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Adverse Drug Effects

Introduction-Classification-Categorization

Concept & Idea by- Solution Pharmacy

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Drug/ Medicine Adverse Effect
Drug is a chemical moiety (either natural or synthetic) Any effect produced by the drug which is not
which is used for the prevention, diagnosis and Disease expected or not desired and unintended is called
treatment of any disease or disorder. Disease is caused Disorder adverse drug effects. It is one of the broad definitions
by microorganism mainly and disorders And Disorders which cover many subtypes from simple to serious
are result of imbalance of various biochemicals within effects.
body itself.
Diagnosis

Treatment

Drug/Medicine

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Desirable Effects Undesirable Effects

Desirable effect means all those effect produced by All those effect given by drug which is not good
drug which we are expecting and willing to get. for us and it may cause simple to dangerous
effect.
Example
Paracetamol, Nimesulide, Ibuprofen, Aspirin,
Indomethacin Aspirin
Different Categories

Predicted Unpredicted
NSAIDS Type A or Augmented Side Effects Type B or Bizarre
Rashes, Etching
Non Steroidal Anti-inflammatory Drugs
Secondary Effects
Suspension of bacterial flora

Analgesic Effect Toxic Effects- Poisoning

Reduce pain by inhibiting PG synthesis Intolerance

and increasing pain threshold potential.

Antipyretic Effect Drug Allergy- Humoral & Cell Mediated

Photosensitivity- Phototoxic and Photo allergic

Reduce fever by controlling thermoregulatory center in brain
Drug Dependence
Physiological-Physical-Drug Abuse-Drug Addiction-Drug Habituation

Anti-Inflammatory Effects
Drug Withdrawal reaction- Alcohol and LSD

Reduce inflammation by inhibiting COX-I and COX- Teratogenicity- Thalidomide

II
Mutagenisity or Carcinogenicity

Drug Induced Disease- Peptic Ulcer by NSAIDS

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