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Lecture #1
יסודות תכן ביו-חשמלי 3.5- 334011נקודות זיקוי
מרצה :פרופסור ראמז דאניאל
בניין אמרסון קומה 7
שעות קבלה:לפי תיאום מראש
ramizda@bm.technion.ac.il
אתר הקורס:
מקצועות קדם :תורת המעגלים החשמליים
מקצועות מקביל :אותות ומערכות
חומרי לימוד:
• Medical Instrumentation Application and Design, 4th Edition, John G. Webster 2009
• Foundations of Analog and Digital Electronic Circuits, 1st Edition, Agarwal & Lang
• Physics of Semiconductor Devices by S.M. Sze
נקודות זיקוי3.5- 334011 חשמלי-יסודות תכן ביו
Syllabus:
1. General introduction
2. Introduction to semiconductor
3. PN Junction
4. Diode Devices
5. MOS capacitor
6. MOS Transistor
7. Circuits - Small signal analysis Analog
7. Circuits – MOSFET amplifier Design
8. Circuits - MOSFET advanced
9. Differential amplifier
10.Negative feedback
Digital
11.Digital circuits Design
Why should we study electronic devices and circuits
Ultrasound
Electrocardiogram
potential (EKG)
Why should we study electronic devices and circuits
Simply it is the best way to measure and display biological signals
Frequency Response
Every signal can be represented
as a Sum of periodic signals with
different frequency and
amplitude (linear operation).
The amplitude value is Fourier
Transform
Analog and Digital
Sampling the analog signal (fs ≥BW)
Computation and signal processing in computers are often digital discrete in time
Biosenors
Transfer function
of sensor
Biosenors
Linearization - Small Signal Analysis
𝑉=𝑓 𝑥
𝑑𝑓
∆𝑣 = ∙ ∆𝑋
𝑑𝑥 𝑋𝐷
For example:
𝑉 = 𝑉0 𝑒 𝑥/𝑋0
1
∆𝑉 = 𝑉0 𝑒 𝑋𝐷 /𝑋0 ∙ ∆𝑋
𝑋0
∆𝑉 𝑉𝐷
𝑆𝑙𝑜𝑝𝑒 = =
∆𝑋 𝑋0
Biosenors
First Order Biosensor:
𝐼𝐵 = 𝐼𝑅 + 𝐼𝐶
𝐼𝐵 = 𝑓 𝑥
𝑑𝑉 𝑉 𝑉 𝑡 = 𝜏 = 𝐼𝐵 ∙ 𝑅 1 − 𝑒 −1 = 0.63𝐼𝐵 ∙ 𝑅
𝐶 + =𝑓 𝑥
𝑑𝑡 𝑅
𝑑𝑉 𝑓(𝑥) 𝑉
= −
𝑑𝑡 𝐶 𝑅𝐶
𝜏 = 𝑅𝐶
Biosenors
First Order Biosensor: Frequency response
𝑑𝑉 𝐼𝐵 𝑉
= −
𝑑𝑡 𝐶 𝜏
Fourier transform
𝑖𝐵 𝑣
𝑗𝜔𝑣 = −
𝐶 𝜏 𝑣(𝜔 = 0) = 𝑅 ∙ 𝐼𝐵
𝑣 𝑗𝜔𝜏 + 1 = 𝑅 ∙ 𝑖𝐵 𝑅 ∙ 𝐼𝐵
𝑣(𝜔 = 𝜔𝑐 ) =
2
𝑅 ∙ 𝑖𝐵 (𝜔)
𝑣(𝜔) =
(𝑗𝜔𝜏 + 1) 𝑣(𝜔 → ∞) = 0
𝑅 ∙ 𝐼𝐵
𝑣(𝜔) =
𝜔 𝜔𝑐 2 +1
𝜔𝑐 = 1/𝜏
Biosenors
First Order Biosensor: Frequency response
𝑅 ∙ 𝐼𝐵
𝑣(𝜔) = 𝜔𝑐 = 1/𝑅𝐶
𝜔 𝜔𝑐 2 +1
𝑣(𝜔 = 0) = 𝑅 ∙ 𝐼𝐵
𝑅 ∙ 𝐼𝐵
𝑣(𝜔 = 𝜔𝑐 ) =
2
𝑣(𝜔 → ∞) = 0
Low pass filter: every
input signal with
frequency higher ωC
will be cut-off
log 1/ 2 ≈ −0.15
Biosenors
Low pass filter
𝑅 ∙ 𝑖𝐵 (𝜔)
𝑣(𝜔) =
(𝑗𝜔𝜏 + 1)
sin 𝜔𝑏 𝑡 𝛿(𝜔 − 𝜔𝑏 )
Fourier transform
ωb > ωc V=0
ωb < ωc V=Biological
Signal
Therefore it is important to
design the biosensor physical
parameters to set the value of
RC (e.g., dimensions )
Biosenors
First Order Biosensor: Frequency response
We can arrive to the same results by KCL and KVL
The impedance of R does not depend on the
frequency (ZR=R)
The impedance of C depends on the frequency
(ZC=1/jωC)
𝑉 = 𝐼𝐵 ∙ (𝑍𝑅 ||𝑍𝐶 )
𝑍𝑅 ∙ 𝑍𝐶
𝑉 = 𝐼𝐵
𝑍𝑅 + 𝑍𝐶
𝑅
𝑉 = 𝐼𝐵
1 𝑗𝜔𝑅𝐶 + 1
𝑅 ∙ 𝑗𝜔𝐶
𝑉 = 𝐼𝐵 𝑅
1 𝑉 = 𝐼𝐵
𝑅 + 𝑗𝜔𝐶
(𝜔𝑅𝐶)2 +1
1
𝑅 ∙ 𝑗𝜔𝐶
𝑉 = 𝐼𝐵
𝑗𝜔𝐶𝑅 + 1
𝑗𝜔𝐶
Biosenors -Photodiode
Biosensor converts one type of energy to electrical energy
Photodiode: is pn junction that converts light to electrical energy
𝑑𝑉 𝑉
𝐶 + = 𝐼𝐿𝑖𝑔ℎ𝑡 − 𝐼𝐷𝑖𝑜𝑑𝑒
𝑑𝑡 𝑅
𝐼𝐷𝑖𝑜𝑑𝑒 = 𝐼𝑑𝑎𝑟𝑘 (𝑒 𝑞𝑉 𝐾𝑇
− 1)
𝑑𝑉 𝐾𝑇
𝑅= =
𝑑𝐼 𝑞 ∙ 𝐼
Low pass filter
C is the junction capacitance
Biosenors - Piezoelectricity
Biosensor converts one type of energy to electrical energy
𝑑𝑞 𝑑𝑥
𝐼𝐵 = =𝐾
𝑑𝑡 𝑑𝑡
𝑑𝑉 𝑉 𝑑𝑥
𝐶 + =𝐾
𝑑𝑡 𝑅 𝑑𝑡
Fourier transform
𝑣
𝑗𝜔𝑣 = 𝐾𝑆 ∙ 𝑗𝜔𝑥(𝜔) −
𝜏
𝐾𝑆 𝑗𝜔𝜏
𝑣(𝜔) = ∙ 𝑥(𝜔)
1 + 𝑗𝜔𝜏
Biosenors - Piezoelectricity
𝐾𝑆 ∙ 𝜔 𝜔𝑐
𝑣(𝜔) = ∙ 𝑥(𝜔)
𝜔 𝜔𝑐 2 +1
𝑅𝑐𝑡
𝑍𝑒𝑞 = 𝑅𝑠 +
1 + 𝑗 ∙ 𝜔 ∙ 𝑅𝑐𝑡 ∙ 𝐶𝑑𝑙
LPF
Amplifier
An input signals (current/voltage) is amplified to a larger output
signals (current/voltage)
Features:
1. Linearity (wide linear range)
2. High Gain
3. Vin=0 Vout=0
4. High signal to noise ratio
5. Stability at time (One dominant half time)
6. Stable gain (not depend on circuit parameters, VDD, temperature …)
Amplifier
Amplifier
• Voltage amplifier
𝑣𝑜𝑢𝑡 = 𝐴𝑣 ∙ 𝑣𝑖𝑛
Vin –input
Vout –output
Av – voltage gain [db]
Ri is input resistance
Ro output resistance
RS source resistance
RL Load Resistance 𝑅𝑖
𝑣𝑖𝑛 = 𝑣𝑠 ∙ 𝑅𝐿
𝑅𝑖 + 𝑅𝑆 𝑣𝑜𝑢𝑡 = 𝐴𝑣 𝑣𝑖𝑛 ∙ 𝑅
𝐿 +𝑅𝑂
𝑖 𝑅 𝑅𝐿
𝑣𝑜𝑢𝑡 = 𝐴𝑣 𝑣𝑠 ∙ 𝑅 +𝑅 ∙𝑅
𝑖 𝑆 𝐿 +𝑅𝑂
𝑣𝑜𝑢𝑡 𝑖 𝑅 𝑅𝐿
𝐴𝑣𝑒𝑓𝑓 = = 𝐴𝑣 ∙ 𝑅 +𝑅 ∙𝑅
𝑣𝑠 𝑖 𝑆 𝐿 +𝑅𝑂
𝑨
𝑽𝒐𝒖𝒕 = 𝑽𝒊𝒏𝟏 ∙ Black’s Formula
𝟏+𝜷∙𝑨