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DEPARTMENT OF BIOINFORMATICS
New Revised Syllabus
M.Sc. Bioinformatics
University Grants Commission
(UGC XIIth PLAN)
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A) Preamble:
sequence.
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In the recent years in this age of Internet and sequenced genome we have
more information at our fingertips than ever before. Organizing this entire data
and combating information overload is becoming more and more important. The
advent of genetic engineering vastly increased size of the information. It is thus
necessary for institutes like university evolve a system, which is most accurate and
more student friendly. Keeping this view in mind we have decided to establish
Department of Bioinformatics. Under this department we would like to start new
post graduate courses such as M.Sc. M.Phil. and Ph.D.
B) Objectives:
thereby society.
iv. Create an advanced research facility to carry out research in frontier areas of
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C) Expertise available:
D) Space required:
There would be need of separate building to run the courses like M.Sc.
M.Phil. and Ph.D. under this department. For time being theory and practical
courses can be conducted in the Department of Biochemistry, and Microbiology.
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• Software and Computer Workstations available for this course in the
Department of Biochemistry, Shivaji University, Kolhapur:
No.
viii. ClustalW
ix. Bio-Edit
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5. Software to do bioinformatics Annexure-I -
and molecular modeling
research.
All laboratories will be provided with the necessary service lines such as
electricity, gas, water, compressed air and required instrumentation along with
good exhaust. General laboratory will be provided with tables of appropriate
height for laboratory work and instrumentation
E) Budgetary Provisions:
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Laboratory expenses, purchase of teaching aids, honorarium to
contributory teachers and T. A. to visiting professors and contributory teachers,
internet bills/stationary are listed in Annexure III.
F) Justification:
This department would be useful for all the faculties of this university who
wish to do computational biology related work. This facility would also be useful
to provide advanced training in bioinformatics to students and teachers of our
university as well as affiliated colleges. Finally it will be useful to do quality
research and get publications in high quality reputed journals. This department
will be helpful to students/researchers of all life science subjects. Considering the
facts that;
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iii) Bioinformatics is an essential subject to understand life processes at
molecular level and which is required for all life science departments
within the university campus for teaching as well as for research purpose.
I) Eligibility for M.Sc. students: B. Sc. degree in Science (Life Sciences, Physical,
Chemical Mathematical, Computational, and Statistics) or B.E./B.Tech, pharmacy,
medical, engineering, agriculture and veterinary science.
J) Ph.D. intake Capacity: 08 Ph.D. students per faculty who has recognition in the
subject of bioinformatics by university.
K) M. Phil. intake Capacity: 05 M.Phil. students per faculty who has recognition in
the subject of bioinformatics by university.
M) Course Fee: Fee structure for M.Sc. M.Phil and Ph.D. course would be as per the
University norms.
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O) M.Sc. M.Phil., Ph.D. Course Structure: As per University norms. This course
syllabus has been approved by Ad-Hoc BOS in Biochemistry.
SEMESTER - I
THEORY
BIOINFO:III Biomolecules
PRACTICAL
Lab Course- I
Lab Course- II
SEMESTER - II
THEORY
BIOINFO:VII Bioenergetics
PRACTICAL
Lab Course- IV
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SEMESTER-III
THEORY
BIOINFO : X Chemoinformatics
PRACTICAL
Lab Course- V
Lab Course- VI
SEMESTER - IV
THEORY
PRACTICAL
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M.Sc. Bioinformatics Syllabus
Unit- I
1. Cell Biology 15
Unit-II
and Pseudogene.
Unit- III
3. Microbiology 15
11
contamination control and Sterility testing.
Unit- IV
4. Virology 15
Unit- I
Amino Acids
Proteins
12
Unit-II
2. Protein structure 15
2.1 Secondary structure - alpha helix and beta pleated structure, triple
helix (collagen) and Super secondary structures.
Unit- III 15
Unit- IV
13
Topic BIOINFO: III Biomolecules Lectures
No.
60
Unit- I
1.2 Epimers, isomers, anomers, chiral carbon atom, chair and boat
form, glucopyranose and fructopyranose.
Unit-II
2.5 Types and general functions, amino sugars, sialic acid and
mucopolysaccharides.
Unit- III
3. Lipids 15
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3.1 Definition and classification of lipids. Fatty acids - general
formula, nomenclature and chemical properties Structure, function
and properties of simple, complex, acylglycerols,
phosphoglycerides, sphingolipids, waxes, terpenes, steroids and
prostaglandins.
Unit- IV
15
Topic BIOINFO: IV Basic of computer, Mathematics and Biostatistics Lectures
No.
60
Unit- I
1. Introduction to Computers 15
Unit-II
2. 15
2.2 Input and Output devices :-Punched card reader, paper tape
reader, magnetic tape, floppy disk, magnetic disk,optimal scanner,
voice data, entry terminal, teleprocessing terminal, visual display
unit,modern input devices, Output devices; CRT, printer, plotter.
Unit- III
3. Modern Computers 15
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3.1 Workstations, parallel processing computers, supercomputers.
Unit- IV
4. Basic Mathematics 15
4.1 Sets:- Finite set, infinite set, null or void set, subset, Intervals;
closed and open, universal set, operations of set. Relations and
functions.
SEMESTER II
Unit- I
1. Genome Organization 15
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1.1Organization of bacterial genome, Structure of eucaryotic
chromosomes.
1.4 Satellite DNA, DNA melting and buoyant density, packing and
organization of chromatin, nucleosome phasing, DNase I
hypersensitive regions, DNA methylation & Imprinting.
Unit-II
Unit- III
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processing,
Unit- IV
Unit- I
19
1.2 Sequence databases: GeneBank, EMBL Nucleotide sequence
databank, DNA Data Bank of Japan (DDBJ), database formats.
Unit-II
20
Unit- III
Unit- IV
Unit- I
21
1.2 Application of first and second law of thermodynamics to
biological systems.
Unit-II
2. Mitochondria 15
Unit- III
Chloroplast 15
3.
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metabolism.
Unit- IV
4. Hormones 15
Unit- I
1. Introduction 15
1.1 History of C
1.2 Characteristics of C
Unit-II
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2.1Arithmetic Unary Assignment Relational & Logical Conditional
2.2 If Statement, Nested if ,Statement else-if.
2.4 Concepts for loop while loop do-while loop Jump Statements.
Unit- III
Arrays & Functions 15
3.
Unit- IV
SEMESTER- III
Unit- I
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1.1 Structure of DNA: A-,B-,Z-, and triplex DNA,
Unit-II
2. Cloning vectors 15
Unit- III
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3. Cloning methodologies 15
Unit- IV
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implications, application in global gene expression analysis.
Applications of recombinant DNA technology in medicine,
agriculture, veterinary sciences
Unit- I
1. Basic Chemistry 15
Unit-II
2. Basics of Chemoinformatics 15
Unit- III
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3.1 Combinatorial chemistry technologies & libraries.
Unit- IV
Unit- I
Unit-II
2. .NET controls 15
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2.1 Activex controls, Forms, Controls & properties Text Boxes,
Labels, Command Button, Radio Button, Option Buttons, Check
Boxes, List Box ,ComboBox,Scoroll Bar, Progress Bar, Group Box,.
Calendar, Date Time Picker, Picture Box, Image List, Rich Text
Box, Popup/Content Menus, List View Control , Tree View Box.
2.2 The array class collections, lists, string class, jagged array, array
list String class and function. OOP using .net Classes Objects,
constructor, destructor Methods, properties, delegates, assemblies,
namespaces.
Unit- III
3.2 Tracing errors: breakpoint, watch, quick watch, locals and autos.
Unit- IV
4 ADO.Net 15
Unit- I
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1.5 Regulation of immune response: - Humoral and Cell mediated
response.
Unit-II
2. Immunity to infection 15
Unit- III
Unit- IV
4 Immunotechnology 15
30
SEMESTER – IV
Unit- I
Unit-II
31
Unit- III
Unit- IV
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Topic BIOINFO: XIV Drug designing Lectures
No.
60
Unit- I
1. Pharmaceutical Biotechnology 15
Unit-II
Unit- III
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Unit- IV
Unit- I
Unit-II
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biodiversity informatics, significant global projects on taxonomic
names; taxonomic character data, descriptions and keys, online keys
and digital keys.
Unit- III
Unit- IV
Unit- I
1.2 Getting started with perl:- A Low and Long Learning Curve,
Perl's Benefits, Installing Perl on Your Computer, How to Run Perl
Programs, Text Editors and Finding Help
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Unit-II
Unit- III
Unit- IV
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Lab Course – I
Sr. Name of the Practical
No.
1 Computer basic knowledge; hardware, connection cables, typing, Windows
98/XP, Internet browsers, search engines.
2 LAN connections, setting up the IP address, network security.
3 Internet surfing and searching information, downloading and installing software.
4 Hands on session with Microsoft Word, Microsoft Excel (Spreadsheet
Application).
5 Hands on session with Microsoft Access (Database related applications).
6 Measures of Central Tendency and Dispersion
7 Statistical Analysis using EXCEL. (Descriptive statistics and graphical
presentation.)
8 Calculation of Mean, Mode and Median using spreadsheet application.
9 Sketching of pmf/pdf of Binomial, Poisson and Normal distributions.
10 Correlation and Regression Analysis.
11 Simple random sampling and stratified sampling.
Lab Course – II
Sr. Name of the Practical
No.
1. Understanding PubMed database.
2 Analysis of protein sequence from protein database.
3 Analysis of gene sequence from nucleotide database.
4 Getting and analysis of primary protein structure.
5 Secondary structure analysis of protein.
6 Tertiary protein structure analysis using Rasmol.
7 Introduction of various bibliographic databases.
8 Getting the gene sequences by exploring and querying the nucleic acid databases.
9 Understanding of Kyto Encyclopedia of Genes and Genome (KEGG) database
for biological pathways, metabolism, cellular process, genetic information
processing.
10 Database retrieval system- SRS of EBI and DBGet.
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11 Investigation of molecular interactions using the program KineMage.
Lab Course – IV
Sr. Name of the Practical
No.
1 Find prime number between 1 to 50.
2 Write a program which uses switch & break case statements.
3 Find out length of given string.
4 Find area of rectangle using constructor
5 Write a program of insertion sort.
6 Write a program which implements stack operation.
7 Multithreading using get property.
8 Multithreading using sleep property.
9 Write a program which implements mouse listener and mouse motion listener.
10 Creating a frame window in an applet.
11 Draw line , rectangle, oval in an applet.
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12 AWT- Control and event handling
Lab Course – V
Sr. Name of the Practical
No.
1 Model building of nucleic acid, protein and organic molecules using the ISIS
draw.
2 Model building of nucleic acid, protein and organic molecules using the chem-
sketch
3 Introduction to PDB.
4 Downloading and analysis of the pdb file of the biomolecules.
5 Analysis of Secondary and tertiary structure of protein using visualizing software
like Rasmol.
6 Analysis of quaternary structure of protein using visualizing software like
Rasmol.
7 Analysis of the secondary structure of protein using web tool.
8 Three dimensional structure prediction by using the homology modeling
technique using SPDBV.
9 Energy calculation of the biomolecules using molecular mechanics and quantum
mechanics. (Argus lab).
10 Calculate PI/MW of protein.
11 Molecular Docking of protein and ligand by HEX.
12 Protein Structure Prediction (Homology Modeling) using SPDBV.
13 Model Building and Energy minimization using Sybyl7.3.
14 Model Building and Energy minimization using SPARTAN.
15 Model Building and Energy minimization Gaussian.
16 Quantum chemical (QM) and molecular mechanics (MM) practical using
SPARTAN.
17 Quantum chemical (QM) and molecular mechanics (MM) practical using
Gaussian.
18 Molecular dynamics (MD) simulation using Gromacs.
19 Molecular dynamics (MD) simulation using Sybyl.
20 Molecular dynamics (MD) simulation using AMBER.
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Lab Course – VI
Sr. Name of the Practical
No.
1 Accept three numbers & find out the largest & lowest among these.
2 Calculate compound interest of given principal amount for given time period
with given rate of interest. Use appropriate controls.
3 Implement a standard calculator.
4 Accept 10 elements in array & perform binary search.
5 Demonstrate string class method & properties.
6 List box & combo box demonstration with differences in properties.
7 Simple class & object based programs.
8 Calculate difference between two dates use proper User Defined data type.
9 Demonstrate simple polymorphism.
10 Connect your application to Ms-Access/SQL server database using ADO.Net
classes.
11 Implement read and write operation of file.
12 Design different application using SQL/MS-Access and ADO.Net.
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