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Up to two million Americans suffer from DVT annually1. Approximately 600,000 Americans are
hospitalized each year for DVT and its primary complication, PE1. DVT-related PE is the most
common cause of preventable hospital death2. Approximately 300,000 die from PE3, the majority
of which result from DVT4. Complications from DVT kill more people each year in the United
States than breast cancer and AIDS combined1.
Venous thrombosis in the lower limb can involve the superficial leg veins; the deep veins of the
calf (calf vein thrombosis); or the more proximal veins, including popliteal veins, the superficial
femoral, common femoral, and iliac veins. Less commonly, thrombosis involves other veins in
the body. Unlike the superficial veins just below the skin surface, most of the deep veins are
surrounded by powerful muscles that contract to force blood back to the heart. One-way valves
inside the veins prevent backflow of blood between muscle contractions. When the rhythm of
circulation slows down due to illness, injury or inactivity, there may be a tendency for blood to
accumulate or “pool.” A static pool of blood provides an ideal environment for clot formation.
As noted above, approximately 300,000 die from PE3, the majority of which result from DVT4.
Complications from DVT kill more Americans each year than breast cancer and AIDS
combined1.
Blockage of the main pulmonary artery by one or more of the emboli may be life-threatening.
Symptoms may include shortness of breath, a feeling of apprehension, rapid pulse, sweating,
and/or sharp chest pain that worsens with deep breathing. Some patients may cough bloody
sputum, while others may develop very low blood pressure and pass out. A number of serious
conditions – including an evolving heart attack and pneumonia – may mimic PE5.
Anticoagulants, or blood-thinning drugs, are commonly used to reduce the risk of and treat DVT.
These agents work by altering the body’s normal blood-clotting process and may help to reduce
the risk of PE. With early treatment, patients with DVT may reduce their chances of developing
PE to less than one percent.
Estimated Annual
Some Causes of Death in the U.S.
Deaths
Approximately
Pulmonary embolism
300,000
AIDS 17,011
Breast cancer 40,910
• More people suffer from DVT annually than from heart attack or stroke.
• Approximately 600,000 people are hospitalized in the United States each year for DVT and
its primary complication, PE.
• DVT-related PE is the most common cause of preventable hospital death.
• Only one-third of hospitalized patients with risk factors for blood clots received prophylactic
DVT treatments, according to a U.S. multi-center study.
• Without prophylactic DVT treatment, up to 60 percent of patients who undergo total hip
replacement surgery may develop DVT.
• Cancer patients undergoing surgical procedures have at least twice the risk of postoperative
DVT and more than three times the risk of fatal PE than non-cancer patients undergoing
similar procedures.
• In the elderly, DVT is associated with a 21 percent one-year mortality rate, and PE is
associated with a 39 percent one-year mortality rate.
4
Murin et al. Thromb Haemost. Comparison of the Outcomes after Hospitalization for Deep Venous Thrombosis
or Pulmonary Embolism. 2002; 88: 407-14.
5
American Public Health Association. Presented at: Public Health Leadership Conference on Deep-Vein
Thrombosis: February 26, 2003: Washington, D.C. White Paper.