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Why you love coffee and beer

Date: May 2, 2019

Source: Northwestern University

Summary: Why do you swig bitter, dark roast coffee while your coworker guzzles sweet cola? Scientists
searched for variations in our taste genes that could explain our beverage preferences, because
understanding those preferences could indicate ways to intervene in people's diets. But to
scientists' surprise, the study showed taste preferences for bitter or sweet beverages aren't based
on variations in our taste genes, but rather genes related to the psychoactive properties of these
beverages.

FULL STORY

Why do some people like both coffee and beer? A new

genetics suggest beverage preferences hinge on psychoactive
effects.

Credit: © amenic181 / Fotolia

Why do you swig bitter, dark roast coffee or hoppy beer while your coworker guzzles
sweet cola?

Scientist Marilyn Cornelis searched for variations in our taste genes that could explain our beverage preferences,
because understanding those preferences could indicate ways to intervene in people's diets.

To Cornelis' surprise, her new Northwestern Medicine study showed taste preferences for bitter or sweet
beverages aren't based on variations in our taste genes, but rather genes related to the psychoactive properties
of these beverages.

"The genetics underlying our preferences are related to the psychoactive components of these drinks," said
Cornelis, assistant professor of preventive medicine at Northwestern University Feinberg School of Medicine.
"People like the way coffee and alcohol make them feel. That's why they drink it. It's not the taste."

The paper will be published May 2 in Human Molecular Genetics.

The study highlights important behavior-reward components to beverage choice and adds to our understanding of
the link between genetics and beverage consumption -- and the potential barriers to intervening in people's diets,

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Why you love coffee and beer -- ScienceDaily https://www.sciencedaily.com/releases/2019/05/190502100814.htm

Cornelis said.

Sugary beverages are linked to many disease and health conditions. Alcohol intake is related to more than 200
diseases and accounts for about 6 percent of deaths globally.

Cornelis did find one variant in a gene, called FTO, linked to sugar-sweetened drinks. People who had a variant in
the FTO gene -- the same variant previously related to lower risk of obesity -- surprisingly preferred sugar-
sweetened beverages.

"It's counterintuitive," Cornelis said. "FTO has been something of a mystery gene, and we don't know exactly how
it's linked to obesity. It likely plays a role in behavior, which would be linked to weight management."

"To our knowledge, this is the first genome-wide association study of beverage consumption based on taste
perspective," said Victor Zhong, the study's first author and postdoctoral fellow in preventive medicine at
Northwestern. "It's also the most comprehensive genome-wide association study of beverage consumption to
date."

How the study worked

Beverages were categorized into a bitter-tasting group and a sweet-tasting group. Bitter included coffee, tea,
grapefruit juice, beer, red wine and liquor. Sweet included sugar-sweetened beverages, artificially sweetened
beverages and non-grapefruit juices. This taste classification has been previously validated.

Beverage intake was collected using 24-hour dietary recalls or questionnaires. Scientists counted the number of
servings of these bitter and sweet beverages consumed by about 336,000 individuals in the UK Biobank. Then
they did a genome-wide association study of bitter beverage consumption and of sweet beverage consumption.
Lastly, they looked to replicate their key findings in three U.S. cohorts.

Alan Kuang is also a Northwestern author on the paper.

Story Source:

Materials provided by Northwestern University. Note: Content may be edited for style and length.

Journal References:

1. Victor W Zhong, Alan Kuang, Rebecca D Danning, Peter Kraft, Rob M van Dam, Daniel I Chasman, Marilyn C
Cornelis. A genome-wide association study of bitter and sweet beverage consumption. Human
Molecular Genetics, 2019; DOI: 10.1093/hmg/ddz061
2. Victor W Zhong Alan Kuang Rebecca D Danning Peter Kraft Rob M van Dam Daniel I Chasman Marilyn C
Cornelis. Erratum: A genome-wide association study of bitter and sweet beverage consumption.
Human Molecular Genetics, 2019 DOI: 10.1093/hmg/ddz087

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