FILENAME: SBTY308.

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Course
BTY308
1 number
2 Course Title Basic Computational Biology
3 Credits 4
Contact Hours
3-1-0
4 (L-T-P)
To acquire a fundamental knowledge of basic computational biology by studying, designing and
Course analyzing in silico experiments. To learn the procedure of sequence alignment and its application
Objective in molecular phylogenetics. To understand different techniques used for gene prediction and
5 creation of biological databases.
After successfully completion of this course students will be able to:
1. Review different biological databases and softwares required for computational biology.
2. Integrate data, perform DNA sequencing and interpret the results.
3. Predict protein structure, function and folding.
6 Course 4. Compute DNA-protein interaction and apply the information in drug designing.
Outcomes 5. Design and predict the function of proteins and genes by different algorithms.
6. Apply different techniques for gene prediction and motifs identification.
7. Design experiments to find ESTs and SNPs.
8. Perform genomic sequencing and determine transcription factor computational biology.
9. Retrieve date using different databases (NCBI, EMBL, SwissPort).
7 Outline syllabus:
7.01 XXXNNN.A Unit A Bioinformatics objectives and overviews
7.02 XXXNNN.A1 Unit A Topic 1 Objectives and Interdisciplinary nature of bioinformatics.
7.03 XXXNNN.A2 Unit A Topic 2 Major bioinformatics databases and tools.
7.04 XXXNNN.A3 Unit A Topic 3 Data integration and data analysis.
7.05 XXXNNN.B Unit B DNA ,Proteins and nucleic acid
7.06 XXXNNN.B1 Unit B Topic 1 Information molecules, information flow and DNA sequencing
7.07 XXXNNN.B2 Unit B Topic 2 Protein structure, functions and protein folding.
7.08 XXXNNN.B3 Unit B Topic 3 Nucleic acid protein interaction.
7.09 XXXNNN.C Unit C Operating Systems
7.10 XXXNNN.C1 Unit C Topic 1 Linux operation System
7.11 XXXNNN.C2 Unit C Topic 2 Basics of PERL
7.12 XXXNNN.C3 Unit C Topic 3 Basics of JAVA and BIOPERL.
7.13 XXXNNN.D Unit D Genome and Genomic Sequencing
7.14 XXXNNN.D1 Unit D Topic 1 Gene prediction, expression, nucleotide databases and genomic sequencing
7.15 XXXNNN.D2 Unit D Topic 2 Expressed Sequence Tag databases and SNPs databases.
7.16 XXXNNN.D3 Unit D Topic 3 Transcription Factor binding sites databases.
7.17 XXXNNN.E Unit E Data Storage and Retrieval
7.18 XXXNNN.E1 Unit E Topic 1 Data retrieval tools
7.19 XXXNNN.E2 Unit E Topic 2 Boolean Search
7.20 XXXNNN.E3 Unit E Topic 3 Indices and fuzzy search
8 Course Evaluation
8.1 Course work: 30% marks
8.11 Attendance None
8.12 Homework 10 assignments, no weight
8.13 Quizzes 7 best quizzes (based on assignments) in tutorial hours; 30 marks
8.14 labs None
8.15 Presentations None
8.16 Any other
8.2 MTE One, 20 marks
8.3 End-term examination: 50 marks
9 References
9.1 Text book Xiong Jin“Essential Bioinformatics”,Cambridge University Press.2006.
1. Attwood TK., “Introduction to Bioinformatics”, Pearson Eduction, 2006.
Other 2. J.S,Ignacimuthu.S, “Basic Bioinformatics”, Narosa, 2013.
9.2 References 3. Roy Darbeshwar., “Bioinformatics”, .Narosa,2009.

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