Status

of the Thyroid Ultrasound Examination (December 27, 2018)

1. Preliminary Baseline Screening (First Round) (Tallied as of March 31, 2018)
【Conducted in FY2011-2013】
Primary examination (completed on April 30, 2015)
• Target population 367,637
• Participants 300,472 (81.7% participation rate)
• Completed test results 300,472 (100.0% completion rate)
• Test result categories
A (A1) : 154,605 (51.5%)
(A2): 143,573 (47.8%)
B: 2,293 ( 0.8%)
C: 1 ( 0.0%)

Confirmatory examination (as of March 31, 2018)
• Target population 2,293
• Participants 2,130 (92.9% participation rate)
• Completed test results 2,091 (98.2% completion rate)
547 participants underwent fine-needle aspiration cytology (FNAC)
Summary of FNAC results
• Suspicious or malignant 116
• Male : Female 39 : 77
• Average age 17.3±2.7 (8-22), 14.9±2.6 (6-18) at the accident time
Ÿ Average tumor diameter 13.9±7.8 mm (5.1-45.0 mm)

Age and sex distribution of 116 suspicious or malignant cases
[Age as of March 11, 2011]

[Age at the date of confirmatory examination]

1

2. Full-Scale Screening (Second Round) (as of March 31, 2018)
【Conducted in FY2014-2015】
Primary examination
• Target population 381,244
• Participants 270,540 (71.0% participation rate)
• Completed test results 270,529 (100.0% completion rate)
• Test result categories
A (A1): 108,718 (40.2%)
(A2): 159,584 (59.0%)
B: 2,227 ( 0.8%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 2,227
• Participants 1,874 (84.1% participation rate)
• Completed test results 1,826 (97.4% completion rate)
207 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 71
• Male : Female 32 : 39
• Average age 16.9±3.2 (9-23), 12.6±3.2 (5-18) at the accident time
Ÿ Average tumor diameter 11.1±5.6 mm (5.3-35.6 mm)

Age and sex distribution of 71 suspicious or malignant cases
[Age as of March 11, 2011]

[Age at the date of confirmatory examination]

2
3. Full-Scale Screening (Third Round) (as of September 30, 2018)
【Conducted in FY2016-2017】
Primary examination
• Target population 336,669
(Excluding those born in FY1992-1993, eligible for Age 25 Milestone Screening)
• Participants 217,526 (64.6% participation rate)
• Completed test results 217,513 (100.0% completion rate)
• Test result categories
A (A1): 76,238 (35.0%)
(A2): 139,790 (64.3%)
B: 1,485 ( 0.7%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 1,485
• Participants 1,024 (69.0% participation rate)
• Completed test results 933 (91.1% completion rate)
54 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 18
• Male : Female 8 : 10
• Average age 16.7±2.9 (12-23), 10.4±2.9 (6-16) at the accident time
Ÿ Average tumor diameter 14.5±7.1 mm (5.6-33.0 mm)

Age and sex distribution of 18 suspicious or malignant cases
[Age as of March 11, 2011]

[Age at the date of confirmatory examination]

3
4. Full-Scale Screening (Fourth Round) (as of September 30, 2018)
【Conducted in FY2018-2019】
Primary examination
• Target population 293,865
(Excluding those born in FY1992-1995, eligible for Age 25 Milestone Screening)
• Participants 41,537 (14.1% participation rate)
• Completed test results 25,982 (62.6% completion rate)
• Test result categories
A (A1): 9,072 (34.9%)
(A2): 16,759 (64.5%)
B: 151 ( 0.6%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 151
• Participants 39 (25.8% participation rate)
• Completed test results 7 (17.9% completion rate)
No FNAC participant yet

5. Age 25 Milestone Screening (as of September 30, 2018)
【Conducted in FY2017-】
Primary examination
• Target population 22,653 (those born in FY1992)
• Participants 2,005 (8.9% participation rate)
• Completed test results 1,989 (99.2% completion rate)
• Test result categories
A (A1): 812 (35.0%)
(A2): 1,085 (54.6%)
B: 88 ( 4.4%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 88
• Participants 67 (76.1% participation rate)
• Completed test results 58 (86.6% completion rate)
3 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 2
• Male : Female 1 : 1

4
Number of suspicious or malignant cases and surgically confirmed cases

Overall status from the first through fourth rounds as well as Age 25 Milestone Screening
Malignant or suspicious cases 207
Surgically confirmed cases 167
[1 benign nodule, 164 papillary thyroid cancer (PTC), 1 poorly differentiated thyroid
cancer (PDTC), and 1 other thyroid cancer]

First round (as of March 31, 2018) 【Conducted in FY2011-2013】
• FY2011 municipalities 15 (5 males , 10 females)
(15 surgically confirmed cases: 1 benign nodule(s), 14 PTC)
• FY2012 municipalities 56 (21 males, 35 females)
(52 surgically confirmed cases: 52 PTC)
• FY2013 municipalities 45 (13 males, 32 females)
(35 surgically confirmed cases: 34 PTC, 1 PDTC)

Total 116 (39 males, 77 females)
(102 surgically confirmed cases: 1 benign nodule, 100 PTC, 1 PDTC)

Second round (as of March 31, 2018) 【Conducted in FY2014-2015】
• FY2014 municipalities 52 (21 males , 31 females)
(39 surgically confirmed cases: 38 PTC, 1 other thyroid cancer)
• FY2015 municipalities 19 (11 males, 8 females)
(13 surgically confirmed cases: 13 PTC)

Total 71 (32 males, 39 females)
(52 surgically confirmed cases: 52 PTC, 1 other thyroid cancer)

Third round (as of September 30, 2018) 【Conducted in FY2016-2017】
• FY2016 municipalities 12 (6 males, 6 females)
(10 surgically confirmed cases: 10 PTC)
• FY2017 municipalities 6 (2 males, 4 female)
(3 surgically confirmed cases: 3 PTC)

Total 18 (8 males, 10 females)
(13 surgically confirmed cases: 13 PTC)

Fourth round (as of September 30, 2018) 【Conducted in FY2018-2019】
Total 0 (0 male, 0 female)
(0 surgically confirmed cases)

Age 25 Milestone Screening (as of September 30, 2018) 【Conducted in FY2017-】
Total 2 (1 male, 1 female)
(0 surgically confirmed cases)