Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
COLLEGE OF MEDICINE
Department of Pharmacology
School Year: 2017 – 2018
CLINICAL PHARMACOLOGY
EVALUATION # 1
July 17, 2017
ANSWER KEY
NAME: ____________________________________________ STUDENT NO. __________
2. Drug A has a volume of distribution of 200L and a half-life of 30 minutes, based on this
statement, you say that Drug A:
a. Is highly hydrophilic
b. Is cleared faster from the body
c. Undergoes zero order elimination
d. All of the above
e. A and B only
4. Clarithromycin has a Cmax of 50 ug/L and an AUC of 2500 hr- ug/L while Klaricid has a
Cmax of 53 ug/L and an AUC of 2560 hr-ug/L. You say that:
a. Clarithromycin is bioequivalent to Klaricid
b. Clarithromycin is therapeutically equivalent to Klaricid.
c. Clarithromycin can be used interchangeably with Klaricid.
d. All of the above
e. A and B only
6. Which of the following can cause an increase in the fraction of circulating unbound drugs?
a. First trimester of pregnancy
b. Plasma albumin of 45 g/L
c. Displacement by other drugs
d. All of the above
e. A and B only
Page 1 of 5
7. The reason/s why pharmacological effect is not being translated into a therapeutic effect will
include:
a. Substandard drug
b. Altered protein binding
c. Incidental adverse effects
d. All of the above
e. A and B only
8. Which of the following mechanisms of antimicrobial synergism are TRUE for the
combination of Trimethoprim+Sulfamethoxazole?
a. Blockade of the sequential steps in a metabolic sequence
b. Inhibition of an enzymatic inacativation
c. Inhibition of the cidal activity by static agents
d. All of the above
e. A and B only
10. Which of the following factors will influence your choice of an antibiotic?
a. Spectrum of activity
b. Ability to be delivered to the site of infection
c. Bacterial resistance
d. All of the above
e. A and B only
11. Drug X has a volume of distribution equal to 25 L and a clearance of 1.5 L/hr. Half-life of the
drug in hours is:
a. 5
b. 8.5
c. 11.55
d. 15
e. 20.30
f. 24
12. If the volume of distribution of the drug is 5L and your target drug concentration in the blood
is 300 mg, your loading dose in mg should be:
a. 300
b. 500
c. 650
d. 1000
e. 1500
Page 2 of 5
For numbers 13 – 48, TRUE OR FALSE.
Following the phrases or statements are choices, choose whether the items in column A are
CORRECT or INCORRECT.
COMBINATIONS ANSWER
C. These drugs produce their pharmacological effects by their direct effect on a receptor:
DRUGS ANSWER
PAIRS ANSWER
TOPICS ANSWER
STATEMENTS ANSWER
35. Concentration of the drug at its site of action and the intensity of effect CORRECT
37. Fraction of the population that respond at each dose against the log of the BONUS
dose administered
DRUGS ANSWER
ROUTES ANSWER
Page 4 of 5
For numbers 49 – 53, Choose A if the drug/s given to the patient is/are RATIONAL, Choose B if
IRRATIONAL
50. 65-year old woman with dementia prescribed Vit C, Vit E, Citicholine and Diazepam. B
52. 10-year old child with high grade fever secondary to viral exanthema given Aspirin. B
For numbers 54 – 58, For the following cases with treatment failures, identify what process of
drug therapy is affected:
A = Pharmaceutical Process C = Pharmacodynamic Process
B = Pharmacokinetic Process D = Therapeutic Process
54. Diarrhea in a 5-year old child prescribed Doxycycline. A patient taking oral hypoglycemic
agent with a bioavailability of 20% noted that his blood sugar is still high despite his regular
intake of the drug. B
55. A patient with decreased GFR, taking Furosemide, came to the clinic complaining that his
medication seems to be not working for his condition. B
56. A patient with severe symptoms of allergy given hydrocortisone sodium succinate still noted
to be grasping for breath. D
57. A diabetic has uncontrolled blood glucose level despite administration of insulin
intracutaneously. B
58. Amlodipine 10mg given three times a day for hypertension. An anemic patient treated with
slow release iron formulation for 30 days still have low hemoglobin levels. B
For numbers 59 – 68, For the following, identify what process will be affected:
A = Pharmaceutical Process C = Pharmacodynamic Process
B = Pharmacokinetic Process D = Therapeutic Process
Page 5 of 5