Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
k0 2.479 2.647 2.670 2.448 2.597 2.464 2.374
Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 10.086 9.445 9.364 10.214 9.627 10.147 10.530
T50 20.173 18.891 18.728 20.429 19.254 20.294 21.060
T75 30.259 28.336 28.093 30.643 28.881 30.441 31.590
T80 32.277 30.225 29.965 32.686 30.806 32.470 33.696
T90 36.311 34.003 33.711 36.772 34.657 36.529 37.908
Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.7699 0.7057 0.7186 0.7030 0.7088 0.7723 0.7923
Rsqr -0.6472 -0.9368 -0.5380 -0.8372 -0.7171 -0.9245 -0.2844
Rsqr_adj -0.6472 -0.9368 -0.5380 -0.8372 -0.7171 -0.9245 -0.2844
MSE 1194.1709 1589.4960 1504.7377 1350.9681 1484.1859 1226.3991 976.5486
MSE_root 34.5568 39.8685 38.7909 36.7555 38.5251 35.0200 31.2498
Weighting 1 1 1 1 1 1 1
SS 8359.1960 11126.4723 10533.1642 9456.7764 10389.3012 8584.7936 6835.8402
WSS 8359.1960 11126.4723 10533.1642 9456.7764 10389.3012 8584.7936 6835.8402
AIC 74.2489 76.5367 76.0983 75.2359 75.9883 74.4620 72.6395
MSC -0.7491 -0.9110 -0.6805 -0.8583 -0.7906 -0.9047 -0.5003
No.1
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.2
180
160 Observed
Predicted
140
Fraction dissolved (%)
120
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.3
180
160 Observed
Predicted
140
Fraction dissolved (%)
120
100
80
60
Predicted
140
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.4
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.5
180
160 Observed
Predicted
140
Fraction dissolved (%)
120
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.6
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.7
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.8
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
120
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.9
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.10
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.11
180
160 Observed
Predicted
No.11
180
160 Observed
Predicted
140
Fraction dissolved (%)
120
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.12
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Mean
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
Fraction dissolved (
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 2.97 3.18 3.20 2.94 3.12 2.96 2.85
2.4 5.95 6.35 6.41 5.87 6.23 5.91 5.70
3.6 8.92 9.53 9.61 8.81 9.35 8.87 8.55
4.8 11.90 12.70 12.81 11.75 12.47 11.83 11.40
6 14.87 15.88 16.02 14.69 15.58 14.78 14.24
7.2 17.85 19.06 19.22 17.62 18.70 17.74 17.09
8.4 20.82 22.23 22.43 20.56 21.81 20.70 19.94
9.6 23.79 25.41 25.63 23.50 24.93 23.65 22.79
10.8 26.77 28.59 28.83 26.43 28.05 26.61 25.64
12 29.74 31.76 32.04 29.37 31.16 29.57 28.49
13.2 32.72 34.94 35.24 32.31 34.28 32.52 31.34
14.4 35.69 38.11 38.44 35.24 37.40 35.48 34.19
15.6 38.67 41.29 41.65 38.18 40.51 38.44 37.04
16.8 41.64 44.47 44.85 41.12 43.63 41.39 39.89
18 44.61 47.64 48.06 44.06 46.74 44.35 42.73
19.2 47.59 50.82 51.26 46.99 49.86 47.30 45.58
20.4 50.56 53.99 54.46 49.93 52.98 50.26 48.43
21.6 53.54 57.17 57.67 52.87 56.09 53.22 51.28
22.8 56.51 60.35 60.87 55.80 59.21 56.17 54.13
24 59.49 63.52 64.07 58.74 62.33 59.13 56.98
25.2 62.46 66.70 67.28 61.68 65.44 62.09 59.83
26.4 65.43 69.88 70.48 64.61 68.56 65.04 62.68
27.6 68.41 73.05 73.69 67.55 71.67 68.00 65.53
28.8 71.38 76.23 76.89 70.49 74.79 70.96 68.38
30 74.36 79.40 80.09 73.43 77.91 73.91 71.22
31.2 77.33 82.58 83.30 76.36 81.02 76.87 74.07
32.4 80.31 85.76 86.50 79.30 84.14 79.83 76.92
33.6 83.28 88.93 89.70 82.24 87.26 82.78 79.77
34.8 86.25 92.11 92.91 85.17 90.37 85.74 82.62
36 89.23 95.28 96.11 88.11 93.49 88.70 85.47
37.2 92.20 98.46 99.31 91.05 96.60 91.65 88.32
38.4 95.18 101.64 102.52 93.98 99.72 94.61 91.17
39.6 98.15 104.81 105.72 96.92 102.84 97.57 94.02
40.8 101.13 107.99 108.93 99.86 105.95 100.52 96.87
42 104.10 111.17 112.13 102.80 109.07 103.48 99.71
43.2 107.07 114.34 115.33 105.73 112.19 106.44 102.56
44.4 110.05 117.52 118.54 108.67 115.30 109.39 105.41
45.6 113.02 120.69 121.74 111.61 118.42 112.35 108.26
46.8 116.00 123.87 124.94 114.54 121.54 115.31 111.11
48 118.97 127.05 128.15 117.48 124.65 118.26 113.96
49.2 121.95 130.22 131.35 120.42 127.77 121.22 116.81
50.4 124.92 133.40 134.56 123.36 130.88 124.18 119.66
51.6 127.89 136.57 137.76 126.29 134.00 127.13 122.51
52.8 130.87 139.75 140.96 129.23 137.12 130.09 125.36
54 133.84 142.93 144.17 132.17 140.23 133.05 128.20
55.2 136.82 146.10 147.37 135.10 143.35 136.00 131.05
56.4 139.79 149.28 150.57 138.04 146.47 138.96 133.90
57.6 142.77 152.46 153.78 140.98 149.58 141.91 136.75
58.8 145.74 155.63 156.98 143.91 152.70 144.87 139.60
60 148.71 158.81 160.18 146.85 155.81 147.83 142.45
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63
Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
k1 0.092 0.114 0.108 0.095 0.106 0.095 0.078
Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 3.129 2.526 2.675 3.034 2.724 3.037 3.669
T50 7.538 6.085 6.444 7.311 6.564 7.318 8.841
T75 15.076 12.170 12.889 14.621 13.128 14.636 17.682
T80 17.503 14.129 14.963 16.975 15.241 16.992 20.528
T90 25.041 20.214 21.408 24.286 21.805 24.311 29.369
Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.9947 0.9921 0.9929 0.9799 0.9884 0.9913 0.9909
Rsqr 0.9533 0.8777 0.8512 0.9247 0.8841 0.9627 0.9575
Rsqr_adj 0.9533 0.8777 0.8512 0.9247 0.8841 0.9627 0.9575
MSE 33.8459 100.3332 145.5980 55.3494 100.2168 23.7737 32.2916
MSE_root 5.8177 10.0166 12.0664 7.4397 10.0108 4.8758 5.6826
Weighting 1 1 1 1 1 1 1
SS 236.9210 702.3321 1019.1863 387.4457 701.5178 166.4161 226.0413
WSS 236.9210 702.3321 1019.1863 387.4457 701.5178 166.4161 226.0413
AIC 45.7418 54.4353 57.4141 49.6766 54.4260 42.9159 45.3657
MSC 2.8143 1.8516 1.6551 2.3367 1.9047 3.0386 2.9089
No.1
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.2
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.3
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
Predicted
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.4
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.5
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.6
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.7
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.8
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.9
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.10
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.11
120
Observed
100 Predicted
No.11
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.12
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Mean
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
80
Fraction dissolved (
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 10.45 12.78 12.11 10.75 11.90 10.74 8.98
2.4 19.80 23.92 22.75 20.35 22.39 20.33 17.15
3.6 28.18 33.64 32.11 28.92 31.62 28.89 24.59
4.8 35.68 42.12 40.33 36.56 39.76 36.53 31.36
6 42.40 49.51 47.55 43.38 46.93 43.35 37.53
7.2 48.42 55.96 53.90 49.47 53.25 49.44 43.13
8.4 53.81 61.59 59.48 54.91 58.81 54.87 48.24
9.6 58.63 66.50 64.39 59.76 63.71 59.72 52.89
10.8 62.96 70.78 68.70 64.08 68.03 64.05 57.12
12 66.83 74.51 72.49 67.95 71.84 67.91 60.97
13.2 70.29 77.77 75.82 71.39 75.19 71.36 64.47
14.4 73.40 80.61 78.75 74.47 78.14 74.43 67.66
15.6 76.18 83.09 81.32 77.22 80.74 77.18 70.57
16.8 78.66 85.25 83.59 79.67 83.04 79.63 73.21
18 80.89 87.13 85.57 81.85 85.05 81.82 75.62
19.2 82.89 88.78 87.32 83.80 86.83 83.77 77.81
20.4 84.68 90.21 88.86 85.55 88.40 85.52 79.80
21.6 86.28 91.46 90.20 87.10 89.78 87.07 81.61
22.8 87.71 92.55 91.39 88.49 91.00 88.46 83.26
24 89.00 93.50 92.43 89.73 92.07 89.70 84.77
25.2 90.14 94.33 93.35 90.83 93.01 90.81 86.13
26.4 91.17 95.06 94.15 91.82 93.84 91.80 87.38
27.6 92.10 95.69 94.86 92.70 94.58 92.68 88.51
28.8 92.92 96.24 95.48 93.48 95.22 93.46 89.54
30 93.66 96.72 96.03 94.18 95.79 94.17 90.48
31.2 94.32 97.14 96.51 94.81 96.29 94.79 91.34
32.4 94.92 97.50 96.93 95.37 96.73 95.35 92.11
33.6 95.45 97.82 97.31 95.87 97.12 95.85 92.82
34.8 95.92 98.10 97.63 96.31 97.46 96.30 93.47
36 96.35 98.34 97.92 96.71 97.77 96.70 94.05
37.2 96.73 98.56 98.17 97.06 98.03 97.05 94.59
38.4 97.07 98.74 98.39 97.38 98.27 97.37 95.07
39.6 97.38 98.90 98.59 97.66 98.47 97.65 95.52
40.8 97.65 99.04 98.76 97.91 98.65 97.90 95.92
42 97.90 99.16 98.91 98.14 98.81 98.13 96.29
43.2 98.12 99.27 99.04 98.34 98.96 98.33 96.62
44.4 98.31 99.36 99.16 98.51 99.08 98.51 96.92
45.6 98.49 99.45 99.26 98.67 99.19 98.67 97.20
46.8 98.65 99.52 99.35 98.82 99.29 98.81 97.45
48 98.79 99.58 99.43 98.94 99.37 98.94 97.68
49.2 98.92 99.63 99.50 99.06 99.45 99.05 97.89
50.4 99.03 99.68 99.56 99.16 99.51 99.16 98.08
51.6 99.13 99.72 99.61 99.25 99.57 99.25 98.25
52.8 99.22 99.76 99.66 99.33 99.62 99.33 98.41
54 99.30 99.79 99.70 99.40 99.67 99.40 98.55
55.2 99.38 99.81 99.74 99.47 99.71 99.46 98.68
56.4 99.44 99.84 99.77 99.52 99.74 99.52 98.80
57.6 99.50 99.86 99.80 99.58 99.77 99.57 98.91
58.8 99.55 99.88 99.82 99.62 99.80 99.62 99.00
60 99.60 99.89 99.84 99.66 99.82 99.66 99.09
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63
Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
kH 16.231 17.453 17.507 16.125 17.078 16.181 15.444
Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 2.372 2.052 2.039 2.404 2.143 2.387 2.620
T50 9.489 8.208 8.157 9.615 8.571 9.548 10.481
T75 21.350 18.467 18.352 21.634 19.286 21.484 23.582
T80 24.292 21.011 20.881 24.615 21.943 24.444 26.831
T90 30.745 26.592 26.427 31.153 27.771 30.937 33.959
Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.8660 0.8125 0.8243 0.8107 0.8152 0.8659 0.8833
Rsqr 0.6917 0.5641 0.6385 0.5765 0.6007 0.6509 0.7605
Rsqr_adj 0.6917 0.5641 0.6385 0.5765 0.6007 0.6509 0.7605
MSE 223.4940 357.7630 353.6682 311.3831 345.1573 222.4824 182.0736
MSE_root 14.9497 18.9146 18.8061 17.6461 18.5784 14.9158 13.4935
Weighting 1 1 1 1 1 1 1
SS 1564.4579 2504.3411 2475.6772 2179.6819 2416.1008 1557.3765 1274.5150
WSS 1564.4579 2504.3411 2475.6772 2179.6819 2416.1008 1557.3765 1274.5150
AIC 60.8424 64.6062 64.5142 63.4955 64.3193 60.8061 59.2026
MSC 0.9268 0.5803 0.7675 0.6093 0.6680 0.8023 1.1793
No.1
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.2
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.3
160
Observed
140
Predicted
120
Fraction dissolved (%)
100
80
60
40
Predicted
120
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.4
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.5
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.6
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.7
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.8
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
100
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.9
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.10
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.11
140
Observed
120
Predicted
No.11
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.12
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Mean
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
Fraction dissolved (
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 17.78 19.12 19.18 17.66 18.71 17.73 16.92
2.4 25.15 27.04 27.12 24.98 26.46 25.07 23.93
3.6 30.80 33.11 33.22 30.59 32.40 30.70 29.30
4.8 35.56 38.24 38.36 35.33 37.42 35.45 33.84
6 39.76 42.75 42.88 39.50 41.83 39.64 37.83
7.2 43.55 46.83 46.98 43.27 45.83 43.42 41.44
8.4 47.04 50.58 50.74 46.73 49.50 46.90 44.76
9.6 50.29 54.08 54.24 49.96 52.92 50.13 47.85
10.8 53.34 57.36 57.53 52.99 56.12 53.18 50.76
12 56.23 60.46 60.65 55.86 59.16 56.05 53.50
13.2 58.97 63.41 63.61 58.58 62.05 58.79 56.11
14.4 61.59 66.23 66.44 61.19 64.81 61.40 58.61
15.6 64.11 68.93 69.15 63.69 67.45 63.91 61.00
16.8 66.53 71.53 71.76 66.09 70.00 66.32 63.30
18 68.86 74.05 74.28 68.41 72.46 68.65 65.52
19.2 71.12 76.47 76.71 70.65 74.83 70.90 67.67
20.4 73.31 78.83 79.07 72.83 77.14 73.08 69.76
21.6 75.44 81.11 81.37 74.94 79.37 75.20 71.78
22.8 77.50 83.34 83.60 76.99 81.55 77.26 73.75
24 79.52 85.50 85.77 78.99 83.67 79.27 75.66
25.2 81.48 87.61 87.89 80.95 85.73 81.23 77.53
26.4 83.40 89.67 89.95 82.85 87.75 83.14 79.35
27.6 85.27 91.69 91.98 84.71 89.72 85.01 81.14
28.8 87.11 93.66 93.95 86.53 91.65 86.84 82.88
30 88.90 95.59 95.89 88.32 93.54 88.63 84.59
31.2 90.66 97.49 97.79 90.07 95.39 90.38 86.27
32.4 92.39 99.34 99.65 91.78 97.21 92.10 87.91
33.6 94.09 101.17 101.48 93.47 98.99 93.79 89.52
34.8 95.75 102.96 103.28 95.12 100.75 95.45 91.11
36 97.39 104.72 105.04 96.75 102.47 97.09 92.67
37.2 99.00 106.45 106.78 98.35 104.16 98.69 94.20
38.4 100.58 108.15 108.49 99.92 105.83 100.27 95.70
39.6 102.14 109.83 110.17 101.47 107.47 101.82 97.19
40.8 103.68 111.48 111.83 103.00 109.09 103.36 98.65
42 105.19 113.11 113.46 104.50 110.68 104.86 100.09
43.2 106.68 114.71 115.07 105.98 112.25 106.35 101.51
44.4 108.16 116.29 116.66 107.44 113.80 107.82 102.91
45.6 109.61 117.85 118.22 108.89 115.33 109.27 104.29
46.8 111.04 119.40 119.77 110.31 116.83 110.69 105.66
48 112.45 120.92 121.29 111.71 118.32 112.10 107.00
49.2 113.85 122.42 122.80 113.10 119.79 113.50 108.33
50.4 115.23 123.90 124.29 114.47 121.24 114.87 109.64
51.6 116.60 125.37 125.76 115.83 122.68 116.23 110.94
52.8 117.94 126.82 127.21 117.17 124.10 117.58 112.22
54 119.28 128.25 128.65 118.49 125.50 118.91 113.49
55.2 120.59 129.67 130.07 119.80 126.89 120.22 114.75
56.4 121.90 131.07 131.48 121.10 128.26 121.52 115.99
57.6 123.19 132.46 132.87 122.38 129.61 122.80 117.21
58.8 124.46 133.83 134.25 123.65 130.96 124.08 118.43
60 125.73 135.19 135.61 124.90 132.29 125.34 119.63
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63
Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
kHC 0.023 0.026 0.025 0.024 0.025 0.024 0.021
Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 3.894 3.567 3.587 3.889 3.651 3.851 4.325
T50 8.786 8.048 8.092 8.774 8.237 8.689 9.758
T75 15.759 14.436 14.514 15.738 14.775 15.586 17.502
T80 17.682 16.197 16.285 17.659 16.578 17.488 19.638
T90 22.820 20.904 21.017 22.790 21.396 22.570 25.344
Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.9885 0.9572 0.9654 0.9670 0.9641 0.9812 0.9893
Rsqr 0.9760 0.8962 0.9028 0.9348 0.9163 0.9610 0.9753
Rsqr_adj 0.9760 0.8962 0.9028 0.9348 0.9163 0.9610 0.9753
MSE 17.3957 85.2054 95.1097 47.9587 72.3539 24.8648 18.7459
MSE_root 4.1708 9.2307 9.7524 6.9252 8.5061 4.9865 4.3296
Weighting 1 1 1 1 1 1 1
SS 121.7699 596.4375 665.7677 335.7110 506.4775 174.0535 131.2210
WSS 121.7699 596.4375 665.7677 335.7110 506.4775 174.0535 131.2210
AIC 40.4171 53.1278 54.0075 48.5300 51.8198 43.2749 41.0151
MSC 3.4799 2.0151 2.0809 2.4800 2.2304 2.9937 3.4528
No.1
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.2
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.3
140
Observed
120
Predicted
100
Fraction dissolved (%)
80
60
40
Predicted
100
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.4
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.5
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.6
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.7
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.8
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.9
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.10
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.11
120
Observed
100 Predicted
No.11
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
No.12
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
Mean
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
80
Fraction dissolved (
60
40
20
0
0 10 20 30 40 50 60 70
Time (h)
Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(h) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 8.22 8.95 8.90 8.23 8.75 8.31 7.42
2.4 15.97 17.34 17.26 15.99 16.97 16.14 14.46
3.6 23.28 25.21 25.09 23.30 24.68 23.51 21.14
4.8 30.14 32.56 32.40 30.18 31.90 30.44 27.46
6 36.59 39.41 39.23 36.63 38.65 36.94 33.43
7.2 42.63 45.78 45.58 42.67 44.93 43.02 39.07
8.4 48.27 51.69 51.47 48.32 50.77 48.69 44.38
9.6 53.53 57.15 56.92 53.58 56.18 53.98 49.37
10.8 58.42 62.18 61.95 58.47 61.17 58.89 54.05
12 62.95 66.81 66.57 63.01 65.78 63.43 58.44
13.2 67.14 71.04 70.80 67.20 70.00 67.63 62.53
14.4 71.00 74.89 74.65 71.06 73.86 71.50 66.35
15.6 74.55 78.39 78.15 74.61 77.38 75.04 69.90
16.8 77.80 81.54 81.32 77.86 80.56 78.28 73.19
18 80.76 84.38 84.16 80.81 83.43 81.22 76.23
19.2 83.44 86.90 86.70 83.49 86.01 83.89 79.03
20.4 85.86 89.14 88.95 85.91 88.30 86.29 81.61
21.6 88.03 91.11 90.93 88.08 90.33 88.44 83.96
22.8 89.97 92.82 92.66 90.02 92.11 90.35 86.10
24 91.69 94.30 94.15 91.73 93.65 92.04 88.05
25.2 93.19 95.56 95.43 93.23 94.98 93.52 89.80
26.4 94.51 96.62 96.51 94.54 96.11 94.80 91.37
27.6 95.64 97.50 97.40 95.67 97.06 95.90 92.78
28.8 96.61 98.21 98.12 96.64 97.83 96.84 94.02
30 97.42 98.77 98.70 97.44 98.46 97.62 95.11
31.2 98.09 99.20 99.14 98.11 98.96 98.26 96.06
32.4 98.63 99.51 99.47 98.65 99.33 98.77 96.87
33.6 99.06 99.73 99.71 99.07 99.60 99.17 97.57
34.8 99.39 99.87 99.86 99.40 99.79 99.48 98.16
36 99.63 99.95 99.94 99.64 99.90 99.69 98.64
37.2 99.80 99.99 99.99 99.80 99.97 99.84 99.03
38.4 99.90 100.00 100.00 99.91 99.99 99.93 99.33
39.6 99.97 100.00 100.00 99.97 100.00 99.98 99.57
40.8 99.99 100.01 100.01 99.99 100.00 100.00 99.74
42 100.00 100.04 100.04 100.00 100.01 100.00 99.86
43.2 100.00 100.12 100.10 100.00 100.05 100.00 99.93
44.4 100.01 100.26 100.23 100.01 100.14 100.02 99.98
45.6 100.04 100.48 100.43 100.04 100.29 100.06 100.00
46.8 100.10 100.80 100.72 100.10 100.51 100.14 100.00
48 100.21 101.22 101.12 100.21 100.83 100.27 100.00
49.2 100.37 101.78 101.65 100.39 101.25 100.47 100.01
50.4 100.62 102.49 102.31 100.63 101.80 100.76 100.03
51.6 100.95 103.36 103.14 100.97 102.50 101.14 100.08
52.8 101.38 104.42 104.15 101.41 103.35 101.63 100.16
54 101.92 105.67 105.35 101.96 104.38 102.24 100.28
55.2 102.60 107.15 106.76 102.64 105.59 102.99 100.47
56.4 103.41 108.86 108.40 103.47 107.02 103.90 100.71
57.6 104.38 110.82 110.29 104.45 108.67 104.96 101.03
58.8 105.52 113.05 112.43 105.60 110.56 106.21 101.44
60 106.83 115.57 114.86 106.93 112.70 107.65 101.94
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63
Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
α 9.673 12.153 19.435 18.869 24.948 3.649 8.876
β 1.043 1.226 1.359 1.377 1.471 0.698 0.985
Ti 2.448 2.415 2.226 1.927 1.698 3.886 3.059
Fmax 101.602 105.523 107.480 97.567 103.497 102.581 99.010
Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 5.068 5.053 5.564 5.415 5.416 4.913 5.679
T50 8.511 7.757 8.512 8.566 8.415 7.474 9.474
Td 11.254 10.082 11.100 10.368 10.609 10.280 12.230
T75 14.106 11.555 12.353 13.060 12.292 13.338 16.120
T80 15.837 12.616 13.376 14.413 13.345 15.467 18.307
Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 4 4 4 4 4 4 4
R_obs-pre 0.9998 0.9998 0.9999 0.9999 0.9996 0.9998 0.9997
Rsqr 0.9997 0.9996 0.9997 0.9998 0.9992 0.9995 0.9994
Rsqr_adj 0.9994 0.9994 0.9995 0.9997 0.9987 0.9992 0.9989
MSE 0.4183 0.5056 0.4446 0.2435 1.1430 0.5196 0.8252
MSE_root 0.6467 0.7111 0.6668 0.4934 1.0691 0.7208 0.9084
Weighting 1 1 1 1 1 1 1
SS 1.6731 2.0226 1.7785 0.9739 4.5720 2.0783 3.3009
WSS 1.6731 2.0226 1.7785 0.9739 4.5720 2.0783 3.3009
AIC 12.1174 13.6349 12.6062 7.7881 20.1596 13.8523 17.5536
MSC 7.0174 6.9517 7.2560 7.5727 6.1880 6.6715 6.3854
No.1
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.2
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.3
120
Observed
100 Predicted
issolved (%)
80
60
120
Observed
100 Predicted
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.4
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.5
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Fr
20
0
0 10 20 30 40 50 60 70
Time (min)
No.6
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.7
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.8
120
Observed
100 Predicted
n dissolved (%)
80
60
Observed
100 Predicted
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.9
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.10
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
20
0
0 10 20 30 40 50 60 70
Time (min)
No.11
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
No.12
120
Observed
100 Predicted
Fraction dissolved (%)
80
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Mean
120
Observed
100 Predicted
ction dissolved (%)
80
60
40
100 Predicted
60
40
20
0
0 10 20 30 40 50 60 70
Time (min)
Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 0.00 0.00 0.00 0.00 0.00 0.00 0.00
2.4 0.00 0.00 0.51 1.82 2.44 0.00 0.00
3.6 11.48 10.17 8.18 9.95 10.14 0.00 5.90
4.8 22.66 22.42 18.24 19.79 19.76 23.29 17.50
6 32.67 34.35 28.87 29.94 30.03 37.96 27.55
7.2 41.53 45.31 39.31 39.74 40.22 48.07 36.31
8.4 49.33 55.08 49.12 48.81 49.88 55.76 43.96
9.6 56.18 63.62 58.09 56.97 58.73 61.89 50.66
10.8 62.16 70.96 66.09 64.14 66.61 66.90 56.53
12 67.39 77.19 73.12 70.32 73.48 71.09 61.68
13.2 71.95 82.43 79.19 75.57 79.35 74.63 66.19
14.4 75.92 86.80 84.37 79.96 84.29 77.66 70.15
15.6 79.37 90.42 88.74 83.59 88.38 80.27 73.63
16.8 82.37 93.39 92.38 86.56 91.71 82.54 76.68
18 84.98 95.82 95.40 88.96 94.39 84.53 79.37
19.2 87.23 97.79 97.87 90.88 96.53 86.28 81.73
20.4 89.19 99.39 99.88 92.41 98.21 87.82 83.80
21.6 90.88 100.67 101.51 93.62 99.52 89.19 85.62
22.8 92.35 101.70 102.81 94.56 100.53 90.40 87.23
24 93.62 102.52 103.85 95.29 101.30 91.49 88.64
25.2 94.72 103.17 104.67 95.85 101.89 92.46 89.88
26.4 95.67 103.68 105.31 96.28 102.32 93.34 90.97
27.6 96.49 104.09 105.82 96.61 102.65 94.12 91.93
28.8 97.19 104.41 106.21 96.86 102.89 94.83 92.77
30 97.80 104.66 106.52 97.05 103.06 95.47 93.52
31.2 98.33 104.86 106.75 97.18 103.19 96.05 94.17
32.4 98.79 105.01 106.93 97.29 103.28 96.57 94.75
33.6 99.18 105.13 107.07 97.36 103.35 97.05 95.25
34.8 99.52 105.22 107.17 97.42 103.39 97.49 95.70
36 99.81 105.29 107.25 97.46 103.42 97.88 96.09
37.2 100.06 105.35 107.31 97.49 103.45 98.24 96.44
38.4 100.28 105.39 107.35 97.51 103.46 98.57 96.75
39.6 100.46 105.42 107.39 97.53 103.47 98.87 97.01
40.8 100.62 105.45 107.41 97.54 103.48 99.15 97.25
42 100.76 105.46 107.43 97.55 103.49 99.40 97.46
43.2 100.88 105.48 107.44 97.55 103.49 99.64 97.64
44.4 100.98 105.49 107.45 97.56 103.49 99.85 97.80
45.6 101.07 105.50 107.46 97.56 103.49 100.05 97.95
46.8 101.14 105.50 107.47 97.56 103.49 100.23 98.07
48 101.21 105.51 107.47 97.56 103.50 100.39 98.18
49.2 101.26 105.51 107.47 97.56 103.50 100.55 98.28
50.4 101.31 105.52 107.47 97.57 103.50 100.69 98.37
51.6 101.35 105.52 107.48 97.57 103.50 100.82 98.44
52.8 101.39 105.52 107.48 97.57 103.50 100.94 98.51
54 101.42 105.52 107.48 97.57 103.50 101.05 98.57
55.2 101.44 105.52 107.48 97.57 103.50 101.16 98.62
56.4 101.47 105.52 107.48 97.57 103.50 101.25 98.67
57.6 101.49 105.52 107.48 97.57 103.50 101.34 98.71
58.8 101.50 105.52 107.48 97.57 103.50 101.42 98.74
60 101.52 105.52 107.48 97.57 103.50 101.50 98.77
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63
tiempo(min) Generico
0 0 0 0 0
5 9.172 8.692 8.027 10.322
10 25.513 27.8 24.553 27.424
15 40.319 46.332 39.261 40.029
20 52.644 60.284 49.871 51.309
25 61.913 69.455 57.609 60.955
30 69.843 75.38 64.392 68.409
45 82.359 85.326 79.692 82.085
60 88.761 91.058 87.623 89.824
AUC 3547.33 3779.44 3393.08 3539.24
MDT 20.04 18.49 21.28 20.60
DE 59.12 62.99 56.55 58.99
ABC
Prueba F para varianzas de dos muestras
Variable 1 Variable 2
Media 5047.61125 3561.38083
Varianza 33441.3706 31364.9597
Observacione 12 12
Grados de lib 11 11
F 1.06620161
P(F<=f) una c 0.4586213
Valor crítico 2.81793047
TMD
Variable 1 Variable 2
Media 10.8806565 19.5833137
Varianza 0.69446129 2.21315677
Observacione 12 12
Grados de lib 11 11
F 0.31378766
P(F<=f) una c 0.03354149
Valor crítico 0.35487036
ED
ABC TMD
REF 5047.61+-52.79(5100.4,4994.82) 10.88+-0.24(11.12;10.64)
GENERICO 1 3561.38+-48.95(3610;3512.43 19.58+-0.41(19.99;19.17)
Generico 2 (si hay)
de HCl 0.1 N, tabletas metronidazol 500 mg.
5 6 7 8 9 10
0 0 0 0 0 0
21.589 26.302 19.428 24.6 23.752 23.981
60.88 63.061 51.925 59.153 61.744 59.963
87.5 80.137 72.752 81.388 80.183 81.391
97.411 87.283 83.814 91.123 86.903 91.933
100.858 91.812 89.303 95.948 91.212 96.203
102.236 95.21 92.614 98.618 94.056 98.293
103.791 99.836 97.58 100.945 98.364 101.778
104.649 101.833 99.496 101.548 101.294 104.131
5205.28 4956.36 4722.17 5023.03 4894.70 5057.94
10.26 11.33 12.54 10.54 11.68 11.43
86.75 82.61 78.70 83.72 81.58 84.30
0 0 0 0 0 0
8.314 8.602 8.696 14.045 15.367 9.929
25.514 23.886 26.654 37.257 32.848 30.188
41.458 37.923 42.61 51.4 47.089 47.006
53.312 49.97 53.884 59.521 58.074 58.471
61.624 58.471 63.151 64.87 67.055 67.832
67.642 65.827 70.89 68.692 74.031 74.426
78.76 80.683 82.546 76.431 86.259 84.17
85.902 89.062 89.426 82.259 92.183 90.19
3453.20 3430.74 3592.76 3585.79 3827.73 3750.37
19.80 21.48 19.82 16.41 18.48 18.42
57.55 57.18 59.88 59.76 63.80 62.51
Prueba t para dos muestras suponiendo varianzas iguales
Variable 1 Variable 2
Media 5047.61125 3561.38083
Varianza 33441.37056 31364.9597
Observaciones 12 12
Varianza agrupada 32403.16513
Diferencia hipotética de las medias 1486.23
Grados de libertad 22
Estadístico t 5.669838E-06
P(T<=t) una cola 0.499997764
Valor crítico de t (una cola) 1.717144374
P(T<=t) dos colas 0.999995527
Valor crítico de t (dos colas) 2.073873068
Variable 1 Variable 2
Media 10.88065649 19.5833137
Varianza 0.694461289 2.21315677
Observaciones 12 12
Diferencia hipotética de las medias 8.7
Grados de libertad 17
Estadístico t -35.35391477
P(T<=t) una cola 1.167976E-17
Valor crítico de t (una cola) 1.739606726
P(T<=t) dos colas 2.335951E-17
Valor crítico de t (dos colas) 2.109815578 El valor de p es menor que 0.05 por lo tanto si existe diferenc
p=0.999 lo que significa que no existen diferencias emtre los valores de ED(eficiencia de disolucion)
entre el medicamento de referncia y el generico.
ED k(constante)
0.88+-0.24(11.12;10.64) 84.13+-0.88(85.01;83.25)
9.58+-0.41(19.99;19.17) 59.36+-0.82(60.18;58.54)
11 12 PROMEDIO DESVEST C.V
0 0 0.00 0.00
30.888 22.101 23.60 3.07 13.00
70.452 58.663 60.82 4.46 7.33
85.562 81.375 82.22 4.75 5.77
93.227 91.129 91.77 4.69 5.11
96.626 95.052 96.16 4.53 4.71
98.455 97.142 98.46 4.11 4.17
101.504 100.452 101.30 3.02 2.98
103.682 102.544 102.75 2.70 2.63 EE
5168.50 4988.88 5047.61 182.87 3.62 52.79
10.15 11.35 10.88 0.83 7.66 0.24
86.14 83.15 84.13 3.05 3.62 0.88