Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
e ar
su s
is ver
ni
an
Interoperability robots e - h e a lt h a c c r e d i t i n g h e a lt h i n f o r m at i c s
A
recent New York Times article highlighted the itself could prove to be beneficial in the long-term. For
adaptation of Information Technology (IT) by example, Telemedicine is the best way of reaching rural
the Wisconsin, US-based Marshfield Clinic. areas and investing in developing the infrastructure for
Considered to be one of the pioneers in adapting IT, this would be ideal.
Marshfield introduced mandatory Electronic Health One of the exciting developments of the year gone
Records (EHRs) way back in 1994. Today, 795 doctors by was the introduction of online Personal Health Record
working with the Clinic use Tablet PCs and it has all but (PHR). At a time when healthcare technology providers
done away with paper charts for patients. This could be are grappling with the problem of interoperability for
termed as the ideal scenario where IT has completely sharing data across healthcare IT systems, the Internet
transformed the way healthcare is provided. Unfortunately, could prove to be the best possible solution to this
while this is true for Marshfield and a few other provid- problem, thanks to its ubiquity. Another important benefit
ers, the same cannot be said about the rest of the US of providing patients’ health records online is that it
healthcare system. This is true for healthcare systems places the onus of maintaining health information on
around the world, including the ones in Asia. Investments the patient, thereby making them an integral part of the
IT is still considered to be a privilege by many providers healthcare system.
who prefer to manage records on paper and insist on As healthcare continues to move slowly, but steadily,
the patient visiting the doctor or the hospital. In such towards a more IT-oriented framework, possibilities
a scenario it’s difficult to imagine a healthcare system abound. It will be interesting to see how things workout
that leverages the benefits of IT to the full. over the next one year.
Efforts by the governments and policy makers to The anniversary issue of Asian Hospital & Healthcare
resolve this situation cannot be doubted. Countries Management has a special focus on Healthcare IT with
around the world are busy working on developing a spread of insightful interviews, articles and features. I,
their own solutions for integrated healthcare delivery along with Prasanthi Potluri, would like to thank all our
and it won’t be wrong to say that incorporating IT (or authors over the years for helping us bring out four issues
Telemedicine) is considered as one of their top priorities. of the magazine successfully. We hope to carry forward
However, success stories are yet to come to the fore. this endeavour with many more issues of the magazine
Notable advancements have been made in countries as we track the changing landscape of healthcare.
like Singapore and Australia. While the former has set
aggressive goals with regards to EMRs, the latter is
focussing on e-Health. Developing countries like India
and China face problems at a much basic level. The
governments here are focussing on increasing access to
healthcare for the masses. This is a reasonable goal, but Akhil Tandulwadikar
incorporating IT into this framework in the initial stage Editor
al
eci
Contents
Sp
IT
Asia
Steven Yeo, HIMSS Asia Pacific, Singapore
Australia
55 Driven by e-Health
Sisira Edirippulige, University of Queensland, Australia
60 An Optimistic Outlook
India
Krishna Ganapathy, Telemedicine Society of India, India
62 An Innovative Transformation
UAE
John R Hawkins, Abu Dhabi Health Service Company (SEHA), UAE
Diagnostics
28 76 20 32 MR Diffusion and Perfusion
Can they replace PET?
Marco Essig, German Cancer Research Center, Germany
85 IT Bookshelf
F e at u r e s
86 Industry Reports
88 Featured Healthcare IT Articles from 2008
90 Happenings in 2008
90 Profiles of IT Companies
92 Techno Trends
95 Healthcare projects
www.asianhhm.com
Advisory Board
Editors
Akhil Tandulwadikar
Prasanthi Potluri
Language Editor
G Srinivas Reddy
Copy Editor
Prity Jaiswal
Art Director
M A Hannan
Visualiser
Sk Mastan Sharief
Designer
Ayodhya Pendem
Sales Manager
Rajkiran Boda
Sales Associates
Sylas Makam
Murali Manohar
John E Adler Savita Devi
Professor
Asst. Manager, Compliance
Neurosurgery and Director Radiosurgery and P Bhavani Prasad
Stereotactic Suregery
Stanford University School of Medicine, USA CRM
Yahiya Sultan
Vijay Kumar Gaddam
Subscriptions Head
Sasidhar Kasina
IT Team
Sandy Lutz Ifthakhar Mohammed
Director Azeemuddin Mohammed
PricewaterhouseCoopers Sankar Kodali
Health Reseach Institute, USA Thirupathi Botla
N Saritha
Finance
A Bhasker Reddy
Chandra Shekar Inguva
Malcom J Underwood
Chief Managing Director
Division of Cardiothoracic Surgery, Ashok Nair
Department of Surgery
The Chinese University of Hong Kong CEO
Vijay Chintamaneni
Prince of Wales Hospital, Hong Kong
A member of
Asian Hospital & Healthcare Management
is published by Confederation of
Indian Industry
In association with
Peter Gross
Senior Vice President and Chief Medical Officer
Hackensack University Medical Center, USA
Ochre Media Private Limited, Media Resource Centre
6-3-1219/1/6, Street No. 1, Uma Nagar, Begumpet,
Hyderabad - 500016, Andhra Pradesh, India
Tel: +91 (0) 40 66655000, Fax: +91 (0) 40 66257633 / 55
Email: pharmafocusasia@ochre-media.com
Pradeep Chowbey
Chairman www.asianhhm.com | www.verticaltalk.com | www.ochre-media.com
Minimal Access, Metabolic and Bariatric
Surgery Centre
Sir Ganga Ram Hospital, India © Ochre Media Private Limited. All rights reserved. No part of this publication may be
reproduced, stored in a retrieval system or transmitted in any form or by any means,
electronic, photocopying or otherwise, without prior permission of the publisher and
copyright owner. Whilst every effort has been made to ensure the accuracy of the
information in this publication, the publisher accepts no responsibility for errors or
omissions.
The products and services advertised are not endorsed by or connected with the publisher
or its associates. The editorial opinions expressed in this publication are those of individual
authors and not necessarily those of the publisher or of its associates.
Copies of Asian Hospital & Healthcare Management can be purchased at the indicated
Vivek Desai cover prices. For bulk order reprints minimum order required is 500 copies, POA.
Managing Director
Printed at Kala Jyothi Process Private Limited. City Office: 1-1-60/5, RTC X Roads,
HOSMAC INDIA PVT. LTD., India Hyderabad - 500 020, Andhra Pradesh, India.
www.asianhhm.com
Healthcare Management
Commissioning
for Improved Patient Safety
Rise of a new era
T
Ensuring the delivery of he end of the 20th century may in the same year by the Department of
well be seen as marking the Health in the UK marked increasing
healthcare as safely as
decline of one era in health- awareness of the importance of and need
possible has become care and the rise of a new era in which to address safety in modern, complex
top priority for the NHS. excellent commissioning is required to health systems. Momentum has grown
The commissioners meet the challenges of increasing life following these publications, spreading
have an important role expectancy, changing patterns in disease understanding of the important need to
and developments in treatments and address safety in healthcare throughout
to play in planning and
technology. Advances in treatment and the professions and public. The National
monitoring services on technology together with the increasing Patient Safety Forum, set up following
the basis of quality and expectation of society mean that health- the publication of Safety First, jointly
outcomes to restore care costs are being driven relentlessly chaired by the Chief Executive of the
primum non nocere (first, upwards. A larger proportion of GDP is NHS in England and the Chief Medical
being consumed by healthcare worldwide Officer, signals the highest leadership
do no harm)as a policy
and the UK faces the same challenge and priority the NHS is giving safety
to its rightful place in the as numerous other countries. How to for patients.
health system. But how make the best use of the resources being Fundamental to improving safety is
should commissioners committed to improve health services and the realisation that it is not, predomi-
set about their task? health outcomes for its citizens. nantly, the responsibility of an individual.
The need for effective use of resources Neither is it solely attributable to a team.
is coupled with a greater desire for qual- Both, of course, do have responsibility
Martin McShane
Director of Strategic Planning and ity. The ‘information society’ is reject- for safety: in a complex and demanding
Health Outcomes ing the paternalism of the 20th century environment, excellent team work will
NHS Lincolnshire – Commissioning, UK health system and increasingly arming improve safety. However, there is abun-
itself with readily accessible insights and dant evidence to demonstrate that the
knowledge from the World Wide Web best way to drive improvements in safety
as to what constitutes not only effective is through ensuring that the systems and
but also safe, high quality care. processes being used by organisations
In these circumstances, as societies make safety a priority. How can that be
change and people’s expectations rise, engendered? What will ensure a focus
health systems must adapt and evolve on safe systems and processes?
to meet these changing needs and new In any industry, regulation has a vital
challenges. role to play. Alongside an increased aware-
The publication of To Err is Human ness of the need to design health systems
in 2000 by the Institute of Medicine that are safe, there has been an increase
and An Organisation with a Memory in regulation as well. In the UK, the
www.asianhhm.com
Healthcare Management
Lean in
Primary Care
Sustaining transformation
P
Lean approaches have rimary care has altogether a differ- find out what patients value the most.
been widely adopted by ent quality improvement environ- This links to a policy in the UK to focus
hospitals, but application ment and a different organisational directly on improving patient experience.
and management structure compared to The methods used may involve paper
in the primary care setting a hospital care setting. It reflects a differ- questionnaires, real-time electronic
has received less attention. ent role, purpose and a different organi- data collection, various focus groups or
Primary care can use a sational culture. See Table 1 for charac- patient participation groups. A useful
Lean approach to structure teristics of primary care general practice development was the use of discovery
and sustain quality in England. interviews (a technique of in-depth
A hospital has many specialist teams interviews with patients to inspire qual-
improvement work but, as within the same organisation (and under ity improvement) and more recently
with all quality improvement the same management), each delivering the model of experience-based design
approaches, needs energy a limited range of patient pathways. In (Bate & Robert, 2006) where patients
and committed leadership. contrast, each primary care team is a small record episodes of emotional importance
independently managed hub that links by either using video, audio or written
John A Bibby
to a huge range of potential pathways media. These emotional ‘touch points’
Clinical Advisor and onward referral points. are then discussed in a facilitated meeting
Beverley Slater The quality improvement strategy, between the patient and care provider.
National Knowledge Management Lead managed and practiced in primary care This process has led to a greater under-
Improvement Foundation, UK on a day-to-day basis is necessarily differ- standing by clinicians of what is valuable
ent from the approaches that are taken to their patients.
in a hospital setting. These insights are then the basis for
In particular, a hospital that is imple- eliminating waste and confidently direct-
menting a quality improvement strategy ing resources towards what increases value
is in a position to provide dedicated to patients (see Table 2 for a summary of
improvement support and expertise. Some Lean principles applied to healthcare).
commentators (Westwood and Silvester,
2007) argue that this sort of support is Increasing patient value in
essential. But for small primary care teams, primary care
this is less likely to be available, and there Delays in the patient journey (at all stages
is greater emphasis on the quality of the from presentation, through diagnosis, to
leadership from within the primary care treatment and aftercare) are the most
practice itself. significant ‘non-value adding’ challenges
to any healthcare system, as they increase
What do patients really want? the risk of adverse outcomes and errors
Over the recent years there has been being associated with significant incon-
an increase in attempts being made to venience and cost. The following examples
www.asianhhm.com 11
Healthcare Management
2. Removing the backlog of appoint- Sustaining Lean in primary care clinician or a manager, anyone with a
ments by a one-off concerted increase The fifth Lean principle is to pursue passion for quality improvement. The
in capacity perfection, continuously, reducing waste leader’s task is to set the environment
3. Re-shaping demand by providing by developing and amending processes for learning, communicate the benefits
different types of consultation (using (Table 2). This then is the challenge: of continuous improvement, provide the
nurses, providing telephone or email how to make improvement a habit and right support and demonstrate how to
consultations) a continuous process? learn.
4. Matching capacity to the calculated Applying a set of Lean tools or using Hines and colleagues’ 2004 review
demand on a daily basis a one-off Kaizen Blitz (rapid improve- of Lean thinking shows how Lean has
5. Monitoring the system daily and having ment event) will not in itself deliver evolved from its narrow origins in 1950s
contingency plans in place for situ- car manufacturing to the extended
ations where capacity could fall (for application in service industries (such
example, doctors’ holidays) Model for Improvement as health) today. Real understanding of
Instead of postponing work to another the customer value stream was developed
day, the work will be completed on the What are we trying to accomplish? during the 1990s. With this understand-
same day. The calculated demand (both ing now driving business processes, rather
type and volume) from patients acts as a How will we know that a change than relying on a mechanistic application
trigger to ‘pull’ the correct capacity into is an improvement? of specific Lean tools, present day Lean
place. The result is that patients are seen draws on a range of tools from diverse
on the day they want to be seen, staff What change can we make that will management approaches.
result in an improvement?
are less stressed and there is less waste One such quality improvement tool
in the appointment system. that has great value in setting a learning
Example 4: Streamlining clinical commu- culture and sustaining improvement in
nication across boundaries Act Plan
primary care is the improvement model,
An example of managing the value with the ‘three questions’ followed by
stream Study
Plan-Do-Study-Act (PDSA) rapid change
Do
In the author’s practice, recent improve- cycles (Figure 1).
ments in the electronic patient record
have meant that if an opinion is required Conclusions
Source: Langley et. al. (1996) The Improvement
from a renal consultation at the local Lean in primary care is more likely about
Guide. San Francisco: Jossey Bass
hospital, then instead of taking several Figure 1 applying ‘Lean thinking’ flexibly rather
weeks, (sending a referral letter, then the than a programmatic step-by-step appli-
patient attending the hospital, and the sustainable continuous improvement. cation of Lean tools. The Lean approach
consultant sending a letter back to the For sustainable quality improvement in can be used by primary care to structure
GP) the system has been redesigned by primary care, there is a key requirement and sustain quality improvement work
removing many intermediate stages so for someone within the practice who is but, as with all quality improvement
that when a GP has a query about what able to lead, encourage and develop an approaches, needs energy and commit-
to do next, he sends an electronic message improvement culture. This may be a ted leadership.
to the consultant and gives the consultant
access rights for a few days to look at the
patient’s electronic record. The consult-
John A Bibby is the Senior Partner in a primary care practice in
ant reviews the problem with access to Shipley, West Yorkshire. He is also clinical lead for the Improvement
the complete patient record including all Foundation, a body that facilitates service redesign within the health
previous investigations and medications. and public services, throughout the UK, Australia and Canada.
A u t h o r s
www.asianhhm.com 13
I
t is terms like ‘The Golden Hour’ Globally prearranged emergency lance service available in the metros and
and the ‘Platinum Ten Minutes’ that services is expanding it to the rural areas.
typify the importance of Emergency Emergencies typically occur in cases like The prearranged emergency services
Medical Services (EMS) all over the road accidents, cardiac problems, convul- currently operate via an emergency services
world. It is a well-accepted fact that sions and so on. Trained technicians or contact system with dedicated telephone
a patient who receives basic care from paramedics provide first aid to the patient numbers.
trained professionals and is transported i.e. pre-hospital care and shift the patient
to the nearest healthcare facility within to an appropriate facility. EMS can be Medical
Country
15-20 minutes of an emergency has the provided in two forms—treatment to emergency no.
greatest chance of survival. EMS is an in-patients and pre-hospital services. UK 999
essential part of the overall healthcare Pre-hospital medical services include Ireland 999
system as it saves lives by providing care ambulatory services, transportation of Poland 999
immediately. It’s this recognition that the patients to or from places of treat- Hong Kong 999
has led to research and development in ment and acute medical care (also called
Malaysia 999
EMS. Over the years several advance- first aid). Ambulance services were largely
ments have been made and research unregulated prior to the 1970s. But over China 119
is underway to create services that the last 2-3 decades, a largely regulated Japan 119
provide medical assistance to patients system has emerged around the world. Republic of Korea 119
at the earliest. However, the state of Earlier, emergency services were being Singapore 995
EMS varies drastically from developed provided only with the means of road
UAE 998 or 999
to developing countries like India. In transport through hammocks and automo-
The most common 112
spite of the development in the health- bile. In 1972, a modern emergency medi-
European countries
care sector over the past decade, India cal helicopter transport—air ambulance
Australia 000
is yet to create a single, comprehensive was introduced in the US. Later, more
EMS that can be accessed throughout standards were formed to make services USA 911
the country. better. India also has a helicopter ambu- Canada 911
Emergency Services
in India
Counting on betterment
www.asianhhm.com 15
Healthcare Management
of EMRI. EMRI has also entered into has collaborated with the Confederation Meeting the demand?
PPP with Indian Emergency Number of Indian Industries (CII) and signed In spite of the work going on in the area
Authority, National Emergency Number an MoU to endorse the growth of the of EMS, the question still remains: is it
Association, American Association of healthcare sector in India, especially in meeting the requirements? The answer is
Physicians of Indian Origin (AAPI), rural areas. This agreement is to provide no. Though there has been a considerable
Shock Trauma Centre, Stanford knowledge and technology transfer and improvement in emergency services in
University USA, Singapore Health provide EMSs to develop healthcare India, but there is still a long way to go
Services, City of Austin in Texas, USA facilities in India. before a comprehensive EMS is imple-
and Government of Andhra Pradesh. Another such facility, Life Support mented across the country. “Available
EMRI also comprises a research Ambulance Service (LSAS) operating in emergency services are not sufficient to
institute, which does medical research, Mumbai for three years in association meet the demand as one ambulance is
systems research and operations research. with London Ambulance Service, UK, needed to cover a population of 50,000
Through this, EMRI provides research has now made inroads into Kerala and to 100,000,” says Mr Venkat Changavalli,
papers for prevention and management has 500 ambulances that can be reached CEO, EMRI. Still numerous deficiencies
of emergencies. EMRI’s other services on a toll free number 1298. exist in the emergency services across the
includes free medical advice on phone on Recently, the Gujarat state govern- country. “India should have far more
another toll free number 104 with access ment set up the Gujarat Emergency accessible and reliable emergency medi-
to more than 200 medical doctors and Medical Services Authority (GEMSA). cal services irrespective of geographical
several more paramedics. It has entered Institute of Kidney Diseases and Research factors,” says Dr Rao.
into a partnership with Stanford Hospital, Centre (IKDRC), U.N. Mehta Institute Another important component
the School of Medicine for training 150 of Cardiology and Research Centre, missing in the current system, and
paramedics and 30 paramedic instructors Gujarat Cancer Research Institute one that will be needed in the long-
over a two-year period in India. Though (GCRI), EMRI and Public Health run, is a body to regulate the EMS in
a positive, this is unlikely to meet the Institute, Gandhinagar have entered into the country. “LSAS in Mumbai claims
demand for paramedics in the country. several other PPP projects to improve the that it had saved 22,000 lives in three
“So far neither of these two services in emergency services in the state. years while EMRI in Hyderabad claims
Mumbai (AAPI) or Hyderabad (EMRI) But these examples are far and few saving 55,000 lives in one year,” says
have the kind of human resources and in a largely fragmented system. The lack Dr Rao, but there is no way to validate
massive training programmes needed”, of a common emergency number across these claims and introduce corrective
concurs Dr N Bhaskara Rao, Chairman, the country is a major hurdle in creating measures.
Centre for Media Studies, New Delhi. a reliable emergency service. The fact
In 2007, with the extension of that there isn’t clarity in the Ministry Awareness
Ambulance Access for All (AAA)’s serv- of Health about the importance of a Awareness of the available services and
ices, American Association of Physicians common EMS does not help either. Says preparedness are mandatory among the
of Indian Origin (AAPI) founded Dr Rao, “The Ministry does not have general public for the success of an EMS
Emergency Medical Service (EMS) for basic data on ambulances for emergency service. People also need to take initia-
Mumbai. AAPI medical services in the country. This is tive in knowing about the services being
despite the state-wise studies on provided by available EMS. Indeed, an
‘health infrastructure’ that EMS that people are not aware of is as
were conducted recently.” good as non-existent. One of the reasons
Clearly, there is an urgent for the success of EMRI is that 108 is
need to appraise the widely recognised and has a great recall
situation and imple- among citizens. “People’s participation
ment corrective is as important as blood donation and
measures that such cooperation is an important aspect
can help put in of emergency medical relief service,” says
place the Dr Rao. In 2006, American Academy for
required Emergency Medicine in India (AAEMI)
infra- made efforts to educate, impart knowl-
structure edge and expertise to emergency care
as soon as workers in Indian hospitals. It was aimed
possible. to increase the awareness and importance
of Emergency Medicine. But this and gency medical service legally compulsory
other similar programmes are restricted without ground level preparedness will
to a few regions. Thus arose a need for not be enough.” He adds that people
an awareness creation programme across need to be aware of their responsibilities
the nation that filled this gap. towards fellow citizens—insist on and
be aware of the best emergency service
Legislation for emergency services available.
The demand for legislation for EMS has
been rising steadily in India. Supporters Conclusion
of such legislation opine that it would The importance of a reliable EMS cannot
mandate a common access number, be overemphasised, especially in India
formation of an EMS council, trained where the government has the respon-
paramedics, gradation of ambulance and sibility of caring for a majority of the
hospitals, network of hospitals and define population. It can be argued that a nation
physical and human resources needed for of a billion people has been deprived of
the service. This could help save lives by a decent EMS for too long now and it is
making access easy for all the patients. high time the government takes defini-
Methods, technology, personal skills tive action. The success of a few services
need to be standardised with formation is evident enough of the need for EMS
of legislation in emergency services to and what it will take to ensure that it
provide protection for the providers. works as expected. In a healthcare system
Associations like Society of that is sprouting and experiencing the
Emergency Medicine-India (SEMI) benefits of involving private players, a
and American Association of Physicians public-private partnership framework
of Indian Origin (AAPI) have submit- could be the right way forward for policy-
ted proposals for EMS legislation to makers. At a time when the emphasis on
the Central Government and State preventing damage is greater than ever,
Government of Gujarat, Maharashtra and the provision of pre-hospital care will be
Andhra Pradesh. A word of caution comes the key to ensure that lives are not lost
from Dr Rao as he says “making emer- due to avoidable circumstances.
www.asianhhm.com 17
Healthcare Management
Personalised Healthcare
A transformational opportunity
I
Despite increasing ncreases in healthcare spending patients’ control over their own health
appear to be a global concern. For by their personal prescription for health,
healthcare costs,
example, the rising costs in Asia incorporating approaches for their unique
healthcare suffers from are being driven by many of the same risk of disease.
suboptimal quality and factors that have triggered the spiralling
inefficiency. Personalised of medical costs in developed countries. Scientific advances are leading the
Healthcare offers Factors include ageing societies with more way to Personalised Healthcare
chronic disease, rising technology costs; Rapid advances in platform technologies,
the transformational
high patient expectations of care; and such as Single Nucleotide Polymorphism
opportunity. This article more frequent coverage by third-party (SNP) analysis, the ‘-omics’ such as
discusses the science, payers such as insurers or employers. genomics, microRNA (miRNA) analysis
enabling technologies, However, the quality of healthcare does and systems biology and network analysis,
opportunities and not necessarily correlate with the total offer the potential for revolutionary change
spending. Take US as an example, total in the practice of medicine. Landmark
challenges of
healthcare costs in the US were US$ 2.2 projects, such as the Human Genome
moving Personalised trillion in 2007, representing 16 per cent Project completed in 2003, have laid the
Healthcare forward. of the Gross Domestic Product (GDP), an groundwork for researchers to identify
amount expected to reach US$ 4.2 trillion genetic causes and genetic contributions
LiHui Xu in 2016. Despite this vast spending, our to complex human diseases.
Program Director healthcare system suffers from suboptimal For example, genome-wide association
Henry Zheng quality and inefficiency, as evidenced by studies have uncovered new genes linked
Director the World Health Organization (WHO) with common diseases, including coro-
Operations
ranking healthcare in the US 37/191 nary heart disease, type 1 diabetes, type
Steven G Gabbe
Senior Vice President
countries in performance. Furthermore, 2 diabetes, rheumatoid arthritis, Crohn’s
Health Sciences studies show that prescription drugs are disease, bipolar disorder and hypertension.
Clay B Marsh effective in fewer than 60 per cent of Identification of disease-specific genes
Professor treated US patients. The current trend is could lead to clinical interventions to
Center for Personalised Healthcare unsustainable and ineffective, emphasis- improve outcome. In addition to genetic
The Ohio State University Medical ing the need for transformational change research, ‘-omics’ technologies, such as
Center, USA to create value-based, patient-centric transcriptomics, proteomics and metabo-
healthcare. lomics have grown rapidly. These powerful
Reversal of this trend will require tools allow researchers to link phenotype
Personalised Healthcare. It incorporates with dynamic protein production, gene-
individual genetic, behavioural and envi- protein and protein-protein interactions
ronmental information to define indi- to identify markers and molecular targets
vidual prescriptions for health mainte- in health and disease.
nance, disease prediction, prevention, and Beyond gene and protein activation
tailored therapy. In addition, it considers as disease triggers, underlying regulatory
individual environments, health-related genetic events have drawn significant
behaviours, cultures and values. This attention. For instance, miRNAs, small
approach is revolutionary and will funda- non-coding RNAs of 21-23 nucleotides
mentally transition medical practice from that bind complementary sequences in
illness to wellness. Equally important is target genes and cause mRNA degradation
or inhibition of target protein production, Mainstream research focusses on iden- outcomes to create novel approaches to
are involved in the regulation of gene tifying individual gene(s), molecule(s), promote health and prevent disease. These
expression in cell proliferation, differ- or pathway(s) that lead to disease. The tools support clinical decision-making
entiation, and apoptosis. miRNAs are rise of systems biology tools facilitates by clinicians and healthcare providers,
implicated in tumorigenesis through regu- dissecting the organisation, regulation thus delivering the best individualised
lating the expression of tumour suppressor and structure of complex systems, such care for each patient. Equally important
genes and oncogenes. miRNA expression as dynamic gene and protein networks is that Personalised Healthcare promises
is abnormal in chronic lymphocytic leuke- that underlie human health and disease. to place information technology in the
mia, solid organ tumours like lung cancer, This approach has great potential in bring- hands of consumers / patients empower-
and non-tumour diseased tissues. A recent ing predictive and preventive medicine ing them to take control of their health
study suggests miRNAs mediate cancer to reality. and managing wellness.
chemoresistance or sensitivity. These tools Information technology and biomedi-
may revolutionise disease classification, cal informatics are key enablers of Personalised Healthcare is already
diagnosis, monitoring, prognosis, and Personalised Healthcare. Electronic and happening, but at a slow pace
potential treatments to drive personal- personal health records make complete The rise of personalised medicine is the
ised care. Similarly, miRNAs also regulate and current patient information avail- result of unprecedented advances in
epigenetic regulation of gene transcrip- able when and where it is needed. biomedical research and technologies,
tion, another actively explored regulatory Electronic patient phenotyping provides such as DNA sequencing and ultra-high
process in the genetic underpinnings of the opportunity to interface genetic and throughput screening. Technological
complex human disease. ‘–omic’ information with patient-specific breakthroughs have dropped the price
The US Department of Health and Human Services (HHS) plays individualised cancer therapy, advanced lung disease and sepsis,
a leading role in advancing Personalised Healthcare. In particular, cardiovascular diseases, women’s health, pharmacogenomics
the HHS has issued two reports with the first one released in and diabetes mellitus. The data generated by these research
October 2007 and the second in November 2008, demonstrating a programmes will then be incorporated into the electronic medical
strong focus and commitment to delivering the best care possible record to support clinical decisions.
to each patient. Michael Leavitt, Secretary of HHS, stated that Personalised Healthcare or Personalised Medicine has become
Personalised Healthcare is not a niche concern. Its promise is a global initiative. Other countries, such as the UK and Canada,
central to the future of healthcare. Under the HHS leadership, have also embarked on this exciting initiative. Furthermore,
National Institutes of Health and the Food and Drug Administration countries in Asia, such as China and Japan, have played a critical
have both embarked on the journey to Personalised Healthcare. role in the international HapMap project. The goal of the project is
The NIH roadmap and FDA critical path are all part of the efforts to develop a haplotype map of the human genome, the HapMap,
for this initiative. and provide researchers around world with free access to the data
Inspired by the vision, both academia and industry are to find genes affecting health, disease, and responses to drugs
advancing Personalised Healthcare research, education and and environmental factors. Combined phase I and phase II projects
clinical practice. Among many of the academic centres, The Ohio have identified over 3 million SNPs in 269 individuals, including
State University is committed to developing and creating the future Han Chinese, Japanese, Nigerian, and European. The data will
of medicine by improving people’s lives through Personalised provide important information to guide genome wide association
Healthcare. Our commitment is to help people maintain healthier, studies and to identify genetic variations in different ethnic groups.
happier, and productive lives. To do so, we are implementing Finally, as part of the 1000 Genomes initiative, Asian countries,
an innovative programme to promote the active participation of such as China, are playing an increasing role in funding genomic
individuals in their own ‘personalised’ health maintenance and research and technologies. Given the low cost of labour and their
to use genetic tests and health markers to predict and prevent intellectual prowess, China and India are on the rise to develop
disease. In addition, Ohio State is developing a general patient research powerhouses. However, science and technology have
informed consent to prospectively collect patient’s biologic always outpaced public policy, regulation and clinical medicine.
specimens and DNA samples for medical research. This biobank Integrating genetics / genomics into clinical practice will be at
will be linked with the patient clinical database to make it highly slower pace than we wish, especially in the developing countries,
useful for translational research, such as human cancer genetics, given the disparity of their healthcare system.
www.asianhhm.com 19
Healthcare Management
from US$ 3 billion to sequence the entire Despite decades of experience and genetics, genetic testing and genetic
human genome to US$ 60,000. Several careful monitoring, the adverse events counselling in the medical community
countries and commercial entities are of warfarin are still among the highest and the public. Therefore, it is critical to
investing in technology to reduce the of all commonly prescribed drugs. The develop Personalised Healthcare-related
cost of sequencing a person’s complete challenge of administering warfarin is due educational programmes through contin-
genome to US$ 1,000. Price reduction in to the wide (20-fold) inter-individual vari- ued medical education and integrate this
this technology will enable each person to ation in dose requirements, the narrow curriculum into medical education for
obtain a blueprint of their genetic code therapeutic range, and the risk of serious medical students, residents and physi-
in the near future. bleeding from overtreatment, or risk of cians.
Moving towards the goal of indi- repeat thrombosis from under-treatment. Personalised Healthcare promises to be
vidualised predictive, preventive and Studies show that age, gender, sex, race, a predictive, preventive and participatory,
personalised care, researchers have devel- body mass index, smoking, diet, and drug and personalised—‘P4’—medicine. To
oped genetic tests that can be utilised to interactions, have a significant impact on be truly participatory and personalised,
diagnose, predict and identify carriers of warfarin sensitivity. Variability in warfarin seamless and logical information technol-
genetic disease and also determine the response can result from polymorphisms ogy interfaces and tools are essential. The
risk of adverse medication reaction. Over in vitamin K epoxide reductase subunit development and application of these tools
1,000 genetic tests are currently available 1 (VKORC1), the pharmacologic target and education targeted to Personalised
and more are being developed. A current of warfarin. In addition, patients with Healthcare is lacking.
example is testing for BRCA1/2 mutations genetic variants of CYP2C9, involved The power of Personalised Healthcare
in women with a family history of breast in improving people’s health and saving
cancer or ovarian cancer. If a women tests cost rests on transforming medicine
positive for BRCA1/2 mutations, she has to disease prediction, prevention, and
The rise of Personalised
an estimated lifetime risk of 36-85 per wellness. This will require re-engineer-
cent for developing breast cancer, a 16-60 medicine is the result of ing current healthcare reimbursements
per cent for ovarian cancer, and should be unprecedented advances and delivery to bring healthcare to each
closely monitored for these diseases. in biomedical research home and community on demand. It is
In addition, companies such as and technologies, such not just the right medicine at the right
23andMe, Navigenics, and deCODE time, but more importantly, a health
as DNA sequencing and
Me, continue to develop tools for genetic and wellness intervention strategy that
analysis marketed directly to consum- ultra-high throughput prevents the onset of diseases. This strategy
ers and physicians. These tests allow screening. will not work without key public-private
consumers to evaluate their genetic risk partnerships to create the tools to start a
of disease and genes defining personal social epidemic of change in healthcare
traits. Consumers can take control of in warfarin metabolism, require lower delivery.
their own health by understanding their doses of warfarin because of reduced
predisposition to disease and modify their drug clearance. By applying genotype Issues and challenges
lifestyle accordingly, providing potential biomarkers at the beginning of warfarin Although Personalised Healthcare offers
long-term benefit. treatment, one can shorten the time to a transformational opportunity to change
Pharmacogenomics / genetics is a reach the proper warfarin dosage, thereby the current healthcare system, many issues
promising area for Personalised reducing adverse drug reactions (ADRs). or challenges must be addressed before
Healthcare, translating scientific discovery Based on these findings, the US Food it can become a reality, including lack of
into clinical application. Pharmacogenetic and Drug Administration changed the public policy, regulation, reimbursement,
testing presupposes the availability of labelling information for warfarin to education, standardisation of healthcare
validated genetic tests, with data link- recommend genetic testing of CYP2C9 information technology such as elec-
ing the presence or absence of specific and / or VKORC1 genes. tronic medical records, clinical valida-
variants with a specific outcome, such tion, adequate funding for research, and
as improved therapeutic response or Increasing the awareness privacy concerns.
reduction in adverse events. A topical As research in Personalised Healthcare Each of these challenges must be
example is the genotyping of CYP2C9 advances, educating healthcare provid- dealt with by all of the stakeholders,
and VKORC1 in guiding the titration ers and consumers is the key to improve including physicians, scientists, health-
of the anti-coagulant warfarin towards healthcare delivery. There is a lack of care organisations such as hospitals and
the optimal maintenance dose. knowledge and utilisation of clinical health networks, private insurers, public
Summary
Henry Zheng is the director of operations at The Ohio State University
Personalised Healthcare holds the promise Center for Personalized Healthcare. Zheng has served in numerous
of transforming the current healthcare leadership positions since joining OSU in 1997, as senior planning
delivery into a value-based and patient- manager, business performance officer, director of Technology and
A u t h o r s
Commercialization Partnerships and director of Data Analysis and
centric healthcare. While advances in Information Services.
science and technology continues at a
dramatic pace, other areas such as public Steven Gabbe recently joined the Ohio State University as senior
policy, regulation, reimbursement, educa- vice president for Health Sciences and Chief Executive Officer of the
tion and clinical validation will continue OSU Medical Center. Prior to that, Gabbe was Dean of the Vanderbilt
University School of Medicine. From 1987-1996, he was professor
at a measured pace. This will require all and chair of Obstetrics and Gynecology at OSU.
stakeholders in the healthcare arena to
work together in years to come to over-
come these hurdles and challenges before Clay Marsh came to The Ohio State University in 1985. He is cur-
rently professor and vice chair for research of Internal Medicine,
Personalised Healthcare can become a director of the Center for Critical Care, and director of Pulmonary,
reality. Allergy, Critical Care and Sleep Medicine.
www.asianhhm.com 21
Medical sciences
Importance
of Traditional
Medicine
In the age of technology
Beverly A Jensen
Associate Professor
Communications
UAE University, UAE
T
he purchase and installation of of homeopathic or herbal remedies.
new technology in any environ- Between the two world wars, great strides
ment generates excitement— Healthcare in Asia were made in surgical techniques.
whether it’s in the office, school, hospital will be most successful if Advances in surgery and the develop-
or home. Owning the latest technology the traditions of Ayurveda, ment of pharmaceutical drugs combined
is exciting. Chinese medicine, and to sweep mainstream medicine towards a
There is a certain seduction in owning more technological approach to health-
the ‘latest and greatest’ technology. And
other tried-and-tested care. By the end of the 20th century the
for decades, the sales departments of indigenous medical consequences have grown dire.
manufacturers have played the ‘status’ treatments remain at the
card in their persuasive sales pitches. In forefront in medical care. Deadly reliance on pharmaceuticals
the education field, school storerooms Americans, who are only 4 per cent of
around the globe are filled with equip- the world’s population, consume about
ment that no one on site was trained to 50 per cent of the world’s pharmaceutical
use properly, and no one was trained to The development of national drugs. A study of US hospital emergency
maintain or repair. Health Information Technology (HIT) room visits published in 2006 showed
Over the last 50 years a revolution programmes, on the other hand, could that 700,000 ER visits annually are due
has occurred in healthcare with pacemak- help to reduce healthcare costs and to interactions or contraindications of
ers, artificial joints, organ transplants, improve safety in delivery to patients. pharmaceuticals. Since most ER admis-
and now, a whole new horizon is open- Others nations’ experiences in develop- sions are undiagnosed or misdiagnosed,
ing with stem cell research. However, ing national HIT provide immediate the authors of the article in JAMA (18
just as in education, many developing and salient lessons for organisations and October, 2006) suspect this number is
countries find themselves flooded with nations just beginning the process. an underestimation.
sophisticated medical equipment they Still, the implementation of any tech- Add to the 700,000 visits to ERs,
can neither fully utilise nor maintain. nology carries the risk of diminished 100,000 deaths annually from phar-
The technology salesmen have sold attention to the patient’s well-being. The maceuticals. So, every year nearly one
medical equipment even to the nations evolution of medical care in the US over million Americans are killed or seriously
in which the local health issues do not the past 60 to 70 years is a demonstration injured due to use of pharmaceuticals,
warrant such expenditure, As a result, of myopia brought on by focussing on but you won’t read this in the mainstream
technology sales usurp the resources that the wonders of technology. American media. The public’s health has
are available for basic healthcare. This Until the mid-1930s the American become secondary to business interests:
misallocation of resources happens not Medical Association coexisted fairly well pharmaceutical advertising is a major
only in the US but also in every other with naturopaths and other health prac- revenue source for broadcasters and
nation. titioners. Many MDs incorporated forms print media since 1998, and American
of natural healing into their practices, media are almost entirely owned by
such as herbs, baths, breathing and exer- conglomerates.
cise programmes. As the chemist labs
cranked up in the 1930s, MDs began The loss of other medical models
prescribing pharmaceutical drugs instead With American medical education heav-
ily supported by the pharmaceutical
companies and medical students learning
no other forms of treatment but ‘pills
and scalpels’ common sense, non-tech
treatments and traditional treatments
for health are being forgotten.
www.asianhhm.com 23
Medical sciences
ment. Over 80 per cent of Americans She has worked as a communications strategist and program
manager in development projects in Africa, the Middle East and
told the Commonwealth Fund in 2008 Eastern Europe since 1993. Currently she teaches strategic
that the US healthcare system needs a communication and health promotion in the UAE.
major overhaul, and two-thirds of the
population has problems in paying
Contrast
Echocardiography
Current indications
F
Contrast agents have been or almost 40 years, Cardiac ultra- is currently not available. All these agents
shown to be useful to sound has been demonstrated to provide intensive opacification of the
be a promising diagnostic tool to left heart chambers when administered
improve the image quality
evaluate patients with pericardial, valvular intravenously. Although infusions are
in echocardiography. heart disease and patients with ischemic preferred for assessment of myocardial
The development of new heart disease. However, inadequate endo- perfusion, bolus injections of agents
ultrasound contrast agents cardial visualisation occurs in up to 20 may be satisfactory for left ventricular
and imaging techniques per cent of cases during echocardiogra- opacification in many cases. All agents
phy and it fails to produce diagnostically are suspensions of microsheres filled with
has enabled the bedside
useful images. Contrast agents have been a perfluorocarbon gas and have a similar
assessment of myocardial shown to be useful to improve the image size as red blood cells. The dosages of
function and perfusion. quality (endocardial definition) in 2D contrast needed for LV opacification are
and 3D echocardiography. This problem minimal (0.1-0.3 ml) compared to those
Robert Olszewski is even greater in patients referred for in other imaging modalities, such as X-
Consultant Cardiologist stress echocardiography when subjective ray for instance. These small dosages are
Military Medical Instytut Warsaw, Poland assessment of regional wall motion is possible because of very sensitive contrast
Harald Becher dependent on the quality of the images specific imaging technologies, which have
Professor
Cardiac Ultrasound recorded. In stress echocardiography opti- been implemented in all state-of-the-art
Oxford University, UK mal endocardial border delineation is ultrasound systems.
needed in all segments. Images are worse
during stress because of cardiac move- Assessment of myocardial
ment and also hyperventilation. Although opacification – An integral part of
image quality has been improved with contrast echocardiography
the introduction of harmonic imaging, Ultrasound contrast agents have been
the quality of many studies still remains licensed for improvement of endocardial
inadequate. To improve the quality of border definition by left ventricular opaci-
images, millions of contrast agent appli- fication. But left ventricular opacification
cations have already been given to the is inevitably associated with myocardial
patients since 90s. opacification—in particular when the
newer contrast specific imaging modali-
Available contrast agents in ties are used. Assessment of myocardial
echocardiography opacification provides very important
At present, three contrast agents information on top of the evaluation
are licensed for left ventricular (LV) of the wall motion. Questionable find-
opacification and endocardial defini- ings of wall motion can be clarified by
tion: SonoVue (Bracco Diagnostics assessing left ventricular opacification
Inc, US), Luminity (Lantheus Medical and vice versa.
Imaging; trade name Definity in US) and Homogeneous myocardial and quick
Optison (GE Healthcare, US). The latter opacification of the myocardial vessels
www.asianhhm.com 25
Medical sciences
after LV ventricular opacification indicate way patient is managed. These consid- Only four fatal events with Definity
normal myocardial perfusion and provide erations are reflected in the most recent occurred within 30 minutes after the
further confirmation of a normal wall published guidelines of European Society application of contrast in a total of 2
motion study. This is particularly help- of Cardiology (ESC), British Society million vials used.
ful in stress echocardiography. Reduced of Echocardiography (BSE) and the But even if we assume that all four
opacification in the subendocardial layers American Society of Echocardiography cases are related to the ultrasound
usually indicates reduced perfusion and (ASE) for the clinical application of stress contrast agent, the fatal event rate would
is often easier and earlier to appreciate echocardiography. Therefore, the use of be only one in 500,000 for Definity
than a new wall motion abnormality. For contrast agents is highest in stress echo and zero for Optison. This rate is far
rest echocardiography, the assessment departments—at the John Radcliffe less than the fatal event rate in exercise
of myocardial opacification is also very hospital about 60 per cent of all stress and Dobutamine stress echocardiogra-
helpful. In an akinetic segment, lack of echocardiograms are performed with phy. Meanwhile, several studies were
myocardial opacification indicates viabil- contrast. conducted on more than 20,000 patients
ity. Thrombi can be distinguished from In the rest, contrast echocardiogra- demonstrating the safety of ultrasound
tumours due its lack of opacification. phy is useful when minor changes of LV contrast agents during stress echocar-
volumes and ejection fraction change diography and myocardial perfusion
Contrast application is only useful, management. Many studies have demon- imaging using the flash-replenishment
if it alters patient management strated that contrast-enhanced assessment technique.
The threshold for ultrasound examina- of LV volumes and LV ejection fraction
tions is usually very low and the results compares favourably with the accepted
of the examinations do not always affect gold standard of cardiac magnetic reso-
the patient management. Considering the nance imaging. Monitoring of LV func-
extra time, additional costs and small risk tion during treatment with cardiotoxic
of intolerance, contrast echocardiogra- drugs like Herceptin is a good example
phy needs a more disciplined approach. for the need of accurate assessment of LV
There are a lot of patients, in whom function. In patients with poor acoustic
echocardiographic images are not opti- windows, the reproducibility of contrast-
mal due to factors such as obesity, lung enhanced studies is comparable to MRI
disease, recent thoracic surgery or posi- recordings.
tive-pressure ventilation. Nevertheless,
echocardiography still gives the correct Safety of contrast
answers to the clinical questions. echocardiography
According to the guidelines of the For ultrasound, side effects have been
American Society of Echocardiography, reported in contrast agents, but they
there is an indication for contrast are usually mild. However, rare allergic,
echocardiography when the endocar- potentially life-threatening reactions may
dial border definition in two or more occur and the investigators have to be Available
segments is poor. In some patients prepared for such an event. imaging techniques
poor visualisation of two myocardial In April 2008, the US Food and Drug Harmonic imaging has been developed
segments may change management, Administration (FDA) performed a safety primarily as a contrast specific imaging
in others Stress examinations present review of the US approved perflutren modality that can be used with a transmit
altogether different situation. For this microsphere contrast agents (Definity power (mechanical index <0.6) lower
kind of examination, image quality is and Optison) and revised a previous black than that used for non-contrast imaging
crucial; suboptimal images of the LV box warning. The new contraindications (mechanical index >1.0). Harmonic imag-
cannot be accepted. are much less restrictive than the previous ing has become the standard imaging tech-
nique for native echocardiography. For clini-
The complexity of protocol and the contraindications and satisfy the needs
cal contrast echocardiographic studies, the
risks of ischaemia can only be justified of clinical echocardiography. contrast specific imaging modalities should
if the test is diagnostic. Therefore, high The FDA revised the benefit / risk be used (see next paragraph). Harmonic
image quality is vital. In these patients, assessment for patients with unstable imaging may be used only if they are not
contrast administration is of great impor- conditions and acknowledged that some available. In order to use it for contrast
tance in delineating the endocardial of the fatal events may be coincidental studies one has to reduce the transmit
border in all segments, thus changing the and not related to the contrast media. power. However, the transmit power is
Data collected during Post-Marketing compare the risks of the procedure—here ography is requested in the case of a false
Surveillance referred to more than contrast echocardiography—with the positive stress echocardiogram. This will
200,000 of SonoVue vials used, indi- risks of an incorrect diagnosis when not expose the patient to significant radiation
cate that serious adverse events (SAE) using the contrast agent. If, for instance, and there is a procedural risk, which
are rare (0.01 per cent). The signs and a new wall motion abnormality is not certainly exceeds the risk of an adverse
symptoms of most of these SAEs indi- detected in stress echocardiogram because event when using an ultrasound contrast
cate an underlying allergy-like mecha- the wall is not adequately imaged, the agent.
nism and they were considered by the diagnosis may be inaccurate and subse- Therefore, it is very important to
European Medicines Agency (EMEA) in quent management of the patient may take a decision whether to continue in a
the context of idiosyncratic, hypersen- be wrong. Although it appears to be very study, which has suboptimal images or do
sitivity reactions. This kind of reactions convincing that patients with a missed other kind of choice considering all the
(allergy-like) is well known from wide diagnosis of coronary artery disease have possibilities in the context of ensuring to
reports in literature to occur with other an unfavourable outcome, there is only the patient the most adequate medical
medical imaging agents such as X ray limited data to quantify the extent to treatment. Even when the risk of serious
or MRI contrast media. which this might happen. adverse events is very low, there should
It appears to be easier to assess the be a clear benefit from the application
Risk / benefit considerations risk / benefit when we consider false of the contrast agent to justify its use. In
Assessment of risk / benefit means to positive studies. Usually coronary angi- patients undergoing stress echocardiogra-
phy, the benefit of using a contrast agent
certainly overweighs the small risks—in
particular when the current contraindi-
cations are not ignored.
Improved endocardial delineation
following SonoVue infusion:
Contrast echo closes the gap between
4, 2 chamber (top left and right), native echo and cardiac MRI in patients
short axis view and multiple with poor acoustic windows.
plane view bottom right and 3D
reconstruction left, obtained from Comparison with other imaging
a native real-time contrast 3D technologies
dataset. The stress recordings There are three aspects, when different
show perfusion defects (arrows). imaging technologies are compared: the
Notice the excellent delineation of
accuracy, the risk / benefit and the costs
the endocardial borders.
/ effectiveness (Table 1). Cardiac MRI,
Figure 1 CT and nuclear methods are known to
be considerably more expensive than
contrast echocardiography. Several
still relatively high and can cause destruc- volume within the myocardial vessels multicentre, and numerous single centre
tion of the contrast in the near field of the makes up only 7 per cent of the myocardial trials as well as series of case reports have
transducer as well as tissue signals of the tissue. Therefore, the myocardial opacifi- demonstrated the accuracy of contrast
myocardium, which impair the delineation cation is always much less intensive than echocardiography for assessment of LV
of the endocardium. the cavity opacification and provides an volumes and ejection fraction (overview
Latest developments, such as Power excellent contrast for endocardial delinea- in 6) . The reproducibility of contrast
Modulation and Power Pulse Inversion, tion (Figure 1). The myocardial contrast is enhanced echocardiography is as good
which use very low non-destructive trans- also very useful for assessing thickening of
as that of MRI. For assessment of global
mit power techniques (mechanical index the myocardium and myocardial perfusion.
Whenever available, low power contrast and regional LV function, controlled
<0.2), allow for real-time imaging without large trials are conducted on a large
the limitations of harmonic imaging. As specific imaging techniques should be the
first choice. These contrast specific imag- number of patients. The accuracy of
tissue returns are not displayed, unlike with
high powered techniques, they are ideal ing modalities are available in all state-of- stress echocardiography is not worse
for accurately delineating the left ventricu- the-art ultrasound machines. compared to myocardial scintigraphy.
lar borders. Low power-contrast specific The settings of the ultrasound scanners and Multi-slice CT is a new technology and
techniques display the contrast within the the contrast dosages are well standardised a better option to display the coronary
cavities and the myocardial blood within and make contrast echocardiography an arteries compared to myocardial ischemia.
the intra-myocardial vessels. The blood easy to use technique. There is an ongoing debate whether
www.asianhhm.com 27
Medical sciences
Heart Valve
Surgeries
Innovations and
new developments
Operation through a smaller incision makes
valve surgery easier on the patient. Because
of improved durability, more tissue valves are
implanted compared to mechanical valves. The
latest development is percutaneous replacement
of aortic valves and repair of mitral valves.
Timothy J Gardner
Medical Director
Christiana Care’s Center for Heart & Vascular Health, USA
S
urgery directed at valvular heart pump with a blood oxygenator became prostheses, both mechanical and those
conditions dates back almost 80 available that heart valve surgery became fashioned from biological material and
years when the first efforts were widely practised. In the early 1960s, ‘open usually derived from pig or cow heart
made to relieve mitral valve stenosis. heart’ surgery became feasible and rela- tissue, have undergone multiple itera-
Rheumatic fever was a common disease tively safe with the development of cardi- tions over the 50 years of heart valve
worldwide and frequently resulted in opulmonary bypass. Surgeons continued replacement. Currently available heart
mitral stenosis. The scarred two-leaflet to treat the still common condition of valve prostheses represent excellent refine-
mitral valve appeared to be an easy target mitral stenosis, including many who ments of earlier devices, but there have
for simple division of the fused valve leaf- persisted in using ‘closed heart’ approaches been few major innovations in design or
lets along the closure plane of the valve. to performing mitral commissurotomy. manufacture of heart valve prostheses over
A few daring attempts by brave surgical The major attention in the early days of the past 20 years. Current innovations
pioneers to open the obstructed valve open heart surgery, however, was directed in heart valve surgery have been directed
while the heart was beating and pump- to the aortic valve which required that more toward refinements to the operative
ing blood throughout the body almost the patient be on full cardiopulmonary approaches and technical aspects of valve
always ended in failure and the death of bypass support in order to work in a surgery itself.
the patient. But occasional by such mitral bloodless field.
commissurotomy was successful and, as Repair, don’t replace,
predicted, when the obstruction to blood The development of heart valve a leaking mitral valve
flow through the valve was relieved, heart prostheses Today’s heart valve surgical innovators
function improved considerably. The other requirement for successful are a relatively small group of heart
treatment of a diseased or deformed surgeons, representing, perhaps, fewer
Arrival of the heart-lung machine aortic valve was a valve substitute, or than 20 per cent of practising cardiac
Despite those rare attempts at direct valve prosthesis, that could be used to replace surgeons. Although heart valve surgery
repair, it was not until the heart-lung the diseased native valve. Heart valve and surgery for the treatment of congenital
heart defects were the most commonly surgeon who is capable of and willing surgery wound inflammation and greater
performed procedures during the first two to repair the incompetent mitral valve blood loss. Patients with these extensive
decades of open heart surgery, coronary whenever anatomically feasible. surgical incisions experience slow recov-
artery bypass surgery has dominated the ery and long convalescence. While many
field since the late 1970s. Most currently Minimally invasive or limited surgeons have eschewed the challenge of
practising heart surgeons are expert coro- incision heart operations minimally invasive approaches, complain-
nary bypass surgeons, but their experience The other important innovation in heart ing that smaller incisions restrict their
with heart valve surgery may be quite valve surgery over the past decade has been procedural options and add unnecessary
limited. This is an especially important the successful development of alternate, risk for the patient, operations performed
consideration today since the most and often less invasive, surgical incisions through smaller incisions generally result
important ‘innovation’ in heart valve for valve repair or replacement surgery. in less discomfort, less blood loss and
surgery over the past two decades has The standard and most common incisional corresponding reduction in the need for
been the successful evolution of mitral approach used by heart surgeons over transfusion, more rapid recovery and few
valve repair surgery for the treatment of many years is the median sternotomy wound complications.
mitral valve insufficiency. In the Western incision. This operative approach entails a
world, with the dramatic decline in midline incision from the base of the neck The hemi-sternotomy incision
rheumatic fever, mitral stenosis is much to the upper abdominal wall, exposing The partial sternotomy approach, some-
less common. At the same time, mitral the sternum which is then completely times referred to as a hemi-sternotomy
insufficiency, due either to structural divided using a bone saw. For most incision, represents an important inno-
deterioration of the valve or secondary cardiac surgical procedures performed vation for heart valve surgery. The most
to changes in left ventricular geometry on cardiopulmonary bypass, full expo- common application of a hemi-ster-
from chronic ischemic heart disease, has sure of the heart and great vessels within notomy incision in heart valve surgery
become a common indication for heart the pericardium and adjacent mediasti- has been the upper partial sternotomy
valve surgery. num facilitates the necessary operative approach for aortic valve repair or replace-
Structural repair of the leaking manoeuvres, provides the surgeon with ment. The sternum is divided from the
mitral valve whenever possible, rather full exposure of the heart to deal with suprasternal notch and may be carried
than replacement of the valve with an any unexpected problems, and is in fact laterally for a short distance into the 3rd
artificial prosthesis, has been shown to be necessary to allow for full exposure of or 4th intercostal space. For an aortic valve
decidedly better in virtually all important the posterior or inferior aspects of the procedure, this ‘J’ incision, as it is often
respects, with fewer perioperative deaths heart. Some negative physiological conse- referred to, may be directed medially to
and better late outcomes. Some estimate quences of a full sternotomy incision, the left or laterally to the right, depending
that as many as 80 per cent of leaking especially when combined with entry upon the patient’s unique anatomy. If the
mitral valves are amenable to successful into one or both pleural spaces, include mitral valve is the target of procedure,
repair. Despite compelling outcomes, respiratory insufficiency, increased post- the partial upper sternotomy is generally
and data favouring repair rather than carried laterally into the 3rd intercostal
replacement, fewer than 50 per cent of space. Less commonly used is the lower
Technical innovations in
patients with mitral valve insufficiency partial sternotomy incision that some
undergo valve repair, but have mitral valve handling diseased valves surgeons have employed for mitral valve
replacement instead. This disappointing procedures. The primary disadvantage
statistic has resulted from the fact that Preferential repair of a leaking mitral of the lower partial sternotomy is poor
valve instead of replacement with a
many cardiac surgeons have not mastered exposure of and access to the ascending
prosthesis
the technical challenges of valve repair. aorta for cannulation and cross clamp-
Valve-sparing replacement of a dilated
The clear advantage of mitral repair over or dissecting aneurysm of the ascending
ing. If the lower sternotomy approach is
replacement with either a mechanical or aorta instead of replacement used for a mitral valve procedure, arte-
biological prosthesis has been established Routine repair of a leaking tricuspid rial access for cardiopulmonary bypass
by multiple surgical series, making repair valve rather than valve replacement with is usually obtained via the femoral artery
rather than replacement mandatory when- a prosthesis and the aorta is not cross-clamped. An
ever feasible. Since many practising cardiac Repair of selected leaking tricuspid additional disadvantage of any hemi-ster-
surgeons are not comfortable attempting and bicuspid aortic valves instead of notomy incision that is carried medially
replacement with a prosthesis
mitral valve repair, the referring physi- or laterally into an intercostal space is the
cian should select for referral of a patient Direct-vision commissurotomy of need to sacrifice the internal mammary
stenotic mitral valves
with mitral valve insufficiency only to a artery on that side.
www.asianhhm.com 31
Surgical speciality
Mitral valve surgery through a right may not be accessible for cannulation or
chest wall incision even cross-clamping from right chest inci- Trends and improvements in
Although some have used a partial lower sion. Despite the procedural challenges, heart valve prostheses
sternotomy incision to expose the mitral the right thoracotomy approach through a
• Improved durability of bioprostheses
valve for repair or replacement, the more small incision has been mastered by many (tissue valve substitutes), resulting
commonly used ‘less invasive’ incisional skilled cardiac surgeons and has been from improvements in harvest,
approach for a mitral valve procedure is a shown to be well tolerated by patients preservation and production
right lateral thoracotomy incision via the as well as hastening postoperative conva- techniques
4th intercostal space. Chest wall muscle lescence and full recovery. • With improved durability of
sparing and careful rib spreading will Another incisional approach that has bioprostheses, the proportion
minimise chest wall trauma and gener- been used by some is the right paraster- of mechanical valve prostheses
ally will provide for excellent exposure nal incision, made over the 2nd to 4th implanted is declining compared to
of the left atrium and mitral valve along intercostal spaces. It is necessary to incise use of bioprostheses
with adequate exposure of the ascending the corresponding costal cartilage tissue • Availability of multiple mitral valve
aorta. Depending on individual anatomic that often resulted in a chest wall defect annuloplasty rings for varied
variations, however, the ascending aorta and lung herniation. For this reason, anatomical conditions for use in
mitral valve repair
the right parasternal approach has been
largely abandoned. While the upper • Recent availability of self-monitoring
partial sternotomy can be reliably used devices for prothrombin time
Innovative operative approaches calculation greatly facilitates daily
in heart valve surgery for exposure of the aortic or mitral valves,
warfarin dosing for patients with
this incision is not suitable if the patient mechanical heart valve prostheses.
• Greater use of smaller incisions to
expose the valve (“limited incision”
requires concomitant coronary artery
or “minimally invasive” heart valve bypass grafting.
surgery) As is the case with mitral valve repair also take into consideration the capability
• Upper or lower “hemi-sternotomy” versus the technically easier mitral valve of the surgical team, especially when the
approaches for isolated aortic or replacement option, undertaking an aortic procedure involves additional technical
mitral valve procedures instead the or mitral valve procedure through a smaller challenges related to valve-sparing repairs
traditional full median sternotomy surgical incision is generally more tech- and smaller incisions.
incision nically challenging and may, in fact, be
• Right lateral thoracotomy approach to riskier. When working on the aortic valve Heart valve repair and replacement
the mitral valve through a partial upper sternotomy, deair- performed without surgery
• Increasing use of peripheral ing of the left heart chambers may be more The most important current innova-
cannulation (femoral or iliac artery, difficult, and accessing a tear or disruption tion in heart valve surgery has been the
internal jugular and/or femoral vein) on the posterior or lateral aspects of the development of transcatheter techniques
for cardiopulmonary support when aorta or adjacent pulmonary artery may for repair or replacement of heart valves.
using a very small chest incision to be very difficult. Conversion to a full Just as has been the case with percutane-
expose the targeted area of the heart
sternotomy incision under such circum- ous transcatheter treatment of coronary
• Use of full Port Access approach stances may be necessary. The dilemma artery disease, catheter delivery of valve
for mitral valve repair via a 10cm or that the surgeon faces when pondering a prostheses for valve replacement is now
smaller right thoracotomy incision,
smaller incision is whether to perform a a reality. In addition, percutaneous cath-
including femoral or iliac artery
cannulation and internal jugular procedure that will be easier on the patient eter techniques have been developed to
and/or femoral vein cannulation to but technically more challenging for the reduce mitral valve insufficiency. To treat
establish cardiopulmonary bypass surgeon. The other important considera- aortic valve stenosis, two transcatheter
support, use of a percutaneous tion is whether any added risk related to devices have been implanted successfully
endo-clamp catheter to arrest limited surgical field exposure is worth in hundreds of patients with excellent
the heart, remote and magnified the benefit of the smaller incision and results in terms of safety and efficacy. Both
visualisation of the surgical site, and reduced surgical trauma. The referring are bioprostheses mounted on a balloon
use of elongated surgical instruments physician bears some responsibility for catheter. In the more common approach,
including scalpel, scissors, suture
determining the appropriateness of the the catheter is threaded into place in the
needle driver and knot tying tools,
all of which allow for extra-thoracic procedure: is surgery indicated and is this aortic root retrograde through the aorta
instrumentation of the valve repair. the right time for the patient to undergo via a trans-femoral or iliac artery inser-
the operation. The referring doctor must tion site. Alternately, the catheter with
the collapsed valve prosthesis is inserted clip is deployed in such a way as to attach of relief from progressive aortic stenosis
through the left ventricular apex into the the central leading edges of both mitral who may not have tolerated surgical valve
aortic root. The balloon is then inflated, leaflets. With this technique, a billowing replacement have, and will be, success-
compressing the native aortic valve, and incompetent mitral valve is converted fully treated. As we have experienced with
followed by deployment and expansion from a single leaking orifice to a more percutaneous stent therapy for obstructive
of the valve prosthesis snugly into place effectively closing double-orifice valve. coronary artery disease, the availability of
in the aortic annulus. While many patients have been percutaneous techniques for heart valve
For transcatheter mitral valve repair, successfully treated with transcatheter disease will greatly increase the number of
two options have been used successfully mitral repair devices or have had transcath- those benefitting for heart valve therapy. It
over the past several years. The technique eter aortic valve replacement, the longterm is remarkable to reflect on the progress in
referred to as transcatheter mitral annu- durability, especially of the mitral repairs, heart valve surgery over the past 80 years.
loplasty involves insertion of a semi-rigid remains to be demonstrated. Regardless, Who could have predicted the success of
device into the coronary sinus directly these innovations have been transform- heart valve surgery or the development
adjacent to the posterior aspect of the ing. In the case of transcatheter aortic of transcatheter heart valve repair and
mitral valve. With successful sizing of this valve replacement, many people in need replacement!
annuloplasty device, the dilated posterior
mitral annulus is compressed or shortened
by the device, reducing the dilation of Timothy J Gardner is a noted heart surgeon and leader in car-
A u t h o r
the annulus and rendering the valve more diovascular medicine in the US. He is Medical Director of Christiana
functional and less insufficient. The other Care’s Center for Heart & Vascular Health. He was chief of the Division
of Cardiothoracic Surgery for the University of Pennsylvania Health
technique involves apical septal puncture System from 1993-2003. He has lectured extensively both nationally
and placement of a catheter into the left and abroad and he is the author of nearly 200 scientific papers and
atrium. Using fluoroscopic and echocar- has edited or contributed to many texts on cardiac surgery.
www.asianhhm.com 33
Diagnostics
W
hile in the past, MRI was vice versa? How and when can MRI be assessment of disturbed cerebral hemo-
praised mainly for its superb used instead of PET? These questions dynamics, e.g. in stroke MRI. In brain
anatomic display and tissue can form key for panel discussions for tumours, the method showed benefits for
contrast, a number of advanced, non- the radiological community. three major fields: differential diagnosis,
enhanced and contrast-enhanced MR Proton magnetic resonance spectroscopy biopsy planning, and treatment monitor-
imaging techniques have been devel- of Chemical Shift Imaging (CSI) is becom- ing. MRI can now provide quantitative
information of the underlying pathologi- diffusion weighted and Diffusion Tensor tumour vessels, which exhibit increased
cal tissue with the help of PWI. It can Imaging (DTI) also play an important role blood volume and permeability compared
also provide better metabolic informa- in the diagnostic workup and monitoring with normal vessels. MR-based techniques
tion about brain tumour biology with of patients with cerebral tumours. like dynamic susceptibility weighted
the help of MRS. PWI in neurooncology Another promising field is diffusion (DSC) MRI or dynamic contrast enhanced
is mostly performed on the basis of T2+ weighted imaging in the assessment of (DCE) MRI can be used to measure the
weighted dynamic susceptibility contrast- lymph node metastases. DTI is a promis- blood volume, the vascularity, the size of
enhanced (DSC) MR echo-planar imag- ing new methodology which allows insight the vascular space within designated areas,
ing approaches. Newer perfusion imaging into the integrity of tissue of the brain. and the behaviour of contrast within those
approaches, which do not need extrinsic Lymph node imaging and prostate cancer vessels. DCE-MRI has been used in a
contrast media application, use the blood variety of tumour entities and oncological
as intrinsic contrast media. DSC (A) MRI DCE (B) MRI applications including cancer detection,
Dynamic Contrast-Enhanced Magnetic diagnosis, staging and assessment of treat-
Resonance Imaging (DCE-MRI) describes ment response. Tumour microvascular
the acquisition of serial T1 weighted measurements by DCE and DSC-MRI
images before, during and after the have been found to correlate with prog-
appearance of extracellular low-molecular nostic factors such as tumour grade,
weighted MR contrast media in the tissue. microvessel density (MVD), and vascu-
The resulting signal intensity measure- lar endothelial growth factor expression
ments of the tumour reflect a composite of DSC acquires a series of EPI images after a (VEGF) and with recurrence and survival
tumour perfusion, vessel permeability, and bolus injection ofcontrast media and using outcomes (Figure 1).
the indicator dilution theory for quantification
the extravascular-extracellular space. A group of researchers from the
of blood flowand volume. DCE MRI
DCE-MRI has been used in quite a acquires a series of GRE images after slow University in Munich are evaluating the
large variety of clinical oncologic applica- contrast mediainfusion for quantification of role of perfusion MRI to monitor the
tions including body cancer detection (e.g. tumor vascularity and vessel permeability. efficacy of anti-angiogenic treatment in
Histology proved the presence of low
The DCE-MRI). It allows to measure the kidney cancer. This type of cancer has been
grade and high grade areas with different
vascular permeability and its aberrations, vascularity and molecular vascular profiling shown to respond well to anti-angiogenic
while the microvascular density (MVD) within the same tumor and in good drugs. Functional measurements related to
describes the histopathologically partial correlation to the imaging findings. the tumour blood supply should provide
picture of the tissue microvasculature. a surrogate marker of whether the treat-
Figure 1
Furthermore, MVD is also a heterogene- ment strategy is working. This may not
ous property of tumours and is limited by are good examples in the description of be obvious from measurements of the
histopathologic sampling and are gener- tumour infiltration potentiality by this tumour size or morphology.
ally hotspot values. The measurement of method. Work to standardise and to quantify
the tumour microvascularity using the All methods can be integrated in diffusion and perfusion MRI procedures is
DCE-MRI method has found to be well the treatment monitoring in anti-cancer just beginning. This will be most essential
correlated with prognostic factors such therapy. As at initiation, tumours in a if multi-centric trials are to be conducted
as tumour grading, angiogenic factors, pre-vascular phase are supplied by oxygen to be used for follow-up assessments and
e.g the vascular endothelial growth factor and nutrients that diffuse from pre-exist- in clinical trials. However, it should be
expression (VEGF) and with the risk of ing normal vessels, ischemia leads to the taken into account that for absolute quan-
recurrence or simple survival outcome secretion of angiogenic factors when the tification both diffusion and perfusion
measurements. tumour reaches a critical size. Angiogenic MRI require specifically tuned sequences
Dealing with modern chemotherapeu- markers, such as VEGF, are responsible and an extensive and time-consuming
tic approaches, the use of DCE-MRI in for the recruitment and maintenance of post-processing.
follow-up studies is becoming more and
more important. Since the anti-angiogenic
therapies focus on the measured DCE Marco Essig is a Professor of Radiology in Heidelberg Medical
A u t h o r
parameters, the method may play an School and Assistant Medical Director in Department of Radiology,
Head of MRI and Neuroradiology, German Cancer Research Center,
important role as a predictive marker. Heidelberg, Germany. He was Professor of Radiology, Heidelberg
Diffusion weighted MRI is used Medical School.
routinely in the assessment of cerebral
infarction and infectious diseases. Both
www.asianhhm.com 35
When
the future is
uncertain
and the
going is
tough
w w w. h o s p i t a l s - m a n a g e m e n t . c o m
Diagnostics
Cardiac Computed
Tomography
Emerging cardiac devices and technologies
O
Recent studies have ver the last five years, the Prior to the advent of 16 slice scan-
confirmed that non-invasive speed and resolution of muti- ners, it was difficult to evaluate the heart,
slice Computed Tomography much less the coronary arteries, due to
coronary imaging using
(CT) has advanced to the point where the constant motion of the beating heart.
Computed Tomographic it can now be used for accurate cardiac With a 16-slice scan, patients would typi-
Coronary Angiography evaluation. Calcium scoring, a popu- cally have to hold their breath for 25
(CTCA) is exceptionally lar method of cardiac evaluation using to 30 seconds for the entire heart to
accurate and at the same Electron Beam CT technology (EBCT), be imaged. This was difficult for some
has been re-evaluated using spiral CT patients to do, and there was accelera-
time, compared with its
technology, and has been validated for tion of heart rates towards the end of
invasive counterpart, is risk assessment of patients’ long-term the scan. In addition, it was difficult for
faster, cheaper and safer. cardiovascular outcomes and in varied
patient ethnicities. Calcium scoring, a
Jeffrey M Schussler gated non-contrast examination of the
Medical Director heart using cardiac CT, is a quick and
Cardiac Intensive Care Unit safe way of evaluating for the presence of
Baylor University Medical Center, USA
calcified atherosclerotic coronary plaque.
The largest drawback of calcium score
is that while a positive test confirms the
process of atherosclerosis, a negative
score does not completely rule out the LAD
disease. While high calcium scores can
assess general risk of coronary events,
they cannot accurately predict individual
coronary stenosis (Figure 1).
Multislice Computed Tomographic
Coronary Angiography (CTCA), unlike
calcium scoring, allows for the evaluation
Calcium score of a 45 year old
of the soft as well as the calcific plaque asymptomatic man with strong family
within the coronaries. The technique is history of coronary disease. Calcified
similar, but the addition of iodinated plaque (arrow) is demonstrated in the
proximal left anterior descending (LAD).
contrast during the scan, and higher
This amount of plaque in a young man
resolution imaging allows for more places him in the highest per centile risk for
anatomic evaluation of the coronary future cardiac events compared to men of
structures and the surrounding cardiac the same age without detectable plaque.
anatomy (Figure 2). Figure 1
www.asianhhm.com 39
Diagnostics
structures (Table 1). The evaluation of patients are now receiving CTCA instead
A coronaries is mostly done to the patients of invasive angiography prior to non-
who suffer from chest pain and have a coronary cardiac surgery in whom the
low to moderate risk of flow limiting pre-test probability of disease is relatively
coronary disease. It is always better to low. The most significant change from
send patient for an invasive angiogram 16 to 64-slice scanners was the reduction
if there is a very high pre-test probability of acquisition time, while the resolution
of significant coronary disease. Many of the scans was essentially unchanged.
patients sent for CTCA have had a prior Beta blockers, which are less necessary
stress test which was thought equivocal with 64-slice scanners, are still typically
or negative, but in patients who had an used as they improve the overall image
B invasive angiogram it is deemed overly quality and allow for larger radiation
aggressive. In this subset of patients, dose modulation.
CTCA can define those patients in whom Recently, there has been an increase
it is unnecessary to proceed with further in the awareness of the potential dangers
testing. of radiation, and in particular those theo-
In high-risk asymptomatic patients, retical dangers associated with ionising
there is still potential use for CT to iden- radiation from the increase in utilisa-
tify patients who have very premature tion of computed tomography. While
or sub-clinical atherosclerosis. This type the dosage of CTCA is higher than that
C of evaluation is currently not being of a typical invasive angiogram, the one-
reimbursed by insurance companies, time dosage of a CTCA is negligible in
and is often paid for by patients out- the total impact of clinical incidence
of-pocket. of cancer.
Coronary anomalies, while uncom-
mon, are potentially lethal. Certain
subsets of these patients are at high Current Indications for Cardiac
Computed Tomography
risk for sudden cardiac death, and so
it is helpful to evaluate the course of • Chest pain in patients with moderate
risk for flow limiting coronary disease
the anomalous arteries (image-anomaly
Figure 3) CTCA is considered the gold • Chest pain in patients with equivocal
Invasive cardiac catheterisation stress testing
(panel A), 3D reconstruction standard for the evaluation of the coro-
(Panel B) and axial image (Panel nary tree for the presence of anomalous • Coronary anomalies
C) of a patient with a single coronaries. While this is its strongest • Cardiac evaluation prior to pulmonary
coronary artery arising from the indication, these patients represent a vein ablation
right coronary cusp. The left main
(arrow) is noted to be traversing much smaller group than the patients • Post coronary bypass evaluation of
between the aorta and pulmonary who are suspected of having flow-limit- graft patency
artery, which has been associated ing coronary disease.
with sudden cardiac death. A large group of patients are now
Figure 3
receiving cardiac scans as part of the Possible Future Indications for Cardiac
Computed Tomography
preoperative evaluation for electrophysi-
dose of ionising radiation. For patients ology procedures such as pulmonary vein • Screening for early presence of
with normal renal function, the contrast ablations for atrial fibrillation (Figure asymptomatic coronary disease
load is very safe. Only about 100 to 120 4). In our centre, as with many others, • Pre-operative coronary evaluation for
cc of contrast is given during a typical this is becoming the standard of care non-coronary cardiac surgery
cardiac CT. The radiation is variable, prior to this type of invasive treatment. • Pre-operative coronary evaluation for
but typically ranges from 10 to 16 mSv A growing number of patients in whom coronary bypass
for a gated study. re-operative coronary artery bypass is • Pre-operative coronary evaluation for
The application for multislice cardiac being contemplated are receiving CTCA non-cardiac surgery
CT generally falls into two categories: to evaluate patency and location of grafts • Post-PCI evaluation of coronary stent
Evaluation of the coronaries and eval- (both readily determined utilising CT) patency
uation of the non-coronary cardiac prior to repeat median sternotomy. Some Table 1
pain triage is feasible and potentially Disease Fellowship, and is the Vice-Chair of the Institutional Review
cost-reducing in the emergency setting. Board at Baylor University Medical Center . Schussler’s research and
It is notable that several hurdles (includ- publications have involved both invasive and noninvasive coronary
angiography and the use of multi-slice CT for cardiac imaging. He
ing rigorous patient selection) need to has written chapters for several current textbooks on CT cardiac
be addressed before this technology is imaging.
utilised in a wider clinical setting.
www.asianhhm.com 41
Diagnostics
Asian innovators have ties in access to care and in the ability are familiar, particularly in developing
the opportunity to design of patients to afford it. economies that face the natural challenge
systems and services Asian systems are facing similar pres- of serving low- and rising-income consum-
sures. As developing nations become more ers. Healthcare is an industry ripe for
that are profitable and urban and affluent, patients will inevita- disruption worldwide, and it is possible
sustainable, yet affordable bly transition from sporadic reliance on that Asia will lead a wave of disruption
and accessible to everyone. local healthcare providers to a model of there as well.
As they do so, they can healthcare consumption that attempts to A more comprehensive discussion of
make major contributions to mirror the systems found in developed disruptive innovation in healthcare can
countries. Industry players will be increas- be found in The Innovator’s Prescription:
solve the global healthcare ingly tempted to compete by developing A Disruptive Solution for Health Care
crisis by collaborating with cutting-edge, centralised and high-cost (available January 1, 2009) and at the
colleagues in other regions infrastructure. However, the outcome of book’s website.
to adapt and export those this model in western systems suggests
new models of care. that this impulse should be questioned, Enabling technology
and, concerted effort should be made to Technological enablers in healthcare often
avoid the traps in which those systems take the form of innovations that precisely
Alexandra Leichtman
Manager
now find themselves. Improved healthcare diagnose the underlying causes of patients’
Jason Hwang
should not come at the expense of creating conditions. They replace the historical
Senior Strategist innovative, convenient, low-cost models process of trial-and-error treatment of
Healthcare Practice that are accessible to everyone. symptoms followed by post-hoc diagno-
Clayton M Christensen Based on 20 years of research at the sis. Precision medicine involves applying
Co-founder Harvard Business School as well as field therapies that are predictably effective
Innosight LLC, USA work designing and deploying innova- for precisely-diagnosed diseases, and this
tions, we have observed the transformation rules-based work can be standardised to
of industry after industry when compli- facilitate treatment by a wider range of
cated, expensive products and services are caregivers and in a wider range of settings
replaced by affordable, accessible alter- than previously possible. This transition
T
oday’s healthcare systems are in a natives. This agent of transformation, enables broader access and reduces over-
critical state of distress in nearly disruptive innovation, has a rich history all system costs in two ways: Procedures
every nation around the world. of success in Asia. Cellular telephony can migrate from specialists to generalist
In developing countries, the prevailing catapulted Southeast Asian countries physicians, nurses, family members and
model equates to adequate care for past stages of expensive infrastructure patients themselves. Additionally, the site
the wealthy and little for the masses. development. The advent of compact and of care can shift to local hospitals, outpa-
Nationalised, single-payer models like inexpensive automobiles, first in Japan tient clinics, offices, and retail locations.
the systems in the UK and Canada face and more recently in India and China, Avoiding the use of centralised hospitals
long waiting lists and spiralling costs. has upended the global auto industry. populated by highly-trained specialists
The notoriously dysfunctional US system Consumer products targeting the bottom eliminate major drivers of healthcare
combines the follies of each: escalating of the pyramid have found early traction costs.
costs that threaten to swamp public in Asian markets. Indeed, innovations in Singapore’s Economic Development
payers and employers, together with Asia have often presaged transformations Board, via its healthcare venture capital
impending workforce shortages in in the US and Europe. In Asian markets, arm Bio*One Capital, has a good grasp
critical areas—fostering both inequali- themes of affordability and accessibility of the concept of technological enablers,
investing in a portfolio of disruptive ultimately shrink in the long run, the same specialised services. The fee-for-service
companies. Building upon the Singapore model can be applied to serve remote or model is appropriate for these problems
government’s investments in medical sparsely-populated communities. With the and is likely to persist in dedicated solu-
research, Bio*One formed Dx Assays, a advent of simple, low-cost, portable imag- tion shops.
joint venture with a European biotech ers and the increasing video capabilities VAP businesses, by contrast, focus
firm. The focus is developing molecular of general telecommunications tools like on transforming incomplete or broken
diagnostic assays to facilitate cost-effec- mobile phones, the telemedicine model things into higher-value outputs. For unre-
tive drug development by identifying may allow health systems in developing fined crude oil, the treatment process to
appropriate candidates for trials based economies to provide widely-accessible transform it into petrol is consistent and
on genetic factors and precise disease diag- quality care without the 30-40 year cycle known. Therefore, the petroleum refining
nosis. On the treatment side, Bio*One of infrastructure development. business conforms to the VAP model.
has also funded ventures aimed at expand- Many medical procedures are likewise
ing access through accurate, simple to Business model innovations suitable for VAP hospitals and clinics,
deploy therapies that would preclude The US and European healthcare systems which take a narrowly-defined slice of
intervention by a professional. One port- have been particularly resistant to business customers with similar needs and apply
folio company, ReVance Therapeutics, is model innovations, with strong inertia due standardised, efficient care—often at a
exploring novel technologies to deliver to entrenched fee-for-service accounting fraction of the cost of a solution shop or
large active molecules through the skin. and payment models and a century-old conflated model. Aravind Eye Hospital
One lead application in clinical trials focus on hospital- and physician-directed in India, a pioneer in the VAP hospital
is delivery of botulinum toxin type A, delivery. The result has been a system in movement, is now the world’s largest and
which, in addition to cosmetic appli- which healthcare providers are economi- most productive eye care facility. From the
cations, can be used to treat a variety cally incentivised to create or inflate outset, Aravind’s founders were committed
of muscular disorders, regulate certain demand for their services. to providing free eye care for the poor,
glandular functions, and possibly treat Generically, there are three distinct creating a powerful incentive to develop
very common conditions like prostate business models: solution shops, value- innovative low-cost treatment models.
hyperplasia and migraines. The technology adding process (VAP) businesses and facili- By some measures, Aravind is more than
also shows promise for delivering insulin, tated networks. In healthcare, these are five times as productive as the average
antibody-derived therapies and non-ster- often conflated in a single organisation, ophthalmologic hospital in India.
oidal anti-inflammatory drugs. creating a complex, confused institution Expanding their reach beyond their
Telecommunications, too, has an that is unable to accurately allocate costs local markets, VAP hospitals like Aravind
important role to play in enabling and drive efficiency and productivity. can serve as models for the emerging trend
healthcare disruptions. Remote care Segregating these business models through of medical tourism. While some early
networks in Asia have been entrusted the creation of single-purpose institutions entrants in medical tourism have simply
with outsourced diagnostic work for is the most promising avenue to increased re-created the high-cost model of solution
years. Using state-of-the-art telecom- access and affordability. shop general hospitals, the savings based
munications technology, Teleradiology Solution shops, like the general hospi- on wage and cost differentials alone are
Solutions, a Mumbai-based radiology tals that excel at diagnosing and solving not a durable advantage. Innovative busi-
services provider, leverages wage and time- unstructured problems, will necessarily ness models like Aravind have a greater
zone differentials to allow hospitals in the have high-cost business models, and the chance of remaining relevant even as wages
US and Singapore to better meet growing payment systems they employ should rise, because unlike solution shops, VAP
demand. Though wage disparities may compensate them sufficiently for their businesses present a more attractive value
proposition by charging fixed prices for
their outcomes—often guaranteeing the
The mechanism of disruptive innovation
results. Because of this output orientation,
VAP hospitals can significantly reduce
• Enabling technologies that simplify and routinise formerly complex and unstructured processes
(e.g. precise diagnostic technologies, telecommunications)
the total system costs.
A final model, facilitated networks,
• Business model innovations that allow companies to profitably deliver affordable, accessible holds promise for treating chronic illnesses
solutions to consumers (e.g. targeted and efficient providers, facilitated user networks)
requiring behaviour changes, coordinating
• Value networks of companies that have mutually compatible economic models which together the response of caregivers and patients to
provide the underlying commercial infrastructure (e.g. drug and device suppliers aligned with
integrated payer-providers and a health information system).
disease outbreaks, and filling persistent
infrastructure and logistical gaps in the
www.asianhhm.com 45
Technology, Equipment & Devices
Industry
report
Scope and Segmentation The first chapter gives an introduction to scientific and technical papers that provide
Research is looking beyond using implants, orthopedics, followed by an overview of the insights into key industry participants and the
screws, metallic cages, to incorporating technology developments observed in ortho- technical processes on which they work.
biologic bone substitutes with regenerative pedics till date. The scope and segmentation The analysts then create a detailed ques-
potential to address orthopedic conditions. of the study and the methodology adopted for tionnaire with content created to address the
For example, Medtronic Sofamor Danek of it are also discussed here. research objectives of the study, which func-
Memphis licensed the growth factor rhBMP-2 A technology primer of the different kind tions as a guide during the interview process.
developed by Wyeth and this powerful bone of biologic substitutes--allografts, demineral- While the analysts use structured question-
stimulant has been coupled with their LT- ized bone matrix (DBM), synthetics, factors naires to guarantee coverage of all the desired
CAGE Lumbar Tapered Fusion Device. and stem cells are discussed in the second issues, they also conduct interviews in a
However, A biologic substitute can be chapter. A heads-up of the trends in the conversational style. This approach results
any material that dynamically alters and orthopedics industry and important clinical in a more thorough exchange of views with
affects the surrounding environment to trials has also been included under relevant the respondents, and offers greater insight
proceed in an active biological manner, headings. into the relevant issues than more structured
which manifests as cellular activity, growth, Developments in technology, products, interviews may provide.
and differentiation. For instance, orthopedic and research studies in orthopedic biologic The analysts conduct primary research
surgery required surgeons to use biocom- substitutes that have osteogenic, osteocon- with the key industry participants and tech-
patible specifically designed metal implants ductive and osteoinductive potential consti- nology developers to obtain the required
to structurally support a fractured bone or in tute the third chapter. Challenges faced by content. Interviews are completed with
some cases to fuse bones in spinal condi- the industry participants, and the drivers to sources located throughout the world, in
tions. Now surgeons are looking towards a the biologics industry are discussed under universities, national laboratories, govern-
biologic component incorporated with the relevant heads in the fourth chapter. This mental and regulatory bodies, trade associa-
metal implant so that the latter serves to chapter also comprises an analysis of the tions, and enduser companies, among other
regenerate living bone tissue while the metal impact of the biologic substitutes (allografts/ key organisations.
implant functions in a structural manner. Defi- DBM, synthetics and factors/cells) on differ- Our analysts contact the major commer-
nitely, the next stages of technology develop- ent orthopedic applications. cial players to find out about the advantages
ment would reduce the amount of metal in
The factors include funding, partnerships, and disadvantages of processes, and the
implants and use biodegradable scaffolds for
intellectual property (IP) portfolio, regulatory drivers and challenges behind technologies
the structural function.
impact, biocompatibility, and scalability. and applications. Our analysts talk to the
An ideal biologic bone substitute is principal developers, researchers, engineers,
Patents and the contact details of
required to have either or all of the follow- business developers, analysts, strategic
company officials and university faculty
ing--osteogenic, osteoconductive, and oste- planners, and marketing experts, among
members who have participated in the study
oinductive properties. Steady progress in other professionals.
are listed in the fifth chapter. (Patents are
biologic material sciences assures that the
listed by area and contacts are listed sepa- The project management and research
future treatment of injury and tissue loss will
rately for companies and universities). team reviews and analyses the research data
be altered and more biologically correct.
Decision support database tables form that are gathered and adds its recommenda-
The objective of this research service tions to the draft of the final study. Having
the sixth chapter of this study. Frost & Sulli-
is to analyse and report new and emerging conducted both published studies and
van’s healthcare decision support database
orthopedic biologic substitutes; advances in custom proprietary research covering many
service offers a valuable collection of tables
research and development (R&D) and prod- types of new and emerging technology activi-
that provide historic and forecast data for
uct development in the orthopedics arena. ties as well as worldwide industry analysis,
medical devices.
The research service plans to identify key the management and research team adds
players (with contact information)--those in Methodology
its perspective and experience to provide an
the forefront of technology development and To provide a thorough analysis of each topic,
accurate, timely analysis.
commercialisation pertinent to this market Technical Insights’ analysts perform a review
of patents to become familiar with the major The analysts then prepare written final
and end-user information. The scope has
developers and commercial players and their reports for each project and sometimes
been sketched to include bone substitutes or
processes. Building on the patent search, present key findings in analyst briefings to
biologics that fill voids, support and enhance
the analysts review abstracts to identify key clients.
the repair of biological defects.
www.asianhhm.com 49
Facilities & operations management
Registrar
acknowledged and given the opportunity to state his problem.
Greeter
Triage
Bed
This is done by a non-clinical “greeter” who conducts ‘quick reg’
(registration)—a basic set of identifiers to register the patient into
the hospital’s record system. This should take but a few minutes.
When beds are available, the patient is placed immediately therein.
High impact intake flow The registration process can be completed at the bedside.
Patient Patient
But, what to do when the beds are all full? After the quick reg,
Quick reg
Registrar
Bed the patient is given an initial assessment by a clinician—generally
a nurse in a triage station. This triage will determine the severity
of the patient’s condition and allow the emergency personnel to
establish the priority to provide care. The patient, and in many
cases with family members or escorts, is then shown to an ‘inner
Contemporary emergency department waiting area’ in the treatment zone. The patients can be watched
and reprioritised, thereby getting the right patients into a bed more
Ambulatory Entrance quickly. The traditional concept of a main waiting room is altered.
Distributed Imaging Since patients and some family members are waiting within the
treatment areas, the main waiting room can be much smaller, as
Ambulance it will be serving family and visitors who shouldn’t be or prefer not
Entrance to be accompanying the patient.
To improve patient flow, a scheme for treating patients with
low-risk problems such as sprains and lacerations should be
Low acuity Inner waiting developed. This notion of a ‘fast-track’ should be incorporated
"fast track" Acute care within the context of the total treatment area. All beds should be
Critcal care capable of severing any acuity level. The fast track patients can
Inner waiting be clustered in one area of the overall department not isolated in
a discreet or separate unit. This will permit flexibility in assigning
patients to rooms based upon the variation in volumes throughout
Swing spaces Inner waiting Distributed the day.
Imaging
Ambulance patients have a different track into the ED. The
Acute care condition of these patients is generally communicated to the
Distributed
Imaging
ED by the ambulance personnel—paramedics or emergency
medicine technicians. Their arrival is then anticipated and care
protocol can be promptly implemented. However, there are occa-
sions when multiple arrivals occur at essentially the same time.
When this happens, a triage of these incoming patients becomes
necessary. In high-volume EDs, especially trauma centres, plan-
ning for an ambulance triage station will afford appropriate space
to handle this traffic.
Figure 1
clean supply and utility rooms, more which includes items like procedure Diagnostics
time will elapse in the patient visit. trays, IV fluids, assorted catheters etc., Getting diagnostic information in a
Moreover, evidence now shows that is essential to this concept. These items timely manner has significant impact
when nurses spend a lot of time walking, must be located within just a few steps upon patient flow through the ED. A
this can result in increased stress and from the patient bedside. An often used high per centage of patients require x-
concomitantly decreased effectiveness configuration is to have the second rays. Sending the patient to the Radiology
in direct patient care. When supplies tier supply in carts or cabinets at the Department has become too onerous in
are decentralised and evenly distributed perimeter of the nurse and doctor terms of time—transport time, queuing in
throughout the department, walking work area that is in the centre of an the department, waiting for a radiologist’s
distances are reduced and access time array of exam rooms or patient care reading and so on. The quest to improve
is improved. A three-tier supply system stations. A central storage room, the patient throughput has resulted in plac-
has proven to be highly successful in third tier supply system, is located on ing medical imaging within the ED. The
supporting improved throughput. The the unit out of the area of direct care. volume of patients seen in the department
first tier system includes items common This is where infrequently used items will, of course, determine the number
to each bedside, alcohol wipes, blood and backup supplies for Tier 1 and of radiographic devices required, but in
draw tubes etc. The second tier system, Tier 2 are kept. high volume EDs, multiple devices can be
ProductShowcase
YOUR PARTNERS IN HEALTHCARE...
...ALWAYS
Feasibility Studies Turn key Projects Facility Planning Hospital Design
MEP Design Project Management Commissioning Service Blueprinting
Soft Launch Standardization Clinical Engineering Process Reengineering
Operations Management Strategic Management Pricing strategies
Materials Management Marketing Group Purchasing Cost Analysis
Operational Audits.
www.asianhhm.com 53
al
eci
Sp
IT
Ready for
A s i a
Global Experience
• The only way out of system failure The scenario for China is slightly
is increased efficiency—this can be different. The country is likely to leap-
achieved through the growth of the frog the rest of the world in healthcare
Healthcare Information Technology IT adoption if they are able to do the
adoption. following:
• Learning quickly from the interna-
Do you think Asia is ready to accept tional / global experience
the changes in technology? • Overcoming the resistance to
Developed countries in Asia are under- change
taking national initiatives to develop • Knowing how to manage change
national EHR policies, with hospitals • Developing more expertise in these
focussing on digital integration and areas of need.
operational efficiency. These initiatives Other countries like Malaysia and
are being undertaken with the ultimate Thailand are focussing on Telehealth
goal of improving productivity and qual- and improving primary care by providing
ity of care, while also helping to reduce accessibility to remote communities and
overall healthcare costs. building healthcare infrastructure.
As for the developing economies in
Asia, they are also working on healthcare How do you see the adoption of PHRs
reform and are building their infrastructure and EMRs in Asia? Do you think Asian
to meet the needs of the new demands hospitals are self sufficient to shift
Steven Yeo
in healthcare. Some of these economies, toward the trend? Vice President and Executive Director
such as China, may eventually leap-frog EMRs and PHRs are still at a very early HIMSS Asia Pacific, Singapore
the rest of the world through the adop- stage of adoption both globally as well
tion of new technologies. as in Asia.
Asian hospitals can learn from
What is the scenario in Asia? international HCO experiences through to measure Access to Care, Workflow
Different countries in Asia are facing successful EMR implementation. They Optimisation, Employee Productivity and
different challenges and will need to will also need to work with national Patient Satisfaction are also important
respond accordingly. health authorities on policies and EHR contributing factors to the success of
For example, due to their rapidly /EMR plans pertaining to legal, stan- Healthcare IT adoption in a hospital
ageing populations, countries such dards and infrastructure matters. environment.
as Australia, Japan and Singapore are Events such as HIMSS AsiaPac09,
already placing a focus on the ‘silver What are the areas of Healthcare IT happening from 24–27 February 09 in
industry’, which is potentially one of in which do you think improvement is Kuala Lumpur, provides health IT stake-
the fastest growing markets. In such required? holders with a platform to connect and
countries, PHRs and home-care initia- It depends to a great extent on the goal exchange ideas in order to help advance
tives are part of the national focus to and plan of each hospital. Having said quality healthcare delivery through
empower patients to have the same that, hospitals should focus on manag- the use of IT. It is a place for intensive
level of care at home, while bringing ing change, and measure the busi- learning and knowledge exchange and
down costs and improving the quality ness value that Healthcare IT brings networking with leaders from healthcare,
of care beyond the hospital itself. to its operations. Developing KPI(s) government and IT.
w
wwww
w .. aa ss ii aa nn hh hh m
m .. cc oo m
m 55
55
al
eci
Sp
IT
A s i a
Peter Gross
Senior Vice President and
Chief Medical Officer
Hackensack University
Medical Center, USA
Start
with the
Basics
In your experience, how has IT helped radiology results reporting, then follow accomplish what was described in the
improve patient care, what are your up with a pharmacy system that helps first question. They also will be the
expectations from it in the coming manage physician orders. Build in some basis for a country wide RHIO (Regional
years? clinical decision support to help reduce Health Information Organization) or HIE
IT when properly implemented in an errors from medication ordering. Putting (Health Information Exchange) which
orderly fashion should improve patient transcripts of history and physical dicta- will permit doctors and patients wher-
safety, facilitate compliance with perfor- tions and those of operative notes ever they are in that country to access
mance measures, reduce costs, and online could come next. Add electronic there medical information.
improve physician and nurse satisfac- signatures. Nursing documentation and
tion with their jobs and their health the electronic medical administration What are the areas of Healthcare IT
care institution. record can follow. This approach is that you think need to be further devel-
reviewed in Gross and Bates. JAMIA oped?
Considering that a majority of Asian 2007;14:25-28. Virtually all areas of Healthcare IT need
countries are still developing, do you further development. In fact, they will
think Asia is ready for the rapid tech- How do you see the adoption of PHRs be in a state of evolution for a long
nological changes shaping healthcare and EMRs in Asia? Do you think Asian time.
globally? hospitals are prepared to shift toward
I think you need to start with the the trend?
basics. Automate laboratory and PHRs and EMRs are inevitable to
Driven by
e-Health
public health and education. Disciplines peer-support. E-health can also provide
such as teleradiology and telepsychiatry alternative ways of care delivery to
have proven being efficient and cost meet needs of patients. But the main
Sisira Edirippulige effective in delivering care. In general, problem in developing countries has
Coordinator a large number of research studies been the lack necessary infrastructure,
e-Healthcare Programme have shown the effectiveness of tele- funding and expertise to establish and
Centre for Online Health
health / telemedicine applications in sustain e-health. This is true with a
University of Queensland
Australia providing improved care, particularly substantial number of countries in Asia
to communities otherwise are deprived which fall into the category of develop-
of such services. These include rural ing countries. The level of ICT use in
and remote communities and popula- the health sector of these countries is
In your experience, how has IT helped tions in developing countries. Evidence limited. The barriers mentioned above
improve patient care, what are your suggests that the use of ICT in health, will prevent these countries benefiting
expectations from it in the coming i.e. e-health / telehealth / telemedi- from this new tool.
years? cine has a potential to address critical Another reason for slow progress
It is not an overstatement that new problems in the health sector. There is in e-health in Asia can be the magni-
information and communication tech- a growing awareness in health profes- tude of health problems themselves.
nologies (ICT) have revolutionised sionals, policy makers and business Countries like India and China—world’s
the way people access information communities that ICT has a major role most populous countries—have enor-
and communicate with each other. to play in health sector. These factors mous challenges in terms of health
All spheres of human society have will facilitate the use of e-health in the care provision. Restructuring health
impacted by these developments. future. systems in these countries is an enor-
Undoubtedly, the impact of ICT devel- mous task. However, the good news
opments on health sector and medi- Considering that a majority of Asian is that the rapid economic growth and
cine has been significant. However, the countries are still developing, do you the technological development have
changes prompted by ICT in health care think Asia is ready for the rapid tech- already begun to re-shape the health
are limited compared to other areas nological changes shaping healthcare sector in these countries.
such as trade, banking or media. The globally? Meanwhile, it is worth mentioning
influence of ICT can be seen in clinical The irony is that despite its limited that there are some good examples
practice, administration, education and use, e-health is better suited to in Asia where progress in e-health
research. The use of the Internet by address critical problems in devel- has been substantial. South Korea,
patients and practitioners to access oping countries. e-Health can be Singapore, and Taiwan, for example,
health information has tremendously helpful to support limited (and often have been able to use modern tech-
increased in recent years. The Internet isolated) health professionals by provid- nological developments to advance
also has become a powerful media of ing better education, information and their health systems.
www.asianhhm.com 57
al
eci
Sp
IT
scenario in australia
The level of success in e-health in Australia, like in many other coun- expected that the National e-Helath Transition Authority (NEHTA)—
tries has been mixed. There have been some success stories in imple- nation’s peak e-health body—is to play a key role in Australia’s frag-
mentation and sustained use of e-health while others have shown mented e-health fabric.
disappointing results. In general, there is a rapid increase in the use of Having said that, a number of e-health projects have shown the
computers and the Internet within health care sector. A recent survey potential to be feasible, cost- effective and sustainable. One good
revealed that 94 per cent of GPs nationwide are computerised, 90 per example is the telepaediatric service managed through the Centre
cent GPs use clinical software packages and nearly 80 per cent use for Online Health (website http://www.uq.edu.au/coh/) at the Royal
broadband connection. The growth of ICT use can be seen in both Children’s Hospital in Brisbane which provides services to rural and
public and private health sectors. remote communities in Queensland. It is estimated that some 15 per
As mentioned, the use of e-health in Australia is patchy. There cent of all burns consultations are now done via telehealth.
are number of different research projects underway to investigate the Attempts are being made to use telehealth applications to improve
effectiveness of ICT use in improving health care provision. Some the health services in the indigenous communities in Australia. If
e-health projects are initiated and funded by federal and state govern- successful, these models can be used to in similar contexts in other
ments while others by business partners. However, the majority of parts of the world, particularly in developing countries.
these initiatives are run as research projects, but few have been inte-
Australian government’s emphasis on expanding broadband
grated to mainstream care provision.
coverage and funding IT education will have an impact on the growth
One key feature of the current state of e-health in Australia is a of e-health. At the same time, Federal Government has also shown
clear lack of coordination. This is probably due to the absence of an interest in supporting e-health.
authorised body to oversee and coordinate e-health activities. It is
How do you see the adoption of PHRs What are the areas of Healthcare IT adopt a ‘techno-skeptical approach’
and EMRs in Asia? Do you think Asian that you think need to be further devel- to treat technology as a tool to serve
hospitals are prepared to shift toward oped? the purpose.
the trend? When you look at the global scenario,
Electronic storage and access of you can see that the key emphasis in Any other comments?
patients’ data has been a topic of ICT use in health has been on adminis- I think there is a critical need for a
the day in many parts of the world. tration and education. A limited atten- global governing body for e-health.
Progress in electronic health records in tion has been put on the use of ICT Setting up such an organisation with
Asia has been slow due to understand- in clinical practice. I think it is vital to appropriate legal and regulatory rights
able reasons, such as lack of funding, explore new ways of using technol- should be a priority. While this peak
infrastructure and expertise. Unlike ogy for clinical practice and for better body would have authority relating to
European Union (EU) or some other clinical outcomes. e-health across the world, it should also
industrialised nations, Asian countries It is also important to explore have the necessary financial capability
have not been able to invest heavily ways to use low cost technology as to fund its activities.
into electronic health records. However, opposed to expensive technologies. The importance of e-health educa-
there are some impressive examples There is some good evidence that tion has so far been overlooked.
in Asia; for example to certain extent, simple and inexpensive technologies Evidence shows that access to system-
Singapore, Taiwan and South Korea can be effectively used in providing atic education in e-health is limited
have made headway in implement- quality health care. One such example in both industrialised and develop-
ing electronic health records. These can be email. ing countries. Systematic education
examples show the trend in Asia. The I strongly believe that technology in e-health for health professionals
transition from paper based patient must NOT be the focus of e-health / must be at the heart of the strategy
records to electronic health records telehealth. While technology is impor- to promote e-health. It is important
has not been an easy and smooth tant, the primary focus of e-health to increase funding for post-graduate
process even in industrialised coun- must be on the clinical need. Evidence studies in e-health/health informatics.
tries. Continuing economic and social shows that technology driven prac- The accreditation of e-health qualifica-
progress along with the technological tices are doomed to fail. Technology tions is another way to attract health
advancement are the key for Asia to must be a tool to address the need. professionals and help address the
achieve this goal. Therefore, e-health practitioners must critical skills shortage.
P
atients’ data in hospitals must be timely, Key characteristics…
accurate and reliable as it could make the The key characteristics of SaaS software, includes:
difference between life and death. The benefits • network-based access to, and management of,
of Information Technology can effectively address the commercially available software
challenges faced by healthcare providers. • activities that are managed from central locations rather
Wipro HealthCare IT (Wipro HCIT) is a dedicated than at each customer’s site, enabling customers to
Health Informatics Company and is part of Wipro access applications remotely via the web
Ltd ,which is the World’s first CMMi Level 5 certified • application delivery that typically is closer to a one-to-
software services company and the first outside USA to many model (single instance, multi-tenant architecture)
receive the IEEE Software Process Award.Wipro HCIT than to a one-to-one model, including architecture,
has a talent pool of over one hundred professionals pricing, partnering, and management characteristics
with healthcare domain, Information Technology and • centralised feature updating, which obviates the need
management expertise. There are more than 50 satisfied for downloadable patches and upgrades
global healthcare customers who have successfully SaaS applications are generally priced on a per-
implemented the healthcare information systems in user basis, sometimes with a relatively small minimum
private and government hospitals, clinics, pharmacies number of users and often with additional fees for extra
and diagnostic centres. band width and storage.
Wipro has recently launched SaaS model called as
“Pay per use” or the “Utility Computing Model” Managing the Risks of Software Acquisition
of Hospital Information System in India. Especially In a small hospital or nursing home setup it may-not be
designed for medium and small sized hospitals and viable to install, run and maintain an application and the
clinics who work on very low IT maturity and shy away hardware infrastructure by the hospital team. Not only
from automation. does it require a substantial commitment of financial
Software as a service (SaaS, typically pronounced resources , it also requires space , manpower, power,
‘sass’) is a model of software deployment where an air-conditioning etc. With this there is always the fear
application is hosted as a service provided to customers of the initiative not being successful and hence the risk
across the Internet. By eliminating the need to install and of failure. Hence in a smaller setup the management is
run the application on the customer’s own computer, looking for a risk free software acquisition where the cost
SaaS alleviates the customer’s burden of software of sunk investment is low. SaaS is a perfect solution for
maintenance, ongoing operation, and support. SaaS this since it is on a monthly rental model with no upfront
has the potential to transform the way information- investment in either the software or hardware or AMC.
technology (IT) departments relate to and even think SaaS model of hospital information system doesn’t
about their role as providers of computing services to require the deployment of a large infrastructure at the
the rest of the enterprise. hospital location, which eliminates or drastically reduces
Simply put, SaaS can be defined as “software the upfront commitment of resources.
deployed as a hosted service and accessed over
the Internet.” Managing IT Focus
Today, SaaS applications are expected to take With SaaS, the job of deploying the hospital information
advantage of the benefits of centralisation through a system and keeping it running from day to day—testing
single-instance, multi-tenant architecture, and to provide and installing patches, managing upgrades, monitoring
a feature-rich experience competitive with comparable performance, ensuring high availability, and so
on-premise applications. forth—is handled by the provider ie Wipro.
The Product–Modules offered are Wipro will be your partner and take care of your IT and
The modules and functionality are as foll. automation needs.
Advertorial
www.asianhhm.com 61
al
eci
Sp
IT
IN D IA
An
Optimistic
Outlook
Krishna Ganapathy
Co-founder
Telemedicine Society of India, India
In your experience, how has IT helped continue to make a significant differ- an end by itself. IT has improved patient
improve patient care, what are your ence in patient care. Whether it be in care in many, many ways. Providing real
expectations from it in the coming the field of diagnosis, investigations, time appropriate relevant information
years? treatment, documentation, retrieval of to every stakeholder in the healthcare
It was Rudyard Kipling who once information, access to state of the art industry makes all the difference. Well
remarked “What do they know of knowledge, medical instrumentation, informed patients and doctors can
England, who only England know”. In teaching, research etc IT has made a make a significant differences in the
the 21st century this aphorism could major difference. standard of healthcare. Rapid increase
be replaced thus “What do they know IT in healthcare will level the playing in computing power is accompanied
of healthcare who only medicine know”. field. It will bridge the gap between the by exponential reduction in costs.
21st Century is the age of informatics. haves and the have nots. In spite of Though the healthcare IT market in
Today’s doctor needs to be as well the obvious short term and long term India has grown 200—300 per cent
versed in the basics of Information benefits it is a matter of deep concern in the last 10 years, it is accepted that
Technology as he/she is in anatomy, that the use of IT in the healthcare the healthcare sector has to be more
physiology and pharmacology No man industry is far less than its use in bank- IT-oriented. Studies indicate that the
is an island unto himself. In the 21st ing, commerce, travel, automobile or use of IT in healthcare has enormous
century the physician or surgeon is almost any other industry. Less than 2 benefits—short term and long term for
only a member of a multi disciplinary per cent of gross revenues are set apart all stake holders, for e.g. a patient’s
healthcare team which necessarily must for deployment of ICT, compared to 5 hospital stay could be reduced by up to
include experts from various domains. to 8 per cent in most other industries. 39 per cent with improved use of IT.
Information Technology should neces- IT improves patient care, by enabling
sarily be an integral part of any modern processes and systems to be intro- Considering that a majority of Asian
healthcare system. Having been trained duced and repeatedly monitored. countries are still developing, do you
in the BC era (before Computers and Standard operating procedures and think Asia is ready for the rapid tech-
Before Christ are essentially one and audit processes can be introduced in nological changes shaping healthcare
the same!!). It has been my good almost every aspect of healthcare. globally?
fortune, to have witnessed the growth Viewing healthcare as an industry A major advantage that developing
and development of medical care in and attempting to achieve a sigma six countries in Asia have, with regards
the last 35 years in India including though improbable is not impossible. to being ready for the rapid techno-
the gradually increasing use of HIT. Using ICT should not be viewed as a logical changes shaping healthcare
It would be no exaggeration to state dehumanising process. IT should be globally, is the fact that they have no
that IT has made, is making and will viewed as a tool to achieve an end. Not colonial legacy to ‘disinherit’ in the field
of modern healthcare; for example, they the healthcare industry is considerably health information online. Microsoft also
do not have to ‘unwire’ to introduce lagging behind. continued with its strong strategic alli-
mHealth. One does not have to undo to ance plans to promote several of its
keep up with technology simply because How do you see the adoption of PHRs healthcare offerings. The development
e-Health is still not a reality. We do not and EMRs in Asia? Do you think Asian of a common strategy and roadmap
have to follow the advanced countries. hospitals are prepared to shift toward for e-health standards development,
We do not have to piggy back. We can the trend? to support interoperability and the
leap frog. The apparent lack of progress Universal adoption of Personal Health adoption of electronic patient records
in the field of healthcare during the last Records (PHRs) and Electronic Medical is crucial. One of the barriers in the
few decades is not a deterrent. It can Records (EMRs) is a challenging and adoption of international e-health
actually be viewed as an incentive so far daunting task even in the most advanced standards in hospitals, is the priority
as introduction of e-Health is concerned. countries. The very fact that we have given to internal process functionality.
We may not have achieved ‘health for all started talking about it in India is itself a Standardisation of data and processes
by 2000’ but the target e-health for all by good sign. It was Confucius who once across hospitals will go a long way in
2020 is not impossible. The exponential remarked “a journey of a thousand enforcing the use of PHR, EMR etc.
growth in mobile telephony and in ICT miles begins with the first step”. The A Hospital Information Management
in India clearly shows that we are more concept of Personal Health Records System (HIMS) should essentially inter-
than ready to embrace technology. While (PHR) continues to gather steam as connect all departments of the hospital
it is a matter of justifiable pride that e- several healthcare and insurance seamlessly and attempt to minimise
Governance is slowly being introduced providers established connectivity with operations on paper. No doubt it will
and that mBanking and mCommerce PHR platforms like Google Health and take a long, long time before PHRs and
has also commenced it is a matter of Microsoft HealthVault, which allows their EMRs become a reality in India, but it
deep concern that the use of ICT in members to access and store personal will certainly happen.
www.asianhhm.com 63
al
eci
Sp
IT
What are the areas of Healthcare two way audio video contact with a example, patients need to access their
IT that you think need to be further tertiary center. Virtual skills laboratories health records, get reminders and be
developed? where a large number of medical and advised by doctors even when mobile.
With the exponential increase in mobile surgical procedures are simulated on Data needs to be captured at source,
telephony and the imminent deploy- virtual patients are now a reality in whether from doctor’s written/spoken
ment of 3G, it is imperative that broad advanced countries. We need to have word or from equipment or even at
band wireless technology be exploited such learning centres. To achieve all patients’ home. On the output end,
and used to develop mHealth. While this, IT should be a part of the medical portable health information should be
mBanking, mCommerce, mEntertain- curriculum. Similarly, Applications of disseminated to patients’ families and
ment is becoming a reality we need IT in Healthcare should be taught to their general physicians.
to develop mHealth. Pilot studies all IT students. Many hospitals are committed
carried out by Apollo Telemedicine to the use of innovative technology.
Networking Foundation in conjunction Any other comments? Apollo Hospitals is working on a proj-
with Erricson in Tamil Nadu, Bhutan HIT strategy should be driven broadly ect with Tata Consultancy Services
and Bangladesh have shown that by business, clinical and societal that would give each of its patients
mHealth can be a reality in India. The requirements. Business needs are a Universal Hospital Identification
number of ‘Hospital on Wheels’ are around administrative work, finan- Number (UHIN), thereby providing
very few. This needs to be considerably cial and procurement. Clinical and access to the entire medical records
increased, with facilities for real time social needs are quite specific. For of the patient. The medical data will
UAE An Innovative
Transformation
John R Hawkins
Director
Information and Technology Services
Abu Dhabi Health Service Company (SEHA), UAE
In your experience, how has IT helped begin to drive population based disease
improve patient care, what are your management initiatives which will drive
expectations from it in the coming continuous healthcare improvements
years? for the citizens of Abu Dhabi. Last, I
Health Information Technologies are expect that social networking tools like
streamlining patient care and provid- Facebook will flourish to launch online
ing data to foster improved and communities focused around diseases
faster clinical decision making. The or conditions to improve patient aware-
SEHA ecosystem is implementing an ness and information sharing.
Electronic Medical Record which will
be seamless across 14 hospitals and Considering that a majority of Asian
65 clinics. Patient Data will be acces- countries are still developing, do you
sible throughout our ecosystem which think Asia is ready for the rapid tech-
will drive efficiencies and reduce dupli- nological changes shaping healthcare
cate procedures. I expect that HIT will globally?
continue to drive efficiencies at the Asia and the Middle East are uniquely
clinical level, and that researchers will positioned to harness and implement
64
64 A
Ass ian
ian H
Hoos
s pp ii tt a
a ll &
& H
H ea
ea lt
lt h
h ca
ca re
re M
Maan
naa ge
ge ment
ment ISSUe - 18
ISS Ue 2009
- 18 20 09
be stored for life. Any doctor anywhere performance indicators—patient deploy, Easy to use and Easy to pay”
in the world will be able to access services, clinical outcome and financial best describes the project. Revenue
the patient’s medical history using health of user companies. This will Management, Learning Management
the number. Apollo has been at the help the companies in creating satis- and CME, Performance Management,
forefront of technology adoption for fied patients and create knowledge including Decision Support and
healthcare in India. The complex issues for the community. Reduced process Knowledge Management, and Clinical
in healthcare arising due to non-adop- and process time will deliver enhanced Information Systems form the core of
tion of technology, in managing data, patient care, lowering operational the system
burgeoning manpower cost, quality costs. In the long term, HealthHiway While several pilot projects and
costs etc. and its impact has been will deliver a National Health Data proof of concept validation studies
understood. HealthHiway is an Apollo Network which will create an have been carried out, confirming how
Hospitals and industry initiative to interoperable, standards based IT in healthcare can make a significant
build and provide a comprehensive healthcare network that will enable difference, these need to be scaled
National Health Data Network ensur- the healthcare community to inter- up. A solution is not a solution unless
ing global best practices in healthcare act and share data in an efficient it is universally available. The time is
processes and solutions HealthHiway and secure environment, with the now ripe to go all out and make sure
will ensure efficiency in day to patient in the center of the universe. that in the next decade India will be in
day processes in a healthcare According to Ashvani who spearheads the forefront of e-Health. Improbable?
system, thereby impacting the key the HealthHiway initiative, “Easy to Perhaps. Imposible? No.
new technologies during this period initiatives are transforming healthcare EMR. Asian hospitals, and the commu-
of rapid growth and development. In in the UAE. nity are well prepared to shift towards
addition, these emerging markets can this trend.
learn from legacy markets to harvest the How do you see the adoption of PHRs
best of bread for hardware, software, and EMRs in Asia? Do you think Asian What are the areas of Healthcare IT
and communication tools. hospitals are prepared to shift toward (HIT) that you think need to be further
the trend? developed?
What is the scenario in United Arab There is a convergence of consumers, I am excited about extending the HIT
Emirates (UAE)? technologies, and providers that are footprint beyond the clinical walls and
Healthcare in the UAE is undergoing driving the adoption of PHRs and EMRs. into the patients home. This extension
innovative transformation to better meet Consumers are demanding PHRs to will be fueled by the development of
the needs of the current as well as the facilitate ownership of their healthcare, integrated technologies traditionally
anticipated population growth. Brand to become smarter consumers, and live found in the clinic, e.g. blood pressure,
new state-of-the-art hospitals are being healthier lives. Technology companies blood sugar or wound management
designed and built. Insurance reforms are providing the hardware, software, tools that are connected electronically
are shifting the healthcare economic security, and communication tools to to the PHR or EMR. Imagine a patient
risk from a government funded model to integrate disparate data elements to living in a digital home, where the blood
a more traditional managed care model. create the PHRs and EMRs. Providers, sugar is measured and tracked elec-
The UAE Health Authority (HAAD) is regardless of structure: government tronically which is correlated to the diet
defining health data standards to ensure funded, for-profit, or non-profit, are driv- and the exercise program all connected
that providers and insurers are reporting ing the deployment of EMR to foster electronically through components like
data consistently; HAAD is leveraging improved and more efficient clinical the smart refrigerator and work-out
this empirical data to drive popula- decision making. The convergence equipment. Extending the HIT foot-
tion based healthcare reforms and of these three vectors—the consum- print into the home will foster patients
healthy lifestyle initiatives. Hospitals ers who are demanding it, technology owning their own healthcare, to allow
are investing in new healthcare tech- companies who are supplying it, and patients to see the benefits of healthier
nologies, albeit, Software Based, or the providers who are leveraging it are lifestyle choices, and to avoid costly
Therapeutic based. These innovative all driving the adoption of the PHR and hospitalisations.
w
wwww
w .. aa ss ii aa nn hh hh m
m .. cc oo m
m 65
65
al
eci
Sp
IT
David W Bates
Chief
Division of General Internal
Medicine, Brigham and
Women’s Hospital, USA
www.asianhhm.com 67
al
eci
Sp
Banking on
IT
Market Demand
Gerard Anthony Dass
Leader
Healthcare Solutions, Nortel Asia, Australia
see a significant change. While we don’t seamless flow between all the solutions,
see this happening in the next one to we will see a significant time savings
two years, there are already forums in patient care.
and user groups that come together
to work out a common ground for all What could be the role of Internet in
solutions to co-exist and operate in an overcoming interoperability?
What is your take on the issue of interop- eco-system. More industry players are starting to
erability in healthcare IT? adopt web 2.0 in the healthcare industry.
I believe there is still a lot of room for How are vendors responding towards With Web 2.0 technology, the belief is
improvement for interoperability in this trend? that we will fix some of the issues that
healthcare. We still see issues in solu- The key challenge is cost. Vendors are are creating the current bottle neck with
tions that are not able to be integrated, taking steps to address this issue but healthcare applications.
which costs healthcare institutions a lot it’s moving at a slow pace.
of money to fix and causes delays to the Are the existing standards enough to
implementation of critical solutions. How is it affecting patient care? support healthcare data exchange?
As hospitals spend more money to fix I think the current standards need to
What is currently being done (in terms the issues of interoperability, the cost be reevaluated to take into account the
of regulations and standards) to over- is passed to the patients. We also see current technology trends in the health-
come this issue? delays with patients being discharged care market. This is already being looked
User groups have been formed around from a hospital or for a patient to get at and we hope to see some changes
the region to look into this issue, but with his/her medical records. Once there is a in the next 12 to 24 months.
so many vendors providing solutions
to the healthcare market, it will take
some time to see any change. The main New technologies, powered by unified communications, are also now being implemented
driver for change would be the cost of within healthcare, ensuring the right information is available at the right time, regardless of
location. A range of wireless communications are in already in use, such as mobile PDAs
customizing the solutions.
or tablets that allow practitioners to make bedside care decisions more quickly. When
equipped with mobile devices, they can connect with doctors or specialists at other loca-
What is the interoperability scenario tions for an immediate consultation or quickly access information from a facility’s digital
with respect to Asia? files without losing valuable time running back to the central nursing station on the floor.
In Asia, the problem with interoperability Doctors can also now share medical imaging files with distant colleagues for an
is the same as in North America and immediate second opinion and can receive real-time alerts wherever they are, from the
Europe. Healthcare institutions are still moment a patient’s condition worsens and needs attention.
faced with the challenges of integrating For example, Kyushu University Hospital in Japan upgraded its current IT system to
solutions. Hospitals are currently spend- a new medical service infrastructure to enable information to be more efficiently stored,
ing a lot of money to fix issues as we managed, retrieved and shared amongst physicians and medical staff. Built on the hospital’s
see with the NHS project in the UK. vision to offer patient-oriented, one-stop medical services, the new clinical grade next-gener-
ation network provides anywhere, anytime, quick access to information such as diagnosis
What, according to you, could be the data, X-ray and ultrasound imaging - and real-time readings of patient vital signs and operat-
ing theater monitoring. Real-time access to this important information creates an environ-
panacea to health IT systems interop-
ment for primary physicians, specialists and medical staff to collaborate more efficiently for
erability?
remote consultations, diagnosis and patient care. The network from Nortel is an example
I think if key stakeholders in the health- of how technology can improve quality healthcare services and patients’ quality of life by
care market demand something to be simplifying the complexity for medical providers to access and share information.
done, then the interoperability issue will
Adoption
in Asia Pacific
Challenges such as
W
e have seen the influence by the federal government. At present,
rising healthcare costs, of Information Technology the State of South Australia is developing
(IT) in many different Australia’s first fully integrated state-wide
demand for better sectors such as banking, finance and electronic health record system through
quality of healthcare, education but healthcare is one sector its careconnect.sa programme. In
increasing labour where the impact of IT has not been so Western Australia, eHealthWA is a major
shortage and fragmented conspicuous. Healthcare organisations reform programme designed to provide
healthcare system are have been slow adopters of IT solutions a modern and integrated platform of
in the past. However, they presently Information and Communications
making it imperative for aggressive in adopting IT solutions due Technology (ICT) for public health
healthcare organisation to various challenges to healthcare deliv- care services in the state.
to integrate IT solutions ery. In Asia Pacific (APAC), Singapore, Globally, countries are trying to
in their administrative Japan, South Korea and Australia have achieve an integrated healthcare delivery
and clinical workflow. been at the forefront of technology adop- structure in their quest to improve the
tion in the healthcare sector whereas quality of patient care. Singapore has
China, India, Malaysia and Thailand been successful in its progress towards
Sourabh Kankhar
Consulting Analyst
are the emerging markets. a well-integrated quality healthcare
Frost & Sullivan, Singapore service. This success can be attributed
Factors driving the adoption of HIT to the country’s focus on achieving
in Asia Pacific immediate HIT goals rather than holis-
Strong government support for HIT initiatives tic ones along with the recognition of
In Australia, the state and federal the importance of integrating IT into
government are supporting state-wide health system by the hospital admin-
and country-wide HIT initiatives. A few istrators and clinicians. In 2003, the
examples of such initiatives in the past country’s health minister identified the
are HealthSmart, a four-year technol- use of information technology as one
ogy programme in the state of Victoria of his priorities with the aim of ‘One
and HealthConnect, the nationwide Singaporean, One EMR.’ With the
electronic health records programme announcement of the Intelligent Nation
Impact of clinical IT solutions on the challenges to healthcare delivery
Challenges Clinical IT solution Outcome
Fragmented Integration
EHR, Telehealth
healthcare delivery of agencies
1999 - Restructuring
By2003 - Single EMR 2003 - NHG's project
of healthcare facilities 2004 - EMRX program Future - iN2015 plan
system in SingHealth Naut1cus
into two clusters
• SingHealth had a single • Government rolls out the EMR Exchange (EMRX)
EMR system for the entire cluster. initiative to share electronic medical records
• NHG institutions had different EMR across all the public hospitals and polyclinics.
systems linked through a Cluster • Plan to extend EMRX initiative to the private
Patient Record Sharing system. sector healthcare agencies in the future
Source: NBR Center for Health and Aging / NHG Annual reports Figure 1
2015 (iN2015) plan, the government Challenges to adoption in APAC especially in countries such as India,
has accentuated that HIT will always Under-investment in healthcare IT China and Australia. These systems lack
be a priority for them. In many APAC countries, there has been industry standards as well as pose a big
an under-investment in healthcare IT challenge in the integration with new
Challenges to healthcare delivery in the past. Even now, healthcare agen- modules. In Australia, the state health
drives investment in HIT cies in APAC are spending considerably departments are currently spending
Healthcare facilities are facing daunt- lower on IT initiatives as compared to millions of dollars in replacing these
ing challenges such as rising health- their counterparts in Europe and North legacy systems with solutions that are
care costs, demand for better quality America. In countries such as India based on industry standards.
of healthcare, increasing labour short- and China, the government funding
age and fragmented healthcare system. for healthcare IT initiatives is limited Conclusion
There will be a huge rise in demand and there has not been a strong push There has been a successful imple-
for healthcare services in the future from the government regarding HIT mentation and wide use of IT solu-
due to ageing of population, lifestyle initiatives. tions in administrative workflow of
changes and increasing incidence of Economic slowdown healthcare organisations in Japan,
chronic diseases. The present economic slowdown is Singapore, Australia and South. The
For example, Japan has the fastest bound to have an impact on the IT focus in these countries will now be on
ageing population in the world. Today, budgets of healthcare agencies in APAC. clinical IT solutions such as Electronic
one in five Japanese people are over the The Chief Information Officers (CIO) Medical Records (EMR), Electronic
age of 60. The population aged 60 years in majority of the hospitals will react Health Records (EHR) and decision
and above is estimated to be around 28 to the economic slowdown by cutting supports systems. Countries such as
per cent in 2025. From around 13 per down on their overall IT budgets. India and China will concentrate on
cent of the total population in 2006, Legacy systems the implementation of administrative
the population aged 65 years and over The lack of awareness of the right solutions. Clinical IT solutions will play
in Australia is projected to be around systems and limited budgets has led a major role in developing an efficient
28 per cent in 2056. Today, one out to the installation of legacy systems in and patient-centric healthcare delivery
of every 12 Singaporeans is aged 65 or many healthcare facilities in APAC, structure in the future.
above. By 2030, this ratio will become
one out of five.
A u t h o r
These challenges are making it Sourabh Kankhar is a Consulting Analyst with the Frost & Sullivan
imperative for healthcare providers to Asia Pacific Healthcare Practice. He focusses on monitoring and
analysing emerging trends, technologies and market dynamics in the
integrate IT solutions in their adminis-
Medical Technologies Group in Australia.
trative and clinical workflow to bridge
the gap between the demand and supply
for health services.
www.asianhhm.com 71
al
eci
Sp
IT
Future
the future, the professional
may be a robot. Historically,
technological changes have
come at a manageable
pace; today, the potential
danger is that a lot of
new technologies are
emerging very quickly.
We, therefore, need to
look forward to what may
happen in order to be better
prepared for the future.
w
wwww
w .. aa ss ii aa nn hh hh m
m .. cc oo m
m 73
73
al
eci
Sp
IT
how visual and audible conditions have and social / business impacts. He writes the BT technology timeline,
which lists possible technology changes and their impact. Currently
changed over time. Instead of subjective he is working on an area dubbed the ‘Internet of Things’ within BTs
measurements, it would be possible to foresight team and working on his doctorate.
see (or hear) how a treatment is actually
working.
www.asianhhm.com 75
al
eci
Sp
IT
Enhancing
self-management of
chronic
low back pain
Role of a patient-centred website
C
hronic pain can have a profound general knowledge of back pain and the kind of knowledge technically labelled
impact on sufferers’ lives, and application of this knowledge to amelio- declarative. This is the ‘knowledge of
it is often associated with a loss rate the individual’s condition. the what’ that patients have or develop
of confidence and self-esteem. While Between June 2006 and October when they hear / read and understand
the majority of cases of low back pain is 2008 the Institute of Communication certain medical-related statements, e.g.
self-limiting and resolve on their own, and Health of the University of Lugano diagnoses, explanations of what certain
the risk of recurrence and development conducted a project to explore to what conditions are and of what the benefits
of chronic disease is significant. extent an interactive website, that / side effects of treatments and drugs
The Internet is praised in the provides tailored information to patients are. On the second level, another type
literature for its potential of enhanc- affected by chronic low back pain, is a of knowledge plays a key role in the
ing patients’ coping with conditions. proper response to enhance their self- development of health literacy, namely
Yet online websites on back pain are for management of this condition. procedural knowledge. This term refers to
the most part affected by a main limita- The conceptual framework behind the ‘knowledge of the how’. Procedural
tion: Due to their mainly informative ONESELF is based on the notion of knowledge is knowledge directly applied
nature, websites provide generic advice health literacy. Most recently health to a task, e.g. to treat a certain disease. It
that often does not spark users’ interest literacy—as the cognitive and social skills tends to be less general than declarative
and does not meet their expectations. which determine the ability of individu- knowledge and results in the ability of
The comprehensiveness of generic als to gain access to, understand and doing specific activities, e.g. to follow
material is based on the assumption use information in ways which promote a certain treatment, to take a certain
that, as people have different informa- and maintain good health—has been drug or to do a specific exercise. Above
tional needs, individuals will select the given increasing attention in attempts these two types of knowledge, health
content that is relevant to them and to understand people’s health promot- literacy includes, on a third level, a set
sift out what does not apply to them. ing capacities. Patients’ health literacy of skills derived from patients’ ability to
Despite the avalanche of advice on how is a competence that integrates factors integrate their knowledge and all sorts
to prevent or manage low back pain, working at three main levels. On the first of information received in the context
there exists an information gap between level, health literacy is made up of the of their own existence and goals.
Sara Rubinelli
Senior Researcher
Maria Caiata Zufferey
Senior Researcher
Peter J Schulz
Director
Institute of Communication and Health
University of Lugano, Switzerland
www.asianhhm.com 77
al
eci
Sp
IT
in majority ONESELF’s contribution Development of self-confidence: ONESELF for the consultation on more urgent
to managing their back pain: 12 per helped people to acquire confidence in matters; second, ONESELF could help
cent said the site had contributed much, their ability to manage cLBP. Some users screening requests from patients that
and 57 per cent said it had contrib- felt reassured because they had a trust- do not need face-to-face encounters
uted sufficiently to managing pain. worthy place where they could address to be answered.
The next most frequently acknowl- concerns. Overall, the conceptual model
edged benefits were improvement of From the point of view of the health of ONESELF proves its potential
communication with doctors (56 per professionals’ daily practice, the project in improving techniques of self-care
cent) and family and colleagues (55 ONESELF appeared to be succesful through new technologies. Effective
per cent). A majority of users (55 per in the creation of a bridge between self-management of chronic low back
cent) also reported that their search clinic-based methods for treating back pain can reduce healthcare costs and
for information had decreased (includ- pain and the humanistic approach from increase worker productivity because
ing decidedly decreased) as far as other communication sciences. There were of fewer work-related absences. Beyond
websites are concerned, and 45 per cent several difficulties linked to the amount the simple financial savings, ONESELF
reported the same of other sources of of time that health professionals can has the potential of improving substan-
information. Roughly one in three users devote to projects of medical websites. tially the quality of life of patients
reported they exercised more (including ONESELF has minimised the risk of who suffer from back pain and from
decidedly more) since starting to use overloading health professionals by chronic conditions that require similar
ONESELF, while just 2 per cent said sub-dividing their tasks and schedul- management.
they exercised less since then. ing exactly when each of them had to The authors wish to thank the
Results from the qualitative study enter the website and answer patients’ National Research Programme NRP 53
highlight additional information on the requests. Despite their initial concerns, ‘Musculoskeletal Health – Chronic Pain’
way patients used the website. The partic- the health professionals involved in of the Swiss National Science Foundation
ipants mentioned several positive effects this project became more and more for the financial support of this study
of the use of the website on attitudes and interested in conducting online inter- (project 405340–104841/1), as well as
behaviours related to self-management. actions with users. From the point of the Lega Ticinese per la Lotta contro
In the following section we reported the view of their daily practice, ONESELF il Reumatismo, which has enabled its
main effects recorded, namely: has helped them in at least two ways: feasibility.
Self-comprehension: The interviewed First, by referring patients to ONESELF
sample considered ONESELF very for general background, health profes- References are available at
useful to build an individualised under- sionals could focus the time at disposal http://www.asianhhm.com/magazine
standing of their situation: the richness
and trustworthiness of the information,
the possibility to interact with health
professionals to obtain specific answers Sara Rubinelli holds a PhD from the University of Leeds (UK) in the
and the stability of the material helped areas of ancient logic, argumentation theory and rhetoric. She is a
them to construct their personal frame Senior Researcher at the Institute of Communication and Health of
the University of Lugano (CH), where she collaborates in national and
of reference about the nature and the international research projects in the field of health.
course of their cLBP.
Improvement of argumentative abilities:
A u t h o r
ONESELF helped people in learning Maria Caiata Zufferey holds a PhD in social science from the
how to speak about their health condi- University of Friburg (CH). She is currently Senior Researcher at the
Institute of Communication and Health of the University of Lugano
tion. Users could improve their capacity (CH). She currently works, on a qualitative basis, on doctor-patient
to frame and explain their situation in a communication in the information era.
way that people—and especially health
professionals—could comprehend and
Peter J Schulz is a Professor of Semiotics and Health Communication
assess correctly.
at the School of Communication Sciences and Director of the Institute
Orientation: ONESELF provided of Communication and Health of the University of Lugano (CH).
users with basic information on how He currently holds several project grants from the Swiss National
Science Foundation in the area of health communication.
to behave towards cLBP. For example,
people could learn new exercises or
brush up on old ones.
I
n a nation like India, where population multiplies in eMedReport has launched an integrated web based
leaps and bounds, delivery of healthcare involves solution eMedReport.com. This cost effective and
numerous challenges and barriers. This is not feature-rich solution ensures flawless communication
just because of the lack of infrastructure and skilled among all the healthcare providers and patients for
resources but also because of the unavailability of the exchange of health information.
patient’s medical records to provide the right treatment The solution ensures unlimited and secured storage
at the right time. Though, India being a strong and of patient’s health records, along with other benefits
preferred destination in Information Technology, the such as sending prescriptions to pharmacies and test
penetration of IT into healthcare sector is much below requests to pathological labs and diagnostic centers.
the supposed mark. Whereas in countries like Australia, Patients can create a free health account which would
Canada, US and many European countries, most of the help them access their health records, prescriptions, test
hospitals and group-practitioners are using integrated reports and radiological images “Anywhere-Anytime”.
healthcare solutions like Hospital Information Systems Patients can also search for doctors in a specific area
(HIS), Electronic Medical Records (EMR), Electronic and request appointments which would save time and
Health Records (EHR) etc. to substantially reduce money to a large extent. All the above features ensure
medical errors and treatment costs besides focusing on that the patient gets the right treatment at the right time-
the quality of healthcare delivered to the patients. All this happens with a single click at eMedReport.com
Doctors can manage their calendar, view patient
Reasons for lagging behind appointments, previous health records, review notes,
Although there are numerous benefits associated when prescriptions and test reports which would help them in
adopted to healthcare IT systems, the acceptance rate providing a better patient care. In addition, doctors can
is not high in the Indian healthcare sector both in the also refer a patient to other doctor for a second opinion
public and private sectors. There are many reasons for with all the previous health records of the patient. All
slow adoption rates, but the major reasons include, the this critical information is stored in a secured doctor’s
bare minimum spending by hospitals, lack of technical account that no one else has access to.
expertise and lack of common standards. Apart from eMedReport also offers SMS alerts and system
the above, the lack of awareness about the benefits reminders to patients, doctors and other healthcare
associated in adapting to these systems both among providers about appointments, prescriptions, test
the healthcare providers and people is also one of the requests and test reports.
important reasons. eMedReport offers inexpensive subscriptions for the
web solution for a period of 3 months, 6 months and 1
Need for a unique solution year.
Realizing the fact that Internet along with recent
innovations in open source technologies can be For more information
combined to deliver a cost effective comprehensive Please logon to www.emedreport.com or
healthcare solution, the Hyderabad based company send an email to info@emedireport.com
Advertorial
www.asianhhm.com 79
al
eci
Sp
IT
Benchmarking
and Accrediting in
Health Informatics
Driving up quality and reducing risk
I
Quality assurance and nformation has always been at the In an increasingly litigious world,
heart of healthcare delivery. Today, is this an issue healthcare delivery
continuous development new information systems and tech- organisations can continue to
of health information and nologies are becoming ubiquitous in ignore?
IT services in healthcare health and give rise to new opportu- Further, commercial pressures, whether
is a key patient safety and nities and challenges to the ways care in State—funded healthcare services
business issue. A part of is delivered and the way professionals which exists in the UK or private or
work. Information sharing between insurance-based services (or indeed
this is the need to assure professionals, care providers and sectors; a mixed health economy)—have an
the professionalism of and patient access to and management obligation to deliver best value, high
individual practitioners of their own records are driving changes quality services that demonstrably use
as well as the services in inter-professional relationships and accepted standards and be committed to
themselves. care delivery processes. the principles of continuous improve-
So, information and information ment. Commissioners of services want
systems underpinned by technology are to know they are buying a quality, value
Di Millen
Head
increasingly impacting directly on patient for money service; and service deliverers
Informatics Development experiences of healthcare delivery and want a competitive edge in an increas-
NHS Connecting for Health, UK on their treatment and on the outcomes ingly pressured free market.
of their care. There is, as a result, an In England, a further driver in the
increasingly vocal group of profession- push for benchmarking and accreditation
als in health who would argue that if of both informatics practitioners and
information, information systems and services and teams has been a continuing
IT can positively impact upon patient concern that recruitment and retention
care, then the converse must also be true. in informatics in health is problematic
The UK Council for Health Informatics and that we just don’t have access to
Professions (UKCHIP) has collected a the right people with the right skills.
catalogue of examples of healthcare When we find and appoint staff, the
delivery failures where information and employment package is not sufficiently
IT systems are implicated in errors and attractive to retain the best. Whilst there
even loss of life. is a perception that pay is not as high
Our information and IT systems, in the public sector as it might be in
therefore, need to be safe; and the profes- the private sector, it is actually lack of
sionals—individuals and teams, who status and lack of opportunities for career
design, implement, support, manage progression that drive staff out into the
and develop these systems must also more lucrative private sector.
be assured, as far as possible, as safe The adoption of standards and
to practice. the accreditation of people and
www.asianhhm.com 81
al
eci
Sp
IT
Str long
at e t e
duplication is essential.
gic rm
Four critical
Checking out what standards,
ing suc
success factors
red ces
measures and metrics already exist will •Leadership
ien s
•Governance
not only save time and ensure appro-
ts f
•Strategic development plan
or
priate links and connections are made •Long term resource framework
with other complementary schemes; but
will make the task of scheme members
less burdensome. If an organisation Balanced scorecard for
Tac of p
already has been through a process of effective informatics services
tica rior
Delivery of services
l ev itie
accreditation to, for example, ISO 9000, Meeting user expectations
alu s
any accreditation scheme comprising Benefitting care delivery
atio
Positive effect on informatics staff
n
a comparable standard should accept
a statement of compliance (to be
supported by evidence if required) as Functional descriptions for each IM&T service component
Op eckpo
ch
Best practice service delivery models
era in
sufficient for its purpose. Reference to Options for deployment and management
tion ts
existing standards either as guides to Potential for standardisation and critical mass
al
Benchmarks and success criteria
good practice or as required evidence
of quality should be built into a scheme
Figure 1
and references to sources of information
and support be made available within
the scheme. information management and training In the English NHS, a Health
Measures and metrics should also be and development) to those delivering Informatics Service Benchmarking
both clearly defined and meaningful to just some of the possible elements of Club has been established with support
stakeholders. In designing any assessment service. from NHS Connecting for Health but
tool, stakeholders—service providers owned and managed by the constituent
and service purchasers / commission- Conclusion members (over 100 services have joined
ers—should be involved and the tool Quality improvement and value for the Club at the time of writing). The
tested in a robust way to ensure sense, money, together with large scale invest- next phase of the development, during
appropriate use of language and ease ment in health informatics systems, are early 2009 will be to appraise a number
of use. A simple glossary to help define at the heart of the need to ensure effec- of modes and models of accreditation
terms might help avoid misunderstand- tive, efficient and safe health informat- already in existence and to consult
ings and a loss of credibility for the ics services available to support clinical service commissioners and providers
scheme and its content further down professionals twenty-four hours a day, on the business benefits and merits of
the line; as will testing and piloting in seven days a week, 52 weeks of the year. a national accreditation scheme. If such
a cross section of organisation types and The accreditation of individual practi- scheme is supported and there is opti-
environments. tioners, teams and services to agreed mism that this will be the case a service
A high level description of the tool national / international standards are provider will be procured during 2009
developed in England is provided below. themselves at the core of service improve- with a view to the scheme becoming
Behind the framework is an online tool ment goals. live in 2010.
comprising 300+ measures and metrics.
It started life as a complex and macro-
A u t h o r
rich MS Excel spreadsheet and is in the Di Millen has worked in the area of informatics education, training
final stages (early 2009) of conversion and development and workforce and service development for more
that fifteen years at local, regional and national levels.
into a web-based tool flexible enough to
support the assessment of services and
teams, from those delivering the full
range of informatics services (including
Patient Proxies in
Decision-Making
What computers can't capture
www.asianhhm.com 85
al
eci
Sp
IT
of improved health.
Understanding
Healthcare Information
Product Description of different user groups, including
In an age of internet resource guides, healthcare professionals and consumers
which suffer from the malaise of being and goes on to highlight areas of research
outdated before they are published, this into healthcare information, including
book addresses the information chain evaluation studies, user studies, impact,
in its entirety, providing a timeless way bibliometrics, metadata and web 2.0. This
of understanding healthcare information title features themes such as: healthcare
resources. The book takes a holistic information background, nature and
approach in its consideration of healthcare drivers for change; healthcare information
information with the aim of building an resources, users and services; and,
overall understanding of healthcare healthcare information research. This book
information within the information society. would be of interest to anyone working
Author: Lyn Robinson The contents cover the domain of in the field of library and information
Pages: 256 healthcare information; its organisational science wishing to understand healthcare
Year of Publication: 2009 structures and history, and the nature of information, especially public librarians,
its resources and the factors affecting who are increasingly called on to advise
them. It looks at examples of healthcare on health resources, as well as anyone
information resources from the perspective interested in ‘healthcare literacy’.
e-Business in Healthcare
From eProcurement to Supply Chain
Management
Product Description by the contributions of international
eProcurement in Healthcare is a book experts and their particular views on
that aggregates 5 years of experience eProcurement, which gives the book a
of three successive R and D projects global perspective and hence allows its
(ELCH, GetTogether, GROPIS) covering readers to learn from a variety of different
technical and organizational issues of approaches. Each chapter of the book
eProcurement. The projects, which were is structured in a way that satisfies the
funded partly by the government and needs of executives as well as academics.
partly by industry and hospitals, looked A management summary, tables and
at the characteristics of procurement graphics together with key statements of
processes and at standard technologies. experts allow the quick reader to capture
Authors:
Two of the projects included case studies the main message of each chapter,
D Karagiannis
(ELCH, GROPIS), the third project whereas background information and
N LeMaster
focused on the development of standard reference to the literature address readers
Ursula Hübner
business objects for eProcurement in who wish to gain a deeper and more
Marc A Elmhorst
healthcare (GetTogether). Together they comprehensive insight into the field. The
Pages: 328 pages
form a rich source of information worth management summary and the expert
Year of Publication: 2007
communicating to a large audience of statements will appear in boxes separated
experts and newcomers alike. Results from the main text by visual cues, e.g.
from the projects are supplemented background color, font size, font type.
www.asianhhm.com 87
al
eci
Sp
IT
www.asianhhm.com 89
al
eci
Sp
IT
Integration Services
Vendors
Market Engineering $ 396.4 million Growth Rates $697.71 Distribution Structure
Measurements (2005) Million • Sales Subsidiaries and Independent
(2010)
Distributors, Partnerships
Market Metrics
2008
Highlights Featured Applying Path Innovation
Healthcare IT Seeking revolutionary HIT
articles Healthcare requires a revolution in the way
we deliver care by utilising IT in new and
innovative ways. Path innovation allows
experts to work together in the develop-
ment of workflows that best leverage HIT.
Semantic Web and Patient Records Online Barry P Chaiken, Fellow of HIMSS, USA
90
90 A
Ass ian
ian H
Hoos
s pp ii tt a
a ll &
& H
H ea
ea lt
lt h
h ca
ca re
re M
Maan
naa ge
ge ment
ment ISSUe - 18
ISS Ue 2009
- 18 20 09
Industry
reports
Commoditising Healthcare IT
The next wave
With the costs of healthcare rapidly increasing, the monolithic model of
HIT is no longer sustainable. HIT commodity capability that provides a
new level of convenience and serviceability to the healthcare environ-
ment while being cost-effective.
Werner van Huffel, Health and Social Services, Industry Strategist
Regional Public Sector Group, Microsoft Asia Pacific, Singapore
w
wwww
w .. aa ss ii aa nn hh hh m
m .. cc oo m
m 91
91
al
eci
Sp
Microsoft and HIMSS launch
IT
draft Microsoft HUG comprises more than 5,000 members and 31 corpo-
rate supporters across North America.
The Health Level Seven (HL7) Personal Health Record
System Functional Model (PHR-S FM) is available as a
draft standard. It has been made available for download Intel introduces Health Guide
as a trial use. The PHR-S FM allows global users to Intel introduced a new device, Intel Health Guide in a series of health
work with a stable standard for up to two years while monitoring devices aimed at tracking chronic and age-related conditions.
it is being refined into an American National Standards The technology offers interactive tools for personalised care management
Institute-accredited version. and includes vital sign collection, patient reminders, surveys, multimedia
The PHR-S FM defines the set of functions that educational content and feedback and communications tools such as
may be present in PHR systems to create and manage video conferencing and alerts.
an effective PHR. It also offers guidelines that facilitate The Intel Health Guide combines an in-home patient device with an on-
health information exchange among different PHR line interface—the Intel Health Care Management Suite—making it possible
systems and between PHR and EHR systems. for clinicians to monitor patients in their homes and manage care remotely.
PHENIXVISION
PhenixVision is a company with a conscience and a soul. Our exist- • It improves diagnostic utility as well as the properties of soft and
ence is governed by our belief in these core values. PhenixVision hard tissues
provides the software solution like the lifeblood of digital radiography • It provides the ability to reduce noise and unwanted background
system. Its products and services have always been designed to that may affect the visualization quality of digital radiograph.
meet the needs of enterprises and consumers alike. PhenixVision DXView, an optimized and easy-to-use operating workstation,
has been focused like a laser on high quality, high speed, high cost- fully conforms to international standard protocols, and the acquired
efficiency of Digital Radiography system. digital images are immediately sent to PACS network, or laser cam-
PhenixVision established FUMA as an image processing tool era for film printing:
and DXView as an operating workstation for various kinds of digital • Its workflow, in conjunction with digital x-ray control interface and
radiography systems based upon amorphous-silicon, amorphous- elegant graphical-user-interface, assures maximum diagnostic
selenium, and CCD, and linear scan detector, etc. PhenixVision is flexibility and increased patient throughput
composed of experts with many experiences in medical imaging • It supports full integration of digital radiography system
field. Since its inception in 2001, as a global digital radiography solu- • Synchronization of the timing between the detector and x-ray
tion provider, PhenixVision has provided the products and services of equipment
unparalleled quality which can accommodate a wide variety of needs • Digital control interface of various x-ray generator.
in a dynamic environment. PhenixVision’s customers are now satisfying their customers
FUMA is the PhenixVision’s unique software technique which in- completely. It is very encouraging for all of us.
corporates the fuzzy concept into the image enhancement method:
• It creates homogeneous image (pre-processing)
• It provides an important step to aid a physician in visualizing detail For more companies,
and structure of the lesions visit www.hospitals-management.com
www.asianhhm.com 93
2008
Highlights featured
non-healthcare it
articles
94 For
A smore
ian H technology
o s p i t a l & Htrends,
ea lt h cavisit
re M knowledge
a n a ge mentbank ofUewww.asianhhm.com
ISS - 18 20 09
Global Health Landscape
Healthcare “beyond borders”
At a time when the global citizen is transforming how healthcare
is delivered worldwide, there’s a need for a vision for delivering
coordinated, high-quality and affordable care “beyond borders.”
Ori Karev, CEO, UnitedHealth International, USA
Digital Ward
Hospital of the future
Imagine a future where hospital wards have no paper case
notes or files. Information on a Patient’s medical condition is
automatically captured via intelligent context-aware devices and
sent directly to the central computer systems.
Noah Tay Chin Seng, Manager
Telemonitoring in Fong Choon Khin, Group Chief Technology Officer
w
wwww
w .. aa ss ii aa nn hh hh m
m .. cc oo m
m 95
95
96 A s ian H o s p i t a l & H ea lt h ca re M a n a ge ment ISS Ue - 18 20 09
HEALTHcare
projects
March
events February 24, 2009
Reducing Medication Errors 2009 March 10 - 12, 2009
Venue: Manchester Conference The 5th Annual World Health
Centre, Manchester, UK Care Congress - Europe
Organiser: Healthcare Events Venue: Berlin, Germany
Email: matt@healthcare-events.co.uk Organiser: World Congress April
www.healthcare-events.co.uk/conf/ Email: indsay.pater@worldcongress.com
February booking.php?action=home&id=240 www.worldcongress.com
April 1-3, 2009
13th Southeast Asian Healthcare
February 12- 13, 2009 February 26 – 27, 2009 March 11-13, 2009 & Pharma Show 2009
Chronic Heart Failure and Hypertension Hospital Management 5th Health Asia 2009 Venue: Kuala Lumpur, Malaysia
Venue: Institute of Physics, London Sydney Harbour Marriott Venue: Karachi Expo Centre, Pakistan Organiser: ABC Exhibitions
London, United Kingdom Sydney, NSW, Australia Organiser: Ecommerce Gateway Email: sales@abcex.com
Organiser: MA Healthcare Ltd Organiser: Informa Pakistan (Pvt.) Ltd www.abcex.com
Email: lisa.f@markallengroup.com Email: info@iir.com.au Email: info@health-asia.com
www.mahealthcareevents.co.uk April 16 - 19
www.iir.com.au/bedmanagement www.health-asia.com The 6th Annual World
Health Care Congress
Venue: Washington DC, USA
Organisers: World Health Congress
February 21 - 23, 2009 March 14-16, 2009 Email: amy.wilder@worldcongress.com
Meditec-Clinika 2009 HOSPIMedica India 2009 www.worldcongress.com/events/
Venue: Hitex Convention Centre, Venue: Bombay Exhibition Center HR09000/index.cfm?confCode=HR09000
Hyderabad, Andhra Pradesh, India Goregaon, New Delhi, India
Organisers: Orbitz Exhibitions Pvt. Ltd. Organiser: Messe Dusseldorf India For more events,
Email: sksingh@meditec-clinika.com Email: UllalS@md-india.com visit www.hospitals-management.com
www.meditec-clinika.com www.hospimedica-india.com and www.asianhhm.com
www.asianhhm.com 97
Company Page No.
Products&Services
Classifieds Diagnostics
Inverness Medical Innovations, Inc.............................................5
Greiner Bio-One GmbH.............................................................41
Facilities & Operations Management
Ratcliff Architects . ..................................................................47
Robinsons Global Logistics......................................................49
Healthcare Management
Aavanor Systems Pvt. Ltd........................................................67
International Business Conferences .........................................15
Inverness Medical Innovations, Inc. ...........................................5
Information Technology
Aavanor Systems Pvt. Ltd........................................................67
Acuity Information Systems Private Limited........................... OBC
Binary Spectrum .....................................................................84
Elekta Limited .........................................................................27
Plus ninety one .......................................................................19
Wipro HealthCare IT Limited.....................................................57
Medical Sciences
Elekta Limited .........................................................................27
Shimadzu (Asia Pacific) Pte Ltd . .............................................45
Surgical Speciality
Rx Professions is offering end-to-end Staffing Solutions Shimadzu (Asia Pacific) Pte Ltd . .............................................45
for major Corporate Hospitals, Pharma & CRO industries
in India and Overseas for top-level, middle and entry-level Technology, Equipment & Devices
positions. Electrolux Professional SpA ....................................................IFC
Hitachi Medical Systems (S) Pte Ltd....................................... IBC
Services include short-listing and conducting first Inverness Medical Innovations, Inc ............................................5
round of interviews via our pool of vast database & HR Shimadzu (Asia Pacific) Pte Ltd . .............................................45
Management.