Health and Medicine - Immunology; Studies

Conducted at University of Queensland on

Immunology Recently Reported (Recruitment of
Antigen Presenting Cells To Skin Draining
Lymph Node From Hpv16e7-expressing Skin
Requires E7-rb Interaction)
Info publikasi: Health & Medicine Week ; Atlanta [Atlanta]15 Mar 2019: 4480.

Link dokumen ProQuest

TEKS LENGKAP
2019 MAR 15 (NewsRx) -- By a News Reporter-Staff News Editor at Health &Medicine Week -- Investigators discuss
new findings in Health and Medicine - Immunology. According to news originating from Brisbane, Australia, by
NewsRx correspondents, research stated, "High-risk' human papillomaviruses (HPV) infect keratinocytes of
squamous epithelia. The HPV16E7 protein induces epithelial hyperplasia by binding Rb family proteins and
disrupting cell cycle termination."
Financial supporters for this research include Merchant Charitable Foundation, Cancer Council Queensland.
Our news journalists obtained a quote from the research from the University of Queensland, "Murine skin
expressing HPV16E7 as a transgene from a keratin 14 promoter (K14.E7) demonstrates epithelial hyperplasia,
dysfunctional antigen presenting cells, ineffective antigen presentation by keratinocytes, and production of
immunoregulatory cytokines. Furthermore, grafted K14.E7 skin is not rejected from immunocompetent non-
transgenic recipient animals. To establish the contributions of E7, of E7-Rb interaction and of epithelial hyperplasia
to altered local skin immunity, K14.E7 skin was compared with skin from K14.E7 mice heterozygous for a mutant
Rb unable to bind E7 (K14. E7xRb(Delta L/Delta L) mice), that have normoplastic epithelium. Previously, we
demonstrated that E7-speicfic T cells do not accumulate in K14.E7XrB(Delta L/Delta L) skin grafts. Here, we further
show that K14.E7XRb(Delta L/Delta L) skin, like K14.E7 skin, is not rejected by immunocompetent non-transgenic
animals. There were fewer CD11b(+) antigen presenting cells in skin draining lymph nodes from animals recipient
of K14.E7XRb(Delta L/Delta L) grafts, when compared with animals receiving K14.E7 grafts or K5mOVA grafts.
Maturation of migratory DCs derived from K14.E7xRb(Delta L/Delta L) grafts found in the draining lymph nodes is
significantly lower than that of K14.E7 grafts. Surprisingly, K14. E7xRb(Delta L/Delta L) keratinocytes, unlike
K14.E7 keratinocytes, are susceptible to E7 directed CTL-mediated lysis in vitro."
According to the news editors, the research concluded: "E7-Rb interaction and its associated epithelial hyperplasia
partially contribute to the suppressive local immune responses in area affected by HPV16E7 expression."
For more information on this research see: Recruitment of Antigen Presenting Cells To Skin Draining Lymph Node
From Hpv16e7-expressing Skin Requires E7-rb Interaction. FRONTIERS IN IMMUNOLOGY, 2018;9():. FRONTIERS IN
IMMUNOLOGY can be contacted at: Frontiers Media Sa, Avenue Du Tribunal Federal 34, Lausanne, Ch-1015,
Switzerland.
The news correspondents report that additional information may be obtained from I.H. Frazer, University of
Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld, Australia. Additional authors for this research
include P. Kuo, S.M. Teoh, Z.K. Tuong, G.R. Leggatt and S.R. Mattarollo. and can be your direct source for a journal
article and its citation.

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Keywords for this news article include: Brisbane, Australia, Australia and New Zealand, Antigen-Presenting Cells,
Health and Medicine, Hemic and Immune Systems, Immune System, Immunology, Lymph Nodes, Lymphoid Tissue,
University of Queensland.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2019, NewsRx
LLC
The citation for this news report is: NewsRx. Studies Conducted at University of Queensland on Immunology
Recently Reported (Recruitment of Antigen Presenting Cells To Skin Draining Lymph Node From Hpv16e7-
expressing Skin Requires E7-rb Interaction). Health &Medicine Week. March 15, 2019; p 4480.

DETAIL

Subjek: Medicine; Antigens; Recruitment; Lymphatic system; Cell cycle; Immunology

Lokasi: New Zealand Australia Queensland Australia Switzerland

Perusahaan / organisasi: Nama: University of Queensland; NAICS: 611310

Pengidentifikasi/kata kunci: Brisbane Australia Australia and New Zealand Antigen-Presenting Cells Health and
Medicine Hemic and Immune Systems Immune System Immunology Lymph Nodes
Lymphoid Tissue

Judul: Health and Medicine - Immunology; Studies Conducted at University of Queensland

on Immunology Recently Reported (Recruitment of Antigen Presenting Cells To Skin
Draining Lymph Node From Hpv16e7-expressing Skin Requires E7-rb Interaction)

Judul publikasi: Health &Medicine Week; Atlanta

Halaman pertama: 4480

Tahun publikasi: 2019

Tanggal publikasi: Mar 15, 2019

Penerbit: NewsRx

Tempat publikasi: Atlanta

Negara publikasi: United States, Atlanta

Subjek publikasi: Medical Sciences

ISSN: 15316459

Jenis sumber: Wire Feeds

Bahasa publikasi: English

Jenis dokumen: News

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 ID dokumen ProQuest: 2190691703

URL Dokumen: https://search.proquest.com/docview/2190691703?accountid=25704

Hak cipta: Copyright 2019, NewsRx LLC

Terakhir diperbarui: 2019-03-13

Basis data: Consumer Health Database

Hak cipta basis data  2019 ProQuest LLC. Semua hak cipta dilindungi.

Syarat dan Ketentuan Hubungi ProQuest

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