Proposal Synthesis Matrix Analysis of Literature

Last Name: Desai First Name: Sarang Period: 4

Overarching question: How can data science be used to allow providers to have a complete view of a patient’s health?

Key Terms (list and define in the space below)

Big Data - extremely large and complex databases that aggregate information of different types and scales, that collect data across
time and distance from multiple sources, and that often require complex data processing applications. In healthcare, big data may
include EHR, administrative claims, and clinical trial data as well as data collected from smartphone applications, wearable
devices, social media, and personal genomics services (Hernandez & Yuting, 2017, p. 1495).
Predictive Analytics - The new methods of analysis developed to overcome these challenges are often referred to as predictive
analytics. Predictive analytics include a variety of statistical techniques, from predictive modeling to machine learning to data mining,
that analyze historical and current data to predict future or other unknown events (Hernandez & Yuting, 2017, p. 1495).
Integrated Healthcare Model - using different treatment approaches and techniques for a certain patient to maximize patient
outcome (Funderburk et al, 2010, p. 146).
De-identified - removing patient identity from patient data to keep data anonymous (Hernandez & Yuting, 2017, p. 1496).
EHR - electronic health record. Digital copy of a patient’s chart detailing their basic information (Baro et al, 2015, p. 3).
PROM - patient reported outcome measures (Warrington et al, 2015, p. 601).
Pharmacist Intervention - the act of a pharmacist coming between a patient and their treatment because of a certain stimulus that
could affect the patient (Hernandez & Yuting, 2017, p. 1495).
Patient Wellness - the overall health of a patient (Hernandez & Yuting, 2017, p. 1495)
Self-reported healthcare utilization - the method of using patient reported data to improve treatment plans(Chiu, Lebenbaum,
Cheng, de Oliveira, & Kurdyak, 2017, p. 2)

Synthesis Matrix Analysis of Literature

 Foundational Sub Problem 1: What kind of patient data requires careful collection and thorough statistical analysis?

APA Purpose Framework Sample Design Variables/ Results Controversies, Assumptions, Implications
format instruments disagreements Limitations for practice,
reference Overarching Hypothesis/ with other and research,
Question Objective How the Validity How the authors Delimitations theory
data was and hypothesis was
collected? Reliability supported/rejected You will add a
list of authors
Conclusion and referenced in
further studies this section on
a separate
page
Yao, D., The The By the A A pilot The pharmacy None There are Our
Xi, X., literature purpose of sampli questionn survey of 5 department of a several findings
Huang, retrieval of this ng aire was county hospital in China limitations of suggest that
Y., Hu, clinical research is method designed hospitals in is required to the present the low
H., Hu, pharmacy or to assess s for the Nanjing of establish and study due to equipment
Y., the hospital the current above, clinical Jiangsu apply rules, uncontrollabl rate of
Wang, pharmacy status of 317 pharmacis province guidelines, and e issues and clinical
Y., & system in the clinical medica ts of was records of clinical conditions. pharmacy
Yao, W. China in pharmacy l county conducted pharmacy services Firstly, the service
(2017). several service institut hospitals in June and clinical representativ software,
A journal system in ions (See S1 2015 as a pharmacists in the eness of hardware,
national databases county from Survey test for the scale of the county and
survey of indicated a hospitals, all 31 and S2 designed hospital. hospitals personnel
clinical lack of using a provin Survey). questionnai However, 23.4% among the are the main
pharmac studies in national cial The re, of the sample entire hindrances
y this country. questionnai admini design of sampling, hospitals in our Chinese to full
services There was re survey strative the and survey. survey lack public coverage of
in county no based on units in questionn 3 clinical functioning hospital clinical
hospitals comprehensi stratified mainla aire items pharmacist management system is pharmacy
in China. ve and sampling, nd was based s of each rules. only valid in services,
PLoS substantial in order to China on a pilot . According to our key elements whose
ONE, conclusion form an were related hospital data, the services of clinical quality is
12(11), on the accurate, selecte research, were provided by pharmacy also
e018835 current comprehen d to be the included in 89.9% of services. Due lowered by
4. status. Most sive, and the current the sample, respondents are to significant the wide
Retrieve of the valuable sample situation and the not charged, and differences in variance in
d from literature on understandi institut of clinical sample size among the size, educational
the China just ng. Based ions of pharmacy is 15 in charged services, capability, training of
Opposin focuses on on the this practice total. pharmaceutical function, and pharmacists
g one aspect conclusions survey. in China, Additionall care/monitoring other aspects at county
Viewpoi of the whole , Hong and the y, a face- and of different hospitals.
nts in picture [17– suggestions Kong, aim of to-face pharmaceutical types of This
Context 19] or a will be Macau, this study. interview consultation public condition
database. small provided to and The of the account for the hospitals or shows an
geographic the main Taiwan questionn hospital largest private opportunity
scale [19, bodies were aires were director(s) proportions. hospitals, the to include
20]. involved in exclud structured of each (Yao et al, 2017, illustration of more
(Yao et al, the practice ed to mainly pilot p. 7) the whole pharmacists
2017, p. 3) and related becaus cover the hospital picture trained in
administrat e the following was requires a pharmacy
ors. public items: (1) launched series of or clinical
(Yao et al, health basic by our studies pharmacy
2017, p.3) system informati researchers narrowed than other
of on about to collect down to related
these the valuable specific type fields such
three medical comments of hospital. as
provin institution and advice Secondly, the pharmacolo
cial ; (2) the on the pilot purpose of gy, and
admini coverage survey our research more
strative of the questionnai being pharmacists
regions clinical re. reaching a with higher
is pharmacy Accordingl comprehensi degrees.
distinct service; y, some ve and full- And, as a
ively (3) the detailed scale conclusion,
differe status of adjustment description the clinical
nt from the s of the of the present pharmacy
the clinical questionnai clinical service
system pharmacy re were pharmacy system in
applied service made. service county
in software To ensure system of the hospitals of
mainla and the validity county China still
nd hardware; and quality hospitals in requires
China. (4) the of the data, China, some further
(Yao et charge all issues developmen
al, mode of questionnai derived from t and
2017, the res were the improveme
p. 4) clinical administere discussion nt.
pharmacy d through require (Yao et al,
service; an additional 2017, p. 12)
(5) the interview data and
education survey. references
al Collected for further
backgrou data was discussion
nd of the examined and precise
clinical by our conclusions.
pharmacis researchers (Yao et al,
ts; (6) the , and for 2017, p. 12)
professio data with
nal flaws or
training missing
of the data, return
clinical interviews
pharmacis were
ts; (7) the conducted.
practical (Yao et al,
 experienc 2017, p. 5)
e of the
clinical
pharmacis
ts; and (8)
the entry
path of
the
clinical
pharmacis
ts. Each
aspect
above
involves
two or
three
specified
variables.
(Yao et
al, 2017,
p. 4)
Baro, E., With the The For To be We then Among the 48 None This It should
Degoul, advance in objective this fully attempted papers describing systematic also be
S., genomics, of this literatu inclusive, to retrieve a dataset, three search should pointed out
Beuscart, proteomics, work is to re we did the full- main categories of ensure that that there is
R., & metabolomi provide a review, not define text papers. studies were we an
Chazard, cs, and other definition we a start We used identified: omics, accumulate a undeniable
E. types of of big data conduc date. We online medical relatively current
(2015). omics in ted a used the search specialties, and complete trend of big
Toward technologies healthcare system following facilities public health. The census of data, which
a during the through a atic PubMed (the Free term “omics” relevant leads to the
literature past review of search query: (a) PMC refers to biology literature of fact that the
-driven decades, a the of the (big database, fields of study big data in term “big
definitio tremendous literature. PubMe data[Title Google, ending in -omics, healthcare. data” is now
n of big amount of (Baro et al, d /Abstract] and Google such as genomics, However, we used to
data in data related 2015, p. 1) databas ) AND Scholar), metabolomics, or may have qualify
healthcar to molecular e for (“1900/01 resources, proteomics. The missed datasets
e. biology has all /01”[Date and main area papers that that, in the
BioMed been papers - services of represented is do use big past, would
Research produced publish Publicatio the Lille omics: 23 papers data in the not have
[2]. In ed n]: University (48%, CI95 = [33; research but been called
Internati addition, the until “2014/05/ library and 63]). It is followed were not this way.
onal, 1- transition May 9, 09”[Date tried to by medical included in Moreover,
9. from paper 2014, - directly specialties our query we can
doi:10.1 medical using Publicatio contact the (endocrinology, because the consider
155/2015 records to the n]). first or infectology, term was not that the size
/639021 EHR keywor For each correspond immunology, mentioned in of datasets
systems has ds “big paper, we ing author. neurology, the abstract that qualify
led to an data.” collected (Baro et al, andimaging): 15 or keywords as big data
exponential We the 2015, p. 1) papers (31%, of the paper. may keep
growth of then following CI95 = [19; 46]) Nevertheless, on
data [3]. As attempt informati and public health as there is no increasing
a result, big ed to on: title, (bioinformatics, definition of due to the
data retriev year of Electronic Health big data, the main
provides a e the publicatio Records (EHR), literature can property of
wonderful full- n, journal epidemiology, itself be big data,
opportunity text title, pharmacovigilanc wrong. It is a which is the
for papers. specialty e, and public limitation of challenge
physicians, We area, type health): 10 papers this inductive on data
epidemiolog used of paper (21%, CI95 = [10; approach: we processing
ists, and online (paper 35]). use and the fact
health search using a (Baro et al, 2015, observations that
policy faciliti dataset, p. 2-3) to build a computation
experts to es (the dissertatio definition. al
make data- Free n, and The problem infrastructur
driven PMC literature of defining a e that is
decisions databas review), threshold required to
that will e, the field illustrates process
ultimately Google of study, this these large-
improve , and and difficulty: the scale
patient care Google characteri threshold of datasets
[3]. Schola stics 107 may may
(Baro, r), given by appear in progress
Degoul, resourc authors to disagreement with time.
Beuscart, & es, and big data with the (Baro et al,
Chazard, service and to results of 2015, p. 6)
2015, p. 1) s of the data Figure 7.
Lille reuse. (Baro et al,
Univer (Baro et 2015, p. 6)
sity al, 2015,
library p. 2)
and
tried to
directl
y
contact
the
first or
corresp
onding
author.
Full-
text
papers
were
then
read.
(Baro
et al,
 2015,
p. 1)
Meriki, The Center As one of This A A trained Based on anti- None. Another Sensitizatio
H. D., for Disease the was a standard phlebotomi HBs quantitative issue worth n on the
Tufon, Control and objectives hospita pretested st collected ELISA, 35 questioning importance
K. A., Prevention of this l- semi- about 5 ml (51.4%) of the here is the of HBV
Anong, (CDC) has study, we commu structured of blood vaccinated cases potency of vaccine
D. N., outlined evaluated nity questionn from each (3 dose taken) had the vaccine really needs
Tony, N. some the based aire was participant anti-HBs administered. to be
J., recommend antibody cross- administe in tubes concentration Unfortunatel intensified
Kwenti, ations that response to section red with no 10mIU/ml while y, we could among
T. E., must be HBV al (interview anticoagula 33 (33.8%) had only visit 4 high-risk
Bolimo, considered vaccine study based) to nt. The anti-HBs out of the 7 groups so
A. F., for HBV (after that all samples concentration < recognized that some
...Nkuo- vaccine complete enrolle participan were 10mIU/ ml. institutions recurrent
Akenji, non- administrat d both ts to centrifuged Thirty-seven that reasons for
T. responders ion of 3 HBV assess at 1000g (54.4%) of the administered not taking
(2018). in order to doses) and vaccin their for 5 vaccinated cases vaccines to the vaccine
Vaccine limit their tried to ated knowledg minutes to (3 dose taken) had our like
uptake chances of identify and e on HBV obtain sera. their samples participants. ignorance
and contracting possible non- infection The sera collected and All the four and
immune the reasons of vaccin (nature of were first tested within 1–2 were using negligence
response infection. no or poor ated the of all months after their multi-dose can be
s to HBV As such, the responses but disease, screened 3rd dose while 31 vials vaccine eliminated.
infection need to in our expose transmissi for HIV (45.6%) were and none of (Meriki et
amongst identify community d on routes, and HCV collected and them al, 2018, p.
vaccinate such people . individ risk antibodies tested > 2 months discarded or 14)
d and in a country (Meriki et uals factors using after their 3rd stopped
non- with a high al, 2018, p. 18 and HBV Abbot dose (the least using the
vaccinate HBV 2) years vaccine Determine duration was 4 content of
d endemicity old. awareness and Acon1 months while the the vials after
healthcar especially We . Laboratorie highest duration 28 days of
e from high needed (Meriki et s Inc. was 7 years after usage
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househol cannot be recruit p. 4) y. All participants whose day it was
d and overemphasi at least samples samples were opened as
sexual zed. 237 were tested collected 1–2 day 1) as
contacts (Meriki et partici for the months after the recommende
to al, 2018, p. pants presence of 3rd dose recorded d by WHO
chronical 1-2) for this HBsAg, a significantly [58] or as
ly study. anti-HBs higher (p = 0.037, indicated on
infected Chroni and anti- 95% CI: 1.18– the package
HBV c HBc total 36.41) mean insert of the
individua hepatiti qualitativel antiHBs vaccines.
ls in the sB y using concentration They only
South patient Blue Cross (36.46 ± 42.33 stopped
West s who Bio- mIU/ml) as using the
Region consult Medical compared to the vaccine when
of ed at Co., Ltd mean it finished or
Cameroo the and concentration of when it got
n. PLoS Buea subjected those collected >2 expired. One
ONE, Region to months after the of the
13(7), 1- al quantitativ 3rd dose (17.66 ± institutions
18. Hospit e anti-HBs 27.16 mIU/ml) did not have
doi:10.1 al ELISA test (Table 3). Their evidence of
371/jour betwee with difference was as monitoring
nal.pone. n BIOELISA well statistically the
0200157 Januar anti-HBs significant (p = temperature
y 2016 testing kit 0.016) when of the fridge
and following investigating were their
Decem manufactur number of cases vaccines
ber er’s that had antiHBs were stored
2017 instructions concentration and 2 did not
linked . In order 10mIU/ml (Table have any
us to to get the 4). Fig 5 shows reliable
their anti-HBs decline in anti- contingency
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and ons (in over time (4 of power
househ mIU/ml) a months to 7 years) failure or
old calibration for all the 68 equipment
contact curve was vaccinated (fridge)
s who generated participants who breakdown
were using the have received 3 despite the
enrolle negative doses of the constant
d in control, vaccine. Male power failure
this low gender, 40 years and poor
study. positive of age, alcohol service
(Merik calibrator consumption, maintenance
i et al, and high smoking and body of equipment
2018, positive mass index (BMI) in the study
p. 3-4) calibrator. 25 did not seem to area.
(Meriki et affect the response (Meriki et al,
al, 2018, p. to the vaccine in 2018, p. 14)
5) our population as
none of these
factors recorded a
statistically
significant
difference (Tables
4 and 5). Two of
the participants
were diabetic
while 4 where
positive for anti-
HBc (1 of them
was collected 1–2
months after 3rd
dose) and all these
individuals had
 anti-HBs
concentrations
<10mIU/ml after
3 doses of the
vaccine.
(Meriki et al,
2018, p. 7-8)
van Healthcare- This The We All Models are often None This review Transmissio
Kleef, associated review, databas searched databases used to increase has some n models
E., infections conducted e Medline were epidemiological limitations. concerning
Robotha (HCAI) in 2006, search (1950 to search understanding. First of all HCAI have
m, J. V., continue to primarily retriev present), identically, Hospital we have showed a
Jit, M., cause a aimed to ed EMBASE with surveillance data, exclusively general
Deeny, major explain the 2461 (1947 to exception which is considered enhancemen
S. R., & burden on capacities unique present), of the frequently used to peer- t in
Edmunds society, of models papers Scopus MeSH inform HCAI reviewed complexity,
, W. J. affecting and (Figure (1823 to terms, models, can lack publications but have
(2013). more than 4 therefore 1). present), which were detail in what is in English. been almost
Modellin million was limited After CINAHL altered to needed for This might completely
g the patients to a screeni (1937 to the subject- modelling have resulted limited to
transmiss annually in detailed ng the present) heading purposes. For in a slight high-
ion of Europe description titles and dictionary example, inaccuracy in income
healthcar alone, and of a and Global used in information on our results, settings, and
e causing an number of abstrac health each asymptomatic e.g. with have
associate estimated 16 studies. ts, 302 (1910 to particular carriage and regards to the strongly
d million (van Kleef, papers present). database. timing of events modelling of focused on
infection additional et al, 2013, met the Results The final (e.g. infection) are particular MRSA
s: a bed-days p. 2) inclusi were search was often lacking. pathogens in transmissio
systemati responsible on limited to conducted Several studies alternative n in hospital
c review. for €7 criteria peer- on 11 use new statistical national settings.
BMC billion in and reviewed December methods to settings. We Further
Infectiou direct were publicatio 2011. Each overcome such were improveme
s medical thus ns in title and difficulties exclusively nts in the
Diseases costs [1]. eligible English. abstract in [31,36,48] and to interested in availability
, 13(1), (van Kleef, for full Search the search allow for models of data and
1-13. Robotha, Jit, text terms and result was estimation of exploring the statistical
doi: Deeny, & evaluat Medical independen important patient-to- methods
10.1371/ Edmunds, ion. Subject tly epidemiological patient could
journal.p 2013, p. 1) Revie Headings screened parameters (e.g. transmission enhance the
one.0188 w of (MeSH) by EvK transmission of HCAI and insight
377 the full for and at least rates) from antimicrobial gained from
text nosocomi one of the different data resistance these
publica al other sources, varying within models.
tions organisms authors. from routinely healthcare (van Kleef,
resulte and Full text collected hospital settings et al, 2013,
d in the antibiotic evaluation data [56,57] to (either p. 10)
inclusi resistance was strain typing [63] directly, or
on of were conducted or genotype data mediated by
94 combined by EvK [64]. Others use healthcare
relevan with and in case modelling workers
t search of techniques to and/or the
papers and uncertainty determine the healthcare
based MeSH , relative environment)
on our terms for discussion importance of . This has
selecti healthcare took place potential resulted in
on settings with JR transmission the exclusion
criteria and Proportion reservoirs or of a higher
. An mathemat of models acquisition routes number of
additio ical that are (of C. difficile models that
nal two models as fitted to [58,60], VRE elucidate the
papers follows: data, have [50,53], dynamics of
were Nosocomi included cephalosporin- antimicrobial
identifi al uncertainty resistant resistance in
ed via infections and are Enterobacteriacea its own right,
referen in general validated e (CRE) [65] and which are
ce (e.g.”heal by SARS [66]. summarised
screeni thcare consultatio (van Kleef, et al, elsewhere
ng associated n of two 2013, p. 5) [120,121].
[11,12] infection$ different Moreover,
. The ” or datasets by this review
distrib “hospital- total intended to
ution acquired number of provide
of infection$ publication overall trends
these ”) OR s in each in the field of
96 Nosocomi time HCAI
papers al period. modelling,
over organisms (van Kleef, rather than a
time (e.g. “C. et al, 2013, detailed
demon difficile” p. 8) account of
strates or the quality of
that “Staphylo individual
HCAI coccus models and
transmi aureus”) of what these
ssion OR models have
models Antimicro shown,
have bial which could
been resistance be a valid
increas AND future area of
ingly Nosocomi investigation.
employ al (e.g. (van Kleef, et
ed “hospital$ al, 2013, p.
since ” or 9)
the “healthcar
introdu e”) AND
ction Mathemat
of the ical
first modelling
model or
of economic
nosoco evaluatio
mial n model
pathog (e.g.
ens “stochasti
spread c” or
[13] “determin
(Figure istic”
2). AND
(van “model”)
Kleef, We
et al, decided
2013, not to use
p. 2) search
terms for
nosocomi
al
infection
types
(e.g.
surgical
site
infections
or urinary
tract
infections
), since
our
review
focuses
on the
transmissi
on of
infections
from one
individual
to
another,
which
cannot
generally
be
accurately
represente
d without
knowing
the
causative
organism
Eligible
studies
had to
fulfil the
following
criteria:
1)
mathemat
ical
modelling
of HCAI
transmissi
on and/or
the
dynamics
of
antimicro
bial
resistance
; 2)
dynamic
transmissi
on
models
only (i.e.
a model
which
tracks the
number
of
individual
s (or
proportio
n of a
populatio
n)
carrying
or
infected
with a
pathogen
over time,
while
capturing
the effect
of contact
between
individual
s on
transmissi
on [9]); 3)
 a primary
focus on
HCAI
transmissi
on in
healthcare
settings.
(van
Kleef, et
al, 2013,
p. 2)
Chiu, Previous The We Using In our From a total of None. This study The
M., costing primary used individual study, the 10,662 initial also has elevated
Lebenba studies for objective the encrypted major survey some rate of
um, M., depression of this Ontari health depressive respondents, we limitations contact with
Cheng, have study was o card disorder excluded 356 that need to the
J., de focused on therefore to sample numbers, (MDD) respondents with be healthcare
Oliveira, patients in determine of the we group other serious considered. system
C., & primary care the direct Canadi anonymo included mental illnesses First, the among
Kurdyak, or healthcare an usly respondent and 145 CCHS patients
P. psychiatric costs Comm linked s who met individuals excluded with
(2017). care settings associated unity survey the criteria without healthcare certain psychologic
The rather than with Health responden for past 12- eligibility at vulnerable al distress
direct population- psychologi Survey ts to month baseline and a populations provides an
healthcar based cal distress on multiple MDD [16]. year prior to [16], some of opportunity
e costs samples, and major Mental health Among baseline, and 6 whom may for them to
associate which may depression Health administr those who individuals with have elevated be
d with be more in Ontario. and ative did not data errors (i.e. 4 burden of identified
psycholo representati The Well databases meet the with a survey date psychiatric and receive
gical ve of all secondary Being, housed at criteria for outside disorders, mental
distress people with objectives cycle the MDD, recruitment therefore our healthcare.
and depression, were to 1.2 Institute those who window, 2 with a cost Further
major particularly understand (CCHS for scored 8 or death data prior to estimates are research is
depressio those who how these 1.2) Clinical more out of the survey date likely needed to
n: A do not seek costs vary conduc Evaluativ 24 on the suggesting a conservative. examine
populatio health by ted by e Kessler 6 possible data Second, whether
n-based services [9– healthcare Statisti Sciences (K6) scale linkage error). given that identifying
cohort 11]. Many sector and cs (ICES) [17] were There was a total MDD or and treating
study in studies have what Canada (S1 included in of 190 (1.7%) distress psychologic
Ontario, also proportion in Table). the missing status and al distress
Canada. estimated of total 2002 We psychologi observations covariates will result
PLoS costs with costs were to excluded cal distress which were were only in short- or
ONE, limited for mental select responden group. The excluded from the assessed at long-term
12(9), 1- adjustment health and our ts with K6 has analysis. Our final baseline and cost
13. doi: for addictions study invalid been sample consisted costs were savings.
10.1371/ confounding (MHA) cohort. health shown to of 9,965 assessed over (Chiu et al,
journal.p factors, such versus non- The card be an individuals: 651 an 11-year 2017, p. 10)
one.0184 as age, sex, MHA CCHS numbers effective with follow-up
268 income, related 1.2 is a or those screening psychological period, we
lifestyle risk healthcare nationa without instrument distress, 409 with were unable
factors, and services lly eligibility for MDD and 8,905 to
somatic . represe at psychologi comparison group appropriately
illnesses (Chiu et al, ntative baseline cal distress individuals (Table account for
[10,12,13]. 2017, p. 2) commu or a year in the 1). The weighted time. It is
Moreover, nity prior general prevalence of conceivable
previous mental which population psychological that
studies health were [7,18]. The distress and MDD individuals
examining survey required remaining was 6.6% and may have
the cost of of for data individuals 3.9%, moved
psychologic individ linkage comprised respectively. between
al distress uals and the Median follow-up exposure
did not have aged ascertaini comparison time was 10.6 groups
an MDD 15 ng group. years in all during the
group for years covariates (Chiu et al, exposure groups. 11-year
cost or . Given 2017, p.3) Individuals with follow-up
comparison older our focus psychological period or
and often living on distress and MDD major
relied on in psycholog were significantly (ecological)
self-reported private ical younger than the events have
healthcare dwellin distress comparison group occurred
utilization gs. The and (40.8 and 39.3 vs. during the
[14,15]. survey depressio 44.3 years, 11-year
Finally, exclud n, we respectively) and follow-up
there is ed excluded were less likely to period that
insufficient individ responden be married or in may have
evidence on uals ts with a common-law affected
which living hospitaliz relationships costs. Third,
healthcare on ation for (p<0.001) (Table we were not
sectors are Indian bipolar 1). able to
most Reserv disorder capture drug
associated es and or (Chiu et al, 2017, costs for
with on schizophr p. 4) adults under
depression Crown enia/schiz age 65 years
and Lands, oaffective or
psychologic institut disorder community
al distress. ional in the past mental health
(Chiu, residen 5 years, and
Lebenbaum, ts, full- as well as addictions
Cheng, de time those who services.
Oliveira, & membe self- Moreover,
Kurdyak, rs of reported costs for
2017, p. 2) the schizophr outpatient
Canadi enia, any psychologica
an other l counselling
Forces, psychoses were not
and , past year captured as
residen mania, they are
ts of dysthymi largely
certain a, or covered
remote eating through
regions disorders employer-
(98% (see S1 based
covera Table for insurance or
ge; codes). paid out-of-
77% Given the pocket.
respon cohort (Chiu et al,
se rate) was 2017, p. 10)
[16]. recruited
(Chiu in 2002,
et al, the year
2017, ICD10
p. 2) was
implemen
ted in
Ontario
Canada,
parts of
the 5-year
lookback
period
used both
ICD10
and ICD9
codes.
(Chiu et
al, 2017,
p. 2)
 Synthesis Matrix Analysis of Literature

Foundational Sub Problem 2: How can patient data be used to make future predictions about patient wellness?
APA Purpose Framework Sample Design Variables/ Results Controversies, Assumptions, Implications
format instruments disagreements Limitations for practice,
reference Overarching Hypothesis/ How the with other and research,
Question Objective How the Validity hypothesis was authors Delimitations theory
data was and supported/rejected
collected? Reliability You will add a
Conclusion and list of authors
further studies referenced in
this section on
a separate
page
Warringt Recent The aim of None - None When Patients reported None However, None
on, L., initiatives this paper article selecting that the graphs statistically
Absolom are is to docum PROMs, it depicting significant
, K., & focussing on discuss the enting is symptom results are
Velikova improving potential import important scores over time limited,
, G. outcomes use of ance of to consider was another and effect
(2015). for people patient patient the goals of motivation to sizes are
Integrate living with reported reporte data complete generally
d care and beyond outcome d collection. PROMs regularly. small to
pathways cancer by measures outcom The There is an moderate.
for moving (PROMs) e purpose of emerging Heterogeneit
cancer towards care in future measur PROMs in literature on y
survivors pathways care es to eRAPID is patient between
- a role with a more pathways future to assess engagement with studies
for patient for cancer treatme symptoms technology makes it
patient- centred survivors. nt and side called ‘ the difficult to
reported approach (Warringto plans. effects of quantified self ’ , assess
outcome and an n et al, cancer which is the true
measures emphasis on 2015, p. treatment particularly impact of
and quality of 601) and relevant PROMs as
health life, rather therefore for health studies differ
informati than we decided applications in their
cs. Acta survival to use the where symptoms implementati
Oncologi alone, by Common or on of
ca, encouraging Terminolo health behaviours PROMs
54(5), self gy can be monitored interventions,
600-608. management Criteria for over time [34]. and the
doi:10.3 with Adverse Research has outcomes
109/0284 appropriate Events shown that while measured
186X.20 risk (CTCAE) many patients can [20].
14.99577 stratification [27], accurately (Warrington
8 and reworded interpret et al, 2015, p.
intervention into graphically 3)
s to support language presented quality
rehabilitatio suitable for of
n back into patient self life data, this may
an report be more difficult
active life [28]. for older and less
[2,5]. Clinicians educated patients
(Warrington are already [35], and therefore
, Absolom, familiar it is important
& Velikova, with these to facilitate other
2015, p. items, and options for data
 601) have presentation
established where
manageme possible.
nt (Warrington et al,
strategies 2015, p. 5)
for most
side
effects.
(Warringto
n et al,
2015, p. 4)
Hernand The recent Predictive In the n putting The first Through the None In addition to Predictive
ez, I., & shift from analytics study together step in creation of this the need to analytics
Yuting, payment can be used of the applying variable, we train that
Z. based in antide analytic predictive aggregated claim- clinicians leverage
(2017). on volume identifying mentia data analytics in level in this big data will
Using to value has patients drugs set for the healthcare information into discipline, become an
predictiv brought the who can mentio study, we is to beneficiary-level the indispensabl
e implementat benefit the ned first had construct a information, application e
analytics ion of most from above, to unified and which was then of predictive tool for
and big outcome- pharmacist 22 identify often added to a analytics in a clinicians in
data to based interventio pharma relevant deidentifie patient-level data health mapping
optimize reimbursem ns and in cy and informati d set containing system faces intervention
pharmac ent models predicting medica on data set other 3 other major s and
eutical to the U.S. pharmaceut l contained (Figure 1). relevant patient limitations. improving
outcome healthcare ical claims in When characteristics. First, even if patient
s. system. outcomes. data different predictive (Hernandez & predictive outcomes.
America (Hernandez Predictive from a data files analytics Yuting, 2017, p. techniques (Hernandez
n & Yuting, analytics 5% and are used in 1496) are & Yuting,
Journal 2017, p. can provide rando merge it population developed to 2017, p.
Of 1494) pharmacist m into health overcome the 1499)
Health- s with a sample an manageme limitations
System better of aggregate nt associated
Pharmac understandi Medica d data set approaches with the use
y, ng of the re at the , the of
74(18), risks of benefic patient data set is conventional
1494- specific iaries level. usually statistics in
1500. medication were (Hernand constructed large
doi:10.2 -related analyz ez & at the databases,
146/ajhp problems ed. Yuting, patient their results
161011 that each (Herna 2017, p. level. are still
patient ndez & 1496) However, subject to a
faces, Yuting different high chance
enabling , 2017, levels of false
the p. of data scientific
delivery of 1496) consolidati discoveries.
interventio on may be Second, the
ns tailored preferred storage and
to the for other analysis of
patient’s application large
needs. s of quantities of
(Hernandez predictive patient data
& Yuting, analytics. require
2017, p. (Hernandez the
1495) & Yuting, development
2017, p. and
1496) maintenance
of
a complex
and secure
infrastructure
with high
computing
power,
Finally, the
conventional
 procedures
commonly
used to
assure
privacy
protection
may not be
sufficient to
prevent
patient
identification
.
(Hernandez
& Yuting,
2017, p.
1499)

Asante- Many Transparen None - None - Several of Transparency on None None Although
Korang, paediatric cy and review review these quality, price, and data about
A., & institutions public article article databases, safety can healthcare
Jacobs, are reporting including help reduce the are
J. P. aggressively of data Pediatric costs of healthcare currently
(2016). promoting about Health and improve being
Big Data evidence- patient Network, outcomes managed by
and based outcomes attempt to by empowering existing
paediatri medicine by will help utilise Big consumers to relational
c integrating bridge the Data on a make informed databases
cardiova patient- gap national choices. The and
scular specific data between and proper use of Big enterprise
disease into clinicians even Data can facilitate data
in the era complex and internation transparency. warehouse
of algorithms families. In al stage. Furnishing systems, it
transpare to help paediatrics, The patients, their is becoming
ncy in physicians the Pediatric families, and increasingly
healthcar streamline integration Health insurance evident that
e. care. In of parents Network companies with several
Cardiolo order to exemplifies is a data about institutions
gy In The achieve this, the desire collaborati comparative have
Young, Big Data to move on of performance, so begun to
26(8), combines towards children’s that they can direct their
1597- electronic patient hospitals make informed attention
1603. health engagemen and a data healthcare towards the
doi:10.1 records, t in all coordinatin choices, is one of more
017/S10 patient aspects g the few strategies sophisticate
4795111 generated of care. centre that for d systems of
6001736 data (Asante- conducts creating Big Data,
sources, bio- Korang & research consequences for that are
specimens, Jacobs, studies in low quality of capable of
etc., from 2016, p. children care or acquiring,
several 1597) with high quality of storing,
healthcare congenital care analysing,
facilities or acquired (Asante-Korang & and
and from heart Jacobs, 2016, p. reporting
millions of diseases. 1602) large
patients. (Asante- amounts of
(Asante- Korang & data. Big
Korang & Jacobs, Data is an
Jacobs, 2016, p. evolving
2016, p. 1599) domain of
1598) healthcare
with far-
reaching
implications
.
(Asante-
Korang &
 Jacobs,
2016, p.
1601)
Shams, Hospital The goal of The The In this Hence, we end up None First, the data In future
I., readmission our study is dataset dataset study, having 786 PARs, used in the work, we
Ajorlou, is disruptive twofold: set used in since our from which 588 study is from plan to use
S., & to patients (1) to contain this goal is examples belong one region our
Yang, K. and costly to develop s 7200 retrospect more to to a (Veteran proposal to
(2015). healthcare and records ive cohort develop PAR series with Integrated compare
A systems. internally that study is and only one PAR, Service and
predictiv Unnecessary validate an corresp provided validate and 71 match to a Network profile the
e return to administrat ond to by a risk PAR series 11, Veterans hospitals on
analytics hospitals ive 2985 the prediction with two or more In their
approach shortly after algorithm distinct Veteran model that PARs. Partnership) readmission
to discharge for adult Health can be used Consequently, the in the State rates using
reducing has been characterizi patient Administr for clinical total number of of Michigan, proper
30-day increasingly ng s with ation application unique PAR series with a risk
avoidabl perceived as avoidable princip (VHA), s becomes 659, and veteran adjustment
e a marker of readmissio al (or which is (rather than the PAR rate (see population for case mix
readmiss the ns from all second the hospital section that is mostly and service
ions quality of types of ary) largest profiling IX of the PAR male and mix.
among care that readmissio dischar single and algorithm) is veteran, and (Shams et
patients patients ns, and (2) ge medical payment found to be 11.77 a al, 2015, p.
with receive to diagno system in adjustment %. Following government 33)
heart during create and ses of the ), the same funded care
failure, hospital validate a HF, United we derive a approach, rates of delivery
acute admission simple and AMI, States, hybrid PAR for heart system;
myocardi [1]. real-time PN, with 152 approach failure (HF), acute hence the
al About one readmissio and medical adopting myocardial results
infarctio in five n risk COPD centers both the infarction (AMI), may not be
n, Medicare prediction (the and CMS and pneumonia (PN), identical in
pneumon fee-for- model that origina nearly 3M and COPD are other health
ia, or service can l 1400 rationales 13.26, 12.47, care systems.
COPD. beneficiaries produce set outpatient to choose 11.16, and 11.18 Second, the
Health , totaling more include clinics. from the %. study is
Care over 2.3 desirable s 7237 We patient (Shams et al, limited to
Manage million prediction records analyze outcomes. 2015, p. 26) administrativ
ment patients, are accuracy form inpatient … e data (that
Science, rehospitalize than the which administr The are regularly
18(1), d within 30 literature 37 are ative algorithm, available to
19-34. days after (c-statistics droppe records which we all health
doi:10.1 discharge, >80 %). d since gathered call plans) and it
007/s107 incurring an (Shams et they from for Potentially does not
29-014- annual cost al, 2015, p. have medical Avoidable have
9278-y of $17 20) severe facilities Readmissio laboratory
billion, data in the n test results
which quality State of (PAR). and vital
constitutes issues). Michigan, (Shams et signs such as
nearly (Shams namely,A al, 2015, p. hemoglobin
20%of et al, nn Arbor, 21) or serum
Medicare's 2015, Battle level
total p. 20) Creek,Det at discharge,
payment [2]. roit, and which may
(Shams, Saginaw. affect the
Ajorlou, & (Shams et risk of
Yang, 2015, al, 2015, unnecessary
p. 19) p. 20) readmission.
(Shams et al,
2015, p. 33)
Funderb Approximat Both A total A total of PCP Self- The use of t-tests None First, the With the
urk, J. S., ely half of studies of 88% of report and phi data were implementat
Sugarma all were 1,888 the questionnai coefficients to collected in ion of any
n, D. E., individuals designed to electro patients re. This 13- compare the chart primary care new model
Maisto, with a collect nic were item review data in clinics within of service
S. A., mental information medica male, and questionnai Study 1 showed the VA delivery,
Ouimette health on three l they had a re asked that the only health care consideratio
, P., disorder do primary records mean age providers significant system, n for the
Schohn, not seek goals: (a) were of 59.7 how much difference was which limits setting,
M., mental to describe identifi years (SD they agree that the length of the population,
Lantinga health care, the clinical ed of = 14.7). to the initial session generalizabili and
, L., but most elements patient The statements was longer for ty of the provider
...Strutyn will visit (i.e., s who majority assessing BHPs who were findings; the results in
ski, K. their characterist had an of their prescribers (M = elimination practical
(2010). primary care ics of the initial patients practice of 46.03, SD = of issues modificatio
The provider patients, session were working 12.73) compared related to ns to the
descripti (PCP) at reasons for with White with the to nonprescribing health model. This
on and least referral, each (77%), BHP in BHPs (M = 40.55, insurance paper
evaluatio annually for format of integra and 12% primary SD = 12.9). reimburseme describes a
n of the complaints the ted identified care, their (Funderburk et al, nt may method for
impleme associated sessions, BHP in as access to 2010, p. 155) significantly evaluating
ntation with and primar African the BHP, affect how the practical
of an psychologic disposition/ y care American and their the BHP can implementat
integrate al problems follow-up) betwee . A total communica function ion of an
d (Strosahl, that n June of 42% of tion with within a integrated
healthcar 1998) constitute 1, 2004 the the BHP primary care health care
e model. demonstrati the service and patients (see Table setting. model,
Families, ng the provided June 1, were 1 for the However, using data
Systems demand for by the 2005 at married, specific these results collected
& psychologic BHPs in one of 32% were items). provide a from five
Health, al services the five the divorced, Responses view of how VA primary
28(2), in primary Veteran five and 26% were given an integrated care clinics
146-160. care is high. Affairs VA were using a health care as an
doi:10.1 (Funderburk primary setting identified Likert model is example.
037/a002 et al, 2010, care clinics s as scale (1 = practically (Funderburk
0223 p. 146-147) in Upstate identifi separated, Not at all implemented et al, 2010,
New York; ed in widowed, to 9 = and the p.159)
(b) to VISN or Completely subsequent
evaluate 2. A unknown. /Routinely) positive
whether the rando (Funderb . response
PCPs and m urk et al, (Funderbur from
BHPs sample 2010, p. k et al, providers and
reported an of 20 149) 2010, patients.
increased electro p.150) Furthermore,
level of nic the resulting
collaborati medica services
on, a l increased
fundamenta records access to
l objective were behavioral
of the review health
colocated ed services for
collaborati from patients.
ve care patient Another
model; and s limitation
(c) to meetin was the use
examine g with of
PCP, BHP, the retrospective
and nine data.
patients' differe Changing a
satisfaction nt model of
with the BHPs health care
colocated (i.e., 5 affects every
collaborati Psycho aspect of
ve care logists, care over a
model. 1 significant
(Funderbur Psychi period of
k et al, atrist, 2 time;
2010, p. Psychi therefore, in
148-149) atric might be
Nurse useful for
Practiti future
oners, research to
and 1 examine the
Licens progression
ed of integration
Clinica that happens
l as providers
Social obtain more
Worke education
r) and
workin experience
g at working with
these one another.
VA
primar (Funderburk
y care et al, 2010,
clinics p.158)
(i.e., 3
from
Albany
VAM
C, 2
from
Syracu
se
VAM
C, I
from
Canan
daigua
VAM
C, 2
from
Buffal
o
VAM
 C, and
1 from
Roches
ter
CBOC
),
yieldin
ga
total of
180
electro
nic
medica
l
records
.
(Funde
rburk
et al,
2010,
p. 149)
References (Both from FSP 1, FSP 2, FSP 3 etc.; and references from the controversies, disagreements with other authors’
column)

Asante-Korang, A., & Jacobs, J. P. (2016). Big Data and paediatric cardiovascular disease in the era of transparency in
healthcare. Cardiology In The Young, 26(8), 1597-1603. doi:10.1017/S1047951116001736
Baro, E., Degoul, S., Beuscart, R., & Chazard, E. (2015). Toward a literature-driven definition of big data in healthcare. BioMed
Research International, 1-9. doi:10.1155/2015/639021
Chiu, M., Lebenbaum, M., Cheng, J., de Oliveira, C., & Kurdyak, P. (2017). The direct healthcare costs associated with psychological
distress and major depression: A population-based cohort study in Ontario, Canada. PLoS ONE, 12(9), 1-13. doi:
10.1371/journal.pone.0184268
 Funderburk, J. S., Sugarman, D. E., Maisto, S. A., Ouimette, P., Schohn, M., Lantinga, L., ...Strutynski, K. (2010). The
description and evaluation of the implementation of an integrated healthcare model. Families, Systems & Health, 28(2), 146-
160. doi:10.1037/a0020223
Hernandez, I., & Yuting, Z. (2017). Using predictive analytics and big data to optimize pharmaceutical outcomes. American
Journal Of Health-System Pharmacy, 74(18), 1494-1500. doi:10.2146/ajhp161011
Meriki, H. D., Tufon, K. A., Anong, D. N., Tony, N. J., Kwenti, T. E., Bolimo, A. F., ...Nkuo-Akenji, T. (2018). Vaccine uptake and
immune responses to HBV infection amongst vaccinated and non-vaccinated healthcare workers, household and sexual
contacts to chronically infected HBV individuals in the South West Region of Cameroon. PLoS ONE, 13(7), 1-18.
doi:10.1371/journal.pone.0200157
Shams, I., Ajorlou, S., & Yang, K. (2015). A predictive analytics approach to reducing 30-day avoidable readmissions among
patients with heart failure, acute myocardial infarction, pneumonia, or COPD. Health Care Management Science, 18(1), 19-34.
doi:10.1007/s10729-014-9278-y
van Kleef, E., Robotham, J. V., Jit, M., Deeny, S. R., & Edmunds, W. J. (2013). Modelling the transmission of healthcare
associated infections: a systematic review. BMC Infectious Diseases, 13(1), 1-13. doi: 10.1371/journal.pone.0188377
Warrington, L., Absolom, K., & Velikova, G. (2015). Integrated care pathways for cancer survivors - a role for patient-reported
outcome measures and health informatics. Acta Oncologica, 54(5), 600-608. doi:10.3109/0284186X.2014.995778
Yao, D., Xi, X., Huang, Y., Hu, H., Hu, Y., Wang, Y., & Yao, W. (2017). A national survey of clinical pharmacy services in
county hospitals in China. PLoS ONE, 12(11), 1-14. Retrieved from the Opposing Viewpoints in Context database.