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2. CORTICOBULBAR TRACT
Trace from origin to medulla
Specific location in different parts of segments of the CNS
Manner of termination in ff. Cranial Nerve Nuclei: IV, VI, VII, XII, Ambiguus
Originate mainly from AREA 4
From CORTEX, fibers would pass through CORONA RADIATA and would converge to pass through GENU of INTERNAL CAPSULE
Fibers descend into BRAINSTEM to terminate in the different MOTOR NERVE NUCLEI
Terminate BILATERALLY in the following nuclei:
Oculomotor Nucleus (III)
Trigeminal Nucleus (V)
Facial Nucleus (VII) [only to the part supplying the upper part of the face]
Nucleus Ambiguus (IX, X, XI) [only partly supplying muscles of the pharynx and larynx except uvula]
Terminate MAINLY CONTRALATERALLY
Abducens Nucleus (VI)
Hypoglossal Nucleus (XII)
Terminate ONLY CONTRALATERALLY
Facial Nucleus (VII) [only to the part supplying the lower part of the face]
Nucleus Ambiguus (IX, X, XI) [only partly supplying muscles of the uvula]
Terminate IPSILATERALLY
Trochlear Nucleus (IV)
Does not Terminate in the ff:
Optic Nucleus (I)
Olfactory Nucleus (II)
Auditory Nucleus (VIII)
Lesions produce paralysis either same or opposite sides.
3. CORTICAL AREAS
Functions of areas 5 & 7, 9-10-11-12, 19, 39, 43
Effect of stimulation on areas 3-1-2, 41
Effect of lesion/ablation on areas 22, 6, 44 &45
5 & 7 [Sensory Association Area of the Parietal Lobe]
Function: for body scheme or image [knowing the relation of the different body parts]
Ablation: loss of body image [person cannot determine parts of his own body]
9-10-11-12 [Pre-Frontal Areas]
Function: concerned with thinking, judgment, and other complex thought processes or activities
Ablation: on one side, does not produce any defect; if both sides, changes in personality and behavior [Frontal Lobe Syndrome]
Stimulation: produce autonomic responses [such as sweating, salivation]
19 [Occipital Eyefield]
Function: conjugate eye deviation and eye fixation for vertical plane
Ablation: loss of conjugate eye movements and eye fixation [nystagmus]
Stimulation: visual hallucinations
39 [Visual speech center]
Function: interpretation of written language
43
Function: gustatory (not sure hehe)
3-1-2 [Somesthetic Area or Primary Cortical Center for Sensation]
Function: receives complex sensory perception such as discriminative senses [stereognosis, spatial recognition, two-point discrimination, determine
grades of temperature]
Ablation: severe impairment of sensation on opposite side of the body
Stimulation: numbness and tingling but never pain
41 [Primary Cortical Center for Audition]
Function: receive auditory impulses
Ablation: partial bilateral deafness, worse on the opposite side
Stimulation: ringing, buzzing, chirping, or rearing sounds
22 [Auditory Speech Center]
Function: comprehension and understanding of sounds heard
Ablation: Auditory Receptive Aphasia or Word Deafness [cannot understand what others are talking about and cannot take down notes]
6 [Pre-Motor Area]
Function: controls large part of muscles for mass, unskilled, crude and stereotype movements on opposite side of the body
Ablation: muscle spasticity and hyperactivity of deep tendon reflexes
Stimulation: produce aversive movements associated with autonomic responses
44 & 45 [Speech Areas of Broca]
Function: controls the apparatus for speech
Ablation: Broca’s Aphasia [expressive or motor aphasia – cannot express ideas but can understand]
Stimulation: no data
2 fold function
Protect cochlea from damaging vibrations caused by VERY loud sounds
Mask low frequency sounds in loud environments – removes background noise and allows a person to concentrate on sounds above 1000 cycles/second where
voice communication is transmitted.
Another function of the tensor tympani and stapedius muscles is to decrease a person’s hearing sensitivity to his or her own speech. This effect is activated by collateral
nerve signals transmitted to these muscles at the same time that the brain activates the voice mechanism
2. INSULIN ACTION
a. Transport of glucose across skeletal and cardiac muscles: sequence of events
Insulin lowers blood glucose immediately by enhancing glucose transport into adipose tissue and muscle by recruitment of glucose transporters (GLUT 4) from
the interior of the cell to the plasma membrane.
To initiate its effects on target cells, insulin first binds with & activates a membrane receptor protein. It is the activated receptor that causes the subsequent
effects.
The insulin receptor is a combination of 4 sub-units held together by disulfide linkages: 2 alpha subunits & 2 beta subunits that penetrate through the membrane.
Insulin binds with the alpha subunits outside the cell, but because of the linkages of the alpha subunits with the beta subunits, the latter become
autophosphorylated. This activates a local tyrosine kinase, which causes phosphorylation of other enzymes. Within seconds, the membranes of muscle cells
increase their uptake of glucose.
3. THYROID GLAND
Iodide metabolism: Important biochemical process and reactions involved
Get supplies:Iodide concentration in the thyroid is by the use of an energy dependent process which is linked to the sodium-potassium ATPase dependent thyroidal I-
transporter. This is controlled by TSH.
Coupling
DIT + MIT= T3
DIT + DIT= T4
This occurs within a thyroglobulin molecule
THYROPEROXIDASE- by stimulating the free radical formation of iodotyrosine
Formed thyroid hormone stays in thyroglobulin until it is degraded.
Calcitriol (1,25-Dihydroxycholecalciferol)
steroid hormone formed from vitamin D by successive hydroxylations in the liver and kidneys.
Vitamin D-3 (cholecalciferol) is formed in the skin when a cholesterol precursor, 7-dehydroxycholesterol, is exposed to ultraviolet light. Activation
occur when the substance undergoes 25-hydroxylation in the liver and 1-hydroxylation in the kidney.
The primary action of 1,25-(OH)2 D3 is to promote gut absorption of calcium by stimulating formation of calcium-binding protein within the intestinal
epithelial cells. Vitamin D also promotes intestinal absorption of phosphate ion.
In bone, vitamin D may play a synergistic role with parathyroid hormone (PTH) in stimulating osteoclast proliferation and bone resorption.
Compared to parathyroid hormone (PTH), vitamin D exerts a much slower regulatory effect on calcium balance.
Calcitonin
a calcium-lowering hormone that is secreted primarily by cells in the thyroid gland inhibits bone resorption. Its action is entirely the opposite of PTH.
affects blood Ca2+ levels in three ways:
a) Inhibits Ca2+ absorption by the intestines
b) Inhibits osteoclast activity in bones
c) Inhibits calcium and phosphate reabsorption by the kidney tubules
Secretion of calcitonin is stimulated by: an increase in serum calcium, gastrin and pentagastrin.
7. FERTILIZATION
Sperm Transport from Origin to Site of Fertilization:
Sperm deposited in the VAGINA
↓
Enter CERVIX
↓
Cervical mucus secretion aids or impedes sperm movement:
Prior to ovulation: Becomes watery and guides sperm through cervical canal
High progesterone: Becomes extremely viscid and disorganized, impeding movement
↓
Enter UTERUS
↓
FALLOPIAN TUBES
↓
Meets EGG
Capacitation Acrosome reaction
On coming in contact with the fluids of the female genital tract, multiple Before a sperm can fertilize the ovum, it must dissolute granulose cell layers
changes occur that activate the sperm for the final processes of fertilization and then it must penetrate through the zona pellucida.
The uterine and fallopian tube fluids wash away the various inhibitory factors Hyalorunidase depolymerizes the hyaluronic acid polymers in the intercellular
that suppress sperm activity in the male genital ducts cement that hold the ovarian granulose cells together.
After ejaculation, the sperm deposited in the vagina swim away from the Proteolytic enzymes digest proteins in the structural elements of tissue cells
cholesterol vesicles upward into the uterine cavity, and they gradually lose that still adhere to the ovum.
much of their other excess cholesterol over the next few hours, making the When the sperm reaches the zona pellucid, the anterior membrane of the
membranes at the head of the sperm much weaker sperm binds with receptor proteins in the zona pellucid. Then rapidly, the entire
The membrane of the sperm also becomes much more permeable to calcium acrosome dissolves, and all the acrosomal enzymes are released.
ions which change the activity of the flagellum, giving it a powerful whiplash These enzymes open a penetrating pathway for passage of the sperm head to
motion. The calcium ions also causes changes in the cellular membrane of the the inside of the ovum. Within 30 minutes, the cell membranes of the sperm
acrosome, making it possible for the acrosome to release its enzymes rapidly head and of the oocyte fuse with each other to form a single cell.
and easily.
8. MENSTRUAL CYCLE
4 phases: Describe appearance of endometrium – (thickness, glands, arteries, stroma)
PHASE DESCRIPTION/HORMONAL CONTROL THICKNESS GLANDS ARTERIES STROMA
Proliferative Under the influence of estrogen: stromal Increase in size due SIMPLE STRAIGHT Spiral Arteries Dense Abundant ground
Phase cells & epithelial cells proliferate rapidly to repair and growth TUBULAR GLANDS Become longer but substance with numerous
(D: 1-14) of denuded epithelium - Become longer do not extend to mitotic cells
(4-6 mm) - Increase in number superficial surface
- Glandular epithelium
accumulate glycogen
Secretory Occur after ovulation Increased thickening COILED TORTUOS More coiled Edematous with
Phase Correspond to formation of Corpus due to edema of with LATERAL More tortuous but accumulation of intracellular
(D: 15-26) Luteum stroma SACCULATIONS does not reach the fluid and secretion of uterine
Glandular epithelial surface epithelium glands
cells with more
secretions
Premenstrual Correspond to regression of Corpus Decreasing thickness HIGHL COILED but Ischemia of stratum Nonedematous but dense
Phase Luteum (3-4 mm) stop secretion functionale with leukocyte infiltration
(D: 26-28; Blood flow continue (WBC)
24-28hours to basal portion
before Vasospastic
menstruation) Intermittent
contraction of blood
flow
Menstrual Due to reduction of estrogen and Involution of Cease to secrete Blood flow still Invaded by leukocytes
Phase progesterone before and of menstrual endometrium continue to basal
(D: 25-28) cycle Reduced to 65% portion
Lasts for 3-5 Days thickness
10. SEMEN
The components of semen come from two sources: sperm, and seminal plasma. Seminal plasma, in turn, is produced by contributions from the seminal vesicle,
prostate, and bulbourethral glands.
Seminal plasma of humans contains a complex range of organic and inorganic constituents.
The seminal plasma provides a nutritive and protective medium for the spermatozoa during their journey through the female reproductive tract. The normal environment
of the vagina is a hostile one for sperm cells, as it is very acidic (from the native microflora producing lactic acid), viscous, and patrolled by immune cells.
The components and contributions of semen are as follows:
GLAND APPROX % DESCRIPTION
Testes 2-5%[1] Approximately 200- to 500-million spermatozoa (also called sperm or spermatozoans), produced in the testes, are released per
ejaculation.
Seminal 65-75% fructose - the main energy source of sperm cells, which rely entirely on sugars from the seminal plasma for energy.
vesicle prostaglandins – reacting with female cervical mucus to make it more receptive to sperm movement it also causes reverse peristaltic
contraction in the uterus and the fallopian tube to move the ejaculated sperm toward the ovaries
Fibrinogen – forms a weak fibrin coagulum that holds the semen in the deeper region of the vagina where the uterine cervix lies.
Other contents: amino acids, citrate, enzymes, flavins, phosphorylcholine.
Prostate 25-30% zinc - serves to help to stabilize the DNA-containing chromatin in the sperm cells.
secrete a slightly alkaline (pH 7.29) fluid, milky or white of egg in appearance - The alkalinity of prostate fluid helps neutralize the
acidity of the vaginal tract, prolonging the lifespan of sperm.
Profibrinolysin – becomes fibrinolysin that causes dissolution of the coagulum 15-30mins after ejaculation allowing sperm to become
highly motile.
Other contents: acid phosphatase, citric acid, fibrinolysin, prostate specific antigen, proteolytic enzymes
Bulbourethral < 1% mucus - during sexual arousal each gland produces a clear, viscous secretion known as pre-ejaculate. This fluid helps to lubricate
glands the urethra for spermatozoa to pass through, it neutralizes traces of acidic urine in urethra, and helps flush out any residual urine or
foreign matter. It is possible for this fluid to pick up sperm, remaining in the urethral bulb from previous ejaculations, and carry them
out prior to the next ejaculation.
11. AGING