Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Physostigmine (Eserine)
Alkaloid from calabar or ordeal bean (Physostigma
venosum) in West Africa.
Treatment for glaucoma – first therapeutic use by Laquer
(1877).
Neostigmine
Stimulant of GIT
Treatment for myasthenia gravis (1931)
CASE
Pertinent points?
Primary considerations?
A bottle of Malathion was found beside him by the medic. His 7-year old
nephew saw him ingesting something from the bottle.
SUMMARY
Anticholinesterase agents:
Pyridostigmine
Neostigmine
Organophosphates
They inhibit acetylcholinesterase, resulting to accumulation of
acetylcholine – predominance of parasympathetic effects.
Therapeutic uses
Treatment of paralytic ileus
Atony of the urinary bladder
Glaucoma
Prophylaxis in cholinesterase inhibitor poisoning
Alzheimer disease.
Organophosphate poisoning treatment:
Atropine (muscarinic antagonist)
Pralidoxime (reverses neuromuscular compromise)
3
Page
Page
4