Medical Microbiology - Chapter 18 - Haemophilus,

Bordetella, Brucella, and Francisella

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1. Haemophilus - gram negative 15. Brucellosis undulant fever or Malta fever

characterisitcs pleomorphic coccbacilli unpasteurized milk
non-motile can produce secondary bacteremia in
oxidase+ pregnant women; abortion
catalase + treatable; flu-like; enters lymphatic system
2. Haemophilus - obligate parasites 16. Francisella capsule
blood loving require X(hemin) and V(NAD) factors tularensis highly infectous - very virulent
arthropod vector
3. Haemophilus - 10% normal flora of upper respiratory tract
what they do 2-6% children and daycare centers 17. Tularemia often fatal if untreated; beta lactam
to us? H. influenzae was isolated from pandemic resistance
influenza victims - does not cause influenze rabit/squirrel hunting - fever
Ulceroglandular tulaemia - lymphnodes
4. Haemophilus - capsule in some strains
enlarged and necrotis
Virulence outer membrane proteins and LPS, the
Factors LPS paralyzes cilia - can't clear lungs
5. Haemophilus disease in children
influenze bacterima --> other tissues
serotype b Hib vaccine
(Hib)
6. Nontypable no capsule
strains resp. tract and tissues in same area
pneumonia, otitis media, sinusitis
7. Diseases of meningitis
Hib strain epiglotitis
bacterial tracheitis
acute pharyngitis and pneumonia
cellulitis
8. Haemophilus this and H. influenza biogroup can cause
aegyptius conjunctivitis / pinkeye
9. Haemophilus biogroup: aegyptius
influenza brazilian purpuric fever
high mortality @ 70%, tropics
recurrent conjunctivitis, high fever, petechiae
10. Haemophilus STD: Chancroid
ducreyi painful lesions w/ irregular edge
genital/perianal region; buboes
11. Bordetella Gram Neg rods or coccobacilli
Species Seven major species.
12. Bordetella agents of whooping cough
pertussis and highly contagious; 90%
parapertussin breathing in aersols
adults can be transient carriers
13. pertussis and filamentous hemagluttin(attachment),
parapertussin: pertussis toxin(signiling), adenylate cyclase
Virulence (cAMP) toxin, tracheal toxin(ciliostasis)
14. Brucella animals are reservoir
Species fleas, ticks, and mosquitos are vectors
has capsule
subspecies are Brucella melitensis