WBC ANOMALIES

DIVISIONS

• Quantitative variations

• Leukocytosis

1. Increased movement

2. Decreased movement
Neutrophilia Eosinophilia Basophilia - Monocytosis

- Inflammatory - Active allergic - Ulcerative - Infections (e.g.,

conditions disorders (e.g., colitis tuberculosis
asthma and and bacterial
- Infection
 hay fever) - Hyperlipidemia
 endocarditis)
Physical stimuli
(e.g., heat or - Dermatoses
 - Smallpox and - Fever of
cold) chickenpox unknown origin
- Surgery
 - Nonparasitic
infections - Chronic - Inflammatory
- Burns
 - Some forms of sinusitis bowel disease
leukemia

- Stress
 - Chronic - Rheumatoid
- Parasitic myelogenous arthritis
- Some drugs and infections leukemia
hormones
 (nonprotozoan) - Hematological
- Polycythemia disorders (e.g.,
- Some types of vera hemolytic
leukemia anemia)
 • Leukopenia
Neutropenia Eosinopenia Basopenia - Monocytopenia
Hormones (e.g.,
Bone marrow Glucocortico- corticotropin and No known
injury or steroid progesterone) conditions
infiltration hormones - During
ovulation
Starvation
 Acute bacterial - Thyrotoxicosis
or viral
Anorexia inflammation
nervosa


Cyclic
neutropenia

Increased
destruction or
utilization

Entrapment
in the spleen
 DIVISIONS

• Qualitative variations

1. Morphologic abnormalities of mature

granulocytes

2. Normal morphology with functional

abnormalities
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Toxic Granulation
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Döhle Bodies
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Hyper segmentation
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Pelger-Huët Anomaly
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• May-Hegglin Anomaly
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Chédiak-Higashi Syndrome
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Alder-Reilly Anomaly
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Jordan’s Anomaly
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Basket Cells
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Pyknotic Cells
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Barr Body
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Auer Rods
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Vacuolation
MORPHOLOGIC ABNORMALITIES
OF MATURE GRANULOCYTES
• Twinning Deformity
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
• Chronic Granulomatous Disease
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
• Leukocyte Adhesion Disorder
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES

1.Job’s Syndrome

2.Lazy Leukocyte Syndrome

3.Myeloperoxidase Deficiency
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
•Monocyte/Macrophage Lysosomal Storage Diseases

•Mucopolysaccharidoses

1.Hurler syndrome

2.Hunter syndrome

3.Scheie syndrome

4.Sanfilippo syndrome A, B , C

5.Morquio syndrome A, B
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
•Monocyte/Macrophage Lysosomal Storage Diseases

•Lipid Storage Diseases Gaucher cell

•1. Gaucher disease

•Type I

•Type II

•Type III
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
•Monocyte/Macrophage Lysosomal Storage Diseases

•Lipid Storage Diseases

•2. Neimann-Pick disease

NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
•Monocyte/Macrophage Lysosomal
Storage Diseases

•Lipid Storage Diseases

•3. “Macrophage overload”

•4. Sea-blue Histiocytosis

NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
•Inherited Disorders of Immune Leukocytes

•B Cell Deficiency

•Infantile sex-linked agammaglobulinemia

•Common variable
hypogammaglobulinemia
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
•Inherited Disorders of
Immune Leukocytes

•T Cell Deficiency

•DiGeorge
Syndrome

•Nezelof’s
Syndrome
NORMAL MORPHOLOGY WITH
FUNCTIONAL ABNORMALITIES
•Inherited Disorders of Immune Leukocytes

•Severe Combined Immunodeficiency Disease

•Sex-linked SCID

•Swiss-type agammaglobulinemia

•Wiskott-Aldrich Syndrome

•Ataxia Telangiectasia