STRUCTURAL ISOMERISM

Lecture# Description Duration

01 Definition of isomerism, Classification of isomerism, Chain 45

isomerism, Positional isomerism Minutes

02 Functional isomerism, Ring-chain isomerism, Metamerism 40

Minutes

STEREOISOMERISM

Lecture# Description Duration

01 Introduction, Classification of stereoisomerism, Geometrical 20

Isomerism (G.I.) Minutes

02 G.I. in C=C system , G.I. in Ring system , G.I. due to double bond inside the ring , Cummulenes 55
Minutes
03 G.I. in C=N system, E/Z Nomenclature 55
Minutes
04 Number of geometrical Isomers, Cummulenes, Spiranes, 58
Cycloalkylidenes, Diphenyl system, Physical properties of Minutes
geometrical isomers
05 Optical Isomerism , Plane polarised light , Chiral centre , 1 Hr 09
Chirality ' Assymmetric molecules , Dissymmetric molecules , Minutes
Plane of symmetry (POS), Centre of symmetry (COS)
06 POS, COS. Chirality, Optical activity 55
Minutes
07 Wedge-Dash projection fromula , Fischer–Projection formula , 52
Absolute configuration (R/S-configuration) , CIP-Rule Minutes
08 Enantiomers , Diastereomers , Axis of symmetry (AOS)
09 Erythro enantiomers, Threo enatiomers, D/L- Configuration 58
(Relative configuration) , Number of stereoisomers , Pseudo Minutes
chiral carbon (PCC), Racemic mixture (or, R/S-mixture) ,
Polarimeter , Functioning of polarimeter , Percentage
enantiomeric excess (%EE), Optical purity
Lecture# Description Duration

10 Optical Resolution , Tertiary amine optical activity , Optical Minutes

activity in absence of chiral centre , Cummulenes , Spiranes ,
Cycloalkylidene, Diphenyls , Alternating axis of symmetry
(AAOS) , Conformational Isomerism
11 Conformational isomers , Newmann projection formula , 57
Dihedral angle (DHA) , Tortional strain (T.S.) , Vander waals Minutes
strain (V.S.) , Angle strain (A.S.) , Definition of conformational
isomers, Conformational analysis , Sawhorse projection
formula
12 Conversion of Fischer to Newmann, Conformational analysis 51
of cyclohexane , Energy profile Minutes
13 Conformational analysis of dimethyl cyclohexane 15
Minutes
STRUCTURAL INDENTIFICATION & POC

Lecture# Description Duration

01 Structural Identification, Degree of unsaturation 29

(DU), Catalytic hydrogenation H /cat, Monochlorination Cl /hn
2 2 Minutes

02 Structural Identification , Monochlorination Cl /hv ,

2 54
Ozonolysis , Reductive ozonalysis , Oxidation ozonalysis , Minutes
Practical organic chemistry (POC), POC-I , Lassaigne’s test,
Elemental analysis

03 Elemental anlaysis , Test of unsaturation, Test of terminal 35

alkyne , Test of alcohols , Test of carbonyl compounds , Tests of Minutes
aldehydes

04 Iodoform Test, Sodium metal test 19

Minutes

05 Sodiumbicarbonate test (N HCO3), Test of phenols and enols ,

a 33
Test of nitro compounds , Test of amines , Hinseberg’s test , Minutes
POC-II

GENERAL ORGANIC CHEMISTRY (GOC)

Lecture# Description Duration

01 Electornic effect , Inductive effect 36

Minutes

02 Applications of I-Effect , Resonance , Conjugated system 47

Minutes

03 When double bond is in conjugation with vacant -p , When 28

double bond is in conjugation with fully filled -p Minutes

04 When double bond is in conjugation with fully filled -p, When 53

double bond is in conjugation with half filled-p , When Minutes
+ve charge and lone pair are adjacent , d-orbital resonance ,
Conditions of Resonance, Mesomeric effect (M)

05 Stability of resonating structures (R.S), Steric Inhibition of 35

Resonance (SIR) , Equivalent R.S. Minutes

06 Equivalent R.S. , Hyperconjugation HC , Hyperconjugation in 54

carbocations , Hyperconjugation in Alkenes , Heat of Minutes
hydrogenation (HOH)

07 Hyperconjugation in Toluene, Hyperconjugation in Free 38

Radicals, Electromeric effect (E), Applications of electronic Minutes
effects , Dipole moment, Bond length , Aromaticity ,
Benzenoids and Non-benzenoids

08 Examples of aromatic compounds , Heterocyclic aromatic 27

compounds Minutes

09 M.O. Diagram, Polycyclic aromatic compounds 24

Minutes

10 Examples of aromatic systems, [n] Annulenes , NMR- 37

definition of Aromaticity , Resonance energy (RE) Minutes

11 Acidic strength of acids , Acidic strength of dicarboxylic acids 44

Minutes
Lecture# Description Duration

12 Aromatic acids , Ortho effect, Acidic strength of phenols , 52

Feasibility of reactions , Sodium bicarbonate test of acids Minutes

13 Basic strength , Organic Nitrogenous bases. 12

Minutes

14 Basic strngth of Aliphatiec amines , Aromatic amines 43

Minutes

15 Basic strength of Amidines , Basic strength of 31

Guanidines, Proton sponges, Site of protonation , Feasibility of Minutes
Reaction

16 Carbanions (C-), Reactions in which carbanions are formed , 38

Organometallic compounds, Active methylene group., Minutes
Tautomerism, Types of Tautomerism

17 Enolisable –H, Keto-enol Tautomerism, Mechanism of keto- 23

enol Tautomerism Minutes

18 Stability of enol (Percentage enol-content), Racemisation due to 43

enolisation Minutes

19 D-Excharge , Tautomerism in phenols , Ring-chain 37

Tautomerism , Unsymmetrical alpha-hydroxy ketones Minutes

IUPAC NOMENCLATURE

Lecture# Description Duration

01 Basic organic chemistry, Definition of organic compound , 12

Representation of organic compound , Hybridisation Minutes

02 Number of Sigma and PI bonds , Degree of carbon , Degree of 46

hydrogen , Degree of Alkyl halides, Degree of Alcohols Minutes
, Degree of Amines , Degree of unsaturation (DU) , Calculation
of DU , Fundamental definition of DU, Homologous series
(H.S.)
Lecture# Description Duration

03 Classification of organic compound , Aromatic compounds , 38

Homocyclic compounds , Heterocyclic compounds , IUPAC- Minutes
Nomenclature , Scheme of IUPAC, Naming of Alkanes

04 Scheme of IUPAC, Naming of alkanes , Retained Names , 59

Naming of alkenes Minutes

05 Naming of Alkene, Naming of Alkynes , Naming of 33

cycloalkanes Minutes

06 Naming of cycloalkenes , Alkylidenes , Naming of cycloalkynes 42

, Naming of Bicyclo compounds Minutes

07 Functional Groups (F.G.), Naming of carboxylic acids, Special 33

Name of carboxylic acids , Naming of dicarboxylic acids Minutes

08 Naming of sulphonic acid , Naming of Alcohols , Naming of 49

Amines , Naming of thioalcohols, Naming of Aldehydes , Minutes
Special name of Aldehydes

09 Naming of Ketones , Naming of cyanides , Special name of 46

cyanides , Naming of isocyanides , Naming of Amides , Special Minutes
name of amides , Naming of acid halides

10 naming of acid halide, naming of acid anhydride, naming of 41

esters, special name of ester Minutes

11 Naming of haloalkanes , Naming of Nitro compounds , Naming 38

of Nitroso compounds , Naming of Aromatic compound , Minutes
Benzene , Other aromatic compound

REACTION MECHANISM

Lecture# Description Duration

01 Carbocations C+, Hybridisation of carbocations , Stability of 36

carbocations , Rearrangement of carbocations , Type of shifts , Minutes
Migratory aptitude
Lecture# Description Duration

02 Migratory aptitude of aromatic group , Rearrangement in cyclic 42

carbocations , Ring expansion (RE), Ring contracting (RC) , Minutes
Cyclopropyl methyl carbocations (CPM–C+), Stability order of
carbocations , Some extra ordinary stable carbocations, CPM
carbocation , Aromatic carbocations

03 Rearrangement of carbocation, Reaction mechanism , Solvents , 35

Polar protic solvents (PPS), Polar aprotic solvents (PAs) , Minutes
+
Reagents , Nucleophiles, Nu, Electrophilic E

04 Electrophiles, E+, Nucleophiles, Nu, Nucleophilicity , 47

Experimental order of Nu, Strong Nu with weak basic character Minutes
, Strong Nu with strong basic character, Weak Nu with weak
basic character , Solvation of Nu

05 Leaving group (l.g.), Leaving group ability , Unimolecular 36

nucleophilic substitution reaction of first order (for R–X) i.e Minutes
SN1 of R–X , Kinetics of SN1, Stereo of SN1, PE- diagram of
SN1, SN1 with rearrangement in C+, Rate of SN1 reaction

06 SN1 or R–X, Solvolysis reaction , Factors affecting the rate of 50

SN1reactions , SN1 of alcohol R–OH Minutes

07 SN1 of R–OH, Lucas reaction , SN1 of ethers , Hydrolysis of 43

ethers , SN2 reaction of (R–X), Kinetics of SN2 reaction , Minutes
Stereochemistry of SN2 Rxn , PE-diagram of SN2 Rxn

08 Walden's experiment , Walden Inversion , Factors affecting the 48

rate of SN2 Rxn , Halogen exchange reaction , Finkelstien Minutes
reaction , Swart's reaction , SN2 Rxn of alcohol (R–OH),
SNi reaction of alcohol with SOCl2

09 SN2 of ether , Reaction of epoxides , Williamson's ether 29

synthesis Minutes

10 Intramolecular SN2 reactions , Neighbouring group participation 41

(NGP) , Comparison between SN1 and SN2 , SN1 Vs SN2 Minutes
Lecture# Description Duration

11 Elimination Reaction , E1 elimination (of R–X), Saytzeff's rule , 51

Regioselectivity , E1 of Alcohols, Acid catalysed dehydroation Minutes
of alcohol, Dienone- Phenol rearrangement , Pinacol -
Pinacolone rearrangement , Semipinacol- Pinacolone
rearrangement

12 E2 Rxn of (R–X), Stereoselectivity and sterospecificity , 37

Reagents of E–2 Reaction , Order of Rate of E–2, Major Hofmann Minutes
Alkene

13 Summary of SN1/ SN2/E1/E2, Stereo selectivity of E–2 reaction , 40

E1CB reaction , Cases when Hofmann Alkene is the major Minutes
product

14 Tetraalkyl ammonium hydroxide , E–2 Rxn, Didehalogenation , 24

Stereoselectivity , Isotope effect (KH/KD) Minutes

GRIGNARD REAGENT,ALKANE,REDUCTION

Lecture# Description Duration

01 Organometallic compounds , Preparation of G.R. 12

Minutes

02 Preparation of GR, Solvents of GR, Reaction of GR, Acid-base 33

reaction of GR, Zerewitinoff's active hydrogen determination Minutes

03 Nucleophilic addition reaction of GR, SN2- Th reaction of GR 30

Minutes

04 Unstable GR, Mono GR is not possible with dihalide , Reaction 40

of GR with CO2, Reaction of GR with O2, Reaction of GR with Minutes
RCN, Digrignard reagent , Reactions of digrignard reagent

05 Attack of GR on weak bond, 1,2-addtion & 1,4-additon , 42

Reaction of GR with metal halides , REDUCTION , Definition Minutes
of reduction , Table of reducing agents , Catalytic hydrogenation
Lecture# Description Duration

06 Catalylic hydrogenation , Stereoselectivity ,) Partial 44

hydrogenation , Lindlar's catalyst , P-2 catalyst (Nickle Boride), Minutes
Birch reduction

07 Hydroboration Reduction (HBR), Transfer Hydrogenation, 54

Clemmensen reduction , Wolf-Kishner reduction, Lithium Minutes
aluminium hydride (LiAlH4)

08 Sodiumboro hydride (NaBH4) (SBH), Triphenyltin hydride 53

Ph3SnH (TPH), DiBAl-H- Diisobutyl Aluminium hydride , Red Minutes
–P + HI, Mozingo reduction , MPV- reduction , Oppeneaus
Oxidation , Bauvealt-Blanc reduction , ALKANES, Free
Radicals , Formation of free radicals , F.R. Catalyst/ Initiators /
Promotors , F.R. Inhibitors/ Scavangers/Poisons , Stability of
free radicals , Reactions of free radicals , Combination Reactions
, Disproportionation reaction

09 Reactions of Free radicals , Stability of free radicals , 41

Preparation of Alkanes , Wurtz Reaction (WR), Wurtz-Fitting Minutes
reaction , Fitting reaction , Frankland reaction , Kolbe's
Electrolytic synthesis (KES), Corey-House Reaction

10 Corey House reaction, Decarboxylation , Decarboxylation by 40

soda lime , Decarboxylation by heating Minutes

11 Properties of Alkanes , Chemical properties of Alkanes , Free 25

Radical substitution reaction , PE-diagrams , Reactivity order , Minutes
Conditions of halogenation

12 reactivity and selectivity , Percentage yield , Quantum yield , 39

Isomerisation reaction of alkanes , Aromatisation reaction of Minutes
alkanes , Petroleum , Physical Properties of alkanes

ALKENE,ALKYNE,OXIDATION

Lecture# Description Duration

01 Alkenes , Preparation of Alkene , Pyrolysis of ester , Pyrolysis 37

of xanthates (Chaugave reaction ) , Cope reaction , Minutes
Lecture# Description Duration

Didehalogenations

02 Chemical reactions of Alkenes , Electrophilic addition reaction 52

(AE Rxn), Classical carbocation mechanism , Non-Classical Minutes
carbocation mechanism , Markowni Koff's rule , Addition of H–
X, Antimarkowni Koff's rule

03 Addition of H2O on Alkenes , Acid-catalysed hydration of 47

Alkenes , Oxymercuration- Demercuration reaction (OM/DM), Minutes
Hydroboration -oxidation (HBO), Alkoxymercuration
Demercuration , Addition of X2on Alkenes

04 Addition of HOX on alkenes , Stereoselectivity , Order of rate of 48

addition of X2 on alkene , Chemical reaction of Alkynes , Minutes
Addition of H-X on alkynes , Addition of H2O on alkynes ,
Hydration of alkyne with dil H2SO4 and HgSO4, Hydroboration
– Oxidation

05 Addition of HOX on alkynes , Preparation of alkynes , 24

Isomerisation Minutes

06 Isomerisation mechanism , Reaction of terminal alkynes , 35

Dienes , Conjugated diene , Addition NOCl on alkene , Allylic Minutes
substitution , NBS- N-bromosuccinimide

07 Reaction of NBS, MnO2- Oxidising agent , Carbenes , Sources 21

of carbenes , Types of carbenes Minutes

08 Reaction of carbene , Reimmer-Tiemann reaction , Carbyl amine 49

reaction , OXIDATION , definition of oxidation , Oxidation of Minutes
alkenes and alkynes , Ozonolysis of Alkenes and alkynes ,
Oxidation of Ketone , Perhydroxylation of Alkenes (Formation
of diols), Baiyer reaction – Baeyer's reagent , Osmium
tetraoxide (OsO4), Epoxidation by per acid

09 Oxidation-strong oxidising agent , Potassium dichromate 38

K2Cr2O7/H2SO4, Alkaline KMnO4/ OH-, H2CrO4 or CrO3 + H2O, Minutes
Table of oxidising agents , Oxidation of alcohols , Mild
oxidising agents , Oxidation of periodic acid HIO4, Oxidation of
Lecture# Description Duration

aldehydes , Oxidation with NBS, Tollen's reagent , Fehling's

Reagent , Benedict's solution , Schiff's reagent

10 Oxidation of seleniumdioxide SeO2, Side-Chain oxidation 13

Minutes

AROMATIC COMPOUND

Lecture# Description Duration

01 Aromaticity , Benzenoids and Non-Benzenoids , NMR- 44

definition of Aromaticity , Anti Aromaticity , Polycyclic Minutes
aromatic compound , Azulenes , Reaction of AgNO3 and Na-
metal , (n)-Annulenes , Peripheral aromaticity

02 Electrophilic aromatic substitution reaction , Halogenation of 49

Benzene , Baltz-Schiemann reaction , Nitration of benzene , Minutes
Kinetic Isotope effect , Sulphonation of benzene , Friedel-Craft
reaction (F.C. Rxn), F.C. Alkylation

03 Ring-Closure at C-1 and C–2, Dehydrogenation , Limitations of 44

F.C. reaction , Friedel Craft Acylation , Ring closure , Directive Minutes
influence or Directive effect , Table of activating and
deactivating groups

04 Ortho-para ratio , Direction effect on disubstituted benzene , 37

Directive influence in monosubstituted benzene , Directive Minutes
influence in naphthalene , Directive influence in diphenyl ,
Directive influence in Anthracene and phenanthrene, Directive
influence in pyridine & pyrrole , SN2 Ar reaction , PHENOL,
Preparation of phenol

05 Preparation of phenol from acid hydrolysis of cumene , 39

Chemical reaction of phenol , Halogenation of phenol , Minutes
Protection of –OH group, Nitration of Phenol , Sulphonation of
Phenol, Reimer-Tiemann Reaction , Reimer-Tiemann
formylation , Reimer-Tiemann carboxylation , Comparison of
Reimer-Tiemann and carbyl amine reactions , Kolbe-Schmidt
reaction , Some medicinally important compounds , Aspirine,
Salol, Oil of winter green
Lecture# Description Duration

06 Nitrosation of phenol , Use of phenol as nucleophile, ANILINE, 26

Preparation of aniline from reduction of nitrobenzene , Selective Minutes
reduction , Chemical reactions of aniline , Halogenation of
Aniline , Nitration of Aniline, Sulphonation of Aniline

07 Fries rearrangment reaction in Phenol , Claisen rearrangement , 43

Diazotisation of Aniline , Reaction of Benzene diazonium Minutes
chloride (BDC) , Sandmeyer reaction , Baltz-scheimann reaction
, Experimental evidence of formation of phenyl cation ,
Amination – Deamination

08 AMINES, Preparation of Amines , Hofmann Bromamide 32

reaction , Hofmann methylation , Gabriel phthalimide reaction , Minutes
Coupling reaction of BDC

09 Test of Amines ,Isocyanide Test of 1º Amine , Test with nitrous 23

acid HNO2, CYANIDES and ISOCYANIDES , Preparation of Minutes
cyanides and isocyamide , Hydrolysis of cyanides and
isocyanides , IPSO-Substitution

10 Basic Strength, Definition of bases , Scales of basic strength , 12

Organic Nitrogenous bases Minutes

11 Basic strength of Aliphatic amines , Basic strength of Aromatic 43

amines , SH of H2O, SIR effect on Aromatic amines , Basic Minutes
strength of pyridine and pyarole

12 Amidine-basic strength , Guanidine- basic strength , Kb order , 31

Proton sponges , Site of protonation , Feasibility of reaction Minutes

CARBONYL COMPOUND

Lecture# Description Duration

01 Preparation of aldehydes & Ketones , Dehydrogenation , 41

Hydrolysis of gem. dihalide , From dry distillation of Col. salt of Minutes
fatty acid , From acid chloride (Rossenmund's) , Formylation of
benzene (Gattermann Koch Ald. Synthesis) , Chemical reaction
of carbonyl compound , Nucleophilic addition reaction ,
Lecture# Description Duration

Addition of H2O (Formation of hydrates)

02 Addition of R–OH (Formation acetal/Ketal), Addition of G.R., 35

Addition of HCN (Formation of cyanohydrin), Addition of NH3, Minutes
Addition of Ammonia derivative

03 Addition of NaHSO3 (Sodium bisulphite) , Backmann 29

rearrrangment , Cyclic Ketone Minutes

04 Condensation reaction , Aldol condensation reaction , Cross 40

Aldol , Intramolecular Aldol reaction Minutes

05 Perkin condensation reaction , Classen Ester condenstion , 22

Cross-Claisen , Intramolecular claisen (Dieckmann's reaction ) , Minutes
knoevenagel reaction

06 Reformatsky reaction , Favorskii reaction , Cannizaro reaction 23

Minutes

07 Cross Aldol , Cross Cannizaro , Intramolecular cannizaro , 44

Tischenko reaction , Alpha-Halogenation , Haloform reaction , Minutes
Iodoform test

08 Baeyer - Villiger Oxidation , Benzil - Benzilic acid 33

Rearrangement , D-exchange reaction , Witting reaction , Minutes
Benzoin condensation
CARBOXYLIC ACID & DERRIVATIVES

Lecture# Description Duration

01 Carboxylic acid preparation , Arndt-Eistert reaction (Homologation of acid), 18

Chemical reactions of carboxylic acids , Hunsdiecker reaction Minutes

02 Decarboxylication reaction , Decarboxylation of acids by soda lime (SL), 44

Decarboxylation by heating , Hell-Volhard-Zelinsky (HVZ) reaction , Acid Minutes
derivatives , Preparation of acid derivatives , SN2 Threaction , Esters-
preparation , Type-I mechanism of esterification, Type-II mechanism of
esterification

03 Examples of esterification, Hydrolysis of ester , Acid hydrolysis of ester and 28

saponification , Acid amide , Hofmann Bromamide reaction , Curtius reaction , Minute
Schmidt reaction , Lossen reaction

BIOMOLECULES & POLYMER

Lecture# Description Duration

01 Carbohydrates , definition , Classification of carbohydrates , Based on number 18

of units , Based on water solubility , Based on reducing properties Minutes

02 Monosaccharides - Aldoses and Ketoses, D/L-configuration (Relative 47

configuration) , Glucose , Cyclic hemiacetal structure of glucose , ANOMERS , Minutes
EPIMERS , Haworth structure of glucose- glucopyranose structure, Formation
of methyl-O-glucoside , Mutarotation, FRUTOSE , cyclic hemiacetal structure
of fructose , Haworth structure of fructose- Fructofuranose structure

03 SUCROSE, Inversion of sugar , Glycosidic linkage , Maltose ,Lactose , Starch , 45

Amylose and amylopectin , Cellulose , Reaction of carbohydrates , Osazone Minutes
formation of glucose and fructose

04 Amino acids , Types of Alpha-Amino acids (AA), Neutral Alpha-AA, Acidic 21

Alpha-AA, Basic Alpha-AA, Zwitter ion , Iso-electric point (pI), Calculation of Minutes
pI value

05 Peptides , Dipeptides , Peptide link, Polypeptides , Protein , Examples of 18

Lecture# Description Duration

Amino acids Minutes

06 Polymerisation , Classification of polymer , Based on source , Base on 33

Intermolecular force of attraction , Elastromers , Fibres , Thermoplastics, Minutes
Thermosettings , Polyethylene , Nylon-6, Nylon-6,6, Natural Rubber ,
Synthetic Rubber- Neoprene , Buna-S, Buna-N , Dacron , Low density
polyethylene (LDPE)

07 High density polyethylene (HDPE) , Polypropylene , Poly isobutylene , Poly 33

vinyl chloride (PVC), Poly tetrafluoro ethylene (PTFEW Tefflon) , Poly Minutes
acrylonitrile (PAN or orlon), Poly styrene , Poly methyl methanacrylate
(PMMA or Lucite) or (Plexiglas or prespex), Natural Rubber- Polyisoprene ,
Gutta-percha, Vinylidene chloride- Vinyl chloride polymer , Lexan-Poly
carbonate , Glyptal , Bakelite (or phenol- formaldehyde Resin), Melamine-
formaldehyde (Melmac) , Polyurethane