Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
LNTVERSITY OF CALICU'T
1
t
U\IvERSITY OF CALICUT
tMnimumqualifcationforadmissionintoFirstyearoftheB.PharmCourse.
courses in English medium and passed the
A caadidate who has undergone any of the follow'iog year of
opiionar subjeas ii eligibte for admission to Fiist
examination with 50% marks in the aggregare of
will be waived'
ffiiffi;i;;';h"r examiiration approved as equivalent i:i .:i:1
\
tvfinimum qla$fication for admission directly in
to Second year of the B.Pharm course ( Laleral
B.
' admission)
";;;;1"
marks in the final yearo<amination. -,
_ , ..!,
.\ ':.
3. DURATION OF TIE COURSE.
ot Iour acaocllr "--o r^r -*^"' '
The course of study for B-Pbarm shall slall extend P"::9:,i^ry:j:f*T
o<t1d over a penocl
"*'i ii.r' ,-i'
i,ii.,,i
ri." Vi=t
admitted to the .F[st
admttted year ,r,t.
ot tne l'"ru4rru
B-Pharm
l'-ruuru
uuurJv'
Course'
wuJv
Pi'T.lgYi:lTlt
:"--.'.:--l-]--,i --'_ _,;i--
rr rsvrvYrv- -;, -
',,
i
1
4 i\,rEDrLN{ OF INSTRUCI-IO\ I
't
t
Medium of insrruction shajl
be Enehsh
5 ATTENDANCE
FIRST B.PEAR,V
'1-2
l-J
l4
I-5
t-6
THIR.D B-PtL{R,\I
FINAI B-PBARVI
7. SCHEME OF EXAMINATION
The university examioation shallbe held at the end of each academic year, ordinarily in July- August-A
supplementary examination shall also be hel4 ordinarily in Jarmary- February- Candidate shall have to
i
p.odu"e certifcate at tbe end of each academic year from the Head of the krstitution in proof of hisThei
attendance, having rqtrlarly and satisfactorily undergone the course of study by attending not less_than
8091o of ctasses held both in theory and'in practical separately in each zubject. The marks awarded fof;$P
examinations will be as follows.
T,IRST
,!i:
B-PSARM
100 150
SECOND
Theon' I Practical
Sessi \;iva Total Sessi Total
-ional voce Exam onal
,!{ark lUar Mark Mark Mark Mark
k
) 4 5 6 1 8 9
I 2
& Biotechnology
30 150 r00 50 150
)-) Pbarmacology-I 80 40
34 Pharmacartics-tr @ioPhar- 80 40 i0 150 100 50 150
70 30 100
re
GRAI.{D TOTAL l g00 MARIq I 000 900
FINAL B
Th."ry
-T total I
r
)j:aT
::l
,l
--1;I
N{ark I M".k
r5o
I
I
J
30 rso I
I
lso I
r5o
r5o I
roo I
_t
il il
I
ro0 I
--t
I
GRAI.ID' I
t
Note -Duration of uheory examination of each sub.;ect will be I hours and of practical erarrunation will
be 4 hours
the irext higher ctass. But he / she will be eligible io appear for
the o<amination
after passing ia dl srbjects in tbe lower class. But itUor" who are eot lateral ram"",I.Trl;:;::,
/ear slih-ll pass subjects in Mathematics & Bio statistics and Basi
of the Fh yeur B.Pharm and all zubjects of tbe'S cond year B.p
year B.Pharm examiDation.
7
ll. AU'ARD OF CL.q.SS AND DISTI.\ICTIO\
Class shall be arvarded for First year B.-Pharm,, Second r,ear B Pharm
and Third year B.pharm
For calculation of the Class in Final vear examinatiot the aggregate ofthe
marks of Second,
Third and Final year B-Pharm uill be considered. The candidate securing 60
% marks or above in
aggr€ate in all subjects of the Second, Third and Final vear B Pharm examinations
shall be declared to
have passed in First Class. The candidate securing 50 ?o marks or above but less
than 60 %o of the
aggregate in all subjects of the Second, Third and Final vear B Pharm examinations
shall be declared to
have passed in Second Class. Distinction will be awarded if rhe candidare secures
75 yo marksor abore in
the aggregate in all subjeos in Second, Third and Final year B-Pharm in first
appearance.
12 AWARD OF RANKS
Ranks qrd Medals shall be awarded on the basis the Second, Third and Final
year B.${rarm Examinations Candidates who fail during the B-Pharm course shall
not be eligible for award of ranlis. Iv1ore over the completed the B.Pharm course
in the prescribed (minimum) number of years
13 PRtCrrcAL
\^', TRATND{G i
i
-i
2.
--.:qrllF!f,
-i Qualitv assurancc
{ Drug desien and lead identificatron
5 Bioavailablin' and therapeutic drug monrtonnQ
6 Novel drug cielivery system or
7. .{ny other emerging area availing the local expenise
At the end of the year, the project work certified b-r'the supervising teacher wiU be submined to the Head
of.Instirution, The Head of the Institute will constirute a panel of ProfessorV Associate Professors /
Assistant Professors comprising one member each from Pharmaceutics. Pharmaceutical Chemistry,
and Pharmacology Departments. The panel will evaluate the project work on the basis of
and,l or Viva-voce and marks will be sent to the University br the Head of the Institution .
reaching in regards to building, laboratories, Iibran'. equipments and staff patterns as laid down by the
i ;
regulations of All India Council for Technical Education and Pharmacv Council of lndia are available.
The num\6r of admission in an institution shall not be more than 60 as laid down by the All India Council
for Technical Education rezulations
\
\
I
a.--..
-\
COURSE
S\ LL.\BUS FOR B'PIIAR\T
CHEITTSTR\.- I
:' I PH.,{RI\[ACEUT'ICAL
'il;;;=;' & Ph'sical Chemistry)
I hours / week
leor\-
and characterisrics
oiradiat
of Radio-acrtve e
"t'
trclear
v- Theory
in Ivledici
if.ratluPPfl*tions
analysis' applications'
methods of preparation and
of comPlexes'
'j: -trs in Pharmaceutical s1,srem, their PreParation and
caPacitY - Buff
uation and Buffel
stabilitY. -.-i - General procedure
for limit I
=-c.'toPical agen6'
l0
a1
Iivdrogen peroxide. Sodium perborate. Solution
of
Z,nc oode, Zinc undeco nare,zincsulphare.
Bonc acid, Selenium sulphide, A]ums
lodine, Mercuric oxicie, Ammoniued mercun,.
f Medicinal .qases.
Oryget, Nitrous oxide, Cu:bon dioxde
Sedatives etc
; ,ffiil;r' *.ot;'as including
9:"l*:'1A':,T.:,:t":nts'
bri.ia", Barium zulphate' Sodium thiosulphate
carbonate, Sodium
B. Physical ChemistrY:
Inorganic chemistrY
Physical ChemistrY
variatio rof the Refractive index with
t. Determinatio, or'iJffiirl'rri",.lra [quid and ' h Lr--f^?
the percenrag: p.mposition using- Refractometer'
composition ,ri*t";;;-*a "a"uu,e
"f
Determination of Partiilo *-"q.ient of ienzoic
acid between benzeqe and waler .
i;;;"r,";,h;;;;;;;n orr" given solution of sodium ctrloride using Phenol-
watef, sys.t_etll-
Todetermine molar mass by Rast method and cryoscopic method'
method"" ' 'l
To deterurine molar rrils oi"ol"tite liquids by Victor-Mayer
and daermine
To determin" tt ,p""ffi" rotation of srcrose at vanous concentrations
' "
the intrinsic rotation.
heat of neutralization'
7. To daermige JJ- *i ,r*lution, heat qf hydration and
b. To determine rate constant of simple r'eaction'
9. To daermilre adsorption isotherm'
ll
g '-\:
\
I i.lcori \
.l nours'v,eek
l
.-
fur elementalv study of L\/. IR and N-,\tR sDecrra and their aoplications +
in the studv of
structures of theabove mentioned ctass of compounds.
I : 3 PHI{R\I-{COG\OS}'- I,
nr
3 hours/ week
(at Carbo[,"cirares and cie:ired pr6Jucls {s3:. eller gum. acacia- Hone!', Isphagul4 pectin,
starcii sierculia anil trag:.-a:ltt
fbr Licids [Jcrs g1.- if,-sici cr:i .-3i1ir1 bl:itr':. c,....j lir,:r oii. ht'dnocarpus oil, lard. [nseed oil,
rrce bran oil- .shark livei cri a-nii ,,i ool ia:
I i \tudi' ci drurs ccniainrr, :i-)-nr fn.i risi:t J -r;:ltl:tJ:ion-. Colophonr'. Podophvllum. Ja-lap-
-t
t .-Li\:::i-r-s. C'apsi:.,:::t- \1'..:, \:a,1.'iii:-- L,.::s::: ';'I:,u. Baisam of Peru, BenzOin- Turmenc.
( r Itl-I.Jl
l.l Srud,,. r:l- f artriins and ra;pl:t cr-.lrtinins ir-;S-. i;.:
Gambier- Black catechu. gall and myrobalan
l) \-piairlt t.rl< .Generel rnerhco-< t-ric-.L.tarmric.,ci:iije oils from plants. studv of volati.le oils of
rircniha- cr.ria.irtier. cinnamon. c:ssia- lemon [,c'i:. oranqe peel, lemon grass, citronella, ca{away,
ciill- so-l-i?i:rint. clcrve. fennei. nurnrer:- eucaiil::s. chenop6dium, cardamorn valerian- musli
.\
nlinr rosa.\sualtirena. sand:i r" oci,:i
I r' ', l'iri tocirc-nrical screenins
r l r l)reparation of Extracis
roks Recommended
3C)n
I Houri Week
2 Hours/ Week
i :
I i Sr-rSr'Or-'rnF Ph'siologi'oiihe e"'e (\-is:.':rl E.lj tlleannq)- Taste bucs' \ose (Smell) and
,Si.ir: t.SuDcrtlc+al receplors )
I:sri*ari.n ot'l{cnr.uiob,in ir: biood Dete':-::-irir::i.-rn oIBlr':.:in-q tinte. Clotting tinte, R-B C. count
-'l-trtal
leucoc',1e count- D I- C a:lci Er,.-s R
li.r'corriirrg ot'the bod\.temDr-rature. Pulse rar:.'rJ blt--,oi i-lressure Basic understanding
of
[:lectroCardioGram. PQRST u'ave and rtiei' signiiicance
PhvsioIoeical r'xperirnents on \en-e.-musci: I-i3i:iliir-rn
Drlcrmination of Vital caoacitv and e\Denrn'rl5 1'r1 !gircmetn'
'L
\
I : -i \t.tlHIr111y.,S \\t)
UIr)_\t \ ft.\IIC.s
I i:i r ,:',
-l ilours,\\-eek
{. }lathernarics:
2 rleasures of Ceutrar
objecri'es
vvrewl,y.) d_uu
and pre-reqursires
and medjan 'arue: pre-reqursites of
ar
an idea.l
idea.r measure,
n rnean, mode
J Trigonouretn,
r of anere, T_rarics.
rar_ri.."i-.;, submuitjoie'a]ijec
addition. subrracrron
and traasformation
Pharmaceurical .r,d ...t .,-. a,rs,es Appu;;;of Jogarithms ia
5 Calculus:
I
I] io.sta ( istics:
u ares, statistic€J
I inference,
. plications of stitisti"ut .nrc.prs
t *
t_'
Books Recommended
I A Text book of N{arhematics for Xl-XIl Students. NCERT Publicatiors, Vol. I-fV.
2 Sundra Roa, P.S.S and fuchard,.J., lnrrductton to Bio statistics : A Manualfor Studenls rrt
Health Sciences. Prentice HaII of India Prr Ltd New Delhi.
3 Daniel W.W Bio saristics. Afundatton for Anolysrs in Health Sciences. John Wiley NY.
4. Bolton Sanford, Phomaceutical Snnsrrcs \{arcel Dekker lnc. NY.
A. Basic Etectronics:
Senr conducrors. p-n lunclirrns. diooes. LED. Photodiodes and its uses,
Rectifiers (ha-lf wave. filU rvave. nith filters) Transistors, biasing, trarsistor amplifiers, flip-flops,
Logic gares- Boolean aieeb:-a
\
B. \ Comouters:
Small prosrarnmes to demonstrate Input / Outpul Operators- Loops, decisions, functions, array
and strinss, pointers, fi,les in C. Forms and,menu in !'isual Basics.
Books Recommended:
- l. Bhargava, N-N.,Kulshreshitha-D.C. and Gupt4 5.C., Basic Electronic and Lineb Circtit. Tata
-
LV
'+
S ECO.\' D TE.4R B. PHARIT
.Iheory
i hours/ week
I Stereo isomerism and Tetrahedral carborL optical activity, chiralitl,, chiral cerures, racemic
modifications aad resolution of racemic mir,lures, confguration specification of R & S
configriratiorL enantiomerisrq enantiomers, diastereo isomerism, meso structure, conformational
isomeri, reactions of chiral molecules, elements of symmetry, asynmetric synthesis ,E & Z forms
) Stereo selective and stereospecifc reactions. stereochemistry of addition of halogens to alkenes,
mechanism of stereocbemistry ofEI and E2 reactions, Syn and Anti elimination. SNI and SN2
reaaicins.
, Geometric isomerisnt.its nature and formation. rotation abor.rt bond, nomenclature of isomers,
determination of confi-euratioq stereochemistry of cvclic compounds including biphenyl and
st ereochemistr,v of niuogen compounds.
t9
l<
il rE
g
<<!a
peprroc Iinraee.
treor,,err\ cil-lreoirds irnrac:s- iormation.
and -s'nthesis' formarorr determinarion of
of-protern, of neprride:
'enera.L rnrrociuction ro protein *.,,t
.*jlil;:ttt
Ptrq!'cals
3 hoursr rveek
I Quantitatii'e determrnation of orgaruc
comoounds ria frrnctional
aad phenolrt' t-uo'1't.,c groups such as
acid.
ff:l*
.
alciehvde, rJ,o.a^in.s and amine Hcr, carbohvcirare
2 :2 PE4.R\L{CEUTICS _ I
(p h_r. s i c a j p harrn ac__r.)
Theon'
3 hourV week
I \laner
Propenies of maneq
state o
midity,
urement of surface
surface active
solid inrerfaces, sol.id gas and
e, Classification oi
flocculating agents,
'rii.'r'j:irltroductlon'detlrution't'.'::,o"o'l'-riil't-ir-i:l1s''-rDilCSifro0ertles'hneticand
of t"ilbllTl'^?^
cotloids- senting in suspenstons,
-r..r...rcrt propenres intertacta
( oil.r:_ie dispersrons Suspensions- gocculated particles-
l. Martin A.r\ Arthur Cammarat4 James Su'arbrick. , Ptrysical Phomacy., K.M-, Varghese & Co'
lvlumbai.
'Z. ManfuL E.W. Dispensing of lvledicatior Mack Publishing Co. Eastern PA
,i3. Rawlins E.L Beittel.'s lext Book of Pharmaceutics. ELBS lLongman [,ondon
' .1, cartgr, S.l copper-otd Gum's Tutorial Phomacy, cBS PublicatiorL New Delhi'
3 hours / week
Theon'
7. Non-aqueous titratiors
8. Complexometric titrations
TLC, Paper chromatography and
9. Chromatographic trcluriques with relevant examples using
-{/
Colunin ci:iirrl.r t,.lqraphr' I
l0 \[iscell.rneous methocis of ana]r'sis su.'h as Dra.u.tisation Tii;-etron. Kreldahl's method of
Ntroe,en esrimaiion. Karl-Fischei ltrrauo:: o\\'Sten fl ask comoustion- sasometr),
The students should be introduced to the marn analtticaj tools through demonstrarions They
Jrould have a clear understanding of a tlpical anah.tical baiance, the requLrement of agood baJance,
veights, care and use of balance, nrethods of weiehine and errors in weighing. The students should also
>e acquainted with the genera.l apparatus requueci in various anallticai procedures
roks Recommended
I
Bassett, J., Denny. RC., Jeffery, G.H.. Mendham- J L'ogel's Text Book of Ouandative Inorganic
Analy'sis- ELBS i Lon_ernan, London.
?. Beckett, AH. and Stenlake, J.B. Pracncol Pho-oceurical Chemistry t'ol. I & II,The Athlone
Press of the University of London
3. Conners. K.A-, Text Book of Phomaceuical outl-y'is. Wiley' lntersciences New York.
4 K-nevet Al\{ , and Digangi, F.E., Jenkin's quofiraive Pharmaceutical Chemistry, McGi-arv hill
Book Co New York
5. Chatteq I.G., A Text o/ Pharmaceurical Chemisrry l'ol. I & II Marcel Dekker New York.
F.E*
r'1
1. {
PTIAR\L{CEUTICAL CHEJ\I]STR}' f!,
( Brocherrustry')
I Biochemical organisarion of the cell and rranspon processes across celt membrane.
2 The concept of &ee energy, determination of change in free energy from equilibrium consrant
and reduction potendal, bioenergetics, produaion of ATP and its biological significance.
) Enzymes: Nomenclarures, enzvme kinetics and its mechanism of aaion. Mechanism of actiorq
mechanism ofinhibrnorL enrymes and isoenzymes in clinical diagnosis
4 Co- enzymes: Vitamins as cGellzrmes and their signifcance, metals as co- enzlnries and their
significance
5 Carbohydrate metabolsm, Conversion of polysaccharidesto Glucose-l-Phosphate, Glycolysis
and fermentation and their rezulation, g:luconeogenesis and gtycogenolysis. Metabolism of
ealactose and ga.lactosamine- role of suqar nucleotiries in biosynthesis and pentose phosphate
pathu'dr'
6 The Citnc acid cvcle Sienificance ard reactions and enerqetics o[the cvcle Amphibolic roles o
-the cvcle and glvoxa-Lc acid cvcle
Lieids nretabolism. Gxidation of fatt. acids- p-oidation and energeti cs, o-oxidation,
o<rxidation. biosvnrhesis of kerone bodies and their utiiisatiot control of lipid metabolisnq
esslntiaj fatn'acids & Eicosanoids (Pr-ostaqlandins, thrombaxanes), Phospholides and
spiiingolipids
Bioio-(ical ox.idation-reduction Redox-potential enzl,rnes and co-etuymes involved in oxidarion
reciuction & its co-Urol The respiratoryl chain its role in energy capture and its control, energaic
of o.ti_da_tive phosphorl'latioq inhibitors of respiratory chain and oxidative phosphorylatiSrt
mechail itp of oxid.ative phosphorylation.
9 Nit'ogen 4 Sulphur ct'cle. Niuogen fixarion- ammonia assimilatioq nitrification and nitrate
I
assimilatiort- sulfate reduction- incorporation of sulfur in organic compounds. Release of zulfur
from organic compounds.
IO \{etabolisnr of Ammonia ard nitrogen monomers.N'rtrogen balance, Bioslnthesis of amino acids,
catabolism of amino acids- conversion of amino acids to specialised products, assimilation of
ammonia, urea cvcle, metabo[c disorders of urea cvcle. tv{etabolisnr, biosynthesis, formation of7'
bile pigments- hyper bilirubinemi4,purine biosynthesis- purine nucleotide intercnnversio'r1
p-tnmici i ne b i osrnt hesis an d formatio n o f deor-wibonu cleotides.
ll Biosrnthesis of nucleic acids: Brief introductioq of genetic organisation ofnammalian genome,
alteration and rearrangements of genetic marerial. Biorynthesis ofDNA and its replicatiorg
mutatiorL physical and chemical mutagenesis. carcinoeenesis, DNA repair mechanisrrg
bioslnthesis of fu\iA.
l2 Resulation of qene expression
I - Preparation of standard buffers (Citrate- Phosphate and Carbonate) and measurement of pH.
2 Titration curve for amino acids
3 Separation of amino acids by two dimensional paper chromatography and gel electrophoresis.
4 The separation ollipids by TLC.
5 Separation of serum proteins by electrophoresis on cellulose acetate.
.Ly
-"
\'
,oks Recommended.
l. Mttssay, R.Ii Grdnner, D.l(, Mayos, P.A, and Rodwell, V.W., Haryers'Biochemtstry,
HaIl lntersciences. lnc
-Pgentrce
2. Iayaramaq I.l,aboraton']v{arruol in Biochemisrry', Wiler,,Eastern Limited, New Delhi.
3. Harrow, 8., and ivfazur, A , Text Book oi BiochentisrrT,. \\aB Saunders Co. Philadeipiua.
?!_ry
\ 3 hourV week
\
Fluid mechaiiics: Fluid statics- mano melers. Fluid dvnamics- Types of flow, Reynold's
number, Viscosity, concgp!of boundar-v Iaver- basic eqHations of fluid flow, va.lves, flow meters
Nlaterials handlng Liquid handLing- Different rypes of pumps, reciprocating, rotary,
..n,.irrr-nl -?-'diiphrrigm pumps, Gas handling- varior:s 6pes of fanr, blo*.rr'-'J"-Jrpr.rrorrl
Solid handling-Stgrage bins, hoppers and conveyers. \
Hed,t transfer. Sou-ices and usei of heat in Pharmacy. Conduction- Fourier's law of heat
conduction through variable area like pipes, spheres etc
Convection- Natura.l and forced convection. Flow of heat through liquids and equation for rate
gtheat transfer, concept otindividual filrn co-efficient, overall heat transfer coefficienJ, Iog mean
temperature difference
Radiation: Kirchoffs law, Stefan Boltzrnan larv. Black bodl'- Gray body, Na heat transfer
berweert rrvo no- black bodies by radiatioh.
N{echanical s€paration: (a) Filtration and centrifusation- theory of filtration, filter medi4 filter
aids, industrial filters including fi.lter press- fiher leaf. rotarv' fi.lter, edee fi.lter etc.
Prirrciples of centrifugation: Industrial centrifugal filters and centrifugal sedimenters.
(b) Size reduAion and size separation: Definition objectives of size reductiog factors atrecting
size reductioq laws governing enersy and pou'er requteinents of a mill, types of mills including
ball mi[ hammer mill, fluid energy mills etc.
Evaporation- Factors affecting evaporation- Tlpes of evaporators- short tube, forced circulation
and film evaporators. Single effbct and multiple eff'ect evaporators.
Distillation. Raoult's law, Volatiliry, simple, steam and flash distillation. Principles of
rectifeation, Mc.Cabe Thiele metlrod for calculation of number of theoraical plates, azeotropic
and extractive distillation.
Drying:Moisu:re content and mechanism of drying rate of drying and time of drying.
.Classification and types of dryers tray, vacuunL tunnel, rotary, fluidizert bed, spray and drum
dryers. Principles of frxz*drying.
25
H
- ll:;1,'., :;,ll?,li iiii*I:';:'i:;:l'Hi:il1
or.^,r,ri*,i*. n"ttu";;';;;;rsm
cn'stal srowth'
and
*'alker' \'acuulrL circulating
of
masna
:'#X:X'
stud'v
,r CD,sr"ii,r"r,on e.,n.,pt.,
!anous r-rpes 'l?,:;i:ilil;:*'l
of cn,stallisers,,*til'[i;tti
Ctk,5,.."i
l"j,-t-otn'on
and rts'::tJlTliquids
t'-.n-stutt
and cnstal cr-r staizer and
-:-
resistant' properties
r0 n,i*,*
'**sr*z*;ffiil i';'Jlol?;;" *ith
"orrosrorL stainless steel &
ret:i.^,;'.,".i"""i,
glass
rr. Nraterial
"'.:i::::;:;Jr;."nstruttion '.,titt' specra
"ftrenceto:iect life and dust
apptica""";;;;.-rnui".iut, ",""""'l'ttn rtttt'u-cal'
"JJAchemical'
safew #il;;;'
12 tndustnal;;;and Accident records
etc' flow' level and
hazards' J:;;;""*'ut' )ssure'
to
il;; cont,or wst:[t*:r:l:il:il::'J;H.",'.'j:{lp;"oduction
i3 Automaric
,i.i, measureme"--- *-'ructuring (cAM)
o[."fi;t:;lta
vacuum -i ",o-ents
,4Um:;;;'::'::I."J'1T:I:';;;;;';;"'"rchemrca]reac'lions
i hoursi week
Plqqticals
r
2
De""*::li::
]l--ii
Qetemunatrolt Y'.
:i;ffix:$'i1:T,;; il,iJ#[:ffi:]:]:^'::il:
i.-, ,rrr,rft' co-ef,icients
i'.*xffi:o';*'
r dr"rerrr,ination ollveral]111-t srearn and azeorropic distiJJa content
q srrlpie-
Exp-..,.*, based on of dnrng' free moisture co ;;;; equiiibrium molsture
5 Dett,,'"ti;; "i"tt
6 analvsis of-pow'ders
Screen
liquids .. ['-""- number and
nf Reword's
of
; Sedirnentation in a,i theLr pressure' determinatron
-r-arrri. I
fluids
E N{e"rUr.tir'.1,'"iiilrt "flosses
calculatlon of lrictional using different
q e.''aporatron. oe
of ,^.ermination of mltng efficiency
De..'..I,..I""^oiI.u.. -soiid mirrn3'
'10. u^ot"rnJttt to i"'ltttte solid
eo€rSY and power
npes of mixers '-^inleq oi size reduc
-:..o
.llExpenmenrstoillJstrateprirrciplesoisizereduction.lau,sgovernrnS
reductton
r" it'i"ment of size
Books Recommended
Kogakusha Ltd'
l\laCabe.\\,L:and^Snrrttr.JCLinllol,c,attot,oJChemicalEtt$tteerillgN,lcGraw}Iill
International Book
Co. London ineerirtg Handbook
McGrarv
parn.'ffi: / Loneman London
3 "li_c*,i"i ?y ;:::';ii,:;:;;:;;;r.1'rr-ss
pni^;i''cii 'blicati6rL New Delhi
I Rawlins- E A Bentlev's' '
+ carter. I t . copper and;i,7,,,i:;;,ii,'''
& ffiALTH EDUCATION
2:6 PATBOPEYSIOLOGY
2 hgurs/ week
i
) Theory
I
( A.
1 cell injury and adaptatton
t. Basic principles of
l l6
Causes oI ceilular rn]ur., i-.athoc.ene sis. inorititi.,iL){\ of'cel] iniun lntercellular altcratrons tn -
lipids. prorer.ns and caruoirvdrates Cellular ij:Dtairon, atroph'.'. hvpertrophy
Basic mecharLisms inroirecj in the process ol in-ilanlmation and repair
Alterations r-n vascular permeabilit)'and b,lood ilou. m.isration of \48C, acute and chronic
lnflammatior\ mediators of inllammatioq brief outhne of the Process of repair
Pariophysiolog,v oI common diseases
Rheumatoid art}ntis, gout, epilepsy, ps)'chosi,s, depression, mani4 hypertensiorL angln4 CCF,
atherosclerosis, myocardial infarction, diabetes, peptic ulcer, asthm4 ulcerative col-itis, hepatic
disorders, acute and chronic renal failure, tuberculosis, urina:1'tr-act infections, sexually -
transmitted dis(x.s€s, anaemias and common R?es of neoplasms- where ever applicable the
molecu-lar basis should be discussed.
B: Eealth education:
a) Concept of health and disease, disease causing agents and prevention of diseases.
b) Classi-fication of food requirements. balanced diet. nutritional deficiency disorders. their
treatment and preventioq specifications for dnnking water'
c) Demo-eraphy and family planning
d) Brief out line o[communicable diseases. their causative aqents, modes of transmrssion and
prevention (C!-ucken por measles. influenza diphtheria, rvhoopilg mugl\ tuberculosis,
poiiomyelrtis, helmrntluasis. maiaria fiianasis. rabies. trachom:. tetarus, leprosy, syphilis,
eonorrhoea and AIDS)
g) Frst aid. Emereencv treatment of shock- snake bites, burns. poisoning, fractures and
rbsuscitation methods
Books Recommended.
I Russel. J.G. amd Norman D H., Pathologt' and Therapeuics for Phormacists- A basisfor
ehlical Phormacy Pracrice., The Pharmaceutical Press, London. I
3: 1 PHAR\IACELITICAL CE[}IISTR\'- \/
( Chemistry of Natural Products )
ll Purines Cpnsrirurion and srnthesis of uric acid and caffeine, inter-relation ship of caft'eine,
th eo_uh1 ll ine\.th eo bro mine and t h ei r m edi cinal im portance
ll ' Terpenes Introductiort Basic isoprene ruie. classification- mono, di, tri, sesqui terpenes,
structure and constitution of geraniol, camphor. -{lpha terpiniol, structure aad inter-relation ship
of lihonene. dipentene and alpha terpeniol; terpene h-vdrate, cineole and carvone, constitution of
menrhol and rh,,mol. Srnthesis of Ionones (AJpha and beta)
l_1 carotenoids lntroductiorl source. occurTence, skeleul structure of carotenes, conlersion of beta
carotene and Vitamin--A- Constirurion and srnthesis of Vitamin-A.
Books Recommended.
De Mayo, P., The Chemistrv o-f Norural Prducts \-ol 2-i. Intersciences, New
I York
G.Bell and Limitedr London.
2 Rosenthaler, L , The Chemicol Im,esrrgartort of Planls. sons
j Trease, G E , Evans, W.C., Phomacognos-r. Bailliere Tindall' Eastbourne,
U K'
.1 Tyleq V E Jr and Schwarring, AE Expertmetttit! PharmacogTtosf", Burqess Pub Co
ivtinneaphs. Nlinnesota.
5 Frnar, LL , Orgailic Chemtyrv-, \'ot 1 & ll ELBS
Loi:srnaillondon
6 Gurdeep and Chatu'al . organtc chemrsrrt' o-f l'atural Prociucts
vol I & u I
2 hourV week
l-heon,
,\ Ilicrobiology'
I
B. Biotechnologr
29
JI
I '.ft
E=--tl q
,
;
iGenslicRecombinationTransiormattott'cttrtlui:i:on-Trans'iuction'Protoplastfusionand antibodies'
gene ciorune and their appiicarions
o.t.top,r].n' ti'itt'iridonta tor ntono clonal
and methods used for
Srudl.ofdrugsproducedbr'biotechnolo$SuJ|ras\cti...isa.Hurr:ulin,Humstrope,FIBetc.
der.elopmeniof afltiuiotics.,-{i:imtcrobial spectrum
] Antibioucs historical Fermenter' its design'
ro, org.n,r*s orodu.c,ng antibiotics
standardisation Screening of soil
controlofdifferentParameters.Isoladonofmutants.iacrorsint)uencingrateofmutation.Desigrr
prociucts t+ith ,p""i,I reference to
penicillins'
of fermenration process. Er:tracrron ".[i..*.",.tion
ryp., or reacrions mediated bv microorganisms, Desim
, iff3j;[r,',];[ff|,:T'#:J'"?'n,
ra"Jon;i;;-rr-.,"s, Biotransformation
process and its I
of bioransforrnarion processes,
to sterol6s
improvements with special reference Faclors affecting enzyme
of immobilization of e-nz-ymes'
5 Enzyme rmmobilization- Techniques penic,rinase, Streptokinase, Strepto- dornase,
kjnetics. Srudy of enz-vmes zuch *'uar.o,,dase.
of bacteria and plant cells
.A.m!'lases, pr*.;ro' etc' lmmobilizaJon
3 hourJ week'
Practicals
Experime:rtsderisedtoprePareVanousry'"'o-.t::'t:::-*t.tnsub-culturingofvariousaerobic
.r'anous.staining methods, various sterilization
and yeast,
and anaerobic bacrerir. a fungus and
techniques, e=valuation-of antiseptics
techniques ,r,a ii.i. valiriation or rr"ritirr,ion
disinfucl:nts.testrnqofsterilin'orpn*uttuticalL''roduilsasPerI'Prequirements'Mcrobial
assar, of antibiotics and rrtaroins
Books
{(ecommendcd E
\ -f .-.,r...- \trrlrrrr Hill Book cO Inc London
Co Inc' Lonoon'
\escon. and Dunn .l*iusrrro,,yj,:"!::j-lll ,, i;:H,[l4:1.f.:ii'a:'S:tH.
fr:gl. ii.-"'. *rtt.t-AD . "PlwrmacettttL''i; '\ltcrobtolog''
"#
Publicauon, Qxford.
) i'.op*, " i'tt iiijfii a t I&I
Te c luto I og;"' \'ol : 1
3.3 PH..IR\LACOLOG\-' I t
I
3 hourV week
1
ns of theraPeutics, PosologY'
trics, Toxicology and sources
of drugs'
E
ncing the eft'ect of drugs'
;; and stores of drugs in the bodY' t
I
roduction to L.D ,0, E.D so and I D
[nteractlons
_10
t
3 hours *eek
lheory
. Posolos\"
and sources of drugs'
of drugs'
of drugs rn the bodY
to L.D E D so and
so,
recePtors
elauonshiPs' drug
g drug actiorL f)rug
and
to acute' sub-acut e
lnteracttons
General studv
of tos::::?J1,,1ffii
e roxicologl' tonctw ror>uru": "'
vanous flpes of
.r""r"it"Iiw ans
ciq'snrt ln-
Bio-ass
D-n:bocurarine
actton
don- mecharusm of
uses'
a
raclions. Cliru cal
em d somatic
s\
drugs
s., an
ffi:[?-'ffi!'TI:i,ll[iit-r'
anci.ad':'::i:;;;r**;[iolr,.r' Neuromus- i
sttmt
ases. eanqlionic
otics a Estrogens
hrroiC
steroici
anti-asthmaucs'
antitussives' and'
ry s.v$em- dioxide and water
vaPour'
g"", u"li";;;;'
3 hours/ week
Pr-acJicals:
.'ou,apParatus,Physiologicalsoiutionsandrecordingde."icesusedinexperimental
l. SrudY of van
pharmacoloeY. 31
demonsliate Inc
ro demonsrrate
To
potenirat
the putc'trr-" :i::::*I::'..;-il,';:Jlft:',.'"li::
ho6n::tatt,Jn o\ d-tuDocutiilIrrE E:li::::^l-:""
t'^'"?'-- 1-
the inhibruon o'.u::''t..dia: Adrenaline' atropine'
ca' cardtac
i; ;;;""tti'are o::l::;i::'j"i s:r:r.iiriants-
li,l.:Tilil ;;;; "" ;;.'.,'"0
eflect oI orurs
;;;;;- propr':u rtJ rv I and
tne' p'Jp"''olol
K
epressant
depressants-s- Acetvl
Acetvlchol
. IrrJ r.,roua.namrc fr o e
and hr
h eart
d r_.nc nnffflzl
on,l:il.,rrohacerarnio.
on not after inlectron by
;'ffi*;e effects of drugs ^n
io ,*a, the eff1c1s "'-,i,inu.erarnice rn * blood of rabbits
tr,Jilood
the
concenrrations of
o"",.frnution of fie
s
various routes
is Recommended
cY, Kolkatta
cothPeraPeutics
cirugsaCiossbioloeicalbarrier(Passtvediffi-rsion.Activeffansport,f|cilitated
y-rosrs) and pharmaceutical)'
physicochemrcal, phlsiological
uin'g
'=: ffi:ffi ;ffi :ffi*"rd: ,['il"n."rn
P_lrarmacokinetrcsi n msasurernent-
42
.1 j j
Desien oi sln-cle tloi: -'r"-e!ul'' 31':' si:-'ii" :lJ ieievant StailStlCS
.{ -1 r-:: sr*rufrCance in COmbinatiOn therrr.:r
P.harmacOkltl3t:c ,iiL:'li]i3:lCllilils "h:lr
B i o afarlq hi I i t-v q!-d-p-Dgl'.rEig.l c :
Curv'e ('\UC)
5I }leasurement ol-Broaraiirbrirtr- C- mu' T- max and Area uncier
i : Design of sinsle dose brt-r-eQuivalence stucil'and relevant statistics
5j Rerierv of rezulaton, requrements ,oi- conduction of bio-equil'alence
stuciies
given
Experimentstesi,4ed for the estimation of various pharmacokinetic parameters with
data.
2 Analysis of biological speci-ficarions for druq conrent and estimation of the pharmacokinetic
parameters.
) tn vitro eva.luation of different dosage forms ior cirug release.
4 Absorption studies - in vitro and rn situ
Statistical Ireatment of pharmaceutical data
6 preformulation studies including drue-excipient compatibilit.v studies, eft^ect of Stabilisers,
presen'atives etc in dosaee form design
7. E*periments demonstradne improvement in bioavailablity through pro-drug concept'
8 Stabiliry evaluation of various dosa-qe forms and their expiration dating
9. Dissolution testing and data evaluation for oral solid dosage forms.
I0. Evaluation otbioequivalence of some marketed products-
II In l.ivo bioa...;rilability evaluation, plasma druq concentration & urinary excretion curves'
12 Design development and evaluation of controlled release formulations'
Books Recommended.
E
?r
) \lrlo Gibiil dr. 5;o olurntacettitcs Llni! L-lrtt;cc Pharmacoktnettcs' Le'r & Fibiger' Philadelphia
Lirinestone
Aulroii.\l E -,Dltttrnroclrttcs- Titc Sc;ct:c,: ci Do-;aP Form DcstElt ELBSi Churchill
and cltntcal Pharmacohnetics- A
) Brahmankar D \{ and Jaisrval. s.B. Btooiurrnaccutics
Trcattse. \'allabha Praliashan publishine Co \erv Delhi
3: 5 p111ft-\LTTCOGNOS\' - U
2 hourV week
34
I.{ic;'crs.-otrc stuc\ of somr r;llorair:
_i.. rontarrung crude drugs out lined abov.e
corrder:x' irugs ( ar ieasl j,
I S ia,rcie'ci-iat ion oi
some tracir u onal dli ;.)i;r:Li ;a::ons( at least
5)
-1
Idcnri6carion of crude dru_es hsred aborr
r al ieast 25)
5 r\licroscopic studr of characrers oIseieciei
drues given in theorv in entire and powdered
( at leasr I 5.1 form.
6 Chcnucal e'aluatron of po*'ciered drugs ard
enzrmes.( at reast 5)
7 chromatoeraphic srudies of some t,erorr
constiruents. ( at reast 5)
Books Recommended
Itrcqry
i hourV week
A. Dispensqr.g pharmrlr roa Communiq. pharnrac-r L
\
Pn n ci p I esro I D pens
is in._e Handlin-e of prescriprions, Source of error in pr.rt.iptions.
General dlspensing oiocedure;;a,n;'ru"u.il,i,
Forms"#',:ffi:j
::rr1H,Tl._::?^l.gicrnes
products L:tin terms commonh.used
- calcutation of doses
for infants, adutts and elderty
Ilffi,..:,:;:*:.^r]1,,o^T.^,_ro::l9-
snirit lsotoruc
spirir.
sptnt. Isoronic sot;.;;, ;l;;-;;#;;il
Iqnr^nia.^t...i^--
solutions. n' r '
Displacemeirt ;;.
vajues etc.
;,, i'l p,oor il;il;;;"i*,
,l'oll.9 and procedsres adopted in dispensing of.rypicat prescripti
ptions like mlxtures, :i
T::,t]:^t p
:::::,:l: :l:'1':ll?t:'-' I s
j
on s' ;'# ; ; ;; ffi.o.- ;:::";,fi .';H:::;il:l
pastilles. rozenses. pius. todo"r,-t",i;;;;; rilt,til"#,.ifiir, ,o..rr,
i#::::::ii.""l.Tnrmics.
tablet trirurates etc
Incompatibilities Phvsical and chemical incompatibiliries, inorganic incompatibilities
of
fl::r,:,ir",j:L.:1,t,
n n-merats-.adids. alkalies./org",j" ,;;';;;l;ffi;;'ffi:r[LTa,oids
- - j
--
anaesthetics. dyes, surface
rncornpatibiliry.
acdv.e .n"nir- correcrtion ofiincompatibilities, Therapeuti c
5' ' Communitl' Pharmacy: comm
rganisation structure of
retail, u,hole sale_ Iegal requirements
role oflpharmacist in community of records, counselling_
heal
B: I{ospital pharmacr.:
i5
K
I (Jri,a,r:ltir.it anJ:ir-.l .i.i- {ii,,.tll,\.1 1..;t i;:L'ri'll.:i anc hcscttaJ pharmacr. Res!onstbiIitres oi
a 5Osprtai 'phafillaLiSl l;l.ii lll.iL . Jrrd th.I'lil:'i.J "::lnllnee,
bUdeet preparairOn alCi
intplimenla::or,
Formuiary
I Hospiral Formulan contents. Pieoaratton .ulc It-'\rsion of hOspital
I Druq store manaqement and Inr enlon coni:ol
(a) organisation of Drus store. Trpes oimatenals nocked, Storage conditions
(b) Purchase and inventory control- pnncrcies- Dr.lrchases, procdures' purchase order'
procurement and stocking.
4 Drug distribution svstems rn hospitals
(a) Out patient Cispensinq- methods adopted
(b) Dispensinq of j*g, rL inpatients Trpes of drug distribution systerns. Chargin-e
policr',
Labeling.
(c) Dspensing of drugs to ambulatory patrents
I (d) Dispensing of controUed drugs
5 Central sterile Supply Unit and their mana3ement
supply of sterile materials'
Tlpes of materials lor Serilisation, sterilisation equrpments'
Manufacrure of sterile & non-sterile products:
Policy maliing of manufacturable items'
6 practice, master formula card,
demand and cosring personnel ,equiiem.nrs. manutacturing
production control- manufacrurinSt records
ciiseases, treatment schedules'
7 Drug inlormation senices ,orrJ., of inforrnarion on druqs.
procurement of iniormauon- conrputensed str\'rc3s
(eq ivIEDLLLiE) Retrival of informatioq
medication error
SRecordsandReportsPrescnprionfiJling.cirugproEie.patientmedicationprofile,caseondrug
cases etc
irrtelaction and adverse drug reactions' iciios''ncratlc
3 hoursi rveek
Pr_actrcals
Ilooks Recommended:
studetrls cBS Publishers Delhi'
I cater. s 1.. Cooper oul gttrtn's tlispercirtg-[or Pltarmaceurical
C9,
? tr{artin. E w-- \irpuui,ig of Mediianon \fack Ptiblishing Iu:t:T.PO
3. Stoklosa, Nf .1., Piarmaietrtical Calailarto, Lea & Febiger Philadelphia' Dispetse
4. Liberman, H A. Rieger, trl.N{ and Banlier, G.S . Pharmacettical Dosage Forms
sl'stems" Vol I & 2'lvfarcel Dekker NY
5. Hassen \vi1iarn, E., Hospitar ptwnnaq'Lea & Febiger Phcnmacy'
Philadelphia. _
B'S Shah Prakashan
6.-- Merchant, H'S', and Qadry, !'S'' Text Book
of Hospitat
Ahmedabad . r,-. .tr.^n.Lr:^^+'
T.Allwodd,M.C.andFellrJ.T.TextBooko/HospitalPharmaq"BlackwellscientificPublicattoq
oxford. 16
..:
-J
\)
\)
\)
-)
\) 3: 7 P[IAR-\I \(.t_ t'T-ICAL JURISPRUDE]\CE
\)
\) Theor,r'
2 hourV week
J
I Definirion and scope of forensic pha;.,:c'. Pharmacist's
J Pharmacist as a member of the Health Caie
role in drug treatment ard drug usage
Scheme.
J 2 Phatmaceutical legislarion rn India Fl'stoncal
developments of pharmaceutical
rqvvuu,. euuv'rlr.,rr
education in
J India. professionar ethics in pharmacr-pracrice
Legar
) 3 Esrablshment and workine of poisoricenrers in
Hospi
acists.
patient and the public CoirmonJy used poi;ons ur
) and th
poisonine and drues in suicides
) 4' Pharmaq'Act l9'{8 General stud'of ihe Pharmacy
Act with special reference to Education
) regulations,working of central and siate pharmacv
councils. Registration procedure under the Act
) 5 Drugs and cosmetics -{ct I9{0
General r*ar-.oiii. o,"-i .r?'cosrnedcs Act
) there under Studv of the terrns " Drugs" and "cosm.ri.ri -D;;;;;;s, and Rules
prov.isions applicable to
Impon. SaJe and manufacrure of drugs
)
Qua'lifications- duries- responsibiriries or drug rnspecrors.
:
ibrnralities for esrabrisain-s manuraciuirn,,
unirs. Distnbuti Htff:::#t
abii-shment Det X and y.
rical preparations *,ith reference Io tvledicinar and
and Rules 1956.
iega.l analysis with special reference to
Narcotic
ct.
Books Recommended.
J/
FOURTH IIPIT.4RI//
( ivfedicural Chemistry)
3 hours/ week
Theory:
3 hours/ week
t
methods'
I Exerd-sS based on QSAR: Hansch & Free-\\'ilsonand i-a rha
establishing
pharmecnneial
the Pharmacopeial
course conlent
J -"-J-atinaselected drugs fromof the
synthesi\.of
the drugs sptheszed
spectral ,.Jditt
constani 4nd Molar refractiviryof compounds
6 Determination of p"*i,lon lo-.ffi"i"nt, Dissociarion
for QSAR analYsis'
drugs
8 Work shop on stereo model use of some se rected
Experimenis L,ased on drug metabolism- . r - ^ ^--^.^, and "tqaAtrAisrtinn of
6 ol
^^A standardisation
(a) preparation of 59 *4"*oo*mesfrom tissue homogenated
Cytochrome p-450, cytockome b5
u;tffi* orpn"nourrbital pre trearrnenr on mrcrosomal control'
and comparison of microsomes from
and NADpH cytochrome cj reductase p-
and p-nitro anisole
r r ,, (c) Determination of microrornJ*ino pyrione demethylase
.iL...
,i: i
reductase activities'
\/ and nitro
microsomal azo-
lBooks Recommended:
l.Foye,W-C',PinciplesofMedicinotChemisny'Lea&Febiger'Philadelphia
38
ll'rlsott am) (jisvotd 's /c'r/ Bttok of orgarilc
Delagado. J N, and Remers. \\'A R (Eds1
lv.lecltcttul atrl Pharmaceurtcal chemtstrv' J
Lippincott Co Philadelphia
NIartut. \' C , Ornttlitottu Drug Desigrt A )ritrcal
Inrroductiorr ( lvledicinal Research
N'lonoeraph Vo 8) MarcelDekker Inc' NY
q Role of Organic Chemtstr.v m Dntg Research"
Roberts and Price, B-J' " Aledicinal Chemistry':
Acaderruc Press Nerv Yorl:
oxford Uruversiry Press' New
5 Nogrady,,T , lvletlicitnl Chemistry- a Btochemtcal 'lpproach,
York
& Drug Design ' mac Milan Press'
6 Vurter, J G , and N1ark Gardner, ( Eds) N{olecular lvlodeling
New York
4 :2 PE{RI\{ACEUTICAL ANALYSIS- tr
2 hourV week
Theory:
A.Importanceofqualirycontrolofdrugs-Designofqualirycontrollaboratories.Differentntethods
TQM QualiW Review and Qualiry
of standardisation Quaiin.orrrr-..I GLP. iSO 9000,
analytical data'
drug analysis, interpretation of
,.: Documentation. Regulator-v- contro_|, regulaton-
validation of analytical
qrJ;,yr]rait, qirtity or.q,i,p*.nt' validation of equipment'
Validatior\
procedures.
Seoaration techniques:
1t
j Chromatography- Fundamental principles of chromatogaphy- adsorptioq columrL PaPer,
in
chroniatographi' Application of the above techniques
.tgyig & high it"ttrt..tiquid
ical analysis.
(2)
iflectrophoress,
(3) \Celfiltration
Gener.al treatment of the theo(v & application of
the fouoiving optical & electrical instrument
methods in pharmaceutical ana.lysis:
metry-
tive an etry'
and ap I
of
and working on in pharrnaceutical analysis, Ion selective
potentiometry., l-Fischer's method of moisture daermination' -
;5.
|tt; (i!,
.lr
!t
:i.
Ul.l i -' i- I l'l,]ilt'-tllS
tj) Polanmetrv - Theory'. instrumentatron, j,- ..,r': : )ms - Difrerentiai scanning colorimetry and
materials ani
1i) fn..*"f ana.lysis of rarv
of irterpreataion o spectra and application of
lfH:T.1Ht$*r,basic instrumentaoonrienrent
ih. *-.uy diftaction and Radio immunoassl
:
3 hourV week
Pra$iq3l.work:
l.
r
3.
4.
5.
6.
. 7.
8.
BOOKS RECOT'{MENDED
(l)Connors,K.A.,TextBooko!Pharmaceuttcolanalysis.Wrleylntersciecnes,NewYork.
g U Mlcel Dek]<er New York
chemtsrn,. Vol f
(2) ChanerL L.G., A;h**";ncal tr
Pharmaceuncat Chemistry' Vol' I &
{3) Beckett. A.H. -i i'J'te' J'B '' Pracncal
\-' ;;;ifuon" p,.tt < f the Universin of London Text Book of Quantinwe
iu",Eilll,'i^;', lr"nan",, and De,r,i, R c r.ed ) t'oget's
' - - iriri*ric' Amlysis'ELBSI longman Lo ndon.
Settle- F.A "lnsrrumental m€thods
of analysis'
(5) willar( ff,H-,l,r"li i-*, ;"* J A and
phsrmaceurtcat chemistry,McGaw
,rr*tt"lilThHNerv;l-'hn, F., , Jenkirt's ouartrirarive
fflI,Book Co. York'
2 hourV rveek
Theory:
of medicinal imPortance'
genin, Sennosides, Diosgenin
,ro
rd \/inca alkaloicis
Ouinine- Reserpine' \lorphin ssanoidt and.Flavanoids
;;;;;* and ticgenesis o[ rnd Tetracvciines
chenristn- and therapeutic
ac tptti"r reference to Diosgerun
medicin '
.rinf pftnts' Papain' Cinchona'
World-wide trade in
tsc and c
sources'
aqents from marine
s and fungal toxrns .:
ii
ercial scale' *
j hourJ week *
fi
{.t
ri
Practicals: chemical
if,retion of various grouPs of {
iLt
,r, oiPtrt aceutical sigruhcance evaluatt
-^L
:nts o;Pape, Aa tn'I""-yo "ttto'*'5phic
rrv rvvv' * .- -
of sorneselectedpt'v'"iltil1l1lt^:,'"';:'Jr:[::"
rrne selecteu P
matg graphi c p ro
fi le.
volatile oils and their
culture'
,"r,ts in Plant tissue
noof<s neconunen9*:
6. Robbers, r r, tplffiK;;,
wiltir-; & Wrlkins PhiladelPhia'
4'- 4 PEARI\lAcEuTIgs-ry-
a rna"ttial Pharmary)
iro*J"'iut
3 hours/ week
I
T't,ouid dosage rorms: Introductiol try::9r'^di:l:" ffiS,,'li:,::t"#I;I"'I.ifi;;::[Li"
::''r':;il' *i ursions officiar h
"
il*:?""Hni*lt*,=-t"t'i' ;TJi'"*='rfi
PharmacoPoeta'
41
FE
2 ::;J' xiljjlffi':jilil"'iil'il',""i',0''
atlon aglng
human
h*;'RBCs, dned h;; plasma,
human
S.Bloodproduasandplasmasubstirutes:Col]ectionarrdprocess,q&storageofwhole
_bloo4 concentrated 'brinogeg
ideal requirements
human oi-,-,r-.,. pt"r*a substitutes-
thrombrn -al,rr- normar,,,jil^ii*ir,r,- and
formuration, manufacn rring
6
u #*J#;:rh#t"5.rm:r;,'J#,fil,ll"ll;r
metho s or preparairors contarners'
l- ri, n"mml;**nfffi;:H:f":"i#i::Ll
\;Puu='--
evaluation'
I
8.
s' Cosmeticolory and TtT"
funoio"t of skin and hair'
dentifrice and manicure Pre
g CaPsrles: Advantageso
Wd gelatin caPsule' srze
capule content, imPortanc
conrol- stabiiiry testinq an croencapsulation in Pharmacy'
ri6ce, sPraY drying' sPray.
foating'Pan and other techniques'
on large scale
sranulation,t::hn^olo=y
ent D?es of rablers, machinary'
tabl et compression
tablet makine, ti itr;;; rypes
s- formulation of
coating solutiorg
lets'
stration, water for injection
of its adjustments'
PYrogenecrtY, no n- aque
Uj formulation details'
of Pharmaceuticals'
wound dressing absorbents' '
Definitioq primarl' o si c hem
v e s' cellul
saezeac. B and's*: ;u#; Lq::'-
]lt "ct
i
and catguts'
rnd ooo-'absorbable suhrres' Ligaturps
absorbable
rePlacement materi zil s' comPonents'
products: Packaeing
14. Packaging of pharmaceutical
aspdl "ioi"I*g''-P'? kage
mahods of evaluatio* tt''u-irity L"gi ana other official requrem
influencing cholrce-of *nt'i'"" '
ti:stmg.
12
6 hours/ u'eek
Bfacticals:
' - r r:r-^ ^^1" nd emulsions
Preparatiors evaruation and
packrnt
Poff#::,.l:.iJl#ffi1:.:ffi,..=.-"].
aerosolt'
:l'fl:1':i"'
a'op"" '*?illillli
intments etc (i::i:::lfi
t'","u'n"Ja;;;;roJr",r at reast r0 ) i
vanou methods of
Ointments, suppositories' ^-r vanous
r'laleninal nroductS utilizing
extracts
Preparation of Pharmacopoeial
preparations'
hair' dentirrices and manicure
rypes orcosmetics for skrn
ffiLl;l:iffr:il
( at leas l0) and biological evduation of
aration, stabilization, physical
4
s, cap sules.,uUl.t,, p^'"ntt'ul''
i'itto *ptut"t' .:1t?d:.,
expiration dating' disintegratton
ri"Uiit,r, erialuation and their of
Design, developmlnt and evaluation
"*=lr"*s.
( at least 15) . at ,least^ .\3) I
pharmaceutical packagng'(
Books Recommended:
Theory and Practice of Industrial
LacfLmaru L., Lieberman_
H A and Karug, J.L The ,
I
V;;.;)" Lea & Febiser' Pl-ulade.lpl-ua
Banker' G S Plwrmacetttical Dosage
'
Forms: Drsperse
Libermaru H A, fueeer' M'N{' and
2
Dosage-Forms K M Varghese
& Co N{umbai
) H:ri:"' ;,,f,I,*:.';',:;m:::",),,
AttltorgM.E.,Plwrmacettlics-Sctettc,,o{Do,og"no,y2"slg7l,ELBS/London. NY
4
and Ril., C.T tloden, Phor*oiertics Mscei Deltter tnc'
5 Banker, G.S. wiley & Sons NY
o.t[ Cosmetifl:
6. Jelline[ J.S rur-uiotiort and Frnctiori .Joh
1
Kotil.i,.P.S.DntgFormttlatiott}olalttnl.EasternPublishersNewDelhi.
4..5 PHA-R]\IACOLOGY - tr
3 hours/ week
2.
3.
13
ti Anti anqlnal
drues' Vaso dilators and
i arir*'hmrc
emra
e Platelet funcuon'
'crobial'
CfouI4r'
trloramPhenicol'
lcs'
of'
, ChemotheraPY
infections'
of Protozoal
asls
and Disinfectants'
,liceaSeS.
Ii€15turr-^'---' crr^lainthlaStS, /\lrtr r^--1- r\aroc rrSCd lO SfUr diS
:tilffi;;;y:'1:-TITS: hourJ week
bY:-
and Lignocaine
Procaine
rabbit)
ffrog)
otarod)
rat'
mPound in
cat - demonstrauon'
demonstra
dog' rat and
^-opsthetiSed
anaesthetised
rn
:^' rnalqesics'
_,.^tnctt)Churchill Livingstone'
New York' Cfinical P twmacologtChurchill
5- Laurence, D'K' and Bennet' P'N''
1{
4: 6 PHAR\L{CEUTICAL IN D U STRL{I }I.ANA GE J\I E NT
eory:Zhours/week
bank account' Bill of
Accountancy: principles of accountancv- Ledqers- balance sheet- Cheque-
notes and hundies documentary
exchange, treatment of cheques, bills of exchanQe, promissory
bills.
Economics: principles of economics wirh special rderence to Demand and Supply laws,
problenr, General conditions of
Demand schedule- demand qrrves, Labour distribution- l^abour
trade'Procedure for
tabour demand- Supply- Labour welfare- Trade unions- Inland and foreign
General - Fire and
export and Import oigoods- lnternarional trade- Principles of lnsurance-
MarinC Ir-surance.
pharmaceutical marketing. Functions; Buying- Selliry- Transportation- Storag:-.Ii1-T-
shop
Feed back information chlnnels of disuibution- Wholesale - Retail departmental-Multiple
and mail order business.
Siesmanship: principles of sales promotion, Advertising ethics of sales- Merchandisiog-
Literature, detailing iecruitr*t, Trainins. EvaJuation, Compensation to the
pharmacist'
Management: Ad.ministrative maragement: Planning organisation- stafldirecting and
controlling
- measures-in the
Operative managemenr: Anticipation of problems- Preventive
management of personnil, -aterial, finance. Irfarketing- time- space, marging morals-
trincfules of management. Co-ordination communicarion- motivation, decision makin&
leadershiil- Lnnorat-ion creatiriry- deleeation of authoriq', responsibility, record keeping
Identifica}pn of key points Nlarimum thrust for deveiopment and perfection.
4. Market resbarch:
(a) Measuring & forecasdnB market demands- ma-ior concept in demaad measurernent,
esrimating cunent-il.r..iid, geo-demographic ana.lvsis, estimating industry sa-les, market
sharelsifuture demand.
I
45
1: i P[L.{.R\L{.COLOG\'- UI
(Clilnical Pnarrnacv anC Therapeutics)
\
Books Recommended:
I .HerEndal, E.T and ffuschman, J.L., Clinical PharmacS'and Therapeutics Williams and Wlkins.
2. Katzung, 8.G., fu.sic andClinical PhormacologtPreotice Hall Internationals.
3. Winter, M.E. Basic Ctinicat Pharmacokineticsi Applied Therapeutics Inc. San Fransco-
4. Dip-co,J.L, Phomacotturqry: A pathological Approach- Elsevier.
5. Wagner, l.G. PtwnocoAilUcsjorhe Pharmaceutical Scientist. TechnomicPublishing, AGBasal
Switzerland :.
REI.I-RE\CE BOOKS
It is understood that the teachers \\ould foiiori and recommend the latest edition of the books Hence the
specific edition and year of publicaiion are omrtted
16. K.A. Cpnnors, G.L. Amiden and V.J Stella, "Chemical Stabitity o/ Pharmaceuticall', John.
Wiley &Sons, NY
17. H.S. Aulton 'Pharmaceurics- The Sctence of Dosage Form Desigtt', ELBS, Churchill
Livingstone.
18. J.T. Carstenson, "Dnrg Stabilit1,", irlarcel Dekker lnc, Ny.
-, 19' Sa-earin arid M.S. Balsarq "Cosmettc Science otd Technologl" Vol I to 3,
John Wlley and Sons, Ny.
J.S- Jellinek, "Formulatiort and.ifurrcrion o1[ Cosmencs" John wrJey & Sons Ny.
S.G. Thosseo 'i t Cosmetics" Universal Publishing Corporatiorq Mumbai.
H.S. BearL A and J.E. Carless. "Advorces in Pharmacetttical Sciences", Vol I to IV
25.
26- B'T- Loftus and Robert Nash "Pharmaceutical Process l alidation" Marcel Dekker Inc. NY.,
27. M.L. Schroff ',
28: E.W. Martin, .
Hamilton.
17
ll'
l4
t
" "' 1', :: "'
j5
l6 f"i^:l$:,v,,,:#!;;,yx'i;r";i;'yi';'i:l'#;:'*i'|'h'hingAGBaser
Switzerlihd,
)1 IfiloGbaldi,,Biopharmaceutics&ClulcalPharmacokinericl,Lea&Febiger Tablets-
ptriladelphia. "Pharmaceutical DosageJorms"
r p enht'artZ "Pharmace
o- J
& y'Sch*'artz
j8 H.A LieberrnarL L' Lachman N-Y
;;i , ;;i Marcel Deklier Inc r-l'?:*- "Phormaceuttc :at Dosageforms"
Parenrcral
ily.,ffi I;;ff;li*,X'li;i,i',i1ff^;":;;:,';;*:;e'Ji""twe,Scien'rinc
45
16. Delhi'
Fublications'odord' ;eu"wu'r Publishingrrouse'
:euticals"' Narosa -'
["ffi;ile:, "Haru er Inc NY
11.
48. i!r.r C Welling and Fr Indore'
c' N'Y'
49 ir.i. eh*.ti,*brttgs
^sJ; B6iiorr-Pt.' aw Kogakusha
- Fnainec
50. "chemical Engtnee
fff';p, i-dH it'itton
i
61.
60.
62.
{trY{,#,o,^n ,,,H::f;ffill#ff"pubricatipq odorq
_-63.
&. dru
65.
'Microbiolog"'
6. 48
61 Lervin. Gene \',,.\ /tc.r ot,i olo..;,.
[3crryamrn \
68 Prescon
'uJwu(r aru
and Dunn. uteuSlrtol
r_,runn, lttdustrio[ ,lltc.rr.tit,,|
,]{tr.roir,,,' ,,... . \,1:
",\hcrobial lral Hill BOOk COmpant, InC.
69. Peppler. Technolog3,,.. \'ol i.,, II
70.
7t. i'fl|#]rl,X l*::;L;Tj::' \io _ 6_ :"':':'
t ose,,. ,,,u^,"':"'
,16 , UIU SII
r. \ ,E"ry,,eerrtts",Ururversitv
Vtrl orrokTo press .
72. P. f Star,du
I F. ::'5 ry.9:&,\
;).?,:,: lto
ch
Whjtaker, 1-,p
r
ee"ch.rie, *.itzertand
t t
I
rci,iples c,-/'i
e r_i
'tttat i
S
PHARAACOGA'OSY
6.
,of Indian ,,CS\
Medicinal planrs. New
7.
8.
The pharmaceutical press, London.
ts ", 2_3, lnterScience Newyork.
9.
h arm acei'r tical'
ib ffil'#f;'P
I t.
tura I p r od ucri, _ C h emi str y__ (NATO
Conferen ce
t2.
e Culture lulethods,, National
Research Council
| , 'I:, Guytoq AC. and Hall, J.E., Text Book of Medical Phy,siologt, W.B. Sannders Co.
I
' Ll. , c..Q- chatterjee,
r:1,.. fr f..
f-L--
Humot Physiologt. Medicai Allied Agency, calcutta.
i'i:,;, r ...!.ilu;-. ifr.ry.,
' gj;ii".ri:.-Su.
[asn "..-, .Humor ihysrotog,CBs. Publishers & Distributors New Delhi
;C-,q" N;il"i,
5
-Jruf N Sazrson ll'igltt's Apptied Physiologt, Oford Universi-ry
Ganong-W.FReryiew of Medical PhTsiologt: pr.nti"" Hall Internainal.
Press
6. ilH*ci,*:;3tr":tr;:;:,i,li,if,;i'iilff ir^'*I;ffi:;hHarper&Row
h.rblishers, New york.
7 \'ander J . Sirci-ntelr j
{ i{ .rncj l-uc;air.,[) S !i:tntan Plt-y.srolom, -Iata McGraw Hill
Publislung Co , Nerv'Dell-u
8. Best atd Taylor's Phystologrca/ Basts tt{,\letitcal practicc, William & Wilkins, Ba.ltimore
9. Mc Nau-eht.A.B and Callarder R lllusrrated Pltl'siolog,, Churchill Livingstone
10. B.D. Cburasia's Humatt Anotomy. iiegional & Apptied Part I, II, III CBS publishers
and Distributors, New Delhi.
ll Ranade.V.S Text Book of Practical Phv'siolog:. Pune Mdyarthi Griha prakashan, pune
t2. Di,Force Marinom S.H. Atlas of Normal Hisrologt Lea and Febiger, Philadelphia.
t3 Rcibins; S.L. and Kumar.V Basic Patholog,,, W.b. Saunders Company.
l4 Davidson's Principles and Practice of L{edicirte, ELBS/ Churchill Living Stone.
l5 Goodman & Gllman "The Pharmacological Basis of Therapeutics" Editors- A.Goodman, T.W.
RaJl, AS.Nies, P Tavlor, Perqamon Press Na'
16.' C.R. Craig and RRStitze\ lv{odenr Pharmacologt, Linle Brown and Company.
l7 Paul L, Princtples o-f Pharmacolog., Chapman and Hall.
l8 T.C. Theoharides. Pharmacolog,l Linte Brown aad Co.
l9 M.P.Rang, M.lv1. Dale, H.l\[. futter, Pharmacologt Churchill Living Stone.London
20. Iv[J. Mycelq S.B.Gertner and M.M. Perper, Pharmacologt: Lippincott's lllusrrarcd Reviews
J.B.Lippincott Company'.Philidelphia
2l - Crossland J. and Thomson.H .H. Essenriats o-f Pharmacologt, Harper and Row Publishers NY.
2? Katzung.B.G. Basic and Clinical Phormacologg',Prentice HaJl, International.
23- Laurence. D.R aad Bennet. P,N. C/rrical Pharmacolog,,ELBS / Churcirill Living Stone. .
24. Ghosh. lt1.N. Fundanentals of Experintenral Pharmacblogt, Scientific Book Ag.ency Calcuna.
25 Pharmacologt,,Vallabha Prakashan New Oeltri.
26 Pharmacy and Therapeutics,. Williams aud Wilkins,
27. n,oc L^-r:^,r rl^-^-^...:,
z8 Dipiro, t.k.!!yracoiherap.v.: A pathoporrijfi;llf#ir#;:Tlr$;I' .
29' Sathoskar, R.S. and Bhandarkar, S.D.. Pharmacologt and Pharmacotherqezrl'cs, popular
PrdQshan, Ivlumbai.
30 Leon Qtrargel., Pharmacry Revieu'. Johrt \\'ilev & Sons (Sea) PTE ltd. Singapore
P HARMA C E U N CAL ANALY Y S, P HAR,\, LA C E U TI C.4L C H il4T S TRY & B I O C HE.A0I S TRY.
9.
10.
(Ec) Green & Co'
ChemrstrY'
o'f Hereroct'c
lo *, Chtemistn'
F u ndom e n a'
" " ":;: ;; rfl Lt "d,i*#tJ
Hil
Pracfical Organtc
Longmanl London " '
GRa; Hill' New Delhi
Ltd' New Delhi
Biochemistry
York"
and sons' New
Distributors
Publishers and
.
Co. PhiladelPiria'
*- b"' g Design' Pergamon
Research
norr (N'ledicinal
rk.
ork.
it'$f'"-gJii?:f :':l;
;i:;:""fl
44#ffi"SGMediciru,,S!.::fff;JZ:[;:;'#i,i3f
E: Cu,YF'A and Rj' Sundbers
)Z
-