CSF-1

Macrophage colony-stimulating factor (MCSF) o también Colony stimulating factor 1 (CSF-1), es una citoquina secretada que
induce a las células madre hemopoyéticas a diferenciarse a macrófago u otros tipos celulares relacionados. Las células eucarióticas
también producen M-CSF para combatir infecciones virales intracelulares. M-CSF se une a su receptor, el Colony stimulating factor
1 receptor. Puede que el M-CSF también esté involucrado en el desarrollo de laplacenta.

Estructura
Es una citoquina. La forma activa de la proteína se encuentra extracelularmente en forma de homodímero, estando unidos los
monómeros por un enlace disulfuro. Se piensa que esta forma es producida a partir del procesamiento proteolítico de precursores
unidos a membrana.

1
Se han encontrado cuatro variantes transcripcionales codificando tres isoformas diferentes.

Se ha demostrado que MCSF interacciona conPIK3R2.2

Referencias
1. "Entrez Gene: CSF1 colony stimulating factor 1 (macrophage)". [1] (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gen
e&Cmd=ShowDetailView&TermToSearch=1435)
2. Gout, I; Dhand R, Panayotou G, Fry M J, Hiles I, Otsu M, Waterfield M D (Dec. 1992). "Expression and
characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by
using the baculovirus expression system". Biochem. J. (ENGLAND) 288 ( Pt 2): 395-405. ISSN 0264-6021. PMID
1334406.

Lecturas adicionales
Stanley ER, Berg KL, Einstein DB, et al. (1995). "The biology and action of colony stimulating factor-1.". Stem Cells
12 Suppl 1: 15–24; discussion 25.PMID 7696959.

Alterman RL, Stanley ER (1994). "Colony stimulating factor-1 expression in human glioma.". Mol. Chem.
Neuropathol. 21 (2-3): 177–88. doi:10.1007/BF02815350.PMID 8086034.

Stanley ER, Berg KL, Einstein DB, et al. (1997). "Biology and action of colony--stimulating factor-1.". Mol. Reprod.
Dev. 46 (1): 4–10. doi:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V . PMID 8981357.

Sweet MJ, Hume DA (2004). "CSF-1 as a regulator of macrophage activation and immune responses.". Arch.
Immunol. Ther. Exp. (Warsz.) 51 (3): 169–77. PMID 12894871.

Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers.". Clin. Chem. Lab. Med. 42 (12):
1347–54. doi:10.1515/CCLM.2004.253.PMID 15576295.

Pandit J, Bohm A, Jancarik J, et al. (1993). "Three-dimensional structure of dimeric human recombinant macrophage
colony-stimulating factor.". Science 258 (5086): 1358–62. doi:10.1126/science.1455231.PMID 1455231.

Suzu S, Ohtsuki T, Yanai N, et al. (1992). "Identification of a high molecular weight macrophage colony-stimulating
factor as a glycosaminoglycan-containing species.". J. Biol. Chem. 267 (7): 4345–8. PMID 1531650.

Saltman DL, Dolganov GM, Hinton LM, Lovett M (1992). "Reassignment of the human macrophage colony
stimulating factor gene to chromosome 1p13-21.". Biochem. Biophys. Res. Commun. 182 (3): 1139–43.
doi:10.1016/0006-291X(92)91850-P. PMID 1540160.

Praloran V, Chevalier S, Gascan H (1992). "Macrophage colony-stimulating factor is produced by activated T

lymphocytes in vitro and is detected in vivo in T cells from reactive lymph nodes.". Blood 79 (9): 2500–1. PMID
1571567.
 Price LK, Choi HU, Rosenberg L, Stanley ER (1992). "The predominant form of secreted colony stimulating factor-1
is a proteoglycan.". J. Biol. Chem. 267 (4): 2190–9.PMID 1733926.

Pampfer S, Tabibzadeh S, Chuan FC, Pollard JW (1992). "Expression of colony-stimulating factor-1 (CSF-1)
messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript
that predicts a cell surface form of CSF-1.". Mol. Endocrinol. 5 (12): 1931–8. doi:10.1210/mend-5-12-1931. PMID
1791839.

Stein J, Borzillo GV, Rettenmier CW (1990). "Direct stimulation of cells expressing receptors for macrophage colony-
stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1.". Blood 76 (7): 1308–14. PMID
2145044.

Sherr CJ, Rettenmier CW, Sacca R, et al. (1985). "The c-fms proto-oncogene product is related to the receptor for
the mononuclear phagocyte growth factor, CSF-1.". Cell 41 (3): 665–76. doi:10.1016/S0092-8674(85)80047-7. PMID
2408759.

Cerretti DP, Wignall J, Anderson D, et al. (1988). "Human macrophage-colony stimulating factor: alternative RNA
and protein processing from a single gene.". Mol. Immunol. 25 (8): 761–70. doi:10.1016/0161-5890(88)90112-5.
PMID 2460758.

Takahashi M, Hirato T, Takano M, et al. (1989). "Amino-terminal region of human macrophage colony-stimulating
factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal
deletion mutants of human M-CSF.". Biochem. Biophys. Res. Commun. 161 (2): 892–901. doi:10.1016/0006-
291X(89)92683-1. PMID 2660794.

Kawasaki ES, Ladner MB, Wang AM, et al. (1985). "Molecular cloning of a complementary DNA encoding human
macrophage-specific colony-stimulating factor (CSF-1).". Science 230 (4723): 291–6. doi:10.1126/science.2996129.
PMID 2996129.

Rettenmier CW, Roussel MF, Ashmun RA, et al. (1987). "Synthesis of membrane-bound colony-stimulating factor 1
(CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-
1 and c-fms (CSF-1 receptor) genes.". Mol. Cell. Biol. 7 (7): 2378–87.PMID 3039346.

Takahashi M, Hong YM, Yasuda S, et al. (1988). "Macrophage colony-stimulating factor is produced by human T
lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis.". Biochem.
Biophys. Res. Commun. 152 (3): 1401–9. doi:10.1016/S0006-291X(88)80441-8. PMID 3259875.

Rettenmier CW, Roussel MF (1989). "Differential processing of colony-stimulating factor 1 precursors encoded by
two human cDNAs.". Mol. Cell. Biol. 8 (11): 5026–34.PMID 3264877.

Wong GG, Temple PA, Leary AC, et al. (1987). "Human CSF-1: molecular cloning and expression of 4-kb cDNA
encoding the human urinary protein.". Science 235 (4795): 1504–8. doi:10.1126/science.3493529.
PMID 3493529.

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