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DDSolver 1.

0 Dissolution Data Modeling of Zero-order Model

Time Unit min Analyst lapcy


Model Zero-order Date 2018-10-16
Equation F=k0*t Time 2:01:53
7
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 24.39 24.54 20.07 21.54 21.59 26.30 19.43
10 58.51 65.77 60.49 59.19 60.88 63.06 51.93
15 76.95 89.47 87.55 82.37 87.50 80.14 72.75
20 89.36 98.84 98.40 91.85 97.41 87.28 83.81
25 94.70 102.42 104.52 95.30 100.86 91.81 89.30
30 97.37 104.12 106.76 96.68 102.24 95.21 92.61
45 100.73 105.58 107.36 97.71 103.79 99.84 97.58
60 101.85 106.26 107.62 98.06 104.65 101.83 99.50

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 12.39 13.23 13.35 12.24 12.98 12.32 11.87
10 24.79 26.47 26.70 24.48 25.97 24.64 23.74
15 37.18 39.70 40.05 36.71 38.95 36.96 35.61
20 49.57 52.94 53.39 48.95 51.94 49.28 47.48
25 61.96 66.17 66.74 61.19 64.92 61.60 59.35
30 74.36 79.40 80.09 73.43 77.91 73.91 71.22
45 111.54 119.11 120.14 110.14 116.86 110.87 106.84
60 148.71 158.81 160.18 146.85 155.81 147.83 142.45

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
k0 2.479 2.647 2.670 2.448 2.597 2.464 2.374

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 10.086 9.445 9.364 10.214 9.627 10.147 10.530
T50 20.173 18.891 18.728 20.429 19.254 20.294 21.060
T75 30.259 28.336 28.093 30.643 28.881 30.441 31.590
T80 32.277 30.225 29.965 32.686 30.806 32.470 33.696
T90 36.311 34.003 33.711 36.772 34.657 36.529 37.908

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.7699 0.7057 0.7186 0.7030 0.7088 0.7723 0.7923
Rsqr -0.6472 -0.9368 -0.5380 -0.8372 -0.7171 -0.9245 -0.2844
Rsqr_adj -0.6472 -0.9368 -0.5380 -0.8372 -0.7171 -0.9245 -0.2844
MSE 1194.1709 1589.4960 1504.7377 1350.9681 1484.1859 1226.3991 976.5486
MSE_root 34.5568 39.8685 38.7909 36.7555 38.5251 35.0200 31.2498
Weighting 1 1 1 1 1 1 1
SS 8359.1960 11126.4723 10533.1642 9456.7764 10389.3012 8584.7936 6835.8402
WSS 8359.1960 11126.4723 10533.1642 9456.7764 10389.3012 8584.7936 6835.8402
AIC 74.2489 76.5367 76.0983 75.2359 75.9883 74.4620 72.6395
MSC -0.7491 -0.9110 -0.6805 -0.8583 -0.7906 -0.9047 -0.5003

No.1
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.2
180

160 Observed
Predicted
140
Fraction dissolved (%)

120

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.3
180

160 Observed
Predicted
140
Fraction dissolved (%)

120

100

80

60
Predicted
140

Fraction dissolved (%)


120

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.4
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.5
180

160 Observed
Predicted
140
Fraction dissolved (%)

120

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)
No.6
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.7
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.8
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40
120

Fraction dissolved (%)


100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.9
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.10
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.11
180

160 Observed
Predicted
No.11
180

160 Observed
Predicted
140
Fraction dissolved (%)

120

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Mean
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20
Fraction dissolved (
100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 2.97 3.18 3.20 2.94 3.12 2.96 2.85
2.4 5.95 6.35 6.41 5.87 6.23 5.91 5.70
3.6 8.92 9.53 9.61 8.81 9.35 8.87 8.55
4.8 11.90 12.70 12.81 11.75 12.47 11.83 11.40
6 14.87 15.88 16.02 14.69 15.58 14.78 14.24
7.2 17.85 19.06 19.22 17.62 18.70 17.74 17.09
8.4 20.82 22.23 22.43 20.56 21.81 20.70 19.94
9.6 23.79 25.41 25.63 23.50 24.93 23.65 22.79
10.8 26.77 28.59 28.83 26.43 28.05 26.61 25.64
12 29.74 31.76 32.04 29.37 31.16 29.57 28.49
13.2 32.72 34.94 35.24 32.31 34.28 32.52 31.34
14.4 35.69 38.11 38.44 35.24 37.40 35.48 34.19
15.6 38.67 41.29 41.65 38.18 40.51 38.44 37.04
16.8 41.64 44.47 44.85 41.12 43.63 41.39 39.89
18 44.61 47.64 48.06 44.06 46.74 44.35 42.73
19.2 47.59 50.82 51.26 46.99 49.86 47.30 45.58
20.4 50.56 53.99 54.46 49.93 52.98 50.26 48.43
21.6 53.54 57.17 57.67 52.87 56.09 53.22 51.28
22.8 56.51 60.35 60.87 55.80 59.21 56.17 54.13
24 59.49 63.52 64.07 58.74 62.33 59.13 56.98
25.2 62.46 66.70 67.28 61.68 65.44 62.09 59.83
26.4 65.43 69.88 70.48 64.61 68.56 65.04 62.68
27.6 68.41 73.05 73.69 67.55 71.67 68.00 65.53
28.8 71.38 76.23 76.89 70.49 74.79 70.96 68.38
30 74.36 79.40 80.09 73.43 77.91 73.91 71.22
31.2 77.33 82.58 83.30 76.36 81.02 76.87 74.07
32.4 80.31 85.76 86.50 79.30 84.14 79.83 76.92
33.6 83.28 88.93 89.70 82.24 87.26 82.78 79.77
34.8 86.25 92.11 92.91 85.17 90.37 85.74 82.62
36 89.23 95.28 96.11 88.11 93.49 88.70 85.47
37.2 92.20 98.46 99.31 91.05 96.60 91.65 88.32
38.4 95.18 101.64 102.52 93.98 99.72 94.61 91.17
39.6 98.15 104.81 105.72 96.92 102.84 97.57 94.02
40.8 101.13 107.99 108.93 99.86 105.95 100.52 96.87
42 104.10 111.17 112.13 102.80 109.07 103.48 99.71
43.2 107.07 114.34 115.33 105.73 112.19 106.44 102.56
44.4 110.05 117.52 118.54 108.67 115.30 109.39 105.41
45.6 113.02 120.69 121.74 111.61 118.42 112.35 108.26
46.8 116.00 123.87 124.94 114.54 121.54 115.31 111.11
48 118.97 127.05 128.15 117.48 124.65 118.26 113.96
49.2 121.95 130.22 131.35 120.42 127.77 121.22 116.81
50.4 124.92 133.40 134.56 123.36 130.88 124.18 119.66
51.6 127.89 136.57 137.76 126.29 134.00 127.13 122.51
52.8 130.87 139.75 140.96 129.23 137.12 130.09 125.36
54 133.84 142.93 144.17 132.17 140.23 133.05 128.20
55.2 136.82 146.10 147.37 135.10 143.35 136.00 131.05
56.4 139.79 149.28 150.57 138.04 146.47 138.96 133.90
57.6 142.77 152.46 153.78 140.98 149.58 141.91 136.75
58.8 145.74 155.63 156.98 143.91 152.70 144.87 139.60
60 148.71 158.81 160.18 146.85 155.81 147.83 142.45
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63

No.8 No.9 No.10 No.11 No.12


F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
12.50 12.20 12.63 12.76 12.47 12.58 0.44 3.47
25.00 24.41 25.27 25.53 24.94 25.16 0.87 3.47
37.50 36.61 37.90 38.29 37.41 37.74 1.31 3.47
50.00 48.82 50.53 51.05 49.88 50.32 1.75 3.47
62.50 61.02 63.17 63.81 62.35 62.90 2.19 3.47
75.00 73.23 75.80 76.58 74.82 75.48 2.62 3.47
112.50 109.84 113.70 114.86 112.24 113.22 3.93 3.47
150.00 146.45 151.60 153.15 149.65 150.96 5.24 3.47

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


2.500 2.441 2.527 2.553 2.494 2.516 0.087 3.474

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


10.000 10.242 9.894 9.794 10.023 9.947 0.342 3.438
20.000 20.484 19.789 19.589 20.047 19.895 0.684 3.438
29.999 30.727 29.683 29.383 30.070 29.842 1.026 3.438
31.999 32.775 31.662 31.342 32.075 31.832 1.094 3.438
35.999 36.872 35.620 35.259 36.084 35.811 1.231 3.438

No.8 No.9 No.10 No.11 No.12


8 8 8 8 8
7 7 7 7 7
0.7445 0.7642 0.7582 0.7325 0.7489
-0.7780 -0.8017 -0.6855 -1.5430 -0.6363
-0.7780 -0.8017 -0.6855 -1.5430 -0.6363 -0.7775
1298.2554 1198.9149 1275.8256 1505.9628 1255.5493
36.0313 34.6254 35.7187 38.8067 35.4337
1 1 1 1 1
9087.7880 8392.4043 8930.7790 10541.7395 8788.8449
9087.7880 8392.4043 8930.7790 10541.7395 8788.8449
74.9175 74.2807 74.7781 76.1048 74.6499 74.9950
-0.8255 -0.8387 -0.7721 -1.1834 -0.7424
No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
3.00 2.93 3.03 3.06 2.99 3.02 0.10 3.47
6.00 5.86 6.06 6.13 5.99 6.04 0.21 3.47
9.00 8.79 9.10 9.19 8.98 9.06 0.31 3.47
12.00 11.72 12.13 12.25 11.97 12.08 0.42 3.47
15.00 14.65 15.16 15.32 14.96 15.10 0.52 3.47
18.00 17.57 18.19 18.38 17.96 18.12 0.63 3.47
21.00 20.50 21.22 21.44 20.95 21.13 0.73 3.47
24.00 23.43 24.26 24.50 23.94 24.15 0.84 3.47
27.00 26.36 27.29 27.57 26.94 27.17 0.94 3.47
30.00 29.29 30.32 30.63 29.93 30.19 1.05 3.47
33.00 32.22 33.35 33.69 32.92 33.21 1.15 3.47
36.00 35.15 36.38 36.76 35.92 36.23 1.26 3.47
39.00 38.08 39.42 39.82 38.91 39.25 1.36 3.47
42.00 41.01 42.45 42.88 41.90 42.27 1.47 3.47
45.00 43.94 45.48 45.95 44.89 45.29 1.57 3.47
48.00 46.87 48.51 49.01 47.89 48.31 1.68 3.47
51.00 49.79 51.54 52.07 50.88 51.33 1.78 3.47
54.00 52.72 54.58 55.13 53.87 54.35 1.89 3.47
57.00 55.65 57.61 58.20 56.87 57.36 1.99 3.47
60.00 58.58 60.64 61.26 59.86 60.38 2.10 3.47
63.00 61.51 63.67 64.32 62.85 63.40 2.20 3.47
66.00 64.44 66.70 67.39 65.85 66.42 2.31 3.47
69.00 67.37 69.74 70.45 68.84 69.44 2.41 3.47
72.00 70.30 72.77 73.51 71.83 72.46 2.52 3.47
75.00 73.23 75.80 76.58 74.82 75.48 2.62 3.47
78.00 76.16 78.83 79.64 77.82 78.50 2.73 3.47
81.00 79.08 81.86 82.70 80.81 81.52 2.83 3.47
84.00 82.01 84.90 85.76 83.80 84.54 2.94 3.47
87.00 84.94 87.93 88.83 86.80 87.56 3.04 3.47
90.00 87.87 90.96 91.89 89.79 90.58 3.15 3.47
93.00 90.80 93.99 94.95 92.78 93.59 3.25 3.47
96.00 93.73 97.02 98.02 95.78 96.61 3.36 3.47
99.00 96.66 100.06 101.08 98.77 99.63 3.46 3.47
102.00 99.59 103.09 104.14 101.76 102.65 3.57 3.47
105.00 102.52 106.12 107.21 104.75 105.67 3.67 3.47
108.00 105.45 109.15 110.27 107.75 108.69 3.78 3.47
111.00 108.38 112.18 113.33 110.74 111.71 3.88 3.47
114.00 111.30 115.22 116.39 113.73 114.73 3.99 3.47
117.00 114.23 118.25 119.46 116.73 117.75 4.09 3.47
120.00 117.16 121.28 122.52 119.72 120.77 4.20 3.47
123.00 120.09 124.31 125.58 122.71 123.79 4.30 3.47
126.00 123.02 127.34 128.65 125.71 126.81 4.41 3.47
129.00 125.95 130.38 131.71 128.70 129.82 4.51 3.47
132.00 128.88 133.41 134.77 131.69 132.84 4.62 3.47
135.00 131.81 136.44 137.84 134.68 135.86 4.72 3.47
138.00 134.74 139.47 140.90 137.68 138.88 4.83 3.47
141.00 137.67 142.50 143.96 140.67 141.90 4.93 3.47
144.00 140.60 145.54 147.02 143.66 144.92 5.03 3.47
147.00 143.52 148.57 150.09 146.66 147.94 5.14 3.47
150.00 146.45 151.60 153.15 149.65 150.96 5.24 3.47
DDSolver 1.0 Dissolution Data Modeling of First-order Model

Time Unit min Analyst lapcy


Model First-order Date 2018-10-16
Equation F=100*[1-Exp(-k1*t)] Time 2:10:02

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 24.39 24.54 20.07 21.54 21.59 26.30 19.43
10 58.51 65.77 60.49 59.19 60.88 63.06 51.93
15 76.95 89.47 87.55 82.37 87.50 80.14 72.75
20 89.36 98.84 98.40 91.85 97.41 87.28 83.81
25 94.70 102.42 104.52 95.30 100.86 91.81 89.30
30 97.37 104.12 106.76 96.68 102.24 95.21 92.61
45 100.73 105.58 107.36 97.71 103.79 99.84 97.58
60 101.85 106.26 107.62 98.06 104.65 101.83 99.50

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 36.86 43.42 41.60 37.75 41.02 37.72 32.43
10 60.13 67.99 65.89 61.25 65.21 61.22 54.34
15 74.82 81.89 80.08 75.88 79.48 75.85 69.15
20 84.10 89.75 88.37 84.99 87.90 84.96 79.15
25 89.96 94.20 93.20 90.65 92.86 90.63 85.91
30 93.66 96.72 96.03 94.18 95.79 94.17 90.48
45 98.40 99.41 99.21 98.60 99.14 98.59 97.06
60 99.60 99.89 99.84 99.66 99.82 99.66 99.09

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
k1 0.092 0.114 0.108 0.095 0.106 0.095 0.078

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 3.129 2.526 2.675 3.034 2.724 3.037 3.669
T50 7.538 6.085 6.444 7.311 6.564 7.318 8.841
T75 15.076 12.170 12.889 14.621 13.128 14.636 17.682
T80 17.503 14.129 14.963 16.975 15.241 16.992 20.528
T90 25.041 20.214 21.408 24.286 21.805 24.311 29.369

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.9947 0.9921 0.9929 0.9799 0.9884 0.9913 0.9909
Rsqr 0.9533 0.8777 0.8512 0.9247 0.8841 0.9627 0.9575
Rsqr_adj 0.9533 0.8777 0.8512 0.9247 0.8841 0.9627 0.9575
MSE 33.8459 100.3332 145.5980 55.3494 100.2168 23.7737 32.2916
MSE_root 5.8177 10.0166 12.0664 7.4397 10.0108 4.8758 5.6826
Weighting 1 1 1 1 1 1 1
SS 236.9210 702.3321 1019.1863 387.4457 701.5178 166.4161 226.0413
WSS 236.9210 702.3321 1019.1863 387.4457 701.5178 166.4161 226.0413
AIC 45.7418 54.4353 57.4141 49.6766 54.4260 42.9159 45.3657
MSC 2.8143 1.8516 1.6551 2.3367 1.9047 3.0386 2.9089

No.1
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.2
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.3
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40
Predicted

Fraction dissolved (%)


80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.4
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.5
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)
No.6
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.7
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.8
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40
Fraction dissolved (%)
80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.9
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.10
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.11
120

Observed
100 Predicted
No.11
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Mean
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20
80

Fraction dissolved (
60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 10.45 12.78 12.11 10.75 11.90 10.74 8.98
2.4 19.80 23.92 22.75 20.35 22.39 20.33 17.15
3.6 28.18 33.64 32.11 28.92 31.62 28.89 24.59
4.8 35.68 42.12 40.33 36.56 39.76 36.53 31.36
6 42.40 49.51 47.55 43.38 46.93 43.35 37.53
7.2 48.42 55.96 53.90 49.47 53.25 49.44 43.13
8.4 53.81 61.59 59.48 54.91 58.81 54.87 48.24
9.6 58.63 66.50 64.39 59.76 63.71 59.72 52.89
10.8 62.96 70.78 68.70 64.08 68.03 64.05 57.12
12 66.83 74.51 72.49 67.95 71.84 67.91 60.97
13.2 70.29 77.77 75.82 71.39 75.19 71.36 64.47
14.4 73.40 80.61 78.75 74.47 78.14 74.43 67.66
15.6 76.18 83.09 81.32 77.22 80.74 77.18 70.57
16.8 78.66 85.25 83.59 79.67 83.04 79.63 73.21
18 80.89 87.13 85.57 81.85 85.05 81.82 75.62
19.2 82.89 88.78 87.32 83.80 86.83 83.77 77.81
20.4 84.68 90.21 88.86 85.55 88.40 85.52 79.80
21.6 86.28 91.46 90.20 87.10 89.78 87.07 81.61
22.8 87.71 92.55 91.39 88.49 91.00 88.46 83.26
24 89.00 93.50 92.43 89.73 92.07 89.70 84.77
25.2 90.14 94.33 93.35 90.83 93.01 90.81 86.13
26.4 91.17 95.06 94.15 91.82 93.84 91.80 87.38
27.6 92.10 95.69 94.86 92.70 94.58 92.68 88.51
28.8 92.92 96.24 95.48 93.48 95.22 93.46 89.54
30 93.66 96.72 96.03 94.18 95.79 94.17 90.48
31.2 94.32 97.14 96.51 94.81 96.29 94.79 91.34
32.4 94.92 97.50 96.93 95.37 96.73 95.35 92.11
33.6 95.45 97.82 97.31 95.87 97.12 95.85 92.82
34.8 95.92 98.10 97.63 96.31 97.46 96.30 93.47
36 96.35 98.34 97.92 96.71 97.77 96.70 94.05
37.2 96.73 98.56 98.17 97.06 98.03 97.05 94.59
38.4 97.07 98.74 98.39 97.38 98.27 97.37 95.07
39.6 97.38 98.90 98.59 97.66 98.47 97.65 95.52
40.8 97.65 99.04 98.76 97.91 98.65 97.90 95.92
42 97.90 99.16 98.91 98.14 98.81 98.13 96.29
43.2 98.12 99.27 99.04 98.34 98.96 98.33 96.62
44.4 98.31 99.36 99.16 98.51 99.08 98.51 96.92
45.6 98.49 99.45 99.26 98.67 99.19 98.67 97.20
46.8 98.65 99.52 99.35 98.82 99.29 98.81 97.45
48 98.79 99.58 99.43 98.94 99.37 98.94 97.68
49.2 98.92 99.63 99.50 99.06 99.45 99.05 97.89
50.4 99.03 99.68 99.56 99.16 99.51 99.16 98.08
51.6 99.13 99.72 99.61 99.25 99.57 99.25 98.25
52.8 99.22 99.76 99.66 99.33 99.62 99.33 98.41
54 99.30 99.79 99.70 99.40 99.67 99.40 98.55
55.2 99.38 99.81 99.74 99.47 99.71 99.46 98.68
56.4 99.44 99.84 99.77 99.52 99.74 99.52 98.80
57.6 99.50 99.86 99.80 99.58 99.77 99.57 98.91
58.8 99.55 99.88 99.82 99.62 99.80 99.62 99.00
60 99.60 99.89 99.84 99.66 99.82 99.66 99.09
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63

No.8 No.9 No.10 No.11 No.12


F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
38.30 36.78 38.53 43.08 37.60 38.76 3.09 7.97
61.94 60.03 62.21 67.60 61.06 62.41 3.80 6.09
76.52 74.73 76.77 81.56 75.70 76.87 3.52 4.58
85.51 84.03 85.72 89.50 84.84 85.74 2.91 3.39
91.06 89.90 91.22 94.03 90.54 91.18 2.26 2.47
94.49 93.62 94.60 96.60 94.10 94.54 1.69 1.79
98.71 98.39 98.75 99.37 98.57 98.68 0.63 0.63
99.70 99.59 99.71 99.88 99.65 99.68 0.21 0.21

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


0.097 0.092 0.097 0.113 0.094 0.098 0.010 10.241

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


2.978 3.137 2.956 2.552 3.050 2.956 0.313 10.574
7.176 7.558 7.123 6.150 7.348 7.121 0.753 10.574
14.352 15.116 14.246 12.299 14.697 14.243 1.506 10.574
16.662 17.549 16.539 14.279 17.063 16.535 1.749 10.574
23.838 25.107 23.662 20.429 24.411 23.657 2.502 10.574

No.8 No.9 No.10 No.11 No.12


8 8 8 8 8
7 7 7 7 7
0.9921 0.9871 0.9934 0.9913 0.9897
0.9413 0.9537 0.9351 0.9479 0.9331
0.9413 0.9537 0.9351 0.9479 0.9331 0.9269
42.8833 30.7791 49.1105 30.8342 51.3259
6.5485 5.5479 7.0079 5.5529 7.1642
1 1 1 1 1
300.1834 215.4538 343.7733 215.8394 359.2815
300.1834 215.4538 343.7733 215.8394 359.2815
47.6351 44.9820 48.7199 44.9963 49.0728 48.7818
2.5848 2.8236 2.4852 2.7052 2.4547
No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
10.94 10.42 11.02 12.65 10.70 11.12 1.07 9.66
20.69 19.76 20.83 23.70 20.26 20.99 1.91 9.10
29.37 28.12 29.55 33.35 28.79 29.76 2.55 8.56
37.10 35.61 37.32 41.78 36.41 37.55 3.02 8.05
43.99 42.32 44.23 49.15 43.22 44.46 3.36 7.56
50.12 48.33 50.37 55.58 49.29 50.61 3.59 7.09
55.58 53.72 55.84 61.20 54.72 56.06 3.73 6.65
60.44 58.54 60.71 66.11 59.57 60.91 3.79 6.23
64.77 62.86 65.04 70.40 63.89 65.22 3.80 5.82
68.62 66.73 68.89 74.14 67.76 69.05 3.76 5.44
72.06 70.20 72.32 77.41 71.21 72.46 3.68 5.08
75.12 73.30 75.37 80.27 74.29 75.48 3.58 4.74
77.84 76.09 78.09 82.77 77.04 78.18 3.45 4.42
80.26 78.58 80.50 84.95 79.50 80.57 3.32 4.11
82.42 80.81 82.65 86.85 81.69 82.70 3.17 3.83
84.35 82.81 84.56 88.51 83.65 84.59 3.01 3.56
86.06 84.60 86.26 89.97 85.40 86.27 2.85 3.31
87.59 86.21 87.78 91.24 86.96 87.77 2.69 3.07
88.95 87.64 89.12 92.35 88.36 89.11 2.54 2.85
90.16 88.93 90.32 93.31 89.60 90.29 2.38 2.64
91.23 90.08 91.39 94.16 90.72 91.35 2.23 2.44
92.19 91.12 92.34 94.90 91.71 92.29 2.09 2.26
93.05 92.04 93.18 95.54 92.60 93.13 1.95 2.09
93.81 92.87 93.93 96.11 93.39 93.87 1.81 1.93
94.49 93.62 94.60 96.60 94.10 94.54 1.69 1.79
95.09 94.28 95.20 97.03 94.73 95.13 1.57 1.65
95.63 94.88 95.73 97.41 95.29 95.65 1.45 1.52
96.11 95.41 96.20 97.73 95.80 96.12 1.35 1.40
96.53 95.89 96.62 98.02 96.25 96.54 1.25 1.29
96.91 96.32 96.99 98.27 96.65 96.91 1.15 1.19
97.25 96.70 97.32 98.49 97.01 97.25 1.07 1.10
97.55 97.04 97.62 98.68 97.33 97.54 0.98 1.01
97.82 97.35 97.88 98.85 97.61 97.81 0.91 0.93
98.06 97.63 98.11 98.99 97.87 98.04 0.84 0.85
98.27 97.88 98.32 99.12 98.10 98.25 0.77 0.78
98.46 98.10 98.51 99.23 98.30 98.44 0.71 0.72
98.63 98.30 98.67 99.33 98.48 98.61 0.65 0.66
98.78 98.47 98.82 99.41 98.64 98.75 0.60 0.61
98.91 98.63 98.95 99.49 98.79 98.89 0.55 0.56
99.03 98.77 99.06 99.55 98.92 99.01 0.51 0.51
99.14 98.90 99.17 99.61 99.03 99.11 0.46 0.47
99.23 99.02 99.26 99.66 99.14 99.21 0.43 0.43
99.32 99.12 99.34 99.70 99.23 99.29 0.39 0.39
99.39 99.21 99.41 99.74 99.31 99.37 0.36 0.36
99.46 99.29 99.48 99.77 99.39 99.43 0.33 0.33
99.52 99.37 99.54 99.80 99.45 99.49 0.30 0.30
99.57 99.43 99.59 99.83 99.51 99.55 0.28 0.28
99.62 99.49 99.63 99.85 99.56 99.59 0.25 0.25
99.66 99.54 99.67 99.87 99.61 99.64 0.23 0.23
99.70 99.59 99.71 99.88 99.65 99.68 0.21 0.21
DDSolver 1.0 Dissolution Data Modeling of Higuchi Model

Time Unit min Analyst lapcy


Model Higuchi Date 2018-10-16
Equation F=kH*t^0.5 Time 2:16:39

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 24.39 24.54 20.07 21.54 21.59 26.30 19.43
10 58.51 65.77 60.49 59.19 60.88 63.06 51.93
15 76.95 89.47 87.55 82.37 87.50 80.14 72.75
20 89.36 98.84 98.40 91.85 97.41 87.28 83.81
25 94.70 102.42 104.52 95.30 100.86 91.81 89.30
30 97.37 104.12 106.76 96.68 102.24 95.21 92.61
45 100.73 105.58 107.36 97.71 103.79 99.84 97.58
60 101.85 106.26 107.62 98.06 104.65 101.83 99.50

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 36.29 39.03 39.15 36.06 38.19 36.18 34.53
10 51.33 55.19 55.36 50.99 54.01 51.17 48.84
15 62.86 67.59 67.80 62.45 66.14 62.67 59.82
20 72.59 78.05 78.29 72.11 76.38 72.36 69.07
25 81.16 87.26 87.54 80.62 85.39 80.90 77.22
30 88.90 95.59 95.89 88.32 93.54 88.63 84.59
45 108.88 117.08 117.44 108.17 114.56 108.55 103.60
60 125.73 135.19 135.61 124.90 132.29 125.34 119.63

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
kH 16.231 17.453 17.507 16.125 17.078 16.181 15.444

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 2.372 2.052 2.039 2.404 2.143 2.387 2.620
T50 9.489 8.208 8.157 9.615 8.571 9.548 10.481
T75 21.350 18.467 18.352 21.634 19.286 21.484 23.582
T80 24.292 21.011 20.881 24.615 21.943 24.444 26.831
T90 30.745 26.592 26.427 31.153 27.771 30.937 33.959

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.8660 0.8125 0.8243 0.8107 0.8152 0.8659 0.8833
Rsqr 0.6917 0.5641 0.6385 0.5765 0.6007 0.6509 0.7605
Rsqr_adj 0.6917 0.5641 0.6385 0.5765 0.6007 0.6509 0.7605
MSE 223.4940 357.7630 353.6682 311.3831 345.1573 222.4824 182.0736
MSE_root 14.9497 18.9146 18.8061 17.6461 18.5784 14.9158 13.4935
Weighting 1 1 1 1 1 1 1
SS 1564.4579 2504.3411 2475.6772 2179.6819 2416.1008 1557.3765 1274.5150
WSS 1564.4579 2504.3411 2475.6772 2179.6819 2416.1008 1557.3765 1274.5150
AIC 60.8424 64.6062 64.5142 63.4955 64.3193 60.8061 59.2026
MSC 0.9268 0.5803 0.7675 0.6093 0.6680 0.8023 1.1793

No.1
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.2
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.3
160

Observed
140
Predicted
120
Fraction dissolved (%)

100

80

60

40
Predicted
120

Fraction dissolved (%)


100

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.4
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.5
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)
No.6
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.7
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.8
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40
100

Fraction dissolved (%)


80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.9
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.10
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.11
140

Observed
120
Predicted
No.11
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Mean
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20
Fraction dissolved (
80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 17.78 19.12 19.18 17.66 18.71 17.73 16.92
2.4 25.15 27.04 27.12 24.98 26.46 25.07 23.93
3.6 30.80 33.11 33.22 30.59 32.40 30.70 29.30
4.8 35.56 38.24 38.36 35.33 37.42 35.45 33.84
6 39.76 42.75 42.88 39.50 41.83 39.64 37.83
7.2 43.55 46.83 46.98 43.27 45.83 43.42 41.44
8.4 47.04 50.58 50.74 46.73 49.50 46.90 44.76
9.6 50.29 54.08 54.24 49.96 52.92 50.13 47.85
10.8 53.34 57.36 57.53 52.99 56.12 53.18 50.76
12 56.23 60.46 60.65 55.86 59.16 56.05 53.50
13.2 58.97 63.41 63.61 58.58 62.05 58.79 56.11
14.4 61.59 66.23 66.44 61.19 64.81 61.40 58.61
15.6 64.11 68.93 69.15 63.69 67.45 63.91 61.00
16.8 66.53 71.53 71.76 66.09 70.00 66.32 63.30
18 68.86 74.05 74.28 68.41 72.46 68.65 65.52
19.2 71.12 76.47 76.71 70.65 74.83 70.90 67.67
20.4 73.31 78.83 79.07 72.83 77.14 73.08 69.76
21.6 75.44 81.11 81.37 74.94 79.37 75.20 71.78
22.8 77.50 83.34 83.60 76.99 81.55 77.26 73.75
24 79.52 85.50 85.77 78.99 83.67 79.27 75.66
25.2 81.48 87.61 87.89 80.95 85.73 81.23 77.53
26.4 83.40 89.67 89.95 82.85 87.75 83.14 79.35
27.6 85.27 91.69 91.98 84.71 89.72 85.01 81.14
28.8 87.11 93.66 93.95 86.53 91.65 86.84 82.88
30 88.90 95.59 95.89 88.32 93.54 88.63 84.59
31.2 90.66 97.49 97.79 90.07 95.39 90.38 86.27
32.4 92.39 99.34 99.65 91.78 97.21 92.10 87.91
33.6 94.09 101.17 101.48 93.47 98.99 93.79 89.52
34.8 95.75 102.96 103.28 95.12 100.75 95.45 91.11
36 97.39 104.72 105.04 96.75 102.47 97.09 92.67
37.2 99.00 106.45 106.78 98.35 104.16 98.69 94.20
38.4 100.58 108.15 108.49 99.92 105.83 100.27 95.70
39.6 102.14 109.83 110.17 101.47 107.47 101.82 97.19
40.8 103.68 111.48 111.83 103.00 109.09 103.36 98.65
42 105.19 113.11 113.46 104.50 110.68 104.86 100.09
43.2 106.68 114.71 115.07 105.98 112.25 106.35 101.51
44.4 108.16 116.29 116.66 107.44 113.80 107.82 102.91
45.6 109.61 117.85 118.22 108.89 115.33 109.27 104.29
46.8 111.04 119.40 119.77 110.31 116.83 110.69 105.66
48 112.45 120.92 121.29 111.71 118.32 112.10 107.00
49.2 113.85 122.42 122.80 113.10 119.79 113.50 108.33
50.4 115.23 123.90 124.29 114.47 121.24 114.87 109.64
51.6 116.60 125.37 125.76 115.83 122.68 116.23 110.94
52.8 117.94 126.82 127.21 117.17 124.10 117.58 112.22
54 119.28 128.25 128.65 118.49 125.50 118.91 113.49
55.2 120.59 129.67 130.07 119.80 126.89 120.22 114.75
56.4 121.90 131.07 131.48 121.10 128.26 121.52 115.99
57.6 123.19 132.46 132.87 122.38 129.61 122.80 117.21
58.8 124.46 133.83 134.25 123.65 130.96 124.08 118.43
60 125.73 135.19 135.61 124.90 132.29 125.34 119.63
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63

No.8 No.9 No.10 No.11 No.12


F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
36.72 35.81 37.04 37.76 36.56 36.94 1.37 3.69
51.93 50.65 52.38 53.41 51.70 52.25 1.93 3.69
63.60 62.03 64.15 65.41 63.32 63.99 2.36 3.69
73.44 71.62 74.07 75.53 73.11 73.89 2.73 3.69
82.11 80.08 82.82 84.44 81.74 82.61 3.05 3.69
89.94 87.72 90.72 92.50 89.54 90.49 3.34 3.69
110.16 107.43 111.11 113.29 109.67 110.83 4.10 3.69
127.20 124.06 128.30 130.82 126.63 127.97 4.73 3.69

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


16.421 16.015 16.564 16.888 16.348 16.521 0.610 3.695

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


2.318 2.437 2.278 2.191 2.339 2.298 0.169 7.342
9.271 9.747 9.112 8.765 9.354 9.193 0.675 7.342
20.860 21.930 20.503 19.722 21.047 20.685 1.519 7.342
23.734 24.952 23.328 22.439 23.946 23.535 1.728 7.342
30.039 31.580 29.524 28.399 30.307 29.786 2.187 7.342

No.8 No.9 No.10 No.11 No.12


8 8 8 8 8
7 7 7 7 7
0.8453 0.8588 0.8556 0.8327 0.8479
0.6404 0.6573 0.6694 0.4894 0.6633
0.6404 0.6573 0.6694 0.4894 0.6633 0.6336
262.5602 228.0259 250.2756 302.3461 258.3309
16.2037 15.1005 15.8201 17.3881 16.0727
1 1 1 1 1
1837.9211 1596.1812 1751.9293 2116.4225 1808.3162
1837.9211 1596.1812 1751.9293 2116.4225 1808.3162
62.1311 61.0030 61.7478 63.2599 62.0012 62.3274
0.7728 0.8210 0.8567 0.4223 0.8387
No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
17.99 17.54 18.14 18.50 17.91 18.10 0.67 3.69
25.44 24.81 25.66 26.16 25.33 25.59 0.95 3.69
31.16 30.39 31.43 32.04 31.02 31.35 1.16 3.69
35.98 35.09 36.29 37.00 35.82 36.20 1.34 3.69
40.22 39.23 40.57 41.37 40.04 40.47 1.50 3.69
44.06 42.97 44.44 45.32 43.87 44.33 1.64 3.69
47.59 46.42 48.01 48.95 47.38 47.88 1.77 3.69
50.88 49.62 51.32 52.33 50.65 51.19 1.89 3.69
53.97 52.63 54.43 55.50 53.73 54.29 2.01 3.69
56.88 55.48 57.38 58.50 56.63 57.23 2.11 3.69
59.66 58.19 60.18 61.36 59.40 60.03 2.22 3.69
62.31 60.77 62.85 64.09 62.04 62.69 2.32 3.69
64.86 63.26 65.42 66.70 64.57 65.25 2.41 3.69
67.31 65.64 67.89 69.22 67.01 67.72 2.50 3.69
69.67 67.95 70.27 71.65 69.36 70.09 2.59 3.69
71.95 70.18 72.58 74.00 71.63 72.39 2.67 3.69
74.17 72.34 74.81 76.28 73.84 74.62 2.76 3.69
76.32 74.43 76.98 78.49 75.98 76.78 2.84 3.69
78.41 76.47 79.09 80.64 78.06 78.89 2.91 3.69
80.45 78.46 81.14 82.74 80.09 80.94 2.99 3.69
82.43 80.40 83.15 84.78 82.07 82.94 3.06 3.69
84.37 82.29 85.10 86.77 84.00 84.89 3.14 3.69
86.27 84.14 87.02 88.72 85.89 86.80 3.21 3.69
88.12 85.95 88.89 90.63 87.73 88.66 3.28 3.69
89.94 87.72 90.72 92.50 89.54 90.49 3.34 3.69
91.72 89.46 92.52 94.33 91.32 92.28 3.41 3.69
93.47 91.16 94.28 96.13 93.06 94.04 3.47 3.69
95.19 92.83 96.01 97.89 94.76 95.77 3.54 3.69
96.87 94.48 97.71 99.63 96.44 97.46 3.60 3.69
98.53 96.09 99.38 101.33 98.09 99.13 3.66 3.69
100.16 97.68 101.02 103.01 99.71 100.77 3.72 3.69
101.76 99.24 102.64 104.65 101.31 102.38 3.78 3.69
103.34 100.78 104.23 106.28 102.88 103.97 3.84 3.69
104.89 102.30 105.80 107.87 104.42 105.53 3.90 3.69
106.42 103.79 107.34 109.45 105.95 107.07 3.96 3.69
107.93 105.26 108.87 111.00 107.45 108.59 4.01 3.69
109.42 106.72 110.37 112.53 108.93 110.09 4.07 3.69
110.89 108.15 111.85 114.04 110.40 111.57 4.12 3.69
112.34 109.56 113.31 115.53 111.84 113.02 4.18 3.69
113.77 110.96 114.76 117.01 113.26 114.46 4.23 3.69
115.18 112.34 116.18 118.46 114.67 115.89 4.28 3.69
116.58 113.70 117.59 119.90 116.06 117.29 4.33 3.69
117.96 115.04 118.98 121.32 117.43 118.68 4.39 3.69
119.32 116.37 120.36 122.72 118.79 120.05 4.44 3.69
120.67 117.69 121.72 124.10 120.13 121.41 4.49 3.69
122.00 118.99 123.06 125.48 121.46 122.75 4.54 3.69
123.32 120.28 124.39 126.83 122.77 124.08 4.58 3.69
124.63 121.55 125.71 128.17 124.07 125.39 4.63 3.69
125.92 122.81 127.01 129.50 125.36 126.69 4.68 3.69
127.20 124.06 128.30 130.82 126.63 127.97 4.73 3.69
DDSolver 1.0 Dissolution Data Modeling of Hixson-Crowell Model

Time Unit h Analyst lapcy


Model Hixson-Crowell Date 2018-10-16
Equation F=100*[1-(1-kHC*t)^3] Time 2:20:46

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(h) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 24.39 24.54 20.07 21.54 21.59 26.30 19.43
10 58.51 65.77 60.49 59.19 60.88 63.06 51.93
15 76.95 89.47 87.55 82.37 87.50 80.14 72.75
20 89.36 98.84 98.40 91.85 97.41 87.28 83.81
25 94.70 102.42 104.52 95.30 100.86 91.81 89.30
30 97.37 104.12 106.76 96.68 102.24 95.21 92.61
45 100.73 105.58 107.36 97.71 103.79 99.84 97.58
60 101.85 106.26 107.62 98.06 104.65 101.83 99.50

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(h) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 31.25 33.73 33.58 31.28 33.06 31.55 28.48
10 55.20 58.87 58.64 55.25 57.89 55.65 50.96
15 72.82 76.68 76.45 72.88 75.66 73.31 68.16
20 85.08 88.43 88.23 85.13 87.57 85.52 80.78
25 92.96 95.37 95.23 93.00 94.77 93.29 89.52
30 97.42 98.77 98.70 97.44 98.46 97.62 95.11
45 100.02 100.36 100.32 100.02 100.20 100.03 99.99
60 106.83 115.57 114.86 106.93 112.70 107.65 101.94

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
kHC 0.023 0.026 0.025 0.024 0.025 0.024 0.021

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 3.894 3.567 3.587 3.889 3.651 3.851 4.325
T50 8.786 8.048 8.092 8.774 8.237 8.689 9.758
T75 15.759 14.436 14.514 15.738 14.775 15.586 17.502
T80 17.682 16.197 16.285 17.659 16.578 17.488 19.638
T90 22.820 20.904 21.017 22.790 21.396 22.570 25.344

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 7 7 7 7 7 7 7
R_obs-pre 0.9885 0.9572 0.9654 0.9670 0.9641 0.9812 0.9893
Rsqr 0.9760 0.8962 0.9028 0.9348 0.9163 0.9610 0.9753
Rsqr_adj 0.9760 0.8962 0.9028 0.9348 0.9163 0.9610 0.9753
MSE 17.3957 85.2054 95.1097 47.9587 72.3539 24.8648 18.7459
MSE_root 4.1708 9.2307 9.7524 6.9252 8.5061 4.9865 4.3296
Weighting 1 1 1 1 1 1 1
SS 121.7699 596.4375 665.7677 335.7110 506.4775 174.0535 131.2210
WSS 121.7699 596.4375 665.7677 335.7110 506.4775 174.0535 131.2210
AIC 40.4171 53.1278 54.0075 48.5300 51.8198 43.2749 41.0151
MSC 3.4799 2.0151 2.0809 2.4800 2.2304 2.9937 3.4528

No.1
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.2
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.3
140

Observed
120
Predicted

100
Fraction dissolved (%)

80

60

40
Predicted

100

Fraction dissolved (%)


80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.4
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.5
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)
No.6
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.7
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.8
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40
Fraction dissolved (%)
80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.9
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.10
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.11
120

Observed
100 Predicted
No.11
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

No.12
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

Mean
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20
80

Fraction dissolved (
60

40

20

0
0 10 20 30 40 50 60 70
Time (h)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(h) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 8.22 8.95 8.90 8.23 8.75 8.31 7.42
2.4 15.97 17.34 17.26 15.99 16.97 16.14 14.46
3.6 23.28 25.21 25.09 23.30 24.68 23.51 21.14
4.8 30.14 32.56 32.40 30.18 31.90 30.44 27.46
6 36.59 39.41 39.23 36.63 38.65 36.94 33.43
7.2 42.63 45.78 45.58 42.67 44.93 43.02 39.07
8.4 48.27 51.69 51.47 48.32 50.77 48.69 44.38
9.6 53.53 57.15 56.92 53.58 56.18 53.98 49.37
10.8 58.42 62.18 61.95 58.47 61.17 58.89 54.05
12 62.95 66.81 66.57 63.01 65.78 63.43 58.44
13.2 67.14 71.04 70.80 67.20 70.00 67.63 62.53
14.4 71.00 74.89 74.65 71.06 73.86 71.50 66.35
15.6 74.55 78.39 78.15 74.61 77.38 75.04 69.90
16.8 77.80 81.54 81.32 77.86 80.56 78.28 73.19
18 80.76 84.38 84.16 80.81 83.43 81.22 76.23
19.2 83.44 86.90 86.70 83.49 86.01 83.89 79.03
20.4 85.86 89.14 88.95 85.91 88.30 86.29 81.61
21.6 88.03 91.11 90.93 88.08 90.33 88.44 83.96
22.8 89.97 92.82 92.66 90.02 92.11 90.35 86.10
24 91.69 94.30 94.15 91.73 93.65 92.04 88.05
25.2 93.19 95.56 95.43 93.23 94.98 93.52 89.80
26.4 94.51 96.62 96.51 94.54 96.11 94.80 91.37
27.6 95.64 97.50 97.40 95.67 97.06 95.90 92.78
28.8 96.61 98.21 98.12 96.64 97.83 96.84 94.02
30 97.42 98.77 98.70 97.44 98.46 97.62 95.11
31.2 98.09 99.20 99.14 98.11 98.96 98.26 96.06
32.4 98.63 99.51 99.47 98.65 99.33 98.77 96.87
33.6 99.06 99.73 99.71 99.07 99.60 99.17 97.57
34.8 99.39 99.87 99.86 99.40 99.79 99.48 98.16
36 99.63 99.95 99.94 99.64 99.90 99.69 98.64
37.2 99.80 99.99 99.99 99.80 99.97 99.84 99.03
38.4 99.90 100.00 100.00 99.91 99.99 99.93 99.33
39.6 99.97 100.00 100.00 99.97 100.00 99.98 99.57
40.8 99.99 100.01 100.01 99.99 100.00 100.00 99.74
42 100.00 100.04 100.04 100.00 100.01 100.00 99.86
43.2 100.00 100.12 100.10 100.00 100.05 100.00 99.93
44.4 100.01 100.26 100.23 100.01 100.14 100.02 99.98
45.6 100.04 100.48 100.43 100.04 100.29 100.06 100.00
46.8 100.10 100.80 100.72 100.10 100.51 100.14 100.00
48 100.21 101.22 101.12 100.21 100.83 100.27 100.00
49.2 100.37 101.78 101.65 100.39 101.25 100.47 100.01
50.4 100.62 102.49 102.31 100.63 101.80 100.76 100.03
51.6 100.95 103.36 103.14 100.97 102.50 101.14 100.08
52.8 101.38 104.42 104.15 101.41 103.35 101.63 100.16
54 101.92 105.67 105.35 101.96 104.38 102.24 100.28
55.2 102.60 107.15 106.76 102.64 105.59 102.99 100.47
56.4 103.41 108.86 108.40 103.47 107.02 103.90 100.71
57.6 104.38 110.82 110.29 104.45 108.67 104.96 101.03
58.8 105.52 113.05 112.43 105.60 110.56 106.21 101.44
60 106.83 115.57 114.86 106.93 112.70 107.65 101.94
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63

No.8 No.9 No.10 No.11 No.12


F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
31.80 31.17 32.21 33.21 31.70 31.92 1.43 4.48
56.02 55.07 56.63 58.11 55.88 56.18 2.15 3.83
73.70 72.68 74.34 75.89 73.55 73.84 2.31 3.13
85.86 84.96 86.43 87.76 85.73 85.96 2.06 2.40
93.54 92.87 93.96 94.91 93.44 93.57 1.57 1.68
97.77 97.36 98.01 98.53 97.71 97.74 0.98 1.00
100.05 100.02 100.08 100.23 100.04 100.11 0.13 0.13
108.35 106.62 109.62 113.30 108.07 109.37 4.00 3.66

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


0.024 0.023 0.024 0.025 0.024 0.024 0.001 5.093

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


3.818 3.906 3.762 3.632 3.831 3.809 0.204 5.356
8.613 8.812 8.488 8.195 8.643 8.595 0.460 5.356
15.449 15.807 15.225 14.699 15.502 15.416 0.826 5.356
17.335 17.735 17.083 16.493 17.394 17.297 0.926 5.356
22.372 22.889 22.047 21.286 22.448 22.324 1.196 5.356

No.8 No.9 No.10 No.11 No.12


8 8 8 8 8
7 7 7 7 7
0.9808 0.9782 0.9826 0.9647 0.9802
0.9605 0.9561 0.9628 0.9087 0.9583
0.9605 0.9561 0.9628 0.9087 0.9583 0.9424
28.8664 29.1834 28.1323 54.0453 32.0111
5.3727 5.4022 5.3040 7.3516 5.6578
1 1 1 1 1
202.0650 204.2841 196.9260 378.3171 224.0776
202.0650 204.2841 196.9260 378.3171 224.0776
44.4687 44.5561 44.2626 49.4859 45.2959 46.6885
2.9806 2.8768 3.0424 2.1440 2.9268
No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
8.38 8.19 8.50 8.79 8.35 8.41 0.42 4.95
16.27 15.93 16.50 17.05 16.22 16.34 0.79 4.81
23.70 23.21 24.02 24.80 23.63 23.80 1.11 4.66
30.68 30.06 31.07 32.05 30.58 30.79 1.39 4.51
37.21 36.50 37.68 38.81 37.11 37.35 1.63 4.36
43.33 42.52 43.85 45.12 43.21 43.47 1.83 4.20
49.03 48.15 49.59 50.97 48.90 49.19 1.99 4.04
54.34 53.40 54.94 56.39 54.20 54.50 2.11 3.88
59.26 58.29 59.89 61.40 59.11 59.42 2.21 3.72
63.82 62.82 64.46 66.01 63.67 63.98 2.27 3.55
68.02 67.01 68.67 70.23 67.87 68.18 2.31 3.38
71.89 70.87 72.54 74.09 71.73 72.04 2.31 3.21
75.43 74.42 76.07 77.60 75.28 75.57 2.30 3.04
78.66 77.67 79.29 80.78 78.51 78.79 2.26 2.87
81.59 80.63 82.20 83.64 81.45 81.71 2.20 2.69
84.24 83.32 84.83 86.21 84.10 84.35 2.12 2.52
86.63 85.74 87.18 88.49 86.50 86.72 2.03 2.34
88.76 87.92 89.28 90.50 88.63 88.83 1.93 2.17
90.65 89.86 91.14 92.27 90.53 90.71 1.81 1.99
92.32 91.59 92.77 93.80 92.21 92.36 1.68 1.82
93.77 93.11 94.18 95.11 93.67 93.80 1.55 1.65
95.03 94.43 95.40 96.23 94.94 95.04 1.41 1.48
96.11 95.57 96.43 97.16 96.03 96.10 1.26 1.31
97.02 96.54 97.30 97.92 96.95 97.00 1.12 1.15
97.77 97.36 98.01 98.53 97.71 97.74 0.98 1.00
98.39 98.04 98.59 99.01 98.34 98.35 0.84 0.85
98.88 98.59 99.04 99.37 98.84 98.83 0.70 0.71
99.26 99.03 99.38 99.63 99.22 99.20 0.58 0.58
99.54 99.36 99.63 99.81 99.51 99.48 0.46 0.46
99.74 99.61 99.80 99.92 99.72 99.68 0.35 0.35
99.87 99.78 99.91 99.97 99.86 99.82 0.26 0.26
99.95 99.90 99.97 100.00 99.94 99.90 0.18 0.18
99.99 99.96 99.99 100.00 99.98 99.95 0.12 0.12
100.00 99.99 100.00 100.00 100.00 99.98 0.07 0.07
100.00 100.00 100.00 100.02 100.00 100.00 0.05 0.05
100.00 100.00 100.01 100.07 100.00 100.03 0.05 0.05
100.03 100.01 100.05 100.16 100.02 100.08 0.10 0.10
100.08 100.03 100.13 100.32 100.07 100.16 0.17 0.17
100.18 100.09 100.26 100.57 100.16 100.30 0.27 0.27
100.34 100.19 100.46 100.90 100.31 100.51 0.41 0.40
100.57 100.35 100.75 101.36 100.53 100.79 0.57 0.57
100.89 100.58 101.14 101.94 100.84 101.17 0.78 0.77
101.31 100.90 101.64 102.67 101.24 101.66 1.02 1.00
101.85 101.32 102.27 103.57 101.76 102.27 1.30 1.28
102.53 101.84 103.05 104.64 102.41 103.02 1.63 1.58
103.34 102.50 103.99 105.91 103.20 103.93 2.01 1.93
104.32 103.29 105.10 107.40 104.15 105.00 2.43 2.31
105.47 104.23 106.40 109.11 105.27 106.26 2.90 2.73
106.81 105.34 107.90 111.07 106.57 107.71 3.42 3.18
108.35 106.62 109.62 113.30 108.07 109.37 4.00 3.66
DDSolver 1.0 Dissolution Data Modeling of Weibull Model

Time Unit min Analyst lapcy


Model Weibull Date 2018-10-16
Equation F=Fmax*{1-Exp[-((t-Ti)^β)/α]} Time 2:23:44

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 24.39 24.54 20.07 21.54 21.59 26.30 19.43
10 58.51 65.77 60.49 59.19 60.88 63.06 51.93
15 76.95 89.47 87.55 82.37 87.50 80.14 72.75
20 89.36 98.84 98.40 91.85 97.41 87.28 83.81
25 94.70 102.42 104.52 95.30 100.86 91.81 89.30
30 97.37 104.12 106.76 96.68 102.24 95.21 92.61
45 100.73 105.58 107.36 97.71 103.79 99.84 97.58
60 101.85 106.26 107.62 98.06 104.65 101.83 99.50

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7


(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 24.41 24.46 20.00 21.48 21.45 26.25 19.28
10 58.26 66.19 60.87 59.47 61.47 63.67 52.70
15 77.71 88.70 86.65 81.86 86.43 79.01 71.95
20 88.57 98.89 99.26 91.94 97.70 87.33 83.14
25 94.55 103.07 104.54 95.77 101.80 92.31 89.68
30 97.80 104.66 106.52 97.05 103.06 95.47 93.52
45 101.03 105.49 107.46 97.56 103.49 99.95 97.88
60 101.52 105.52 107.48 97.57 103.50 101.50 98.77

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
α 9.673 12.153 19.435 18.869 24.948 3.649 8.876
β 1.043 1.226 1.359 1.377 1.471 0.698 0.985
Ti 2.448 2.415 2.226 1.927 1.698 3.886 3.059
Fmax 101.602 105.523 107.480 97.567 103.497 102.581 99.010

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 5.068 5.053 5.564 5.415 5.416 4.913 5.679
T50 8.511 7.757 8.512 8.566 8.415 7.474 9.474
Td 11.254 10.082 11.100 10.368 10.609 10.280 12.230
T75 14.106 11.555 12.353 13.060 12.292 13.338 16.120
T80 15.837 12.616 13.376 14.413 13.345 15.467 18.307

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 8 8 8 8 8 8 8
DF 4 4 4 4 4 4 4
R_obs-pre 0.9998 0.9998 0.9999 0.9999 0.9996 0.9998 0.9997
Rsqr 0.9997 0.9996 0.9997 0.9998 0.9992 0.9995 0.9994
Rsqr_adj 0.9994 0.9994 0.9995 0.9997 0.9987 0.9992 0.9989
MSE 0.4183 0.5056 0.4446 0.2435 1.1430 0.5196 0.8252
MSE_root 0.6467 0.7111 0.6668 0.4934 1.0691 0.7208 0.9084
Weighting 1 1 1 1 1 1 1
SS 1.6731 2.0226 1.7785 0.9739 4.5720 2.0783 3.3009
WSS 1.6731 2.0226 1.7785 0.9739 4.5720 2.0783 3.3009
AIC 12.1174 13.6349 12.6062 7.7881 20.1596 13.8523 17.5536
MSC 7.0174 6.9517 7.2560 7.5727 6.1880 6.6715 6.3854

No.1
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.2
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.3
120

Observed
100 Predicted
issolved (%)

80

60
120

Observed
100 Predicted

Fraction dissolved (%)


80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.4
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.5
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)
Fr
20

0
0 10 20 30 40 50 60 70
Time (min)

No.6
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.7
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.8
120

Observed
100 Predicted
n dissolved (%)

80

60
Observed
100 Predicted

Fraction dissolved (%) 80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.9
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.10
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)
20

0
0 10 20 30 40 50 60 70
Time (min)

No.11
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Mean
120

Observed
100 Predicted
ction dissolved (%)

80

60

40
100 Predicted

Fraction dissolved (%)


80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 0.00 0.00 0.00 0.00 0.00 0.00 0.00
2.4 0.00 0.00 0.51 1.82 2.44 0.00 0.00
3.6 11.48 10.17 8.18 9.95 10.14 0.00 5.90
4.8 22.66 22.42 18.24 19.79 19.76 23.29 17.50
6 32.67 34.35 28.87 29.94 30.03 37.96 27.55
7.2 41.53 45.31 39.31 39.74 40.22 48.07 36.31
8.4 49.33 55.08 49.12 48.81 49.88 55.76 43.96
9.6 56.18 63.62 58.09 56.97 58.73 61.89 50.66
10.8 62.16 70.96 66.09 64.14 66.61 66.90 56.53
12 67.39 77.19 73.12 70.32 73.48 71.09 61.68
13.2 71.95 82.43 79.19 75.57 79.35 74.63 66.19
14.4 75.92 86.80 84.37 79.96 84.29 77.66 70.15
15.6 79.37 90.42 88.74 83.59 88.38 80.27 73.63
16.8 82.37 93.39 92.38 86.56 91.71 82.54 76.68
18 84.98 95.82 95.40 88.96 94.39 84.53 79.37
19.2 87.23 97.79 97.87 90.88 96.53 86.28 81.73
20.4 89.19 99.39 99.88 92.41 98.21 87.82 83.80
21.6 90.88 100.67 101.51 93.62 99.52 89.19 85.62
22.8 92.35 101.70 102.81 94.56 100.53 90.40 87.23
24 93.62 102.52 103.85 95.29 101.30 91.49 88.64
25.2 94.72 103.17 104.67 95.85 101.89 92.46 89.88
26.4 95.67 103.68 105.31 96.28 102.32 93.34 90.97
27.6 96.49 104.09 105.82 96.61 102.65 94.12 91.93
28.8 97.19 104.41 106.21 96.86 102.89 94.83 92.77
30 97.80 104.66 106.52 97.05 103.06 95.47 93.52
31.2 98.33 104.86 106.75 97.18 103.19 96.05 94.17
32.4 98.79 105.01 106.93 97.29 103.28 96.57 94.75
33.6 99.18 105.13 107.07 97.36 103.35 97.05 95.25
34.8 99.52 105.22 107.17 97.42 103.39 97.49 95.70
36 99.81 105.29 107.25 97.46 103.42 97.88 96.09
37.2 100.06 105.35 107.31 97.49 103.45 98.24 96.44
38.4 100.28 105.39 107.35 97.51 103.46 98.57 96.75
39.6 100.46 105.42 107.39 97.53 103.47 98.87 97.01
40.8 100.62 105.45 107.41 97.54 103.48 99.15 97.25
42 100.76 105.46 107.43 97.55 103.49 99.40 97.46
43.2 100.88 105.48 107.44 97.55 103.49 99.64 97.64
44.4 100.98 105.49 107.45 97.56 103.49 99.85 97.80
45.6 101.07 105.50 107.46 97.56 103.49 100.05 97.95
46.8 101.14 105.50 107.47 97.56 103.49 100.23 98.07
48 101.21 105.51 107.47 97.56 103.50 100.39 98.18
49.2 101.26 105.51 107.47 97.56 103.50 100.55 98.28
50.4 101.31 105.52 107.47 97.57 103.50 100.69 98.37
51.6 101.35 105.52 107.48 97.57 103.50 100.82 98.44
52.8 101.39 105.52 107.48 97.57 103.50 100.94 98.51
54 101.42 105.52 107.48 97.57 103.50 101.05 98.57
55.2 101.44 105.52 107.48 97.57 103.50 101.16 98.62
56.4 101.47 105.52 107.48 97.57 103.50 101.25 98.67
57.6 101.49 105.52 107.48 97.57 103.50 101.34 98.71
58.8 101.50 105.52 107.48 97.57 103.50 101.42 98.74
60 101.52 105.52 107.48 97.57 103.50 101.50 98.77
No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
24.60 23.75 23.98 30.89 22.10 23.60 3.07 13.00
59.15 61.74 59.96 70.45 58.66 60.82 4.46 7.33
81.39 80.18 81.39 85.56 81.38 82.22 4.75 5.77
91.12 86.90 91.93 93.23 91.13 91.77 4.69 5.11
95.95 91.21 96.20 96.63 95.05 96.16 4.53 4.71
98.62 94.06 98.29 98.46 97.14 98.46 4.11 4.17
100.95 98.36 101.78 101.50 100.45 101.30 3.02 2.98
101.55 101.29 104.13 103.68 102.54 102.75 2.70 2.63

No.8 No.9 No.10 No.11 No.12


F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
24.48 23.67 23.83 30.86 21.92 23.51 3.10 13.18
59.78 62.75 60.75 70.71 59.67 61.36 4.39 7.16
80.39 78.45 80.56 85.37 80.00 81.42 4.70 5.77
91.18 86.81 91.09 92.65 90.53 91.59 4.99 5.45
96.51 91.73 96.66 96.69 95.87 96.60 4.55 4.71
99.02 94.79 99.60 99.07 98.54 99.09 3.94 3.98
100.91 98.98 102.39 102.09 100.83 101.51 2.94 2.89
101.06 100.35 102.79 102.96 101.10 102.01 2.72 2.66

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


12.396 3.701 8.197 3.086 8.769 11.146 6.874 61.669
1.165 0.713 1.013 0.699 1.052 1.067 0.268 25.079
2.115 4.020 2.860 3.863 2.937 2.788 0.794 28.472
101.067 101.206 102.859 103.430 101.133 102.246 2.664 2.606

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)


5.061 5.091 5.119 4.661 5.317 5.197 0.289 5.560
8.364 7.677 8.202 6.635 8.412 8.167 0.707 8.660
10.786 10.283 10.844 8.882 10.814 10.628 0.794 7.474
13.369 13.572 13.253 11.101 13.439 13.130 1.286 9.798
14.871 15.734 14.806 12.701 14.999 14.706 1.598 10.868

No.8 No.9 No.10 No.11 No.12


8 8 8 8 8
4 4 4 4 4
0.9998 0.9993 0.9994 0.9998 0.9992
0.9996 0.9987 0.9988 0.9996 0.9985
0.9993 0.9977 0.9980 0.9993 0.9973 0.9989
0.5333 1.5257 1.5343 0.4207 2.0340
0.7303 1.2352 1.2387 0.6486 1.4262
1 1 1 1 1
2.1334 6.1027 6.1373 1.6829 8.1361
2.1334 6.1027 6.1373 1.6829 8.1361
14.0617 22.4699 22.5151 12.1641 24.7704 16.1411
6.7815 5.6376 5.7608 6.8092 5.4925
No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.87 0.00 0.00 0.00 0.00 0.55 0.92 166.55
12.13 0.00 8.84 0.00 7.21 7.00 4.55 65.04
22.75 20.50 21.84 27.54 19.92 21.35 2.69 12.58
32.80 36.02 33.12 43.80 31.29 33.20 4.47 13.46
41.98 46.58 42.88 54.67 41.26 43.16 4.89 11.32
50.23 54.57 51.30 62.70 49.92 51.72 4.73 9.15
57.54 60.91 58.56 68.93 57.41 59.12 4.46 7.55
63.96 66.08 64.81 73.91 63.86 65.50 4.30 6.56
69.54 70.37 70.19 77.96 69.40 70.98 4.30 6.06
74.37 73.99 74.81 81.32 74.14 75.66 4.43 5.86
78.53 77.08 78.79 84.13 78.20 79.66 4.61 5.79
82.10 79.73 82.20 86.51 81.67 83.05 4.78 5.76
85.14 82.02 85.14 88.53 84.62 85.92 4.92 5.72
87.73 84.02 87.66 90.27 87.14 88.35 4.99 5.65
89.92 85.77 89.82 91.76 89.28 90.41 5.01 5.54
91.77 87.30 91.68 93.06 91.10 92.13 4.97 5.40
93.33 88.66 93.27 94.19 92.65 93.59 4.90 5.23
94.64 89.86 94.64 95.18 93.96 94.82 4.79 5.05
95.73 90.93 95.81 96.04 95.07 95.86 4.66 4.87
96.65 91.88 96.82 96.81 96.01 96.73 4.52 4.68
97.42 92.73 97.68 97.48 96.81 97.47 4.38 4.49
98.05 93.49 98.42 98.07 97.49 98.10 4.23 4.31
98.58 94.18 99.06 98.60 98.06 98.64 4.08 4.14
99.02 94.79 99.60 99.07 98.54 99.09 3.94 3.98
99.39 95.34 100.07 99.49 98.95 99.48 3.81 3.83
99.69 95.84 100.47 99.86 99.29 99.81 3.69 3.70
99.94 96.30 100.81 100.20 99.58 100.10 3.58 3.57
100.14 96.70 101.11 100.50 99.83 100.35 3.47 3.46
100.31 97.08 101.36 100.76 100.03 100.56 3.38 3.36
100.45 97.41 101.57 101.01 100.21 100.75 3.30 3.27
100.56 97.72 101.76 101.22 100.36 100.91 3.22 3.19
100.66 98.00 101.92 101.42 100.48 101.05 3.16 3.12
100.73 98.25 102.05 101.60 100.58 101.18 3.10 3.06
100.80 98.49 102.17 101.76 100.67 101.29 3.04 3.01
100.85 98.70 102.27 101.90 100.75 101.38 3.00 2.96
100.89 98.89 102.35 102.03 100.81 101.47 2.96 2.91
100.92 99.07 102.43 102.15 100.86 101.54 2.92 2.88
100.95 99.23 102.49 102.26 100.90 101.61 2.89 2.84
100.97 99.38 102.54 102.35 100.94 101.67 2.86 2.81
100.99 99.52 102.59 102.44 100.97 101.72 2.84 2.79
101.00 99.64 102.63 102.52 101.00 101.77 2.82 2.77
101.02 99.76 102.66 102.60 101.02 101.81 2.80 2.75
101.03 99.86 102.69 102.67 101.04 101.85 2.78 2.73
101.03 99.96 102.71 102.73 101.05 101.88 2.77 2.71
101.04 100.05 102.73 102.78 101.07 101.91 2.75 2.70
101.05 100.13 102.75 102.83 101.08 101.94 2.74 2.69
101.05 100.21 102.77 102.88 101.09 101.97 2.73 2.68
101.05 100.28 102.78 102.92 101.09 101.99 2.72 2.67
101.06 100.35 102.79 102.96 101.10 102.01 2.72 2.66
Aparato 2 a 75 rpm. 900 ml de HCl 0.1 N, tabletas metronidazol 500 mg.
Referencia
tiempo (min) 1 2 3 4
0 0 0 0 0
5 24.385 24.54 20.073 21.543
10 58.506 65.773 60.485 59.191
15 76.946 89.465 87.546 82.374
20 89.356 98.842 98.404 91.852
25 94.698 102.42 104.52 95.298
30 97.369 104.124 106.761 96.677
45 100.73 105.575 107.364 97.712
60 101.85 106.255 107.622 98.056
AUC 4967.97 5326.98 5340.38 4919.16
MDT 11.22 9.87 10.38 9.83
DE 82.80 88.78 89.01 81.99

tiempo(min) Generico
0 0 0 0 0
5 9.172 8.692 8.027 10.322
10 25.513 27.8 24.553 27.424
15 40.319 46.332 39.261 40.029
20 52.644 60.284 49.871 51.309
25 61.913 69.455 57.609 60.955
30 69.843 75.38 64.392 68.409
45 82.359 85.326 79.692 82.085
60 88.761 91.058 87.623 89.824
AUC 3547.33 3779.44 3393.08 3539.24
MDT 20.04 18.49 21.28 20.60
DE 59.12 62.99 56.55 58.99
ABC
Prueba F para varianzas de dos muestras

Variable 1 Variable 2
Media 5047.61125 3561.38083
Varianza 33441.3706 31364.9597
Observacione 12 12
Grados de lib 11 11
F 1.06620161
P(F<=f) una c 0.4586213
Valor crítico 2.81793047

si P es menor a 0.05 las varianzas son diferentes


en este caso P es mayor a 0.05 por lo tanto las varianzas
son iguales.

TMD

Prueba F para varianzas de dos muestras

Variable 1 Variable 2
Media 10.8806565 19.5833137
Varianza 0.69446129 2.21315677
Observacione 12 12
Grados de lib 11 11
F 0.31378766
P(F<=f) una c 0.03354149
Valor crítico 0.35487036

P es menor que 0.05 por lo tanto las varianzas son diferentes

ED

Prueba F para varianzas de dos muestras


Variable 1 Variable 2
Media 84.1268542 59.3563472
Varianza 9.2892696 8.71248881
Observacione 12 12
Grados de lib 11 11
F 1.06620161
P(F<=f) una c 0.4586213
Valor crítico 2.81793047

P es mator a 0.05 por lo tanto las varianzas son iguales

ABC TMD
REF 5047.61+-52.79(5100.4,4994.82) 10.88+-0.24(11.12;10.64)
GENERICO 1 3561.38+-48.95(3610;3512.43 19.58+-0.41(19.99;19.17)
Generico 2 (si hay)
de HCl 0.1 N, tabletas metronidazol 500 mg.

5 6 7 8 9 10
0 0 0 0 0 0
21.589 26.302 19.428 24.6 23.752 23.981
60.88 63.061 51.925 59.153 61.744 59.963
87.5 80.137 72.752 81.388 80.183 81.391
97.411 87.283 83.814 91.123 86.903 91.933
100.858 91.812 89.303 95.948 91.212 96.203
102.236 95.21 92.614 98.618 94.056 98.293
103.791 99.836 97.58 100.945 98.364 101.778
104.649 101.833 99.496 101.548 101.294 104.131
5205.28 4956.36 4722.17 5023.03 4894.70 5057.94
10.26 11.33 12.54 10.54 11.68 11.43
86.75 82.61 78.70 83.72 81.58 84.30

0 0 0 0 0 0
8.314 8.602 8.696 14.045 15.367 9.929
25.514 23.886 26.654 37.257 32.848 30.188
41.458 37.923 42.61 51.4 47.089 47.006
53.312 49.97 53.884 59.521 58.074 58.471
61.624 58.471 63.151 64.87 67.055 67.832
67.642 65.827 70.89 68.692 74.031 74.426
78.76 80.683 82.546 76.431 86.259 84.17
85.902 89.062 89.426 82.259 92.183 90.19
3453.20 3430.74 3592.76 3585.79 3827.73 3750.37
19.80 21.48 19.82 16.41 18.48 18.42
57.55 57.18 59.88 59.76 63.80 62.51
Prueba t para dos muestras suponiendo varianzas iguales

Variable 1 Variable 2
Media 5047.61125 3561.38083
Varianza 33441.37056 31364.9597
Observaciones 12 12
Varianza agrupada 32403.16513
Diferencia hipotética de las medias 1486.23
Grados de libertad 22
Estadístico t 5.669838E-06
P(T<=t) una cola 0.499997764
Valor crítico de t (una cola) 1.717144374
P(T<=t) dos colas 0.999995527
Valor crítico de t (dos colas) 2.073873068

P=0.999.lo que significa que no


existe diferencia entre los valoes de
ABC de la prueba de dislolucion del
medicamento de referencia y el
generico

Prueba t para dos muestras suponiendo varianzas desiguales

Variable 1 Variable 2
Media 10.88065649 19.5833137
Varianza 0.694461289 2.21315677
Observaciones 12 12
Diferencia hipotética de las medias 8.7
Grados de libertad 17
Estadístico t -35.35391477
P(T<=t) una cola 1.167976E-17
Valor crítico de t (una cola) 1.739606726
P(T<=t) dos colas 2.335951E-17
Valor crítico de t (dos colas) 2.109815578 El valor de p es menor que 0.05 por lo tanto si existe diferenc

Prueba t para dos muestras suponiendo varianzas iguales


Variable 1 Variable 2
Media 84.12685417 59.3563472
Varianza 9.289269601 8.71248881
Observaciones 12 12
Varianza agrupada 9.000879203
Diferencia hipotética de las medias 24.77
Grados de libertad 22
Estadístico t 0.000413898
P(T<=t) una cola 0.499836744
Valor crítico de t (una cola) 1.717144374
P(T<=t) dos colas 0.999673487
Valor crítico de t (dos colas) 2.073873068

p=0.999 lo que significa que no existen diferencias emtre los valores de ED(eficiencia de disolucion)
entre el medicamento de referncia y el generico.

ED k(constante)
0.88+-0.24(11.12;10.64) 84.13+-0.88(85.01;83.25)
9.58+-0.41(19.99;19.17) 59.36+-0.82(60.18;58.54)
11 12 PROMEDIO DESVEST C.V
0 0 0.00 0.00
30.888 22.101 23.60 3.07 13.00
70.452 58.663 60.82 4.46 7.33
85.562 81.375 82.22 4.75 5.77
93.227 91.129 91.77 4.69 5.11
96.626 95.052 96.16 4.53 4.71
98.455 97.142 98.46 4.11 4.17
101.504 100.452 101.30 3.02 2.98
103.682 102.544 102.75 2.70 2.63 EE
5168.50 4988.88 5047.61 182.87 3.62 52.79
10.15 11.35 10.88 0.83 7.66 0.24
86.14 83.15 84.13 3.05 3.62 0.88

PROMEDIO DESVEST C.V


0 0 0.00 0.00
7.716 9.623 9.88 2.40 24.28
26.267 23.345 27.60 4.05 14.66
44.328 38.637 43.03 4.19 9.75
55.222 51.538 54.51 3.74 6.86
62.292 58.511 62.81 3.84 6.11
68.598 63.192 69.28 3.89 5.61
84.359 71.886 81.21 4.08 5.03
93.437 78.287 88.17 4.26 4.83 EE
3631.27 3205.63 3561.38 169.56 4.76 48.95
21.14 19.05 19.58 1.42 7.27 0.41
60.52 53.43 59.36 2.83 4.76 0.82
0.05 por lo tanto si existe diferencia entre el TMD(Tiempo Medio de Disolucion)de ambos medicamentos.

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