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24 October 2010
14:58
1. BOB
Cl=Qx(1-(Cvenous/Carterial))
Cl: Clearance L/min
Q: flow of plasma through an organ or the whole body L/min
E=ClxCarterial
E: Drug Elimination rate mg/min
Rolling Veins
Thiopental 10 70
Methohexital 3.4 10
Etomidate 0.21 15
Propofol 2 10
Suction pot
Liver 100 2
Heart 69 0.4
Brain 54 2.3
Skin 11 7
Fat-soluble drugs: rapid onset; Vc, Vd >> plasmaV; eg.: thiopental, propofol
Fat-insoluble, highly ionised drugs: slower onset; Vc, Vd ≥ plasmaV; eg: muscle relaxants
Highly protein bound drugs: Vd, Vc > plasmaV; eg: opiates