muscular dystrophies, myasthenia gravis, multiple sclerosis

Halitosis Zenker's diverticulum

Dysphagia relieved with repeated swallows Achalasia

Dysphagia made worse with cold foods Neuromuscular motility disorders

Information from Johnson A. Deglutition. In: Scott-Brown WG, Kerr AG. Scott-Brown's Otolaryngology. 6th ed. Boston: Butterworth-Heinemann, 1997.

A patient's general health information should be reviewed, including long-term illnesses, current prescription medications, and alcohol and tobacco use. While the
literature does not describe dysphagia caused by non-prescription drugs, it is always reasonable to inquire about this. Commonly prescribed medications can cause
dysphagia in either the oropharyngeal or esophageal stages of swallowing (Table 3).10,11 Antibiotics (doxycycline [Vibramycin], tetracycline, clindamycin [Cleocin],
trimethoprim-sulfamethoxazole [Bactrim, Septra]) and nonsteroidal anti-inflammatory drugs are the most common causes of direct mucosal injury to the esophagus,
while potassium chloride tablets can cause the most severe injury. Anticholinergics, alpha adrenergic blockers, angiotensin-converting enzyme (ACE) inhibitors and
many short- and long-acting antihistamines can cause xerostomia.

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TABLE 3.
Medications Associated with Dysphagia

Medications that can cause direct esophageal mucosal injury10

Antibiotics

Doxycycline (Vibramycin)

Tetracycline

Clindamycin (Cleocin)

Trimethoprim-sulfamethoxazole (Bactrim, Septra)

Nonsteroidal anti-inflammatory drugs

Alendronate (Fosamax)

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Zidovudine (Retrovir)

Ascorbic acid

Potassium chloride tablets (Slow-K)*

Theophylline

Quinidine gluconate

Ferrous sulfate

Medications, hormones and foods associated with reduced lower esophageal sphincter tone and reflux11

Butylscopolamine

Theophylline

Nitrates

Calcium antagonists

Alcohol, fat, chocolate

Medications associated with xerostomia11

Anticholinergics: atropine, scopolamine (Transderm Scop)

Alpha adrenergic blockers

Angiotensin-converting enzyme inhibitors

Angiotensin II receptor blockers

Antiarrhythmics

Disopyramide (Norpace)

Mexiletine (Mexitil)

Ipratropium bromide (Atrovent)

Antihistamines

Diuretics

Opiates

Antipsychotics

*—Especially the slow-release (SR) formulation.

Information from Boyce HW. Drug-induced esophageal damage: diseases of medical progress. [Editorial] Gastrointest Endosc 1998;47:547–50, and Stoschus B, Allescher HD. Drug-
induced dysphagia. Dysphagia 1993;8:154–9.

A carefully conducted patient history should answer two general questions: (1) is the dysphagia oropharyngeal or esophageal in nature and (2) is it caused by
mechanical obstruction or a neuromuscular motility disorder?8 Figure 28 presents an algorithmic approach to the history.

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Differential Diagnosis of Dysphagia

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FIGURE 2.

Differentiating symptoms of dysphagia.

Information from Castell DO. Approach to the patient with dysphagia. In: Yamada T, ed. Textbook of gastroenterology. 2d ed. Philadelphia: Lippincott Williams & Wilkins, 1995.

OROPHARYNGEAL LOCALIZATION
Patients with oropharyngeal dysphagia present with difficulty in initiating swallowing and may also have associated coughing, choking or nasal regurgitation. The
patient's speech quality may have a nasal tone. These dysphagias are most often associated with stroke, Parkinson's disease or other long-term neuromuscular
disorders. Local structural lesions are less common.

ESOPHAGEAL LOCALIZATION
Patients with esophageal dysphagia present with the sensation of food sticking in their throat or chest. The patient's description of the perceived location of the
obstruction often does not correlate well with actual pathology, especially if the perceived location is in the cervical area. Motility disorders and mechanical obstructions
are common. Several medications have been associated with direct esophageal mucosal injury while others can decrease lower esophageal sphincter pressures and
cause reflux (Table 3).10,11

NEUROMUSCULAR MOTILITY DISORDERS

Patients with neuromuscular dysphagia experience gradually progressive difficulty in swallowing solid food and liquids. Cold foods often aggravate the problem.
Patients may succeed in passing the food bolus by repeated swallowing, by performing the Valsalva maneuver or by making a positional change. They are more likely
to experience pain when swallowing than patients with simple obstruction. Achalasia, scleroderma and diffuse esophageal spasm are the most common causes of
neuromuscular motility disorders.

MECHANICAL OBSTRUCTION
Obstructive pathology is typically associated with dysphagia of solid food but not liquids. Patients may be able to force food through the esophagus by performing a
Valsalva maneuver, or they may regurgitate undigested food. Close questioning of the patient may reveal a change in diet to one of predominantly soft foods. Rapidly
progressive dysphagia of a few months' duration suggests esophageal carcinoma. Weight loss is more predictive of a mechanical obstructive lesion.12 Peptic stricture,
carcinoma and Schatzki's ring are the predominant obstructive lesions.

Physical Examination
A general physical examination and focused organ- or symptom-specific examinations based on the patient's history often identify the etiology of dysphagia.

Neurologic evaluation should include assessments of the patient's mental status, motor and sensory functioning, deep tendon reflexes and cranial nerves, and a
cerebellar examination. Patients with impaired cognitive functioning and those who are under sedation should be carefully assessed, because these neurologic states
can interfere with swallowing. Motor and sensory examinations may reveal a new stroke or identify a long-term illness. Special attention should be focused on the
cranial nerves that are associated with swallowing, particularly the motor components of cranial nerves V, VII, IX, X and XII, and sensory fibers from cranial nerves V,
VII, IX and X. A decreased gag reflex is associated with an increased risk of aspiration.13 A “wet voice” may suggest long-term laryngeal aspiration, while a weak,
breathy voice may indicate vocal cord pathology.

Adequate saliva production results in a pink, well-hydrated oral cavity. Certain medications induce xerostoma preventing adequate mixing and propulsion of the food
bolus into the posterior oropharynx (Table 3).10,11 A tongue blade and handheld mirror allow indirect inspection of the soft palate and vocal cord mobility. Physicians
who are skilled in nasopharyngoscopy can directly view the vocal cords and hypopharynx. Bimanual palpation of the floor of the mouth, tongue and lips with a gloved
hand detects masses and abnormal motor function. Examination of the teeth can reveal signs of inflammation or other structural disorders.

Observing the patient swallowing a variety of liquids and solids can be helpful. The patient should demonstrate enough neuromuscular control to chew food, mix it into
a bolus with saliva and propel it to the posterior pharynx without choking or coughing. Elevation of the larynx during the swallowing reflex protects the airway and
opens the upper esophageal sphincter. Normal laryngeal ascent can be palpated by placing the index finger above the patient's thyroid cartilage when the patient
swallows. The cartilage should move cephalad against the physician's finger.

Thyroid masses and lymphadenopathy that cause obstructive dysphagia can be palpated on examination of the neck. A widened anteroposterior chest diameter and
distant breath sounds are signs of chronic obstructive pulmonary disease, which could be caused by long-term aspiration. The patient's abdomen should be examined
for masses and organomegaly. The presence of occult blood in the stool may be a sign of neoplasms or esophagitis.

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Laboratory Evaluation
Initial laboratory evaluations should be limited to specific studies based on the differential diagnosis generated after the completion of a history and physical
examination. A complete blood count screens for infectious or inflammatory conditions. Thyroid function studies may detect hypo- or hyperthyroid-associated causes of
dysphagia (e.g., Grave's disease or thyroid carcinoma). Other studies should be based on specific clinical conditions.

Special Studies
Although a patient history and physical examination identify the etiology of dysphagia in most patients, further testing may be indicated to confirm the diagnosis or to
establish the patient's risk of aspiration (Figure 314 and Table 4). Subspecialists in radiology or gastroenterology will most often conduct these tests. Some centers
have multidisciplinary dysphagia teams available to offer comprehensive diagnostic evaluations and therapeutic interventions.

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Evaluation of Dysphagia

FIGURE 3.

An algorithmic approach to the diagnostic evaluation of dysphagia.

Adapted with permission from Trate DM, Parkman HP, Fisher RS. Dysphagia. Evaluation, diagnosis, and treatment. Prim Care 1996;23:417–32.

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TABLE 4.
Adjunct Studies to Evaluate Patients with Dysphagia

Barium swallow studies

Suspected obstructive lesion (e.g., Schatzki's ring, tumor)

Suspected esophageal motility disorder

Double-contrast upper gastrointestinal evaluation

Suspected esophageal mucosal injury

Evaluation of oropharyngeal anatomy and function (fluoroscopy)

Suspected gastroesophageal reflux disease

Gastroesophageal endoscopy

Suspected acute obstructive lesion (impacted food bolus)

Evaluation of the esophageal mucosa

Confirmation of a positive barium study with biopsies or cytology

Manometry

Abnormality not identified on barium study or by endoscopy

pH monitoring

Suspected gastroesophageal reflux disease

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Videoradiography

Suspected risk of aspiration

NASOPHARYNGOSCOPY
Nasopharyngoscopy is particularly useful in evaluating patients with oropharyngeal dysphagias. This procedure quickly identifies structural masses and lesions, and
assesses laryngeal sensitivity to contact. Overuse of topical anesthetics can anesthetize the pharynx and confuse the interpretation. Under direct observation from the
level of the soft palate, the physician assesses oral containment of a colored fluid bolus in the mouth and observes pooling of fluids around the vallecula or clearing of
the fluid from the oropharynx into the esophagus. Patients who show aspiration without cough are at high risk of pulmonary complications.

BARIUM STUDIES
A barium study (esophagram) is often the first step in evaluating patients with dysphagia, especially if an obstructive lesion is suspected. It identifies intrinsic and
extrinsic structural lesions but lacks precision in identifying the nature of obstructive lesions. A barium study assesses motility better than endoscopy and is relatively
inexpensive with few complications; however, it can be difficult to perform in sick or uncooperative patients.

Double-contrast studies provide better visualization of esophageal mucosa. Barium marshmallows or pills localize obstructive lesions in the mouth or esophagus.
Fluoroscopy can identify abnormalities in the mouth and oropharynx and, if observed closely, can provide some detail about function, detecting reflux and abnormal
peristalsis.

ENDOSCOPY
Gastroesophageal endoscopy provides the best assessment of the esophageal mucosa.15 Masses or other lesions identified by barium studies should initiate
esophagogastroscopy with biopsy and cytology. In patients with acute onset of dysphagia while eating, gastroesophageal endoscopy can directly remove an impacted
food bolus and dilate strictures. Endoscopy has the added benefit of detecting infection and erosions, and providing biopsy capability. While endoscopy does not
assess motor function or subtle strictures as well as barium studies15 (its sensitivity for detecting Schatzki's rings is only 58 percent, compared with 95 percent for
barium study), a consensus panel making final diagnoses in patients with dysphagia found that for all dysphagia diagnoses, gastroesophageal endoscopy is more
sensitive (92 percent versus 54 percent) and more specific (100 percent versus 91 percent) than double-contrast upper gastrointestinal radiography.16 One author
suggests that the higher cost of gastroesophageal endoscopy may be offset by lower subsequent medical costs because of its improved accuracy in diagnosing
dysphagia.17

VIDEORADIOGRAPHIC STUDIES
Patients at risk for silent aspiration (e.g., stroke, neurologic impairment) may benefit from videoradiographic studies that are performed by a team composed of a
radiologist, an otolaryngologist and a speech pathologist with expertise in swallowing disorders.17 This evaluation uses quantifiable measures of swallows of a variety
of bolus consistencies to help objectively identify the presence, nature and severity of oropharyngeal swallowing problems and to assess treatment options. Compared
with upper gastrointestinal radiography, videoradiographic studies are better in identifying patients with mild strictures and extrinsic compressions (e.g., tumors or
osteoarthritic spurs of the vertebrae).12 These studies are more expensive because of the special expertise, equipment and facilities required.

MANOMETRY
Manometry assesses motor function of the esophagus and is indicated if no abnormality is identified by barium study or gastroesophageal endoscopy.18 A catheter
with multiple electronic pressure probes is passed into the stomach, measuring esophageal contractions and defining upper and lower esophageal responses to
swallowing. Manometry detects definitive abnormalities in only 25 percent of patients with nonobstructive lesions. Its use in disorders of the oropharyngeal upper
esophageal sphincter is not particularly effective, because patients do not tolerate the procedure well.

PH MONITORING
Despite several drawbacks, esophageal pH monitoring remains the gold standard for diagnosing patients with suspected reflux disease.19 A nasogastric probe is
inserted into the patient's esophagus and records pH levels. These levels are compared with the patient's record of symptoms over a 24-hour period to determine if
acid reflux contributes to the symptoms. Combined recordings of esophageal pH levels and intraluminal esophageal pressure may aid in diagnosing patients with
reflux-induced esophageal spasm.

OTHER IMAGING TECHNIQUES

Plain radiographic films of the chest or neck offer limited information unless structural abnormalities are noted. Computed tomography and magnetic resonance
imaging scans provide excellent definition of structural abnormalities, particularly when used to evaluate patients with suspected central nervous system causes of
dysphagia. Ultrasonography of the pharynx and tongue offers no benefit compared with videofluorography, but ultrasonography may aid in the evaluation of
submucosal and extramural lesions of the esophagus. Radionuclide studies may be used to evaluate transit function through the esophagus.

Final Comment
Family physicians can reduce the symptoms and risks of complications by early and aggressive evaluation and management of stroke patients. Physicians should
recommend that all patients, especially the elderly, take their medications with a full glass of water while in an upright position well before bedtime. Patient referral is
warranted when the cause of dysphagia is unclear, when there is evidence of aspiration or if further diagnostic or therapeutic expertise is necessary.

The Author show all author info

MICHAEL R. SPIEKER, CAPT, MC, USN, is currently director of residency training at the Naval Hospital, Jacksonville, Fla., and is an assistant professor at the
Uniformed Services University of the Health Sciences F. Edward Hébert School of Medicine, Bethesda, Md. He earned his medical degree at the Oregon Health
Sciences University School of Medicine, Portland, and completed a family practice residency at the Naval Hospital, Camp Pendleton, Calif....

REFERENCES show all references

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1. Lindgren S, Janzon L. Prevalence of swallowing complaints and clinical findings among 50–79-year-old men and women in an urban population. Dysphagia.
1991;6:187–92....

Members of various family practice departments develop articles for “Problem-Oriented Diagnosis.” This article is one in a series coordinated by the Department of
Family Medicine at the Uniformed Services University of the Health Sciences, Bethesda, Md. Guest editors of the series are Francis G. O'Connor, LTC, MC, USA, and
Jeannette E. South-Paul, COL, MC, USA.

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