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o ACTH
Thyrotropin Releasing Hormone (TRH) Acromegaly – overproduction of GH
o TSH & PRL Somatomedin C/ IGF-1
Gonadotropin Releasing Hormone (GRH) o screening test
o FSH & LH o IGF-1 = acromegaly
Growth Hormone Releasing Hormone (GHRH) Oral Glucose Tolerance Test (OGTT)
o GH o Extraction every 30 mins for 2 hrs
INHIBITION
3B-
o T4 & TSH
hydroxysteroid Female
HSD3B2
dehydrogenase Pseudohemaphroditism
isomerase def.
PARATHYROID GLAND (PTH)
- Ca levels
- Prevents hypocalcemia
o Regulates Ca in 3 Mechanism Aldosterone
Bone reabsorption of Ca Most abundant mineralocorticoid
Renal reabsorption of Ca Regulates water
Activation of Vit D3 Electroregulator
Main determinant for renal secretion of
ADRENAL GLAND K+
ADRENAL CORTEX
Conn’s Disease - 1 hyperaldosteronism
Zona Glomerulosa – mineralocorticoids
Saline Suppression Test
Zona Fasciculata – glucorticoids
confirmatory
Zona Reticualis – sex hormones
Plasma Aldosterone
Concentration/Plasma Renin Activity
GO MAKE (PAC/PRA ratio)
FIND GOOD Screening
REX SEX >30 = suggestive
>50 = diagnostic
ADRENAL MEDULLA – cathecolamines Weak or Adrenal Androgens
Dehydroepiandrosterone (DHEA)
Androstenedione
Virilization – dse associated in females
ADRENAL MEDULLA MISCELLANEOUS HORMONES Smctn
Norepinephrine/Noradrenaline Human Chorionic Gonadotropin ghl
Highest in brain o Fertility eval. In female
Neuroblastoma – fatal malignant Human Placental Lactogen
tumor of the neural plate o Stimulates dev’t in mammary gland
Gastrin
Urinary Metabolites o Secretion of HCl by parietal cells
o Vanillylmandelic acid (VMA) o Respond to vagal stimulation & food in
o 3-methoxy-4-hydroxyphenylglycol stomach
Epinephrine/Adrenaline Zollinger-Ellison Syndrome
Produced from norepinephrine Gastric carcinoma
2 amine gastrin = HCl
Comes only from adrenal medulla Serotonin
Flight/fight response o Binds to platelets
Pheochromocytoma – tumor of the o Stimulates vasoconstriction
adrenal medulla due to overproduction o Released during coagulation to
of catecholamines stimulate vasoconstriction
Hypogonadism
o prolactin, /absence of secretory
activity of gondas
o Disproportionate upper & lower
segments
Pre-testicular infertility
o 2 hypogonadism
o Hypothalamic/pituitary lesions
Testicular infertitily
o 1 infertility
Klinefelter’s Syndrome
“XXY Syndrome”
Azoospermia & Gynecomastia
Varicocele
Enlargement of veins in
scrotum
Post-testicular infertility
o Problem in sperm fxn & transport
Estrogen
o 2 sex female char.
o Breast dev’t
o Maturation of external genitalia
Estrone (E1)
Post menopausal
Estradiol (E2)
Pre-menopausal
Most potent
Ovarian fxn. assessment
Estriol (E3)
Maternal, women
fetoplacental viability
Marker for down syndrome
Progesterone
o Fertility eval. In women