Autori: Teodor Blidaru & Horea Chirila

Proiect realizat in chinurile pre-examen. Make it better and share it. Cheers
rs
Nume Clasa Receptori Subclasa
Metacolina Parasimpatomimetice RM + Ester al colinei
Carbacol Parasimpatomimetice RM + Ester al colinei
Betanecol Parasimpatomimetice RM + Ester al colinei
Pilocarpina Parasimpatomimetice RM + Alcaloid
Muscarina Parasimpatomimetice RM + Alcaloid
Arecolina Parasimpatomimetice RM + Alcaloid

Atropina Parasimpatolitice RM - Amina nepolara

Scopolamina Parasimpatolitice RM - Amina nepolara
Butilscopolamina Parasimpatolitice RM - CCA (trav greu mb)
Pirenzepina Parasimpatolitice RM - CCA (trav greu mb)
Propantelina Parasimpatolitice RM - CCA (trav greu mb)
Metantelina Parasimpatolitice RM - CCA (trav greu mb)
Butantelina Parasimpatolitice RM - CCA (trav greu mb)
Homatropina Parasimpatolitice RM -
Tropicamida Parasimpatolitice RM -
Trihexifenidil Parasimpatolitice RM - Amina tertiara (++ BHE)
Benztropina Parasimpatolitice RM - Amina tertiara (++ BHE)
Ipratropiu Parasimpatolitice RM - CCA (trav greu mb)

Nicotina Nicotinice Nn +
Vareniclina Nicotinice Nn + (+a4b2 creier)

Trimetafan Ganglioplegice Nn -
Mecamilamida Ganglioplegice Nn - amina sec (bhe)

Tubocurarina Curarizante Nm +- CCA - Pahicurare (antidep)

Galamina Curarizante (sinteza) Nm +- CCA - Pahicurare (antidep)

Pancuroniul Curarizante (sinteza) Nm +- CCA - Pahicurare (antidep)

Suxtametoniul Curarizante (asem ach) Nm +- CCA - Leptocurare (dep)

Neostigmina Anticolinesterazice - rev bl situs ach Carbamat- CCA (nu bhe)

Fizostigmina (Ezerina) Anticolinesterazice - rev bl situs ach Carbamat- amina (bhe)
Edrofoniul Anticolinesterazice - rev bl situs ach Alcool Cuaternar Amoniu
Somanul Organofosforice -irev bl situs ach gaze de lupta
Sarinul Organofosforice -irev bl situs ach gaze de lupta
Tabunul Organofosforice -irev bl situs ach gaze de lupta
Parationul Organofosforice -irev bl situs ach insecticid
Utilizari, efecte RA
Raynaud, HTA, TPSV, Intox Bella etc tipic PSM
Glaucom local + sistemic
Atonii intest, Xerostomie tipic PSM
Glaucom, Xerostomie oculare, tulb acom

Bradi, BAV, FO, reducere PS, sinechii, intox organofosf simpatic like
Raul de miscare, preanestezie atropina like
Antispastic, Antidiareic atropina like dar fara snc (nu bhe)
Antiulceros, glaucom (mai bun pe duodenal)
Digestive
Preponderent digestiv, mai bun decat atropina (se abs greu)

FO, profilax sinechii, rupere sinechii (+PSM)

Parkinson, tulb induse de antipsihotice (neuroleptice)

Parkinson, tulb induse de antipsihotice (neuroleptice)
Astm Bronsic, BPOC scad secr, +vasco, - escalator ciliar

coagulare+, SNC, Br spasm, tremur, durere, uscaciune, diaree,

hiper insu, +- FC, tahi, constrictie coro
Insomnie, greata, cefalee, apetit

Vasodilatatie (in crize hipertens, anevr aort, anestezie) atentie la alergii (hist elib)
efecte snc (se fol rar ca anti hta)

curarizant 1, ganglioplegic 2, histaminoelib 3 (RA+)

are si efect gangliopl si histaminoelib (at
potenta mai mica decat Tubocurarina, mai slab 2,3 alergii)

potenta mai mare decat Galamina, mai slab 2, 3

Facilitare IOT

MG, atonii intest, antag blocuri produse de curarizante PS like

glauc (pilocarpina like), Alz (acum tacrina, donepezil) toxic pe snc (nu sistemic!!!)
diagn MG , TPSV (PS like) PS like
coma, hta+bradi, mioza, hipersecretie totala, TD cu diaree,
incontinenta, facciculatii, paralizie
Important

Rezistenti la colinesteraze, durata lunga de actiune,

pot traversa bhe

60% renal 40% hepatic

Rau miscare
Antispastic, antidiareic
Antiulceros. SELECTIV M1

Oftalmo 1-3 zile (atropina ++)

Oftalmo 6 ore
Parkinson
Parkinson
AB, BPOC (nu se abs dupa inha)

Nn - F EPSP

Pe pred PS => S like, Pe pred S => PS like

nu dep mb=> paralizie, -tonus. Antagonizat

competitiv de ach. Utilizari: anesteziologie, stari
tetanice, reducere fr, relax conv, relax musc bronho

dep mb => fasciculatii, paralizie(inhibitie post

exces). asem ach, degr achcolin. Potentat de
anticolinesterazice

Tratament prin: inlaturare sursa (1), multa atropina

(2), reactivatori colinest - oxime (3), aspiratie tr br
(4)
Nume Clasa Receptori Subclasa
Adrenalina SM Directe Fizio a+b polara (putin bhe)
Noradrenalina SM Directe Fizio a (slab b) polara (nu oral)

Dopamina SM Directe Fizio Dopa

Fenilefrina SM Directe A1 sel A1 (part A2)

Xilometazolina SM Directe A1 sel A1 (part A2)
Oximetazolina SM Directe A1 sel A1 (part A2)
Clonidina SM Directe A2 sel A2

Izoprenalina SM Directe B sel B1 + B2 CA sinteza (nu oral)

Dobutamina SM Directe B sel B1
Salbutamol SM Directe B sel B2
Salmeterol SM Directe B sel B2
Orciprenalina SM Directe B sel B2
Fenoterol SM Directe B sel B2

Efedrina SM Indirecte putin polara (ok oral, bhe)

Nazofolina SM Indirecte
Cocaina SM Indirecte
Amfetamina SM Indirecte

Tolazolina SL Directe A1 + A2 A1 + A2
Fentolamina SL Directe A1 + A2 A1 + A2 (bl sero, agonist hista)
Fenoxibenzamina SL Directe A1 + A2 A1 + A2

Prazosin SL Directe A1 A1
Terazosin SL Directe A1 A1
Doxazosin SL Directe A1 A1
Tamsulosin SL Directe A1 A1 a si d (nu B)

Propanolol (+anxio) SL Dir B1 + B2 neselect bloc Gen 1 liposol

Timolol SL Dir B1 + B2 neselect bloc Gen 1
Metoprolol SL Dir B1 sel bloc Gen 2 liposol
Atenolol SL Dir B1 sel bloc Gen 2 hidrosol
Bisoprolol SL Dir B1 sel bloc Gen 2
Betaxolol SL Dir B1 sel bloc Gen 2
Labetalol SL Dir B + A bloc Gen 3
Carvedilol SL Dir B + A bloc Gen 3
Celiprolol SL Dir B1 bloc + Ago B2 + NO
Nebivolol SL Dir B bloc + NO
Pindolol SL Dir B bloc (activ SM intrins)
Acebutalol SL Dir B bloc (activ SM intrins)

Guanetidina SL indirecte scade elib in fanta

Rezerpina SL indirecte scade depozite
Ergotamina A1. Alcaloizi peptici
Ergotoxina A1. Alcaloizi peptici
Bromocriptina dopa Alcaloizi peptici
Ergometrina A1. Amide acid lisergic
Metisergida A1. Amide acid lisergic
Lisergida (LSD) A1. Amide acid lisergic
Utilizari, efecte
AB, soc anafil, stop crad, hemostatic loc, anest
vasoconstr (+RVP), contr splenica (+Vol) - in HipoT

1. ICC cu oligurie, 2. soc cardiogen/septic cu

monitorizarea functie renale.

A1=> VC si +TA (trat HipoTA ortost), dec nazal+conj, midri

Decongestionant nazal
Decongestionant nazal
A2 = scade tensiunea (trat HTA)

Cord (B2+)- soc, bradi, BAC; Astm Br (B2)

Cord (B2+)- ino, dromo, crono

AB (produc bronhodil si vasodil pulm), relaxare uterina

(ameliorare contractii, intarziere nastere prem)

Decongest Nazal, efecte SNC

Decongestionant nazal sau conjunctival
eudorie, perf intelect, forta musculara, rezist la effort

Feocromcitom, ischemie perif

Tratament HTA, adenom de prostata

Tratament HTA, adenom de prostata
adenom de prostata
adenom de prostata (nu scade HTA)

_x0001_ HTA – un beta-blocant +/- diuretic

_x0001_ BCI – angina pectoral
_x0001_ IMA – in faza initiala – supresia aritmiilor
_x0001_ Aritmii cardiace – supraventriculare si ventriculare
_x0001_ IC – metoprolol, bisoprolol, carvedilol – scad remo
Glaucom-scad secretie CC (-T) - mai util decat pirenzepina pt
Hipertiroidism – exista un exces de CA
_x0001_ Migrene – propranolol, metoprolol – mec. Neprecizat
_x0001_ Anxiolitice – propranolol
scade tremor (chir, muzicieni)
scade T in porta in HTP

Trat HTA - potenteaza SL dir

Trat HTA - potenteaza SL dir
vasoconstrictor
vasodilatatoare
parkinson
 RA
palpitatii, cefalee, tremor, aritm, hem cerebrale
Scaderea irigarii renale si activare PS (bradi)

Exces = rinita medicamentoasa

sedare, uscaciunea gurii (mec central)

aritmii prin stimulare excesiva cord

aritmii prin stimulare excesiva cord

tremor (B2 musc), anxietate, creste excitab SNC

tahifilaxie= fara efect (epuizare rezerve)

tahifilaxie= fara efect (epuizare rezerve)
anxietate, insomnie, apetit -, disforie, perf sept, palpitatii
aritmii etc

palpitatii, aritmii etc (Simpatic like)

Fenomen de prima doza

Bradicardia
_x0001_ hipoTA
_x0001_ Agravarea unui BAV
_x0001_ Agravarea unei boli vasculare periferice – alfa 1
_x0001_ Agravarea AB
_x0001_ Sedare, tulburari de somn, depresie –liposolubile
_x0001_ In general contraindicate lau DZ insulino-dependen
mec. Neprecizat
Important
contraindic la pacienti cu B blocante

Doza: 1. mica 1.5-7.5 μg/kg/min – vd ren, mez, coro – R-D1; 2.

Medie 10 μg/kg/min – efect ino + R-beta 1 si + TA; 3. Mare 10-15
ug/kg/min – actioneaza pe R-alfa 1 => vc general

T1/2 = 2 min (dutrata perfuziei are efect)

creste CA in fanta, efecte adr (mai slabe si ma scurte)

BIXTONIM = efedrina, nazofol, hidrocortizon, tiomersal (antiseptic)
Blocheaza mec de recaptare a Dopa, Nadr, sero
Creste elib de dopa si nadr

Bl A1 + A2 => - TA => +Simpatic (+cord, +renina)

Bl A1 => vasodilatatie (nu produc + simpatic); scad LDL, HDL

Cord - scad activitatea (-FC, dromo, batmo => utile in aritmii si CI) ;
- consum de oxigen (BCI, angina); -DC (util in HTA);
-vasoconstrictie prin A1 glaucom
Respirator - Bronhoconstr imp (!! de folosit B1)
Ochi - tratament glaucom (scad Tensiune)
Metabolic- acopera simptome hipogl dat S
SNC - anxiolitic
Nume Curs Clasa Receptori ++
Nitrazepam Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)
Flurazepam Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)
Trilazolam Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)

Diazepam (+anxio +conv) Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)

Clordiazepoxid (+anxio) Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)
Bromazepam Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)
Oxazepam (+anxio) Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)
Lorazepam (+anxio) Sedativ - Hipnotice BZD cresc frecv c Cl (+GABA)

cresc durata c Cl
Fenobarbital Sedativ - Hipnotice BT (+/inlocuiesc GABA)
cresc durata c Cl
Amobarbital Sedativ - Hipnotice BT (+/inlocuiesc GABA)

cresc durata c Cl
Ciclobarbital Sedativ - Hipnotice BT (+/inlocuiesc GABA)
cresc durata c Cl
Secobarbital Sedativ - Hipnotice BT (+/inlocuiesc GABA)

Hidroxizina Sedativ - Hipnotice Altele

Zolpidem Sedativ - Hipnotice Altele asem BZD
Zopiclona Sedativ - Hipnotice Altele
Zaleplon Sedativ - Hipnotice Altele Bz1 sau omega
Melatonina Sedativ - Hipnotice Altele MT1, MT2, MT3 - ritm circ

Clorpromazina Antipsiho-Neurolep Clasice: Fenotiazine catena lat alif

Levomepromazina Antipsiho-Neurolep Clasice: Fenotiazine catena lat alif
Tioridazina Antipsiho-Neurolep Clasice: Fenotiazine nuc piperidinic la cat lat
Flufenazina Antipsiho-Neurolep Clasice: Fenotiazine nuc piperazinic la cat lat
Trifluoperazina Antipsiho-Neurolep Clasice: Fenotiazine nuc piperazinic la cat lat

Clorprotixen Antipsiho-Neurolep Clasice: Tioxantene catena lat alif

Flupentixol Antipsiho-Neurolep Clasice: Tioxantene catena lat piperazinica

Haloperidol Antipsiho-Neurolep Clasice: Butirofenone

Clozapina Antipsiho-Neurolep Atipic

Risperidona (+SD) Antipsiho-Neurolep Atipic
Olanzapina (+SD) Antipsiho-Neurolep Atipic
Aripiprazol Antipsiho-Neurolep Atipic
Ziprasidona (+SD) Antipsiho-Neurolep Atipic
Meprobamat Anxiolitice altele
Hidroxizina Anxiolitice altele
Propanolol Anxiolitice B Bl
Buspirona Anxiolitice ago part sero 5Ht1a
Clordiazepoaxid, Diazepam, Anxiolitice BZD
Oxazepam, Lorazepam,
Medazepam, Alprazolam,
Halazolam, Clobazam

Litiul Antimaniacale + SD
Carbamazepina Antimaniacale Antiepileptice
Acid valproic Antimaniacale Antiepileptice
Antipsihice atipice Antimaniacale fara clozapina!!!!!
Carbamazepina
Acid valproic
Lamotrigina Stab Disp Antiepileptice
Olanzapina Stab Disp NL atipice
Quetiapina Stab Disp NL atipice
Risperidona Stab Disp NL atipice
Ziprasidona Stab Disp NL atipice
Aripiprazol Stab Disp NL atipice

Amitriptilina Antidepresive Triciclice (ADT) Inhiba recaptarea

serotonine (SERT)i si noradr
Trimipralina Antidepresive Triciclice (ADT) (NET)
Doxepina Antidepresive Triciclice (ADT)
Protriptilina Antidepresive Triciclice (ADT)
Desipramina Antidepresive Triciclice (ADT)
Clomipramina Antidepresive Triciclice (ADT)

Fluoxetina (Prozac) Antidepresive SSRIs Scade recaptare serotonina

(specifice recaptare sero)
Setralina Antidepresive SSRIs
Paroxetina Antidepresive SSRIs
Fluvoxamina Antidepresive SSRIs
Citalopram Antidepresive SSRIs
Trazodona Antidepresive SSRIs

Venlafaxina Antidepresive SNRIs ca SSRI (doze mici) + inhiba recapt Nadr (doze m
Duloxetina Antidepresive SNRIs Asem ADT

Atomoxentina Antidepresive NRIs specific recapt adr

Reboxntina Antidepresive NRIs
Nefazodona Antidepresive Alte inhiba 5HT1a
Mianserina Antidepresive Alte bl A2 presinaptici
Bupropiona Antidepresive Alte inh NET, SERT, DAT, VMAT

Fenelzina Antidepresive IMAO asem adt

Tranicipromina Antidepresive IMAO asem adt
Clorgilina Antidepresive IMAO MAO A
Moclobemida Antidepresive IMAO MAO A

Carbamazepina Anticonvulsivante

Blocante NA

Fenitoina Anticonvulsivante

Etosuximida Anticonvulsivante Blocant de CA

Acid valproic Anticonvulsivante

Mecanism complex
Lamotrigina Anticonvulsivante

Fenobarbital Anticonvulsivante
Primidona Anticonvulsivante
BZD (Diaz, Clonazepam) Anticonvulsivante GABA-ergic
Tiagabina Anticonvulsivante
Vigabatrina Anticonvulsivante
Gabapentina Anticonvulsivante
Pregabalina Anticonvulsivante

Acetazolamida Anticonvulsivante Inh Anh Carb

Felbamat Anticonvulsivante
Topiramat Anticonvulsivante Alte
Lebetiracetam Anticonvulsivante

Levodopa Antiparkinson Precursor Dopa

Bromocriptina Antiparkinson Agonist Dopa
Pergolida Antiparkinson Agonist Dopa
Cabergolina Antiparkinson Agonist Dopa
Ropinirol Antiparkinson Agonist Dopa
Pramipexol Antiparkinson Agonist Dopa
Apomorfina Antiparkinson Agonist Dopa

Selegilina Antiparkinson Inhib MAO B

Rasagilina Antiparkinson Inhib MAO B
Entacapona Antiparkinson Inhib COMT
Tolcapona Antiparkinson Inhib COMT
Amantadina Antiparkinson creste elib, scade recapt

Benztropina si Trihexifenifil Vezi curs SNV Col anti M

Subclasa
sed + hip (hip)
sed + hip (hip)
sed + hip (hip)
sed + anxiolotice + mio
sed + anxiolotice
sed + anxiolotice
sed + anxiolotice
sed + anxiolotice
act lunga (instalare lenta)
durata scurta/medie (abs+)
durata scurta/medie (abs+)
durata scurta/medie (abs+)
sedativ, anxiolitic, antiemetic, antihist
imidazopiridinic
sedativ + potenta mica
sedativ + potenta mica
sedativ + potenta medie
incisiv + potenta mare
incisiv + potenta mare
sedativ + potenta mica
incisiv + potenta mare
incisiv + potenta mare
FD FC
scade vigilenta liposol!!!! se absorb bine, se
leaga de pp, trec bhe, metab
scade vigilenta hepatic (pxidare microzomala=>
scade vigilenta metaboliti - glucuronoconjucare
scade vigilenta, anxietate, relax sau direct glucuronoconj, elim
musc renala (+bila)
scade vigilenta, anxietate
scade vigilenta, anxietate
scade vigilenta, anxietate
scade vigilenta, anxietate
liposol - intern, ir, inj; abs buna,
legare pp, metab hepatica
(principal - oxidare, secundar - N
dezalchilare si N glucozilare) +
sed, hip, anticonv, antiepi renal (metab inactivi). Elim
creste prin alcalinizarea urinii-
imp in tratament
sed, hip, anticonv
sed, hip, anticonv
sed, hip, anticonv
hipnotic intern
hipnotic, sed, anxio, miorelax, anticonv
1. Sistem mezolimbic
mezocortical (-D2) -
antipsihotic
2. Sistem nigrostriatal(-D2) -
sdr. Extrapiramidal
3. Sistem tuberoinfund -
creste PRL
4. Sistem medulo periventr
- creste foame si greutate
5. Sistemul incerto hipotal
- necunoscut om
>Blocare
H1 si A1 - sedare >Bl A,
Musc, D - sdr endo
>Antivomitiv (-D2)
>hipotermizant
 anxiolotic, sedativ, mio relax
anxiolotic, sedativ, mio relax

abs + PPH(oral) -instalare tardiv

sedare, relax musc, anticonv

abd complet, eliminare ca atare

renal. T1/2 20 h (o doza pe zi),
sub forma de saruri

de tip sedativ
de tip sedativ
de tip sedativ
de tip psihoton
de tip psihoton
de tip psihoton

liposolubile => abs buna TD,

latenta mare, adm orala, legare
ci) + inhiba recapt Nadr (doze mari) pp 90%, metab hepatica (T1/2 =
20-80 ore => unic pe zi)
inhiba MAO A (sero) si MAO B
(dopa si nadr)
inh MAO A (Sero)
inh MAO A (Sero)

abs lenta oral, 70% legat prot,

Bl Na metab hepatic, inh enz

Bl Na abs buna, 90% leaga pp, ind enzi

Bl Ca abs complet, metab hepat

Bl Na, Ca, +GABA, - glutamic Abs buna, 90% se leaga, metab hep
Bl Na, - glutamic

abs buna, se leaga modrat de

pp, metab hepatic; 20-30% se
elim ca atare
Bl Na Metab hepatica => fenobarbital
adm inj
Inhiba recapt GABA
inhiba Gaba transaminaza
Fav elib GABA
Fav elib GABA

inhiba Anh Carb => modif ph (functionalitate glut)

decarboxilare=> dopamina abs repede, doar 1-2% ajunge

ago D2 T1/2 = 5 ore

ago D2
ago D3
 inj, efect 2 ore

amina triciclica (+dopa in fanta)

Utilizari, efecte RA
anxietate, afect psihosom, insomnie, sedare, reducere psiho (memorie),
preanestezie, postop, pre endoscopie, slabiciune, ataxie, cefalee, vertij,
alcoolism acut, anticonv vedere, greata etc + reactii paradoxale
miorelaxant (diazepam) (la batrani-invers efect)

somnolenta, stare confuzionala,

dereglare somn, alergic, toleranta
creste metab saruri biliare (util in colestaza);
este inductor enzimatic (scade activ AO,
digitox, steroizi)

toate: insomnii, preanest, sedativ, adjuvant,

agitatie psihomotorie, antiepi, antconb, icter
nuclear, colestaza (FB)
!!! Insomnie (FB - deficit de
mentinere si restul in deficit de adormire)

antihist in dermatologie

hipnotic la varstnici
insomnie cu deficit de adormire
insomnie cu somn de slaba calitate - schimbare fus orar

1. Psiatrice (schizofrenie, bipolar, tourette, 1. Comp (pseudodepr). 2.

alzheimer-comportament; anxietate in doze Neurologice (parkinson like, torticolis;
mici) diskinezie tardiva) + vegetatice (S like)
2. Non psihiatrice (antiemetice, 3. Metab
prurit, sedare - prometazina) (greutate, HG, HiperPRL)
Droperidol + fentanil => 4. Alergice (cutanate si
inducerea neuroleptanesteziei agranulocitoza - clozapina)
5. Oftalmologice
(clorpromazina - imbatranire c c,
tioridazina - ret) 6.
Cardio (tioridazina+ziprasidona)
7. Sdr neuroleptic malign
8. Interact
medicamentoase: nu trebuie asoc cu
anticol si A-adr. NL sedative nu cu alte
sedative. Tioridazina si zisapridona
atentie cu antiaritmice
BT like, induct enz
anxio, sed - pref in boli dermato
inlatura simptome (SL like)
anxietate !!!!! Nu fobii greata, cefalee, ameteli, hiperexci

Alprazolam - atac panica si agorafobie

SNC (tremor), Tiro (insuf), Renal

(+diureza=> diab insip, sdr nefrotic),
tratament maniei (5-10 zlle), asoc cu sedative Cord (boala NS, tahi+bradi), Edeme - in
si neuroleptice. Altele: psihoza + alcoolism functie doza
asoc cu litiul. Utila cand nu rasp la litiu si AV
efect in 1-4 zile + sedativ

Carbamazepina (D+M); acid valproic (M>D);

lamotrigina (!!D>M)

D> M
D> M
M> D
M> D
M, nu D!!!!

Depresie (neresp la ssri si snri), durere, sedare (amitript+), antimuscarinice,

enurezis, insomnie, migrene, oboseala
tremor, +sudoratie, hipotensiune (A1),
convulsii, cardiotoxicitate (tahi, aritmii -
atentie la boli cardio), crestere
ponderala, hiponatremie, abstinenta,
interactiuni medic (nu cu alcool!!! Nu
cu imao!!!)

Asem ADT (mai putine RC) fara cardiotoxicitate, greata, dureri

abd, diaree, constipatie, insomnie,
agitatie, rush, hiponatremie, disfunctii
sexuale >sdr serotoninei-creste
sero >sdr
abstinenta- la oprorea brusca
in depresii care nu raspund la altceva, tabagism

MAO si in alte organe: RA frecv -

HipoTA, crize hipertensive, afect
hepatica, polinevrite, agitatie etc
mai bine suportate

sedare usoara, cefalee, vertij, diplopie,

grataa, alergice, eruptii. Hepatic.
crize grand-mal, dureri (NU mic rau) Sanguine

doze mici(nistagmus, ataxie, vertij,

diplopie, rash), doze de durata
(hipertrofie gingivala, hirsutism,
crestere buze nas, neuropatie perif, rc
crize grand-mal, aritmii, dureri (NU mic rau) imuno, discrazii sangvine)

Mic rau epileptic Gastro: greata, vars, dureri, anorexie. Alte: cefalee, oboseala, ameteli. Rar: r

crize partiale complexe, Mic, mare rau toxicitate hepatica + greata, vars, dur
conv tonico cl + mic rau si mare rau + crize partiale

Mare rau epileptic si crize partiale, orice criza

convulsiva sedare, scad cognitiv (copiii)
Mare rau epileptic (NU mic rau)
Orice criza, profilaxie conv la copil, mic rau sedare, toleranta dupa 3 luni

Conv Tonico-clonice
Conv Tonico-clonice + Mare rau epi + analgez
Conv Tonico-clonice + Mare rau epi + analgez

Mic rau epileptic

act pe D: tahi,aritmii, creste cons O2,

faze avansate - amelioreaza spectaculos dar hipotens art, greata, varsaturi, miscari
pe perioada scurta (on-off) coreo-atetozice, psihoze
endocrinologie: - PRL in adenoame hip asem levodopa (mai putin)
stari off varsaturi, greata
forme usoare si mdoerate (mai slab decat Asem Levodopa. La doze mari
levodopa). Folosita si in fome grave, cu blocheaza si Mao A = RA asem antidep
levodopa IMAO

asociere levodopa= ameliorare on-off toxic hepatic, trav bhe

antiviral (gripa)
efect pe hipertonie (mai putin tremor),
adjuvant la medicatie dopa. Sdr
extrapiramidale PSL like
Important

se abs rapid

se abs rapid
se abs mai lent

metab - glucuronoconj
metab - glucuronoconj

se elimina 20-30% nemodificat

Nu are efecte anxi, anticonv, miorelax

doar cazuri severe

de evitat cu medic care influenteaza citocrom p450 si depr SNC

antiemetic

antiemetic

Sdr extrapitramidal putin exprimat -

Blocheaza 5HT 2 A
sedativ slab, nu dependenta, nu anticonv

Ex: diazepam (5-10 mg 3x - anxiolotic; 10

mg seara - hipnonductor)

in psihi M-D se adm litiu+antidep apoi se

continua cu litiu

potentat de NL atipice (34-38)

eficacitate maxima (60-70% bolnavii cu dep

endogena)

ADT si SSRIs precipita episoade de manie

 Asem ADT (putine react) - mecanism
necunoscut - nu inhiba recaptarea!!

asemn ADT dar mai bine suportate

deoarece mai putine RA

Doze mici = cin 1, doze mari = cin 0

anorexie. Alte: cefalee, oboseala, ameteli. Rar: rash, discrazii sangv

electie in mic rau + crize tc

Bloc NA (asem carbamazepina) si apoi gaba ergic (fenobarb)

Clonazepam - de ultima alegere in mic rau
rezerva , cu altele

Se asociaza cu carbidopa si benserazida

pentru mai putine RA (inhiba decarboxilare)
efect redus, duispare dupa luni
Nume Clasa Receptori Subclasa
Morfina Opioizi Agonist Opio Natural
Codeina Opioizi Agonist Opio Natural
Heroina Opioizi Agonist Opio Semi sintetic
Hidromorfona Opioizi Agonist Opio Semi sintetic
Metadona Opioizi Agonist Opio Sintetic
Petidina (Meperidina) Opioizi Agonist Opio Sintetic
Fentanil Opioizi Agonist Opio Sintetic

Pentazocina Opioizi Ago-Antago Opio

Nalorfina Opioizi Ago-Antago Opio

Naloxona Opioizi Antagonist Opio
Naltrexona Opioizi Antagonist Opio
Dextrometrofan (Tussin)
Loperamida (Imodium)
Tramadol (Tramal) Ago

Acidul acetilsalicilic AINS Irev Nesel: Cox 1+2 Salicilat

Ibuprofen AINS Rev Nesel: Cox 1+2 Acid arilalifatic

Metamizol sodic AINS Rev Nesel: Cox 1+2 Deriv Pirazolon
Fenilbutazona AINS Rev Nesel: Cox 1+2 Deriv Pirazolon
Diclofenac AINS Rev Nesel: Cox 1+2 Acid arilalifatic
Celecoxib AINS Selectiv: Cox 2
Etoricoxib AINS Selectiv: Cox 2
Rofecoxib AINS

Fenacetina AINS Deriv paraaminofenol

Paracetamol AINS Deriv paraaminofenol

Indometacin AINS Acizi indolacetici

Ketorolac AINS Acizi indolacetici
Piroxicam AINS Oxicami
Meloxicam AINS mai selectiv COX2 Oxicami
FD
Liganzi-receptori-Gi-scade
adenliat ciclaza => inhiba
transmitere nervoasa si
neurostransm
Receptori: Miu (DEAD -
dependenta, euforie,
analgezie suprasp, depr resp),
K (SAM - sedare, analgezie sp,
mioza), Delta (potenteaza
restul) => efecte centrale si
perif
FC Utilizari, efecte
1. Absorbitei (buna, dar FPP => Analgezie, EPA, antidiareic,
biodisponibilitate mica.) 2. atitusiv, anestezie
Distributie (pp-rapid in tes bine
irigate - depozite) 3.
Metabolizare
>Morfina (glucuronoconh
=>M3G, M6G=activi -renal
>Heroina (esteraze=>
monoacetilmorf=> morf)
>Petidina, Fentanil - oxidare
>Codeina - cit P450 => morf
4. Elim urinar si putin biliar

Antitusiv fara analgezic (nu dep)

Antidiareic fara analgezic (nu dep)
Agonisu miu (elib sero) - alternativa a opioiziloc (oral, inj, ir)

abs gastric, 50% pp, metab hep
t1/2=56 h
Analgezic, antipiretic,
antinflamator, antiagregant
analgezic, antipiretic (antiinfl mai
slab decat indometacin s
diclifenac)
analgezic, antipir (putin antiinfl)
antinflamator, act uricozurica
!! Antiinflamator

antiinflamatoare, analgezice

analgezic, antipiretic. Efic redusa

in dismenoree

antinfl, analgezic, antipiretic - boli

reumatice
analgezic - frecvent postop
T1/2=50 ore (1 doza), metab hep !!antiinflamator, analgezic, antipir
RA Important
1. Acut: Disforie, depr resp, greata,
varsaturi, T intracr, hipoTA
ortostatica, constipatie, prurit,
retentie urinara biodisp mai buna
2. Cronic: toxicomanie si
dep. Toleranta (pt toate efectele,
nu mioza si constip)

.ago pe K, antago pe miu. inainte

de morfina
.ago pe K, antago pe miu.
Combaterea dep resp.
inj. Combatere dep resp + intoxic
oral. Conbatere morfinomanie

gastrice, hep, renale, sangerari,

scade elim AU, sdr Reye

bine suportat digest si naproxen

agranulocitoza, cancerigen
digest, hematologice (leuco, agr)
digest mai bine tol decat indometacin

reduse fata de neselective. Nu antiagregant (pot da chiar

Nefrotoxce, hepatotox, alergii trombi)

alergice, trombocitopenie, anemie

hemolitica, nefrita interstitiala
(+transaminaze), citoliza hep in
intoxicatie

digest, snc, trombocitopenii,

ocular-opacitati

digest++
mai putine digest
Nume Clasa Durata Retentie Potenta
Misoprostol PGE1 Reproducator: av
Dinoprostona PGE2 Reproducator: avort -tIII sau i
Alprostadil PGE2 Reproducator: disfu
Carboprost PGE2a
Reproducator: avort tII, comb
Trometamina PGE2a
Epoprostenol PGI1 Respirator: HT pulm, men
Latanoprost PGF2a
Tavapros Glaucom: scad
Umoprostona

Cortizonul GC Scurta T1/2=8-12h marcanta Mica 20-25mg

Hidrocortizonul GC Scurta T1/2=8-12h marcanta Mica 20-25mg

Prednisonul GC Medie T1/2=12-36 slaba Medie 4-5 mg

Prednisolonul GC Medie T1/2=12-37 slaba Medie 4-5 mg

Metilprednisolonul GC Medie T1/2=12-38 slaba Medie 4-5 mg

Dexametazona GC Lunga T1/2=36-54 fara Mare 0.75 mg

Betametazona GC Lunga T1/2=36-55 fara Mare 0.75 mg

Triamcinolon GC fara
Beclometazona Dipro
Fluticazona propio

Difenhidramina AH Generatia I
Ciclizina AH Generatia I
Meclozina (Emestop) AH Generatia I
Hidroxizina AH Generatia I
Ciproheptadina AH Generatia I
Prometazina AH Generatia I
Difenhidramina AH Generatia I
Clorfeniramina AH Generatia I
Cetirizina AH Generatia I

Loratadina AH Generatia II
Desloratadina AH Generatia II
Levocetirizina AH Generatia II
FD FC Utilizari, efecte RA
Reproducator: avort/nastere
Reproducator: avort -tIII sau inmuiere col prenastere
Reproducator: disfunctie erectila

Reproducator: avort tII, combatere hem postpartum

Respirator: HT pulm, mentinere duct arterial

Glaucom: scad presiunea

fizio se trans in hidrocortizon-activ ICSR cronica. (25-75 mg/zi

fizio ICSR cronica. (20-60 mg/zi

forma activa prednisolon doze 30-80 acut. 5-10 cr

1 delta hidrocort eficace si local

corticodep
1.5-16 g pe zi supresie csr

oral

Inhalator AB

antivom:rau de miscare, vertij Bl M, A, Sero:

slab sedative,
antivom:rau de miscare, vertij scad psiho,
antivom:rau de miscare, vertij potenteaza
antivom:rau de miscare, vertij alcool, snc,
uscaciune gura,
antivom:rau de miscare, vertij apetit
antivom:rau de miscare, vertij
 potenteaza
alcool, snc,
uscaciune gura,
apetit

antivom:rau de miscare, vertij

durata mai lunga 12-24 h trec putin bhe=>snc redus aritmii

Important

1.Hidrocortizon acetat - suspensie injectat

2.Hemisuccinat de hidrocort - inj iv
urgete 3.Hidrocortizon sodiu fosfat -
inj iv im urgente

1. Prednisolon acetat-oral/loc
2.Prednisolon Na succinat - iv
3.Prednsolon Na fosfat - iv urgente 50-
500 mg o data
1. Metilprednisolon acetat - im sau local
2. Metilprednisolon
sodiu succinat - iv urgebte
acetat inj local, Na fosfat im sau iv
Na fosfat im sau iv
Diprophos - Betametazona Na fosfat +
Betametazona dipropionat

1. Triamcinolon diacetat - im/loc

2.Triamcinolon acetonid -
im/intrararicular
3.Triamcinolon hexaacenoid -
intraarticular

anestezic local slab

sedativ hipn
antiserotoninergic
sedativ hipn, anestezic local slab
sedativ hipn
sedativ hipn

Claritine
Aerius
Xyzal
Nume Clasa Receptori Subclasa
Halotan AG Inhalatorii lichide volatile
Enfluran AG Inhalatorii lichide volatile
Izofluran AG Inhalatorii lichide volatile
Desfluran AG Inhalatorii lichide volatile
Sevofluran AG Inhalatorii lichide volatile
Metoxifluran AG Inhalatorii lichide volatile
Eter Fietilic AG Inhalatorii lichide volatile
Protoxid de azot AG Inhalatorii Gaze inh
Ciclopropan AG Inhalatorii Gaze inh

Tiopentan sodic AG Intravenoase BT

Metohexital sodic AG Intravenoase BT
Hexobarbital sodic AG Intravenoase BT
Propofol AG Intravenoase BZD
Etomidat AG Intravenoase BZD
Ketamina AG Intravenoase BZD
Diazepam AG Intravenoase
Flumazenil AG Intravenoase
Droperidol AG Intravenoase
Morfina AG Intravenoase Opioide
Fentanil AG Intravenoase Opioide
Sulfentanil AG Intravenoase Opioide
Alfentanil AG Intravenoase Opioide
Ramifentanil AG Intravenoase Opioide

Lidocaina AL str amidica potenta si durata medie

Mepivacaina AL str amidica potenta si durata medie
Prilocaina AL str amidica potenta si durata medie
Bupivacaina AL str amidica potenta mare si durata lunga
Levobupivacaina AL str amidica potenta mare si durata lunga
Etidocaina AL str amidica potenta mare si durata lunga
Ropivacaina AL str amidica potenta mare si durata lunga
Articaina AL str amidica potenta mare si durata lunga
Cincocaina AL str amidica potenta mare si durata lunga

Procaina AL str esterica Potenta si durata scurta

Clorprocaina AL str esterica Potenta si durata scurta
Tetracaina AL str esterica Potenta si durata scurta
Benzocaina AL str esterica Potenta si durata scurta
Cocaina AL str esterica Potenta si durata scurta
FD FC Utilizari, efecte
Analgezie slaba, relax musc incompleta
Analgezie slaba, relax musc incompleta
idem

Risc mic RA
Risc mic RA
Risc mic RA
Risc mic RA
Risc mic RA
Risc mic RA
Risc mic RA
Risc mic RA
Risc mic RA

mai multe ra decat amidici

mai multe ra decat amidici
durata mai mare mai multe ra decat amidici
mai multe ra decat amidici
mai multe ra decat amidici
RA Important
hepatic, cord
!!Renal

nefrotox
cord fara echipament

!! Este si antiartimic bl na IB
toxic nn

singur natural
Nume Curs Clasa Receptori Subclasa

Digitoxina Tonicardiace Digitalice 1 OH

Digoxina Tonicardiace Digitalice 2 OH

Strofantinele Tonicardiace Digitalice na/k 4 OH

Adrenalina Tonicardiace SM
Izoprenalina Tonicardiace SM
Dobutamina Tonicardiace SM
Inamrinona Tonicardiace Inhib fosfodiest
Milrinona Tonicardiace Inhib fosfodiest
Istaroxima Tonicardiace sterolic na/k si sech Ca
Levosimedanul Tonicardiace trop C

Chinidina Antiaritmice Clasa I Bl canale Na I A - vit medie

Procainamida Antiaritmice Clasa I Bl canale Na I A - vit medie
Disopiramida Antiaritmice Clasa I Bl canale Na I A - vit medie

Lidocaina Antiaritmice Clasa I Bl canale Na I B - vit mare

Fenitoina Antiaritmice Clasa I Bl canale Na I B - vit mare

Mexiletina Antiaritmice Clasa I Bl canale Na I B - vit mare
Encainida Antiaritmice Clasa I Bl canale Na I C - vit scurta
Flecainida Antiaritmice Clasa I Bl canale Na I C - vit scurta
Propafenona Antiaritmice Clasa I Bl canale Na I C - vit scurta

Propanolol Antiaritmice Clasa II B Blocante

Metoprolol Antiaritmice Clasa II B Blocante
Atenolol Antiaritmice Clasa II B Blocante
Esmolol Antiaritmice Clasa II B Blocante

Amiodarona Antiaritmice Clasa III Bl canale K

Sotalol Antiaritmice Clasa III Bl canale K B blo care bl K

Bretiliu Antiaritmice Clasa III Bl canale K

Verapamil Antiaritmice Clasa IV Bl canale Ca

Diltiazem Antiaritmice Clasa IV Bl canale Ca
Alte: Digitalice, Atropina, Adenozina (tahiar supraventr prin reintrare - efect scurt)

Antianginoase Ntrati organici Nitrati - grupari tiolice

=> NO - +GMPc =>
relax (veno>art)

Nitroglicerina Antianginoase Ntrati organici

Izosorbid dinitrat Antianginoase Ntrati organici
Izosorbid mononitrat Antianginoase Ntrati organici
Pentaeritritil tetranitrat Antianginoase Ntrati organici
Molsidomina Antianginoase Ntrati organici
B Blocante Antianginoase B Bloc

Blocanti CA -
Nifedipina Antianginoase DHP predominant pe vase,
nu pe cord
Amlodipina (Norvasc) Antianginoase DHP
Nicardipina Antianginoase DHP
Felodipina (Plendil) Antianginoase DHP

Verapamil Antianginoase Fenilalchilamine Bl Ca si antiaritmic

Diltiazem Antianginoase Benzotiazepine Bl Ca si antiaritmic

Nicorandil Antianginoase Alte activ ca K cu act vasodil de tip nitrat (trat font angina pe
Trimetazidina Antianginoase Alte nu efecte hemodim, dar amelioreaza metab cord prin in
Ranolazina Antianginoase Alte scade curent de Na, scade contractilitatea
Ivabradina Antianginoase Alte scade FC prin inhib directa a canalelor FUNNY, alternati

Clonidina HTA I Simpatolitice stim A2 centrali SL Centrale

Metildopa HTA I Simpatolitice analog DOPA SL Centrale

Moxomedina HTA I Simpatolitice SL Centrale
Rilmetidina HTA I Simpatolitice SL Centrale
Guanabenz HTA I Simpatolitice SL Centrale

Trimetafan HTA I Simpatolitice SL Ganglioplegice

Guanetidina HTA I Simpatolitice scad CA (-elib) Neuro SL
Rezerpina HTA I Simpatolitice scad CA (-recapt) Neuro SL
Fentolamina HTA I Simpatolitice A Bl nesel
Fenoxibenzamina HTA I Simpatolitice A Bl nesel
Prazosin HTA I Simpatolitice A1 Blocante
Doxazosin HTA I Simpatolitice A1 Blocante
Terazosin HTA I Simpatolitice A1 Blocante
Propanolol HTA I Simpatolitice B Blocante
Metoprolol HTA I Simpatolitice B1 Blocante
Atenolol HTA I Simpatolitice B1 Blocante
Bisoprolol HTA I Simpatolitice B1 Blocante
Betaxolol HTA I Simpatolitice B1 Blocante
Carvedilol HTA I Simpatolitice Bl A + B
Labetalol HTA I Simpatolitice Bl A + B
Esmolol HTA I Simpatolitice t1/2 scurt - urgente
Nebivolol HTA I Simpatolitice B1 bloc + vasodilat
Pindolol HTA I Simpatolitice activitate SM intrinseca
Acebutalol HTA I Simpatolitice activitate SM intrinseca

Nifedipina HTA I Bloc Ca

Amlodipina HTA I Bloc Ca
MAI SUS
Verapamil HTA I Bloc Ca
Diltiazem HTA I Bloc Ca

Hidralazinele HTA I Vasodilatatoare creste GMPc

Minoxidilul HTA I Vasodilatatoare creste GMPc
Diazoxidul HTA I Vasodilatatoare creste GMPc
Nitroprusiatul de sodiu HTA I Vasodilatatoare creste GMPc
Fenoldopamul HTA I Vasodilatatoare creste GMPc
Nitroglicerina în p.i.v. HTA I Vasodilatatoare creste GMPc

Captopril HTA I Inh SRAA - IEC

Enalapril HTA I Inh SRAA - IEC
Lisinopril HTA I Inh SRAA - IEC

Trandolapril HTA I Inh SRAA - IEC

Fosinopril HTA I Inh SRAA - IEC

Eamipril HTA I Inh SRAA - IEC

Sartanii HTA I Inh SRAA - inh AT1 rec AT1

Inh SRAA - inh
Aliskirenul HTA I renina

Furosemid Diuretice Diretic Ansa TAL Henle - NaK2Cl

Torsemid Diuretice Diretic Ansa
Bumetanid Diuretice Diretic Ansa
Acid etacrinic Diuretice Diretic Ansa

Hidroxlortiazida Diuretice Diuretic tiazidic TCD - inhib Na/Cl

Indapamida Diuretice Diuretic tiazidic
Spironolactona Diuretice Diuretic anti ald
Amilorid Diuretice Diuretic anti ald
Triamteren Diuretice Diuretic anti ald

Acetazolamida Diuretice Diuretice IAC TCP, TCD

Metazolamida Diuretice Diuretice IAC
Diclofenamida Diuretice Diuretice IAC
Manitol Diuretice Diuretice Osmo
Teofilina Diuretice Blocante A1
Cafeina Diuretice Blocante A1
Rolofilina Diuretice Blocante A1
Carperitida Diuretice Peptide natriuretice
Nesiritida Diuretice Peptide natriuretice
Ularitida Diuretice Peptide natriuretice
Tolvaptan Diuretice Vaptani
Conivaptan Diuretice Vaptani
FD FC Utilizari, efecte
INOTROP + (fara + O2) 1.IC cu functie, IC C, IC A
BATMOTROP + Liposol mare, abs >90%, T1/2=7 z, 2. Fibrilatie atr cronica (-V)
DROMOTROP - pp >90%, Vd=0.6, hep >70%, renal 3. Flutter atrial (-V) 4.
(dir&PS) 30%, ORAL EPA
CRONOTROP - (PS)

Liposol medie, abs 75%, T1/2=1.6

z, pp 20-40%, Vd=6.3, hep 30%,
renal 70%, ORAL/INJ
Liposol mica, abs 0%, T1/2=1 z, pp
0%, Vd=18, hep 00%, renal 100%,
INJ

oral, abs buna, elim renal 10-50%, aritmii A+V (reintrare, focar ect) + efect
restul hep parasimpatolitic +efecte hemodinamice
iv-urgente asem chinidina (mai putin PSL),
aritmii A+V (direct + PSL)
!!oral=> metab. Se administreaza aritmii prin automatism anormal. Aritmii
IV, dupa ima recent
nu scade viteza AV=ok in aritm induse de
asem lido oral este ok digitalice
intre lido si feni eficace aritm V (digitalice sau ima)
aritmii reintrare, aritmii focar ect
aritmii reintrare, aritmii focar ect

tahicardii sinusale, aritmii focar ectopic,

frecvent fol extrasistole la adult, aritmie hipertiro,
control frecv V la tahiaritmii supraventr

iv, t1/2=9 min, frecvent fol

oral, bd 30-70% aritmii reintrare, aa de rezerva

aritmii post ima si mentinere ritm s dupa
reconversia Fia
urgenta in fibrilatia ventr

scad tot la cord + vasodil oral sau iv, metab hep 70%
=> hipoTA
Aritmii supraventriculare (nu ventriculare)
 Liposol-metab hepatica.
Doze mici elim PPH
S.L. (dur minute), transdermic (cat
e plasturele), oral (prep retard-
doze mari-cateva ore), IV (urgente) Tratament angina
Profilaxie angina
Profilaxie angina
Profilaxie angina
oral sau IV urgente dilatare coronare mari. Angina stabila sau i
toate angine (de font)-nu vasosp

prep retard cu elib prelungita (tahic reflexa

imp)

situs V vasodilatatie si depr miocardica

situs D vasodilatatie si depr miocardica

nitrat (trat font angina pecto)

oreaza metab cord prin inhib oxi AG, nu depletie ATP, scade acid lactic, scade radicali liberi
tractilitatea
analelor FUNNY, alternativa la B bloc

scade S perif liposol, t1/2 scuet brahi, -forta, -glux cerebr si splahnic

scade S perif

urgente HT (anevrism ao), EPA,

iv, dutata scurta hipotensiune controlata
hta severe, care nu rasp la altceva
hta severe, care nu rasp la altceva
vasodilatatie si S reflex hta feocromcitom (cu B Bloc)
hta feocromcitom (cu B Bloc)

Vasodilatatie cu -RVP si HTA sau IC HTA+adenom

tahic reflexa redusa prostata

toate hta (+bci, +aritmii)

 toate hta (+bci, +aritmii)

urt - urgente
c + vasodilat
ate SM intrinseca
ate SM intrinseca

linie 2 sau 3 in hta sarcina

HTA usoara, moderata, severa

Insuficienta cardiaca (-postsarc)
infl de alimente, activ ca atare Post IMA (-remodelare)
necesita act hep Boli renale (renoprotector)
activ ca atare
necesita act hep, metab hep,
renal, biliar
necesita act hep, metab hep,
renal, biliar
necesita act hep

HTAE sau IC la pac care nu tolereaza IEC,

renoprotectoare, post ima

scade reabs Na, Cl, K =>

scade Mg, Ca EPA, edeme, hiperpotasemie,
cresc PGE2 la nivel renal hipercalcemie, HTA, IRA, IRC, intoxic
=> vasodilatat oral, creste de 5 ori vol. inferfera medic, IC si ascita (impreuna cu
AINS spironolactona)

cresc reabs Ca=> efect oral. Ajung in lume prin secretie.

vasodilatator Competitie cu AU (hiperuricemie). HTA de fond, ICC, nefrolitiaza, diabet
musculotrop (util HTA) Efect moderat si lent (nu urgente) insipid,
elim biliara
diuretic slab, persista
mult in hiper ald primar, in hiper ald sec,
aceleasi indicatii ca si cele de mai sus, in
asociere

alcaloza metab, antiulceros, rau de munte,

elim Na si HCO3 epilepsie - petit mai
Glaucom acut
Glaucom acut
piv glaucom acut, edeme, ira
slab diuretic
slab diuretic

oral. Bl rc vasporesinei V2 util in hipoNa prin hiperhidr

V2 si V1a (vasodil) util in hipoNa prin hiperhidr
RA Important
bradi, BAV, aritmii, extrasistole
(bigeminism, trigeminism), psihice,
anorexie, greata, dureri musc
contraindicat la afectare hep

acumulare tesuturi na/k. K

inhiba. Ca creste efect.
Contraindic la afectare renala

digestive, cardiovasc, cinconism, de evitat la ICC (-contr), de

proaritmogen, SNC evitat iv
asem chinidina +imuno contraindic asem chin
PSL efect ino neg si vasoc perif

snc, anestezic like mai eficace la V decat la A

risc proaritmogen de rezerva

risc proaritmogen !!creste durata PA

bradi, bav, decompensare ic, efect chinidinic de mb (si

hipota, blocare B2 (neselect) => acebutalolul)
agravare AB, boli vasculospastice

proaritmogen, fibroza pulm,

hipotir, hepatita, teg, ochi etc

proaritmogen
proaritmogen

cardiace si digest nu cu B bloc!!!

asem verapamil dar vasodil mai intensa
cefalee, flush, tahi, hipota,
methemoglobinemie

act prelungita, se trans in IM

asem, ID, dar efect mai bun
efic moderata
nu determina toleranta incrucisata cu nitratii
vezi snv

arteriolodilat excesiva=> edeme, Toate tipurile angina, anti hta,

cefalee, hipoTA cu tahic reflexa
bradi, bav, proaritmo,
ddcompensare ic (nu cu B Bl)
antiaritmice, de ales la BCI
(brinhodil usoara), efect
tocolitic (evitare nasere
prematura)
Verapamil si nifedipina - hta
sarcina (LINIE 2)

sedare, somn, constip, xerostomie, Trat font HTA mod+sev

rebound (+diuretic). Rar in urgente
sedare, somn, constip, xerostomie, HTA mod-sever cu IR, HTA
anemir, rebound sarcina (PRIMA LINIE)

nu cu IR nu trece bhe
sedare, depresie, digest etc trece bhe

activeaza SRAA - de obicei se fol cu

diuretic

hta sarcina

bradi, bav, hipota, agravare ic

 bradi, bav, hipota, agravare ic

contraindicate la pacientii cu
angina deoarece dau tahi
reflexa (cu B Bl si diuretic)

tuse seaca, bronhospasm, obstr

nazala, hipoTA, afectare renala,
hiperpotasemie, angioedem,
neutropenie, tulb gust

toate efectele iec, mai putin cele

det de bradikinina (bronhospasm,
tuse)

hipopotasemie, hiperuricemie,
hipocalcemie, ototoxicitate,
alergice, hiper ald sec, hipoTA,
deshidratare ph urinar scade. Ph sang creste
durata mai lunga

hipopotasemie, hionatremie,
hiperuricemie, hipercalcemie,
hiperglicemie, alergice, oboseala, ph urinar scade. Ph sangv
hiperald sec creste
durata lunga
hiperpotasemie, ginecomastie etc
(spironolactona=sterol)

acitoza etab, litaza, alergice,

hipopotasemie urina alcalina

nu irc pt ca nu poate elim

snc
Nume Curs Clasa Receptori Subclasa
Acid acetilsalicilic Sange I Antiagregant COX1
Sulfinpirazona
Triflusalul
Indobufenul
Rc pt ADP - scade
Clopidogrel Sange I Antiagregant GPIIb/IIIa
Rc pt ADP - scade
Ticlopidina Sange I Antiagregant GPIIb/IIIa
Abciximab Sange I Antiagregant Bl GP Iib/IIIa
Eptifibatide Sange I Antiagregant Bl GP Iib/IIIa
Tirofiban Sange I Antiagregant Bl GP Iib/IIIa

Dipiridamol Sange I Antiagregant Inh fosfo diest

INJECTABIL. Exces
tratat cu protamin
Heparina standard Sange I Anticoagulant INJ 1000x ATIII sulfat
Heparina fractionata Sange I Anticoagulant INJ ATIII
Exemple: Enoxaparina – Clexane
Nadroparina – Fraxiparina
Dalteparina – Fragmina
Fondaparina – secventa pentazaharidica responsabila de efect hep
XABANII Sange I Anticoagulant INJ

leaga trombina (Iia) si o

Dabigatran Sange I Anticoagulant INJ blocheaza oral
Hirudina Sange I
Lepirudina Sange I
Bivarudina Sange I
Argatroban Sange I
Melagatran Sange I

Acenocumarol Sange I Anticoagulant ORAL

Streptokinaza Sange I Fibrinolitic plasminogen-plasmina

Anisreplaza Sange I Fibrinolitic streptokinaza+plasminogen uman activat
Urokinaza Sange I Fibrinolitic activator direct plasminogen
Alteplaza Sange I Fibrinolitic activator tisular plasminogen

Fier Sange II Antianemice de citit

Sulfatul feros Sange II Antianemice Prep ORAL
Gluconatul feros Sange II Antianemice Prep ORAL
Fumaratul feros Sange II Antianemice Prep ORAL
Fier sucrozat (Venofer) Sange II Antianemice Prep INJ
Fier dextran Sange II Antianemice Prep INJ
Fier carboximaltozat Sange II Antianemice Prep INJ
VIT B12 Sange II Antianemice
Acid folic Sange II Antianemice
FD FC Utilizari, efecte
doze mici

Asem acid acetilsalicilic

oral

iv in sdr coronariene acute

impreuna cu ASA = profilax AVC.

Impreuna cu warfarina pt profilaxie
tromb rpoteze

fact II, X, IX, XI, XII TVP, TEP, inschemie, sdr coronariene
fact X tromboze, embolii, tvp

fact X profilaxie trombembolii la ortopedici si fia

TEP, TVP (dupa heparine), IMA,

oral- timp Quick/INR valvular, fia

IMA, TEP, TVP, ocluzie arteriala

Pentru refacerea unui gram de Hb

sunt necesare 150 mg de Fe.
 RA Important
VEZI AINS

digest, neutropenie, trombocit pac cu alergie la ASA

mai putine ra electie post-stent

risc sangerare si tromboitopenie

cefalee, greata, varsaturi

nu trece BFP=ok la
hemoragii, trombocitopen, gravide. Evaluare prin
alergii, osteoporoza APTT
mai putin decat hep nu APTT

rtopedici si fia Rivaroxabanul Apixabanul

hemoragii, eruptii Interactiuni: Fenobarbital (scade efectul-ind enz), ASA (sangerare), Fenilbutazona (risc sanger

alergice si hipoTA

greata, dureri epi, crampe,

constip, diaree
desferoxamina in
intoxic acuta
alergice, anafilactice, colorare,
crestere fier
enilbutazona (risc sangerare), Sulfamidele antidiab (hipogl)
Nume Clasa Receptori Efect
Simpatomimetice Antiasmatic BRONHODIL +++
Parasimpatolitice Antiasmatic BRONHODIL ++
Bronhodil musculotrope Antiasmatic BRONHODIL ++ , antinfl
Inh degran mastocitara Antiasmatic Antialergic, antiinfl

Glucocorticoizii Antiasmatic Antiinflamator (-modulatori)

Antag LT si inh lipoox Antiasmatic Stop leucotriene

Opiopide Antitusive
Neopioide Antitusive

Clorura de amoniu Expectorante Secretostim Reflex indirect

Iodura de potasiu Expectorante Secretostim Reflex si difect
Guaiacolul, guaiacol sulfonatul de potasiu si guaifenezina (Coldrex)

Acetilcisteina Expectorante Secretolitce

Bromhexina Expectorante Secretolitce
FD FC Utilizari RA
C+P
C+P
C+P
P

C+P
P
Important
ADR, Izoprenalina, Salb, Salme - PROFILACTIC, Orcipren -Profilactic
IPRATROPIUL
TEOFILINA + AMINOFILINA
CROMOGLICAT SODIC & KETOTIFEN
BECLOMETAZONA DIPROPIONAT/ FLUTICAZONA = Inhalatorii
PREDNISON = oral
HEMISUCCINAT DE HIDROCORTIZON = inj iv
METILPREDNISOLON ACETAT & TRIAMCINOLONA ACETOID =inj im
MONTELUKAST & ZAFIRLUKAST (receptori) & ZALEUTON (sinteza)

MORFINA, CODEINA, NOSCAPINA, dextrometorfan

BUTAMIRAT (SINECOD), OXELADINA (PAXELADINE)

actiune slaba
Nume Clasa Subclasa
Opiul Antidiareic Opioide
Morfina Antidiareic Opioide
Codeina Antidiareic Opioide
Difenoxilatul Antidiareic Opioide
Loperamida (Imodium) Antidiareic Opioide
Racecadotril (Hidrasec) Antidiareic Opioide
Atropina Antidiareic PSL
Butilscopolamina Antidiareic PSL
Propantelina Antidiareic PSL
Caolin Antidiareic cresc vasco. Abs, protect
Subsalicilat de bsimut Antidiareic cresc vasco. Abs, protect
Carbune medicinal Antidiareic cresc vasco. Abs, protect
Pectinele Antidiareic cresc vasco. Abs, protect
Antagoniștii 5-HT3 Antidiareic
Teduglutida Antidiareic

NaHCO3 Antiulceroase Antiacide Sistemice

CaCO3 Antiulceroase Antiacide Nesistemice

Mg(OH)2 Antiulceroase Antiacide Nesistemice
Al(OH)3 Antiulceroase Antiacide Nesistemice
Cimetidina Antiulceroase Inh secretie gastrica
Ranitidina Antiulceroase Inh secretie gastrica
Famotidina Antiulceroase Inh secretie gastrica
Nizatidina Antiulceroase Inh secretie gastrica
Omeprazol Antiulceroase Inh secretie gastrica
Esomeprazol Antiulceroase Inh secretie gastrica
Lansoprazol Antiulceroase Inh secretie gastrica
Pantoprazol Antiulceroase Inh secretie gastrica

Pirenzepina Antiulceroase Inh secretie gastrica

Telenzepina Antiulceroase Inh secretie gastrica
Proglumida Antiulceroase Inh secretie gastrica
Acetazolamida Antiulceroase Inh secretie gastrica
Misoprostol Antiulceroase Inh secretie gastrica
Enprostil Antiulceroase Inh secretie gastrica

Octreotid Antiulceroase Inh secretie gastrica

Saruri bismut Antiulceroase Protectori mucoasa
Sucralfat Antiulceroase Protectori mucoasa
eliminare HP Antiulceroase

Piperidolatul Antispastice Neurotrope antag musculotropi = PSL

 antag musculotropi = PSL
Dicicloverina Antispastice Neurotrope
Butilscopolamina Antispastice Neurotrope
Oxifenoniul Antispastice Neurotrope
Metantelina Antispastice Neurotrope
Propantelina Antispastice Neurotrope
Oxibutinina Antispastice Neurotrope
Tolterodina Antispastice Neurotrope
Trospiul Antispastice Neurotrope
Darifenacina Antispastice Neurotrope
Solifenacina Antispastice Neurotrope
Mirabegronul Antispastice Neurotrope
Papaverina Antispastice Musculotrope
Mebeverina Antispastice Musculotrope
Drotaverina Antispastice Musculotrope
Trimebutina Antispastice Musculotrope

Metoclopramida Prokinetice Benzamide substituite

Cisaprida Prokinetice Benzamide substituite
Domperidona Prokinetice Deriv Benzimidazol
Neostigmina Prokinetice Colinergic
Betanecol Prokinetice Colinergic
Motilina si analogii Prokinetice
Prucaloprid Prokinetice
Sincalidul Prokinetice
Dexloxiglumida Prokinetice

Prometazina Antivomitive Bl H1
Difenhidramina Antivomitive Bl H1
Feniramina Antivomitive Bl H1
Meclizina Antivomitive Bl H1
Clorpromazina Antivomitive Antag D2-NL fenotiaz
Proclorpromazina Antivomitive Antag D2-NL fenotiaz
Tietilperazina Antivomitive Antag D2-NL fenotiaz
Haloperidol Antivomitive Antag D2-NL butirofen
Droperidol Antivomitive Antag D2-NL butirofen
Metoclopramida Antivomitive Benzamide substituite
Trimetobenzamida Antivomitive Benzamide substituite
Domperidona Antivomitive Deriv benzomidazol
Scopolamina Antivomitive PSL
Ondasetronul Antivomitive antag 5HT3
Ganisetronul Antivomitive antag 5HT4
Nabilona Antivomitive Canabinoizi
Dronabilon Antivomitive Canabinoizi
Aprepitan Antivomitive antag rec neurokininei 1
BZD Antivomitive lorazepam, alprazolam
 prednison, metilprednisolon,
GC Antivomitive dexametozonă

Metilceluloza Laxative-Purgative Laxative de volum

Carboximetilceluloza sodica Laxative-Purgative Laxative de volum
Agar (geloza) Laxative-Purgative Laxative de volum
Seminte de in Laxative-Purgative Laxative de volum
Seminte de Psylium Laxative-Purgative Laxative de volum
Sulfat de sodiu Laxative-Purgative Purgative saline (osmotice)
Sulfat de magneziu Laxative-Purgative Purgative saline (osmotice)
Citratul de magneziu Laxative-Purgative Purgative saline (osmotice)
Hidroxid de magneziu Laxative-Purgative Purgative saline (osmotice)
Macrogolii Laxative-Purgative Purgative saline (osmotice)
Lactuloza Laxative-Purgative Purgative saline (osmotice)
Lactilolul Laxative-Purgative Purgative saline (osmotice)
Xilitolul Laxative-Purgative Purgative saline (osmotice)
Ulei de ricin Laxative-Purgative Purgative iritante
Antrachinonice Laxative-Purgative Purgative iritante
Dantronul Laxative-Purgative Purgative iritante
Fenolftaleina Laxative-Purgative Purgative iritante
Oxifenisatina Laxative-Purgative Purgative iritante
Bisacodil (Dulcolax) Laxative-Purgative Purgative iritante
Ulei de parafina Laxative-Purgative Inmuiere scaun
Docusatul sodic Laxative-Purgative Inmuiere scaun
Laxative pe rec specifici
Mecanism Particularitati
scade secretie, scade motilitate, tonus sfinctere, inhiba
defecatie
tinctura

NU DEPENENTA
asem difenoxilat, dar mai bun efect. NU DEP
inhib enkefalinaza!!!!!!!! Inhiba secretia de h2o si electroliti
scad motilitate si secretii

abs toxine, produsi, +vasc

abs toxine, produsi, +vasc
absorbant
mucilagiu abs protect
alosetron
analog peptida gluc

baze slabe care neutralizeaza HCL, cresc ph, scad activ

pepsinei, fav vindecare leziuni. Creste HCL reflex, creste act rapida, durata scurta. Balonare
motilitatea
act rapida, durata medie. Constip. Ca
act rapida, durata medie. Diaree
Lent, durata lunga. Constipatie, osteoporoza
bl rec H2 scade toate secretiile

Inhib pompa protonica (Na/K)=> scadere marcanta IREVERSIBIL. Inh cit 450

inh cit 450

PSL dezavantaj: scad si secretia de mucus

si bicarb. Scad viteza de golire=
contraindic la reflux

Antigastrinic. Antag receptori

Inh Anhidraza Carbonica inh secr bazala
Derivat PGE1 mai mult secr stimulata
Derivat PGE2 mai mult secr stimulata

analog stomatostatina=>inhiba secretia peptidelor neuroendo

Cresc secretia mucus + bicarb si protejeaza de extindere act antibacteriana. Asoc cu antiacide dezavantajoasa
hidroxid de aluminiu=> gel vascos fixeaza saruri bil care relueaza
Metronidazol, tetraciclina, antisecretor, bismut

Str aminica
Str aminica
CCA
CCA
CCA
CCA
tract urinar
tract urinar
tract urinar
tract urinar
tract urinar
strim receptpori B3 musc neteda
inh fosfodiester s blocheaza Ca antispastic si vasodilat
colon iritabil si colonopatii
NOSPA=antispastic+vasodilatator+B1 bloc
ago recept opioizi DEBRIDAT

rec D2 S+IS
rec 5HT4 S+IS+Colon
rec D2 S+IS
Anticolinesterazic rev
Muscarinic
stim comntractii
Agonist 5-HT4
Agonist R-colecistokinină
Antagonist R-colecistokinină A

H1 bloc si anticol la niv centrului vomei

Putin eficace in rau de miscare

Putin eficace in rau de miscare
Putin eficace in rau de miscare
Putin eficace in rau de miscare
Putin eficace in rau de miscare
Putin eficace in rau de miscare
Putin eficace in rau de miscare
Putin eficace in rau de miscare
rau miscare!!!
Voma medicamentoasa
Voma medicamentoasa
voma citostatice
voma citostatice
 voma citostatice

fibre-cresc continu-stim peristaltism-inmuiere (1-3 zile) constipatie functionala, anorexie

nu se absorb-osmotic-creste volum-peristaltism (scaune la 1- evacuare rapida (inainte de interventii)

3 ore). Doze mici laxativ

iritare-reflexe-peristaltism elim rapida, constipatii

aloe, rubarba, fragula etc

inmuiere hemoroizi, etc

un efect. NU DEP
hiba secretia de h2o si electroliti

atie, osteoporoza
inhibitor enzima de conversie => nu inact estradiol=> ginecomastie etc

contraindic la gravide. Profilaxie ulcer iatrogen

antiacide dezavantajoasa
atator+B1 bloc

nu RA snc (in comp cu metoclopramida)

ileus postop si mecanic
reflux si gastropareza
si eritromicinaaaaaaaa
e interventii)

IS!!!
Colon!!
Nume Clasa Subclasa Subsubcl
Penicilina G INH PERETE BACT B lactamice Peniciline naturale

Benzpenicilina G INH PERETE BACT B lactamice Peniciline naturale

Procainpenicilina G INH PERETE BACT B lactamice Peniciline naturale

Fenoximetilpenicilina (V) INH PERETE BACT B lactamice Peniciline naturale

Meticilina INH PERETE BACT B lactamice Pen. Sint. Antistaph
Oxacilina INH PERETE BACT B lactamice Pen. Sint. Antistaph
Cloxacilina INH PERETE BACT B lactamice Pen. Sint. Antistaph
Dicloxacilina INH PERETE BACT B lactamice Pen. Sint. Antistaph
Flucloxacilina INH PERETE BACT B lactamice Pen. Sint. Antistaph
Nafcilina INH PERETE BACT B lactamice Pen. Sint. Antistaph

Ampicilina INH PERETE BACT B lactamice Pen. Sint. Cu spectru larg

Amoxicilina INH PERETE BACT B lactamice Pen. Sint. Cu spectru larg

Carbenicina INH PERETE BACT B lactamice Pen. Sint. Anti-Pseudomonas
Ticarcilina INH PERETE BACT B lactamice Pen. Sint. Anti-Pseudomonas
Piperacilina INH PERETE BACT B lactamice Pen. Sint. Anti-Pseudomonas
Mezlocilina INH PERETE BACT B lactamice Pen. Sint. Anti-Pseudomonas
Mecilinamul INH PERETE BACT B lactamice Pen. Sint Anti-Enterobact
Temocilina INH PERETE BACT B lactamice Pen. Sint Anti-Enterobact
Sulbactamul INH PERETE BACT B lactamice Pen. Sint. Inh. De penicilinaz
Acid clavulanic INH PERETE BACT B lactamice Pen. Sint. Inh. De penicilinaz

Cefalexin INH PERETE BACT Cefalosporine Gen I

Cefazolin INH PERETE BACT Cefalosporine Gen I
Cefaclor INH PERETE BACT Cefalosporine Gen II
Cefuroxim INH PERETE BACT Cefalosporine Gen II
Cefotaxima INH PERETE BACT Cefalosporine Gen III
Ceftriaxoma INH PERETE BACT Cefalosporine Gen III
Cefoperazona INH PERETE BACT Cefalosporine Gen III
Ceftazidina INH PERETE BACT Cefalosporine Gen III
Cefepima INH PERETE BACT Cefalosporine Gen IV
Cefpiroma INH PERETE BACT Cefalosporine Gen IV

Imipenem INH PERETE BACT Carbapenemi

Meropenem INH PERETE BACT Carbapenemi
Ertapenem INH PERETE BACT Carbapenemi
Astreonam INH PERETE BACT Monobactam si trib Inhiba PBP

Vacomicina INH PERETE BACT ANB Glicopeptidic

Teicoplanina INH PERETE BACT

Bacitracina INH PERETE BACT Anb polipept

Polimixina B sulfat INHIB Membrana
Polimixina E INHIB Membrana

Streptomicina Act Ribozomal Aminoglicozide F. strepto

Neomicina Act Ribozomal Aminoglicozide F. neo
Kanamicina Act Ribozomal Aminoglicozide F. Kanamicinei
Amikacina Act Ribozomal Aminoglicozide F. Kanamicinei
Tobramciina Act Ribozomal Aminoglicozide F. Kanamicinei
Gentamicina Act Ribozomal Aminoglicozide F. Gent

Tetraciclina Act Ribozomal Tetracicline Gen 1

Doxiciclina Act Ribozomal Tetracicline Gen 2
Minociclina Act Ribozomal Tetracicline Gen 2

Cloramfenicol Act Ribozomal GANGLIONI, LCR!!!

Eritromicina Act Ribozomal Macrolid prototip

Claritromicina Act Ribozomal Macrolid semisint
Azitromicina Act Ribozomal Macrolid inrudit

Clidamicina Act Ribozomal Lincosamide

Lincomicina Act Ribozomal Lincosamide

Acid nalidixic Quinolone AND giraza II si IV sparfloxacina,

levofloxacina,
mixofloxacina,
Floroquinolone Quinolone gemifloxacina
Metronidazol Quinolone

Sulfametazol INTERFERA CU Sulfamide antag PABA

Sint de Acid Folic
Ftalilsulfatiazol Sulfamide antag PABA
Sulfacetamida Sulfamide antag PABA

Trimetoprim inhib dihidrofolat reduct

Mecanism Actioneaza pe
Bacili G(+) Coci G(+) Coci G(-) + alte (lepto, actino,
T.Pallidum)
Bacili G(+) Coci G(+) Coci G(-) + alte (lepto, actino,
T.Pallidum)
Bacili G(+) Coci G(+) Coci G(-) + alte (lepto, actino,
T.Pallidum)
Bacili G(+) Coci G(+) Coci G(-) + alte (lepto, actino,
T.Pallidum)
Tip Penicilina G + penicilinazo secretori
Tip Penicilina G + penicilinazo secretori
Tip Penicilina G + penicilinazo secretori
Tip Penicilina G + penicilinazo secretori
BACTERICIDE DEGENERATIV = inhiba transpeptidaze Tip Penicilina G + penicilinazo secretori
perete in multiplicare Tip Penicilina G + penicilinazo secretori
Bacili G(+) Coci G(+) Coci G(-) Bacili G(- (Hi, EC, Salm,
Shic, Proteus)
Bacili G(+) Coci G(+) Coci G(-) Bacili G(- (Hi, EC, Salm,
Shic, Proteus)
Tip Penicilina G + bacil piocianic
Tip Penicilina G + bacil piocianic
Tip Penicilina G + bacil piocianic
Tip Penicilina G + bacil piocianic
Ingust: bacili G-
Ingust: bacili G-
Impreuna cu peniciline
Impreuna cu peniciline

Gram +, Gram-, NU (MRSA, Enteroxoc, PA)

Gram +, Gram-, NU (MRSA, Enteroxoc, PA)
Gram +, Gram-, NU (MRSA, Enteroxoc, PA)
Gram +, Gram- (PA da), NU (MRSA, Enteroxoc)
Gram +, Gram- (PA da), NU (MRSA, Enteroxoc)
BACTERICID DEGENERATIV . Fixeaza PBP(3)
Gram +, Gram- (PA da), NU (MRSA, Enteroxoc)
Gram +, Gram- (PA da), NU (MRSA, Enteroxoc)
Gram +, Gram- (PA da), NU (MRSA, Enteroxoc)
Gram +, Gram- (PA Entero da), NU (MRSA)
Gram +, Gram- (PA Entero da), NU (MRSA)

Spectru larg: G+, G-, anaerobi

Spectru larg: G+, G-, anaerobi
BACTERICID. Inh DHP
Spectru larg: G+, G-, anaerobi
Spectru larg: G+, G-, anaerobi

Gram +
BACTERICID DEGENERATIV

BACTERICID DEGENERATIV Gram +

 BACTERICID ABSOLUT Gram -
BACTERICID ABSOLUT Gram -

Bacili Gram -, uni coci ci bacili Gram +. Nu pe anaerobi

BACTERICID ABSOLUT. IREV 30S

BACTERIOSTATICE. REV 30 S FOARTE LARG: G+, G-, aerobe, anaerobe + Altele

BACTERIOSTATIC (legate 50S0-> BACTERICID (pe HI,

mening) asem Tetracicline. NU PE CHLAMYDII, PA

BACTERIOSTATIC (rev 50S) -> BACTERICID bacterii G+ aerobe

BACTERIOSTATIC -> BACTERICID
BACTERIOSTATIC -> BACTERICID

BACTERIOSTATIC - 50S G-, G+ - bact fargilis

BACTERIOSTATIC - 50S

Larg: G+, G-, chlamydii, mycoplasme, actinomicete,

riketsii
BACTERICID

Larg: G+, G-, chlamydii, mycoplasme, actinomicete,

nocardia, protozoare
BACTERIOSTATIC

asem sulfamide, mai potent

Particularitati

Moldamin

Efitard

Ospen. Rezistenta la hcl=>admin orala

nu oral
ok oral

BILA SI URINA

URINA

plus ampicilină = Unasyn

plus amoxicilina = Augmentin

nefrotoxice-toate

rezerva, inf grave

„sindromul omului rosu”. Nefro si ototox

+neomicina = BANEOCIN)
nefro si neurotox

sinergism cu peniciciline/cefalosp/vanco r. vestib

polare=> nu se abs local r. acust
ototox, nefrotix, bloc musc local r. acust
sistemic r. acust
sistemic
sistemic r. vestib

rezist prin pompa care o trans activ afara

„sindromul cenusiu” inact de acetiltransf

asem eritro, dar mai bun

mai activ fata de clamidii

fav inf cu clostr difficile

urinar

cipro-iv
Antiparazitar

nu se abs
teg + mucoase
concentratie mare urinara. SULFAMETOXAZOL +
TRIMETOPRIM = BISEPTOL. Pot da anemie megalo
INDUCTORI INHIBITORI
Fenobarbital Acid valproic
Meprobamat Cimetidina
Carbamazepina Omeprazol
Fenitoina Lansoprazol
Macrolide (eritromicina)