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© (E) Smooth endoplasms reticulum Explanation “Tho coect answars:(E ) Smooth endoplasmic revcu “Tho smooth endoplasmic oculum (SER) vor activo phase | an phase I datosfcaton acts, Phaso|veactons crease to wa soll of ipephiicmelecls by headin of polar groups via the clecirome Pa8 systom. Tho SER is alse response for sythosis of Phospholipids, poprotans, and tris, [Answer A: Th Golj apparatus responsible or posttansatonal modifications of press [Answer B: Lysosomes engage in enzymatic deqradatoncfmacromcleciles| [Answer C: Ncchondia fncton ATP sess end contain enzymes of the cytochrome PASO system thal are invlved nosifatve posphorysion| [AnawerD: The ough endoplasmic ratclum covered wth ribosomes (making appear rough) ands larga involved in prtainsythoss ottom Line: Cytochrome PASO enzymes tha are involved in detofestonreacons are loca an the cyopisnic side of th membrane of the smoot endoplasmic tcl, ‘Step 1 insight: C20 bokgyauestons 2 ony asked on the USHLE ine cone of dese. Ova, studying cel togy Bra soa ow yee. For mero infoaton, seo wn upstate com Drugs and the ver Metabo and mechani of uy” section on “CYP acy ae 12a (Oy) FIBRE T meetin © (E) Inceasod caste acy Snow / Hide Explanation Explanation “The cotect answers (E )nceased elastase actty “This patent oly has aba antoysin dation. So prosonts wih dyspnea and has ay changes and pulronary futon studies hat ro -supgestvo of emysera So dos ot smoko and as a postive tay stro ung season makes the agnosis of alga ‘anttypsn dtclency they Bocause alpha antitypsin fib elastase, patents wi algha 1 andtypsndoficency have incoased lastaso ‘2ctly Lung and ox manvfestatons ar conmon. Patents can prose wit symptoms of mse a young age and wih minal {Spare axpesurs Patents algo a nceasod sk of Wor ethos and apace carrera ‘Anawer A: Deloctin ype | olagon is ssn in osteegeness mperlect, Paton equonty break bones and have blue sca [Anawer B: This patents isease de fo inceasod thor han decrased, elastase acy [Answer C: Adele te dynein am of cia is See in Kartagene'ssndtome. Paes have frequent epsodes of siusts and brenchcass ie fe mmetie cla Hyperinfated unos 5 na a fear [AnawerD: Marfa’: sydome de 10 a deectn elt cvs oa maton fo he fin gone, Patents are usualy al win ng eters Patni teat creas rc compuestens suchas dsten of he pra sara or ore dssecton ‘otom Line: Ape tantypsin deficiency con cause amphysems, ver cirhosis, and hepatcalula carcinoma duo fo unagposod elastase ctv For more infomaon, see wn ytodse com “nce mentestations, dagnoss, and natal nisry of he-tentvysn decency” (E) ition of pyruvate kinase ‘Show 1 Hite Explanaton Explanation ‘Tho coroct answor (Dj Imnbiton oho ection transport chan This patont's symptoms aro consistent wih cyanide pasonng, Koy fom inhalation of gases ofa burning cx. Cyanide nbs th elocvon transport chan nthe mohondia, preventing exkave posphorylaion, Tho cola oly able to uso gels to produco ATP which leads insoased te actos Pabints can have symptoms of aod nal lus, new onse seizures, Hepat faze, and habdomyatss loading 16 roa fare Ear tho couse, patents have fushod kin wih tachycardia, achypnea, and Pyperinsen Later patnls may havo cyanoss, brayearia,bradypnea, arc hypotension Hyoxccobalznin can be used er wean [Anawer A: Fars disease is a disease caused by deficiency of spha-gsscosdase A leading o accumulation of ceamide teste -Anawer 8: Bele gucocerebrosdasedefcency = seen n Gaucher's daca Patents have symptoms de to reseed accumulation a sjucscerbrosde ‘Answer C: Warn, which is foundin some rst posors, causes impsred sythesis of facto il, hich leas to ncresed sk of teeing ‘Answer E: Asenic polsoning leds notion of yrs Knsse, Pats Oa present wth symptoms of vomng, ce-waer anes, and Denner neuropany Bottom Line: Cyanide tbs te lection transport chain in rochonda, and exposure can fsa lore ental tas, seizes, and Carcpumonary are. For mre infomation 69 wa uptodate com Cyan ptsoning”

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