SUPPLEMENTARY INFORMATION
Table S2 | Some pharmacological or toxicological effects of H2S in humans
Exposure route and level
Levels in the breathing air of
0.02- 0.1 ppm
Levels in the breathing air of
0.2-0.3 ppm
Acute inhalation exposure
during exercise in healthy
men (0.5, 2 or 5 ppm).
Acute inhalation exposure in
healthy men (10 ppm).
Levels in the breathing air of
10-20 ppm
Levels in the breathing air of
30-50 ppm
Levels in the breathing air of
200 -700 ppm
Exposure to various levels of
toxic concentrations of
inhaled H2S (500-1000 ppm
[estimated levels])
1400 ppm in breathing air
(acute exposure)
NATURE REVIEWS | DRUG DISCOVERY
In format provided by Szabó (NOVEMBER 2007)
Effect of hydrogen sulfide
The concentration of sulfide reaches the level of odor detection.
The concentration of sulfide reaches the level of nuisance, headaches,
nausea and sleep disturbances.
Oxygen uptake tended to increase, and carbon dioxide output tended to
decrease. Blood lactate concentrations significantly increased. Heart
rate and ventilation were unaffected.
Oxygen uptake tended to increase, and carbon dioxide output tended to
decrease. Blood lactate concentrations increased. Heart rate and
ventilation were unaffected.
OSHA acceptable ceiling for H2S concentration in the air at a
workplace.
Eye irritation.
Depression of the nervous system: nervousness, headache,
lightheadedness, fatigue, extremity weakness, spasms.
Variable degree of discomfort, ranging (at 5-100 ppm) from eye
irritation from shortness of breath, chest tightness, wheezes to
“knockdown” (losing of consciousness) to fatalities.
Severe intoxication, 2 out of 4 subjects died acutely, 1 died in hospital
22 hours later, 1 survived. High blood concentrations of thiosulfate (1-
100 mg/l) were measured in autopsy samples.
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