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1- Which factor does not cause p53 gene expression?

A) Hypoxia
B) Ionizing radiation
C) Cell proliferation
D) DNA damage
E) Oncogenic activation

2- Which one is not necessary for the PCR method?

A) Template DNA
B) Primers
C) RNA polymerase
D) Deoxynucleotide triphosphates (dNTP)
E) Appropriate buffers, magnesium ions

3- Which one does not determine the rate of movement of DNA particles on agarose gel during electrophoresis?

A) Agarose concentration
B) Primers
C) Electrophoresis buffer
D) Agarose type
E) DNA conformation

4- Which one cannot be an example for multifactorial diseases?

A) Schizophrenia
B) Cancer
C) Rickets
D) Diabetes Mellitus
E) Duchenne Muscular Dystrophy

5-Which one is not a property of autosomal recessive (AR) diseases?

A) 75% chance for normal offspring, 25% chance for affected offspring
B) Males and females are equally affected
C) Phenotypically normal parents
D) Vertical pedigree is specific
E) Phenylketonuria is an example of AR diseases

6- What does the word “proband” mean?

A) The first affected family member who seeks medical attention for a genetic disorder
B) The painted band on electrophoresis gel
C) The expressed protein of a specific gene
D) The relative of a genetically affected person for any disease
E) The DNA band of an autosomal dominant subject on agarose gel electrophoresis

7- Which one is not true about X-linked recessive disorders?

A) Males and females are not equally affected for X-linked recessive disorders
B) Females carriers have 25% chance for normal male offsprings (if the father is normal)
C) Female carriers have the risk to give birth to carrier daughters (if the father is normal)
D) There is no ‘carrier’ status for men, he has to be ill or not.
E) Duchennes Muscular Dystrophy is an X-linked recessive disorder

8- Which one can be calssified as X-linked dominant disorder?

A) Phenylketonuria
B) Galactosemia
C) Vitamin D resistant ricketts
D) Familial Adenomatous polyposis
E) Cystic fibrosis

9- What is “Preimplantation Genetic Diagnosis (PGD)” ?

A) The method that we can detect the diseases of mother before parturition.
B) Determining the possibilities whether the women are available to be pregnant or not.
C) The diagnostic methods used to find out the general tendency to creat a genetic disease.
D) The methods to find out whether the zygote has a genetic disease or not.
E) Amniocentesis

10- Which group do not necessarily need preimplantation diagnosis?

A) Couples who are carriers for single gene disorders

B) Couples who are at risk for translocation arrangements
C) Couples with increased maternal age
D) Couples who have previous affected children or repeated miscarriages
E) Couples who are adolescent

11- What is the main aim of using sodium dodesyl sulphate (SDS) during DNA purification?

A) To amplify the gene region

B) To denature DNA
C) To inhibit DNase
D) To denature proteins
E) To break up nucleotides from each other

12- Which one is the true matching?

A) DNA- northern blotting

B) RNA –southern blotting
C) Sanger sequencing- protein
D) DNA- western blotting
E) RNA-northern blotting

13-Which one is the best purified DNA sample?

A) A280/ A260 = 1.8

B) A260/ A280 = 1.8
C) A260/ A280 = 2.4
D) A280/ A260 = 2.4
E) A280/ A260 = 1.5
14- Which one is not a tumor suppressor gene?

A) Ras
B) WT1
C) Rb
E) P53

15- What is ‘ex vivo’ gene therapy?

A) the gene therapy applied directly through the cell of the animal.
B) the gene therapy applied through the circulation of the animal, then goes through the cell.
C) the gene therapy applied directly through the cell in the culture, then given to the body.
D) the gene therapy done by using the viruses.
E) the gene therapy done by using liposomes, not viruses.