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Arthritis & Rheumatism (Arthritis Care & Research)

Vol. 49, No. 5S, October 15, 2003, pp S184 –S196


DOI 10.1002/art.11409
© 2003, American College of Rheumatology
MEASURES OF FATIGUE AND SLEEP

Measures of Sleep
The Insomnia Severity Index, Medical Outcomes Study (MOS) Sleep Scale,
Pittsburgh Sleep Diary (PSD), and Pittsburgh Sleep Quality Index (PSQI)

Michael T. Smith and Stephen T. Wegener

INSOMNIA SEVERITY INDEX a sample of adults (ages 17– 84 years) with


insomnia complaints (primary and secondary to
General Description medical, psychiatric, or other sleep disorders) (2).
Purpose. The Insomnia Severity Index (ISI) is
designed to be both a brief screening measure of Other uses. The ISI has also been validated on
insomnia and an outcomes measure for use in samples of young adults (mean age 20 years) (3),
treatment research (1,2). and older adults (mean age 65 years) with primary
insomnia (2).
Content. Scale content corresponds in part to
DSM-IV criteria for insomnia, and measures the WHO ICF Components. Body function,
subject’s current (within the past 2 weeks) Impairment, Activity limitation, Participation
perception of symptom severity, distress, and restriction, Environmental factor.
daytime impairment. Items include: the severity of
sleep onset and maintenance (middle and early
morning awakening) difficulties, satisfaction with
Administration
current sleep pattern, interference with daily Method. Self-administration; paper and pencil.
functioning, appearance of impairment attributed
to the sleep problem, and the degree of concern Training. Minimal.
caused by insomnia.
Time to administer/complete. Five minutes or
Developer/contact information. Charles M. less.
Morin, PhD. E-mail: cmorin@psy.ulaval.ca.
Equipment needed. None.
Versions. Primary version is self-administered;
clinician-administered, significant other, and Cost/availability. No cost; available from
French language versions are available. authors. Copy available at the Arthritis Care &
Research Web site at
Number of items in scale. There are 7 items. http://www.interscience.wiley.com/jpages/0004-
3591:1/suppmat/index.html.
Subscales. None.
Scoring
Population. Developmental/target. The
Responses. Scale. Five-point Likert scale (0 ⫽
psychometric properties of ISI were reported from
not at all, 4 ⫽ extremely).
Supported by NIH/NIDCR grant DE-13906 (MTS). Score range. Range is 0 –28.
Michael T. Smith, PhD, Stephen T. Wegener, PhD: Johns
Hopkins University School of Medicine, Baltimore, Mary-
land. Interpretation of scores. Suggested guidelines
Address correspondence to Michael T. Smith, PhD, De- for interpretation: 0 –7 ⫽ no clinically significant
partment of Psychiatry and Behavioral Sciences, Behavioral
Medicine Research Laboratory and Clinic, 600 N. Wolfe insomnia; 8 –14 ⫽ subthreshold insomnia; 15–21 ⫽
Street, Meyer 101, Baltimore, MD 21287. E-mail: clinical insomnia of moderate severity; 21–28 ⫽
Msmith62@jhmi.edu. severe clinical insomnia. Guidelines require
Submitted for publication April 23, 2003; accepted in
revised form April 24, 2003.
additional validation. Smith and Trinder (3) found
a cutoff score of 14 distinguished subjects with

S184
Sleep S185

insomnia from normal controls with a sensitivity ⫽ Sleep Latency). At posttreatment, ISI Total Score
94% and specificity ⫽ 94%. correlated with PSG Sleep Efficiency (⫺0.35; P ⬍
0.05). ISI Sleep Onset and middle insomnia items
Method of scoring. Individual items are summed correlated with PSG Sleep Latency and Wake After
by hand. Sleep Onset (0.39 and 0.45; P ⬍ 0.05, respectively).
In regards to sleep diatries, Bastien and
Time to score. Less than one minute. colleagues (2) reported significant correlations of
select ISI items with corresponding daily sleep
Training to score. Minimal. diary parameters in 2 separate samples, one of
which included correlations between measures
Training to interpret. Minimal. both before and after treatment. Pretreatment
correlations were weak to moderate (0.32– 0.55)
Norms available. Traditional norms are not and posttreatment correlations were moderate to
available. Mean (SD) for insomnia patients (n ⫽ strong (0.55– 0.99). The ISI Total Score correlated
145) is 19.7 (4.1). Mean (SD) older adults with weakly to moderately with diary measures of Sleep
DSM-IV diagnosis of primary insomnia is 15.4 Efficiency (Pearson’s r values ranging between
(4.2). ISI scores for the 5 insomnia subgroups in ⫺0.19 and ⫺0.61).
the original sample were pain conditions (20.2); Correlation coefficients between clinician ISI
psychophysiological (19.5); psychiatric (21.0); ratings and the patient version for ISI total score
idiopathic (19.7); alcohol/substance abuse (19.8); ranged between 0.57 and 0.71, P ⬍ 0.01. Individual
and other (19.5) (2). item correlations between the 2 versions ranged
between 0.50 (difficulty staying asleep) and 0.69
(problem waking up too early).
Psychometric Information
Reliability. Internal consistency. Cronbach’s Predictive. Clinician ratings of insomnia severity
alpha ⫽ 0.74 to 0.78. Individual item correlations predicted ISI Total Score. R2 ranged from 0.37
to the total score ranged from 0.36 (difficulty (pretreatment) to 0.61 (post-treatment) P ⬍ 0.05)
falling asleep) to 0.67 (interference with daily (2).
functioning), with a mean of 0.54. Internal
reliability coefficients of individual items to total Sensitivity/responsiveness to change. Morin and
score demonstrated increased stability following colleagues demonstrated sensitivity to change
treatment with means of 0.69 at post-treatment and following pharmacologic and/or behavioral
0.72 at followup (2). intervention for primary insomnia in older adults (4).

Validity. Content. The ISI has good face validity


with the concept of insomnia as defined by DSM- Comments and Critique
IV. Formal evaluation of content validity was The ISI is a face valid index of insomnia
demonstrated via principal component analysis, severity demonstrating criterion validity and other
which yielded 3 components (impact, severity, and adequate psychometric properties. It has been
satisfaction). These components are consistent with validated against both polysomnographic and
the diagnostic criteria of insomnia and captured prospective sleep diary measures and demonstrates
72% of the variance (2). convergence with clinical interview criteria. It may
be particularly useful for treatment outcome
Criterion. A cutoff score of 14 demonstrated a research in which insomnia is a secondary
sensitivity of 94% and a specificity of 94% in endpoint, and a brief, low subject burden
distinguishing individuals diagnosed with primary instrument is needed. It may also be useful for
insomnia from good sleeper controls. Diagnoses diagnosis and treatment planning. The cutoff score
were established based on integration of expert may be useful as a guideline for clinicians in
clinical interview, polysomnography, and evaluating the clinical significance of the insomnia
psychometric testing (3). complaint. While not specifically developed for
rheumatology patients, scale development included
Concurrent. Bastien and colleagues reported a heterogenous group of patients with insomnia
significant correlations of select ISI items and Total secondary to pain conditions.
Score with relevant polysomnography (PSG) Due to its brevity and Likert scale data, this
variables before and after treatment (2). The ISI instrument would not be an appropriate stand-
Sleep Onset item was the only significant alone measure of sleep disturbance. The scale is
pretreatment correlation (r ⫽ 0.45; P ⬍ 0.05, PSG limited to questions pertaining to insomnia
S186 Smith and Wegener

severity/impact and does not assess frequency of Index II (long form). Additional subscales can be
symptoms. It also does not include items relevant derived: sleep disturbance, snoring, sleep shortness
to other sleep disorders, which may occur more of breath or headache, sleep adequacy, sleep
frequently in chronic pain populations (e.g., somnolence, sleep quantity, and optimal sleep.
periodic limb movements, restless legs syndrome,
or sleep apnea). More research demonstrating the Populations. Developmental/target. Patients
psychometric properties of the ISI, and establishing served in primary care and multi-specialty
cutoff scores and sensitivity to change in practices.
rheumatologic populations is needed.
Other uses. Has been used with congestive heart
failure, patients with depression, diabetes, recent
References myocardial infarction, hypertension, asthma, back
1. (Original) Morin CM. Insomnia: psychological problems, arthritis samples.
assessment and management. New York: Guilford
Press; 1993. WHO ICF Components. Body function,
2. Bastien CH, Vallie’res A, Morin CM. Validation of the
Impairment, Activity limitation, Participation
Insomnia Severity Index as an outcome measure for
insomnia research. Sleep Med 2000;2:297–307.
restriction.
3. Smith S, Trinder J. Detecting insomnia: comparison of
four self-report measures of sleep in a young adult Administration
population. J Sleep Res 2001;10:229 –35.
4. Morin CM, Colecchi C, Stone J, Sood R, Brink D. Method. Self-report instrument that may be
Behavioral and pharmacological therapies for late-life administered in person, by mail, or telephone.
insomnia: a randomized controlled trial. JAMA 1999;
281:991–9. Training. No training needed.

Time to administer/complete. Not reported.


MEDICAL OUTCOMES STUDY (MOS) Estimated to be 2–3 minutes for 12 items.
SLEEP SCALE
Equipment needed. None, other than instrument
General Description
and writing implement.
Purpose. Measure 6 sleep dimensions. The sleep
scale is one subscale of the Medical Outcomes Cost/availability. No cost. Available through
Study (MOS) health status measure (1). source listed above and references listed below.

Content. Consists of 12 items to measure 6 sleep


dimensions: initiation (time to fall asleep), quantity Scoring
(hours of sleep each night), maintenance , Responses. Scale. Sleep Initiation (0 –15
respiratory problems, perceived adequacy, minutes, 16 –30 minutes, 31– 45 minutes, 46 – 60
somnolence (the last 4 items reported using a 6- minutes, 60⫹ minutes); Sleep Quantity (number of
item Likert scale ranging from “All of the time” to hours), 10 items about other sleep activities (All of
“None of the time”). The time frame for the the Time, Most of the Time, A Good Bit of the
responses is “the past 4 weeks.” Time, Some of the Time, A Little of the Time,
None of the Time).
Developer/contact information. RD Hays and AL
Stewart, Medical Outcomes Trust, 198 Tremont Score range. The range for the 12-item version is
Street #503, Boston, MA 02166. Available at http:// 12–71.
www.outcomes-trust.org/instruments.htm.
Interpretation of scores. No formal cutoff scores
Versions. A 6-item Likert-scale short form is are provided. Data from original scale development
available that measures initiation, maintenance, samples are available for comparison.
respiratory problems, adequacy, and somnolence.
A correlation of 0.97 indicates the short version is Method of scoring. Scoring is done by hand,
nearly equivalent to the long version. requires reverse scoring of selected items and only
requires simple arithmetic.
Number of items in scale. There are 12 items.
Time to score. Less than 5 minutes.
Subscales. Two indexes can be derived: Sleep
Problems Index I (short form) and Sleep Problems Training to score. Training is minimal.
Sleep S187

Training to interpret. Training is minimal. would be more appropriate for research focused on
sleep parameters. While not specifically normed on
Norms available. No formal norms have been a rheumatology sample, as it was developed using
published. Data from original scale development a large number of patients served in primary care
samples are available for comparison. and specialty practice settings, the MOS is one of
the few health status measures that has a sleep
Psychometric Information subscale. The MOS scale may be more useful in
studies where the focus is general health status
Reliability. Internal consistency. Cronbach alpha assessment but information on sleep parameters is
ranged from 0.75 to 0.86 for item to subscales. of interest. The short 6-item version is nearly
Item-total correlations were 0.03– 0.64, which is equivalent to the 12-item version and reduces
not surprising given the multiple dimensions of subject burden. It should be noted there is no item
sleep assessed. Intercorrelations among subscales assessing use of sleep medication or assessment of
ranged from 0.05 to 0.88. leg movements, if these are variables of interest.
The sleep somnolence subscale actually measures
Test-retest. Not available. daytime sleepiness. The utility in treatment
outcome studies remains to be established. It
Intra/interrater. Not formally reported or should be noted, while the Short Form-36 is a brief
applicable; self-report data with objective, simple version of the MOS it does not contain items on
scoring. sleep behavior.
Variability. Full range of scores observed with
fairly normal distribution (skewness ranging from Reference
-0.055 to 1.81 for items). 1. (Original) Stewart AL, Ware JE, Brook RH, Davies AR.
Conceptualization and measurement of health for
Validity. Content. The MOS has good face adults in the Health Insurance Study. Vol II. Physical
validity covering multiple dimensions of sleep that health in terms of functioning. Santa Monica (CA):
The RAND Corporation; 1978. p. 236 –359.
are represented in prior sleep measures.

Criterion. The MOS has not been formally Additional References


compared to sleep laboratory observations. Hays RD, Stewart AL. Sleep measures. In: Stewart AL,
Ware JE, editors. Measuring functioning and well-
Concurrent/predictive. Not available. being: the Medical Outcomes Study Approach.
Durham (NC): Duke University Press; 1992. p. 235–
Construct/discriminant. Comparison of the MOS 59.
Sleep scale with other dimensions of the MOS Stewart AL, Hays RD, Ware JE. The MOS Short-Form
indicated correlations in the expected directions General Health Survey: reliability and validity in a
patient population. Med Care 1988;26:724 –732.
(Effects of pain 0.53, Pain severity 0.44, Physical
symptoms 0.57, Energy/fatigue ⫺0.60, Physical
functioning ⫺0.36, Cognitive functioning ⫺0.53, PITTSBURGH SLEEP DIARY
Depression/behavioral-emotional control 0.57,
General Description
Anxiety 0.57, Positive affect ⫺0.55).
Purpose. The Pittsburgh Sleep Diary (PSD) is
Sensitivity/responsiveness to change. Not designed to quantify subjectively reported sleep
established. and waking behaviors for use in research and
practice (1).
Comments and Critique Content. The PSD is organized into 2 daily
The MOS is a face valid index of sleep disturbance questionnaires completed at “bedtime” and
with adequate established reliability but no “waketime.” The bedtime questionnaire gathers
established validity with objective sleep measures. data on 1) the timing of meals; 2) consumption of
It should be noted that the subscales do not caffeine, alcohol, and tobacco products; 3)
necessarily reflect DSM criteria for insomnia medication use; and 4) and the timing and
diagnosis. Criterion validity remains to be duration of exercise and nap periods. The
established and comparison with other sleep waketime questionnaire gathers data on 1) bedtime;
measures is unknown. The lack of a cutoff score 2) “lights out time;” 3) sleep latency (SL); 4) final
undermines its utility as a clinical tool. Other waketime; 5) method of final awakening; 6)
sleep measures have more established validity and frequency of nightly awakenings (FNA); 7) wake
S188 Smith and Wegener

after sleep onset time (WASO); 8) reason for should be instructed to keep the diary on their
nightly awakenings, 9) sleep quality; and 10) mood nightstand with a pen or pencil available. The
on final wakening, and alertness on final wakening. nighttime questionnaire is to be completed
immediately before retiring to bed. The morning
Developer/contact information. Timothy H. questionnaire is to be completed shortly after
Monk, PhD, Sleep and Chronobiology Center waking. Instruction is required on properly
Western Psychiatric Institute and Clinic, University estimating wake after sleep onset time and the use
of Pittsburgh School of Medicine, 3811 O’Hara of visual analog scales. Individuals complete both
Street, Pittsburgh, PA 15213. Fax: 1-412-624-2841. questionnaires each day for a period of 1 to 2
weeks or longer.
Versions. Multiple versions of sleep diaries have
been developed (2– 4). The PSD was selected for Time to administer/complete. Ten minutes a day
review because it is the most comprehensive (5 minutes for the bedtime questionnaire and 5
published diary with psychometric data. minutes for the waketime questionnaire).

Number of items in scale. The bedtime Equipment needed. None.


questionnaire is comprised of 6 general items. The
waketime questionnaire is comprised of 11 general Cost, availability. No cost; available from
items. authors. Copy available at the Arthritis Care &
Research Web site at
Subscales. None. http://www.interscience.wiley.com/jpages/0004-
3591:1/suppmat/index.html.
Populations. Developmental/target. The PSD
was developed from 3 investigations including
samples of sleep disorder patients (n ⫽ 28) and Scoring
healthy adult controls (young [n ⫽ 29], middle- Responses. Scale. The timing (hour:minutes)
aged [n ⫽ 96], and older adult [n ⫽ 81]). Sleep and duration (minutes) of various daytime and
disorder patients included patients with insomnia sleep-wake parameters and activities are hand
or hypersomnia. entered. For the nighttime questionnaire, the
frequency of servings of caffeine, alcohol, and
Other uses. Similar sleep diaries have been used tobacco products are indicated for 4 time periods:
to assess sleep parameters in heterogeneous 1) before or with breakfast; 2) after breakfast,
chronic pain patients (3,5,6) and fibromyalgia (7). before/with lunch; 3) after lunch before/with
Sleep diaries are extensively used in the clinical dinner; and 4) after dinner. Name, timing, and
trials literature of insomnia (8 –10). Diaries have dosage of medications are hand entered. For the
also been found to be useful in evaluating waketime questionnaire, subjects indicate the
circadian rhythm disorders (11). timing of bedtime and final waketime, and the
duration of sleep latency and wake after sleep
WHO ICF Components. Body function,
onset time. Subjects also check on a categorical
Impairment, Environmental factor.
scale the method of final awakening: “alarm/clock
radio,” “someone whom I asked to wake me,”
“noises,” or “just woke.” Frequency of nightly
Administration awakenings is indicated using a 6-point Likert
Method. Questionnaire, paper and pencil scale: 0 –5 or more. Frequency of awakenings to
(electronic and mail versions have been use the bathroom, awakenings by noise/bedpartner,
developed). Standard assessment periods of 1 awakenings due to physical discomfort, and
week, and more preferably 2 weeks, are spontaneous awakenings are indicated on the same
recommended to account for night-to-night 6-point Likert scale. Ratings of sleep quality, mood
variability in sleep disorder populations. on final wakening, and alertness are made on 100-
Compliance problems need to be considered (12). mm visual analog scales.
Electronic versions can be adopted for use with
PDA handheld devices. Electronic delivery Score range. In addition to categorical and
enhances data integrity with audible reminder frequency data generated by the nighttime
features, and time and date stamping of entries (7). questionnaire, the waketime questionnaire permits
the calculation of standard continuity parameters
Training. Brief training of subjects is required to as follows: 1) Sleep latency (SL), minutes; ranges
avoid missing values and erroneous data. Subjects from 0 to total time in bed (TIB); 2) frequency of
Sleep S189

Table 1. Sleep Diary Estimates of Sleep Continuity Parameters*

Groups SL FNA WASO TST SE%

Healthy young adults, 10.7 (7.0) 0.3 (0.5) 6.7 (11.7) NR NR


ages 20–30 years (n ⫽
29), 41% female (1)
Healthy older adult 24.3 (25.4) 1.2 (0.7) 23.4 (24.7) NR NR
females, ages ⱖ81
years (n ⫽ 44) (1)
Healthy older adult 15.7 (21.3) 1.5 (0.8) 21.8 (21.0) NR NR
males, ages ⱖ81 years
(n ⫽ 37) (1)
General sleep disorder NR NR 35.3 (33.2) NR NR
patients, (n ⫽ 28, 14
insomnia and 14
hypersomnia), 40%
female (1)
Mixed outpatient chronic 43.9 (22.3) 2.26 (1.2) 41.8 (40.9) 391.4 (74.3) 71.0 (14.0)
pain, mean age 43 (10),
67% female (5)
Chronic persistent 51.5 (29.1) 2.7 (1.9) 61.8 (39.0) 332.7 (46.6) NR
insomnia, adults age
range 18–80⫹, years,
Mean n ⫽ 217, 65%
female (8)†

* Values are mean (SD). SL ⫽ sleep latency; FNA ⫽ frequency of nightly awakenings; WASO ⫽ wake after sleep onset time; TST ⫽ total sleep time;
SE% ⫽ sleep efficiency percentage; NR ⫽ not rated.
† Based on meta-analysis of clinical trials literature of primary insomnia. Values are pretreatment means. Number of subjects included in averages
varied due to differential reporting of sleep parameters by study. Results are based on a total of 23 clinical trials.

nightly awakenings (FNA); ranges from 0 to 5⫹; 3) Time to score. Scoring time depends on the
wake after sleep onset time (WASO), minutes; number of days data are collected. A week’s worth
ranges from 0 to TIB – SL; 4) total sleep time of entries can usually be manually scored in 10 –15
(TST), minutes calculated by the formula, TST⫽ minutes.
[TIB – (SL⫹WASO)]; ranges from 0 to TIB; 5) Sleep
efficiency percentage (SE), calculated by formula, Training to score. Minimal.
SE ⫽ TST/TIB. Visual analog scales of sleep
quality, mood, and alertness on waking range from Training to interpret. Minimal.
0 to 100 mm.
Norms available. Traditional norms are
unavailable. Table 1 shows diary-based means and
Interpretation of scores. There are no formally
standard deviations that have been culled from the
established research diagnostic criteria for sleep
literature for reference.
diary estimates of sleep continuity. Commonly
used clinical and research criteria for symptom
severity are as follows: mean SL and/or WASO Psychometric Information
⬎30 minutes, mean SE ⬍85% (2). Due to
Reliability. Reliability and validity data are
individual variation in TST, researchers are less
primarily available for the waketime questionnaire
inclined to establish TST criteria. Commonly used
sleep continuity and quality items.
criteria for problem frequency is: ⱖ3 nights per
week (2) for a 1-month period (13). Test-retest reliability. Monk et al reported
significant (P ⬍ 0.001) long-term test-retest
Method of scoring. Scoring is done by hand. correlation coefficients (r) for select waketime
Calculation of previously described sleep questionnaire variables with a mean intertest
continuity parameters can be easily automated. A interval of 22 months (range 12–30 months):
ruler is required to measure the visual analog FNA ⫽ 0.67; WASO ⫽ 0.56; Sleep Quality ⫽ 0.59;
scales. Typically, mean values for each sleep Mood on waking ⫽ 0.61; Alertness on waking ⫽
parameter are obtained (averaged over 1 to 2 0.65; bedtime ⫽ 0.81; Lights out ⫽ 0.80; and Final
weeks). waketime ⫽ 0.66 (1).
S190 Smith and Wegener

Short-term test-retest reliability. Using a sleep more validation studies particularly for sleep
diary similar to the waketime PSD items, Coates et disorder populations are needed (19). Monk et al
al reported test-retest reliability coefficients reported the PSD correlated significantly with
measured over 3 consecutive days for poor sleepers actigraphic measures of TST (r ⫽ 0.43, P ⬍ 0.0001)
of 0.93, 0.88, 0.84 for SL, FNA, and WASO, (1). They also reported PSD estimates of sleep
respectively (Spearman-Brown Prophecy disruption based on WASO were significantly
coefficients) (14). For good sleepers, Coates et al related to mean activity counts between bedtime
reported coefficients of 0.81, 0.84 and 0.64 for SL, and waketime (t ⫽ 4.1, P ⬍ 0.0001).
FNA, and WASO, respectively (14).
Convergent. Monk reported convergent validity
Inpatient chronic pain patients. Haythornthwaite with circadian type and personality measures.
and colleagues used ordinally scaled diary items With respect to circadian type, PSD correlated in
over a 4-day period (3). They reported internal the expected direction on the morningness score of
consistency estimates for standard sleep the Horne-Osteberg morningness questionnaire (P
continuity/quality questions (average interitem ⬍ 0.05). Specific PSD correlations with the
correlations using Fisher’s Z transformation morningness score were as follows: all PSD items
ranging from 0.41 (Sleep Quality) to 0.62 (TST). pertaining to the timing of the sleep episode, rho ⬎
Spearman’s Brown prophesy formula reliability 0.6; ratings of alertness on awakening, rho ⫽ 0.35;
test-retest coefficients ranged from 0.74 (Sleep and mood upon wakening, rho ⫽ 0.22. With
Quality) to 0.87 (SL). respect to personality, elevated scores on
neuroticism as measured by the Eysenck
Validity. Criterion. Several investigations Personality Inventory were associated with PSD
comparing sleep diary data against traditionally estimates of WASO (rho ⫽ 0.28), FNA (rho ⫽
scored polysomnographic criteria have found 0.33), poorer sleep quality (rho ⫽ ⫺0.34), negative
patients with insomnia to reliably overestimate SL mood (rho ⫽ ⫺0.35), and decreased morning
and WASO and underestimate TST compared with alertness (rho ⫽ ⫺0.23) (P ⬎ 0.03).
PSG (14,15). Diary estimates, however, have Haythornthwaite and colleagues also reported
consistently been demonstrated to provide a valid convergent validity of a sleep diary in an inpatient
relative index of insomnia. In a study of 122 men
sample of chronic pain patients. Diary measures
and women with chronic insomnia, Carskadon
correlated in the expected direction with standard
reported significant correlation coefficients
measures of pain severity, depression, and anxiety
between diary and PSG measures of SL (0.62) and
(3).
TST (0.47), (P ⬍ 0.001, WASO not reported).
Coates and colleagues reported a correlation
coefficient of 0.98 for SL and 0.88 for WASO for a Convergent validity with retrospective measures
sample of 12 patients with insomnia, P ⬍ 0.01. of sleep quality. Monk et al reported small, but
Diaries have not been shown to be a valid significant correlation of PSD items with the
indicator of Frequency of Nightly Awakenings Pittsburgh Sleep Quality Index Global Score as
(FNA). follows: FNA rho ⫽ 32, P ⬍ 0.002; WASO rho ⫽
Monk and colleagues reported PSD to be 0.27, P ⬍ 0.01; Sleep Quality rho ⫽ ⫺0.36, P ⬍
sensitive to significant age related differences in 0.0005); Mood rho ⫽ ⫺0.37, P ⬍ 0.0005; Alertness
sleep continuity that were simultaneously verified rho ⫽ ⫺0.37, P ⬍ 0.0005 (1).
by polysomnography (1). Specifically, the PSD In chronic pain patients, Haythornthwaite et
found older adults to report longer WASO al. reported moderate correlations in the expected
compared with young, good-sleeper control direction with their sleep diary and retrospective
subjects (P ⬍ 0.0001). Longer WASO for the adult summary measures of sleep (coefficient ranged
sample was confirmed via PSG. The authors did from 0.31 to 0.48, P ⬍ 0.05) (3).
not report correlation coefficients.
Sensitivity/responsiveness to change. Sleep
Comparison with actigraphy. Actigraphs are a diaries are the most widely used outcome metric in
lightweight, watch-like accelerometer device worn both the behavioral and pharmacologic clinical
on the wrist, which are increasingly being used in trials literatures of insomnia (8). Numerous studies
sleep research to provide objective estimates of and meta-analyses have demonstrated excellent
circadian rhythm (16), and sleep continuity sensitivity to change (9,20 –22). Notably, sleep
(17,18). Algorithms for scoring sleep continuity diary measures have been shown to detect
parameters based on movement counts have been treatment effects for cognitive-behavioral therapy
developed and validated against PSG, although for insomnia secondary to chronic pain. These
Sleep S191

effects were concurrently validated via actigraphy 2. Morin CM. Insomnia: psychological assessment and
(23). management. New York: Guilford Press; 1993.
3. Haythornthwaite JA, Hegel MT, Kerns RD.
Development of a sleep diary for chronic pain
Comments and Critique patients. J Pain Symptom Manage 1991;6:65–72.
4. Akerstedt T, Hume K, Minors D, Waterhouse J. The
Sleep diaries are a valuable tool in sleep research subjective meaning of good sleep, an intraindividual
to quantify subjective sleep disturbance. In approach using the Karolinska Sleep Diary. Percept
rheumatology and pain research, however, sleep Mot Skills 1994;79:287–96.
diaries have been used infrequently. Most clinical 5. Smith MT, Perlis ML, Smith MS, Giles DE. Pre-sleep
trials of chronic pain have relied on brief cognitions in patients with insomnia secondary to
retrospective ratings of sleep quality with dubious chronic pain. J Behav Med 2001;24:93–-114.
validity. This is somewhat surprising given that 6. Wilson KG, Watson ST, Currie SR. Daily diary and
pain diaries have become an important instrument ambulatory activity monitoring of sleep in patients
in the assessment of chronic pain conditions. with insomnia associated with chronic
musculoskeletal pain. Pain 1998;75:75– 84.
Standard sleep continuity/quality items can easily
7. Affleck G, Urrows S, Tennen H, Higgins P, Abeles M.
be added to pain diaries. Electronic diaries with Sequential daily relations of sleep, pain intensity,
data integrity features and automatic scoring and attention to pain among women with
capability will undoubtedly increase their use in fibromyalgia. Pain 1996;68:363– 8.
pain research. 8. Smith MT, Perlis ML, Park A, Smith MS, Pennington
Prospective diary monitoring has distinct JY, Giles DE, et al. Comparative meta-analysis of
advantages over retrospective measures in its pharmacotherapy and behavior therapy for persistent
sensitivity to variations in sleep parameters over insomnia. Am J Psychiatry 2002;159:5–11.
time and its diminished vulnerability to recall bias. 9. Edinger JD, Wohlgemuth WK, Radtke RA, Marsh GR,
Compared to traditional PSG, they permit a Quillian RE. Cognitive behavioral therapy for
relatively unobtrusive, inexpensive assessment of treatment of chronic primary insomnia: a
randomized controlled trial. JAMA 2001;285:1856 –
sleep quality in the natural environment.
64.
Concern that sleep diaries overestimate
10. Morin CM, Colecchi C, Stone J, Sood R, Brink D.
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References actigraphy in the evaluation of sleep disorders. Sleep
1. (Original) Monk TH, Reynolds CF, Kupfer DJ, Buysse 1995;18:288 –302.
DJ, Coble PA, Hayes AJ, et al. The Pittsburgh Sleep 18. Jean-Louis G, von Gizycki H, Zizi F, Spielman A,
Diary. J Sleep Res 1994;3:111–20. Hauri P, Taub H. The actigraph data analysis
S192 Smith and Wegener

software. I. A novel approach to scoring and Versions. Japanese (validated) (2), German (3),
interpreting sleep-wake activity. Percept Mot Skills and French (validated) (4).
1997;85:207–16.
19. Sadeh A, Hauri PJ, Kripke DF, Lavie P. The role of Number of items in scale. The instrument
actigraphy in the evaluation of sleep disorders. Sleep
consists of 19 items. There are 5 additional
1995;18:288 –302.
20. Murtagh DR, Greenwood KM. Identifying effective
questions rated by the bed partner/roommate that
psychological treatments for insomnia: a meta- are not included in the total score, but may be
analysis. J Consult Clin Psychol 1995;63:79 – 89. useful for clinical purposes.
21. Nowell PD, Mazumdar S, Buysse DJ, Dew MA,
Reynolds CF III, Kupfer DJ. Benzodiazepines and Subscales. The 19-items are grouped into 7
zolpidem for chronic insomnia: a meta-analysis of equally-weighted component scores: 1) Subjective
treatment efficacy. JAMA 1997;278:2170 –7. Sleep Quality (1 item); 2) Sleep Latency (2 items);
22. Morin CM, Culbert JP, Schwartz SM. 3) Sleep Duration (1 item); 4) Habitual Sleep
Nonpharmacological interventions for insomnia: a Efficiency (3 items); 5) Sleep Disturbances (9
meta-analysis of treatment efficacy. Am J Psychiatry
items); 6) Use of Sleeping Medication (1 item); and
1994;151:1172– 80.
23. Currie SR, Wilson KG, Pontefract AJ, deLaplante L.
7) Daytime Dysfunction (2 items).
Cognitive-behavioral treatment of insomnia
secondary to chronic pain. J Consult Clin Psychol Populations. Developmental/target. The PSQI
2000;68:407–16. was originally developed on 2 distinct groups of
24. Krystal AD, Edinger JD, Wohlgemuth WK, Marsh GR. poor sleepers, patients with major depression and
NREM sleep EEG frequency spectral correlates of sleep disorder patients. A sample of good sleeper
sleep complaints in primary insomnia subtypes. controls was also used in the original development
Sleep 2002;25:630 – 40. (1). The sleep disorder sample consisted of patients
25. Perlis ML, Smith MT, Orff HJ, Andrews PJ, Giles DE. referred to a sleep disorders center who presented
Beta/Gamma EEG activity in patients with primary
with trouble initiating or maintaining sleep and/or
and secondary insomnia and good sleeper controls.
Sleep 2001;24:110 –7. disorders of excessive daytime somnolence.

Other uses. The PSQI has been subsequently


used and, in some cases, validated in a variety of
PITTSBURGH SLEEP QUALITY INDEX clinical populations including: heterogeneous
(PSQI) samples of chronic pain patients (5–7),
General Description fibromyalgia (8), temporomandibular joint disorder
(9), post acute traumatic brain injury (validated)
Purpose. The Pittsburgh Sleep Quality Index (10), bone marrow transplant (validated) (11), renal
(PSQI) measures retrospective sleep quality and transplant (validated) (11), women with breast
disturbances over a 1-month period for use in cancer (validated) (11), human immunodeficiency
clinical practice and research (1). The PSQI
virus infection (12), irritable bowel syndrome (13),
discriminates between good and poor sleepers, and
Parkinson’s disease (14), older adults (15), primary
provides a brief, clinically useful assessment of
insomnia (validated) (3), panic disorders (16),
multiple sleep disturbances.
posttraumatic stress disorder (17), and sheltered
battered women (18).
Content. Individual self-report items assess a
broad range of domains associated with sleep
WHO ICF Components. Body function,
quality, including: usual sleep wake patterns,
Impairment, Activity liimitation, Participation
duration of sleep, sleep latency, the frequency and
restriction, Environmental factor.
severity of specific sleep-related problems, and the
perceived impact of poor sleep on daytime
functioning. Specific problems contributing to poor
sleep that are assessed include: pain, urinary Administration
frequency, breathing difficulty, snoring, dreams, Method. Self-report, paper and pencil.
temperature, etc.
Training. Minimal.
Developer/contact information. Daniel J. Buysse,
MD, Sleep and Chronobiology Center, Western Time to administer/complete. Five to ten
Psychiatric Institute and Clinic, University of minutes.
Pittsburgh School of Medicine, 3811 O’Hara Street,
Pittsburgh, PA 15213. Fax: 1-412-624-2841. Equipment needed. None.
Sleep S193

Cost, availability. No cost; available from Cronbach’s alpha coefficient of 0.83, indicating
authors. high internal consistency. Component to Global
Score correlation coefficients ranged from 0.35
Scoring (Sleep Disturbance) to 0.76 (Habitual Sleep
Efficiency and Subjective Sleep Quality), with a
Responses. Scale. Items 1– 4 are free entry of:
mean component to global score Pearson’s r
usual bed and wake times, minutes of total sleep
correlation ⫽ 0.58. Individual items were also
time, and sleep latency (minutes). Items 5–18 are
4-point Likert scale responses pertaining to strongly intercorrelated with an internal reliability
problem frequency: “not during the past month coefficient (Cronbach’s alpha) ⫽ 0.83. Item to total
(0)”; “less than once a week (1)”; “once or twice a correlation coefficients ranged from 0.20 (item #8;
week (2)”; and “three or more times a week (3).” difficulty staying awake) to 0.66 (item #9,
Item 19 is a 4-point Likert scale rating of overall enthusiasm to get things done).
sleep quality: “Very good (0)”; “Fairly Good (1)”;
“Fairly Bad (2)”; “Very Bad (3).” Test-retest. The PSQI global score and
component scores demonstrate adequate stability.
Score range. The Global Score ranges from 0 to Paired t-tests indicated no significant differences
21. All component scores range from 0 to 3. between global and component scores measured at
T1 and T2 (mean of 28.2 days later). The Global
Interpretation of scores. Higher Global Scores Score Pearson product-moment correlation
indicate poorer sleep quality. An empirically between T1 and T2 ⫽ 0.85 (P ⬍0.001). Component
derived cutoff score of ⬎ 5 distinguishes poor score test-retest correlation coefficients ranged from
sleepers from good sleepers. A Global Score ⬎5 0.65 (Medication Usage) to 0.84 (Sleep Latency, P
indicates that a subject reports severe difficulties in ⬍0.001) (1).
at least 2 domains, or moderate difficulties in more
than 3 areas. Validity. Criterion. Criterion validity was
originally established by evaluating the PSQI’s
Method of scoring. The PSQI is hand-scored by ability to distinguish “good sleepers” from “poor
assigning ordinal values to quantitative and sleepers” as defined by diagnoses based on the
qualitative items in order to generate seven integration of expert structured clinical interviews,
equally-weighted component scores. The 7 physical exam, and polysomnographic testing (1).
component scores are summed to yield a single
The Global Score and all component scores
Global Score. Scoring instructions are provided in
differentiated poor sleeper groups from controls (P
the original publication.
⬍ 0.001). A post hoc Global Score cutoff ⬎ 5
Time to score. Five minutes. correctly identified 88.5% of all patients and
controls (kappa ⫽ 0.75, P ⬍ 0.001) with a
Training to score. Minimal. sensitivity of 89.6% and a specificity of 86.5%.

Training to interpret. Minimal. Convergent validity with polysomnographic


indices. The individual PSQI estimate of sleep
Norms available. Traditional norms are latency for the previous month was not found to be
unavailable. Mean ⫾ SD Global Score values for different from polysomnographically defined sleep
good sleeper controls (n ⫽ 52, 2.67 ⫾ 1.70; Major latency (Pearson’s r ⫽ 0.33, P ⬍ 0.001) (1). PSQI
depression (n ⫽ 34, 11.09 ⫾ 4.31); Disorders of estimates of usual sleep duration and sleep
Initiating and Maintaining Sleep (n ⫽ 45, 10.38 ⫾ efficiency were significantly greater than
4.57); Disorders of Excessive Daytime Somnolence polysomnographic estimates, however (P ⬍ 0.001).
(n ⫽ 17, 6.53 ⫾ 2.98) (1). Mean Global Score ⫾ SD The PSQI Global Score correlated weakly with PSG
for healthy older adults, ⬎80 years of age (n ⫽ 44, defined sleep latency (r ⫽ 0.20, P ⬍ 0.01). It
age ⫽ 4.75 ⫾ 3) (15). Mean Global Score ⫾ SD for
should be noted that PSG data (2-night laboratory
heterogeneous outpatient chronic pain (n ⫽ 51,
evaluation) and PSQI data (self-report of previous 1
11.57 ⫾ 4.36) (5). Mean Global Score for Primary
month period) were based on different time frames.
Insomnia (n ⫽ 80, 12.5 ⫾ 3.8) (3).
In a study of primary insomnia (n ⫽ 80), PSQI
Global Score correlated significantly (P ⬍ 0.05)
Psychometric Information with PSG measures of Total Sleep Time (without
Reliability. Internal consistency. In the original stage 1) (r ⫽ ⫺0.32), sleep efficiency (r ⫽ ⫺0.32),
report (1), the 7 component scores had an overall and % of stage 2 sleep (⫺0.33) (3).
S194 Smith and Wegener

Convergent validity with daily sleep diaries. In a previous 1-month period, this measure may be less
sample of patients diagnosed with primary sensitive to estimating significant changes over
insomnia, PSQI estimates of sleep duration and time or with brief intervention periods. Combining
sleep latency correlated strongly with daily sleep the PSQI with prospective monitoring such as
diary estimates (r ⫽ 0.81 and 0.71, P ⬍ 0.000, daily sleep diaries or actigraphy is recommended.
respectively) (3). Notably, the PSQI yielded reliably It should also be noted that the cutoff score of 5
longer sleep latency times and shorter sleep has been questioned and a score of 8 may be more
duration times relative to diary estimates. sensitive and specific for certain populations (11).
Another weakness is that the daytime
Convergent validity with other retrospective dysfunction component is comprised of only 2
measures of sleep quality. In medical patients items, enthusiasm and daytime sleepiness, and
(bone marrow transplant, renal transplant, breast does not include an item related to fatigue. Fatigue
cancer, and women with benign breast problems), is considered a hallmark symptom of insomnia,
PSQI Global Scores were found to be moderately to whereas daytime sleepiness is often a primary
highly correlated with single and multiple item feature of other intrinsic sleep disorders. It should
scales of sleep quality/problems (11). Specifically be noted, however, that the PSQI is one of the few
the PSQI global score correlated highly with sleep measures of sleep that incorporate questions
problems on the Symptom Experience Report (11), pertaining to daytime sleepiness. Supplementing
the Sleep Restedness item from the CES-D (19), an assessment of sleep in rheumatology patients
and Sleep Quality from the Sleep Energy, and with measures of fatigue (see review in this series)
Appetite Scale (11) (correlation coefficients ⬎0.69). and one of the two most widely used measures of
excessive daytime sleepiness (23,24) is strongly
Divergent validity. In medical populations, the recommended. The Stanford Sleepiness Scale (SSI)
PSQI global score was poorly correlated with (24) is a 7-item measure, designed to evaluate
measures unrelated to sleep quality such as subjective changes in sleepiness using a 7-point
nausea, vomiting, and taste changes (correlations scale. Items range from 1 ⫽ feeling active, vital,
⬍0.37) (11). alert, or wide awake, to 7 ⫽ no longer fighting
sleep, sleep onset soon; having dream-like
Sensitivity/responsiveness to change. Although thoughts. Strengths of the SSI are that it can be
not designed as a treatment outcome measure, the repeatedly administered within a 24-hour period
PSQI has been shown to be sensitive to change in and it is highly sensitive to change. The Epworth
clinical trials of insomnia (20,21). Notably, Currie Sleepiness Scale (ESS) (23) is an 8-item index
and colleagues found the PSQI to be sensitive to designed to measure the likelihood of falling
improvements in sleep quality after cognitive asleep in certain situations, such as sitting and
behavior treatment for insomnia secondary to reading or in a car, while stopped at a traffic light,
chronic pain (22). etc. Items are ranked on a 4-point scale, from 0 ⫽
would never doze, to 3 ⫽ high chance of dozing.
The ESS is a reliable, well-validated measure of
Comments and Critique “usual” sleepiness and may be of particular value
The PSQI is perhaps the most widely used in the clinical assessment of sleep disorders such
general measure of sleep quality available. The as sleep apnea in individuals with a variety of
strengths of this instrument are its range of rheumatologic conditions.
coverage of multiple dimensions of sleep quality,
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S196

Summary Table for Sleep Measures*


Psychometric properties
Measure/ Method of Time for
scale Content Item formats Response format administration administration Primary scale outputs Validated populations Reliability Validity Responsiveness

ISI Severity of Sleep 7-items. Severity 5-point Likert Self, clinician 5 minutes or less Overall severity index with Primary insomnia and Good Good Good
onset, maintenance ratings of scale interview, and established cut offs medical/psychiatric
and early morning insomnia significant other insomnia, chronic pain
awakening symptoms report
insomnia, sleep
satisfaction,
insomnia-related
distress, daytime
impairment
MOS Sleep initiation, 12 items: sleep Free response and Self, clinician 5 minutes or less Overall sleep problem Primary care and multi- Good Poor Insufficientdata
quantity, continuity, and 6-point Likert interview severity index specialty care patients,
maintenance, graded severity scale Arthritis samples, back
respiratory, of common sleep problems
problems, disturbances
perceived adequacy
of sleep,
somnolence
PSD Timing of meals, 17 items. Diary Free response to Self 10 minutes sleep latency, # of Sleep disorders, Similar Good Good Good
stimulants, entries made standard awakenings, wake after diaries used in chronic
medications, twice a day questions, sleep onset time, total pain and fibromyalgia
exercise, napping, (Morning and some sleep time, sleep
bed and wake Night) categorical and efficiency
times, sleep 6-point Likert
continuity scale items
parameters, sleep
quality, mood and
alertness on waking
PSQI Sleep-wake patterns, 19-items. Questions Some free entry Self 5–10 minutes Global Sleep Quality Score General sleep disorders; Good Good Insufficientdata
sleep duration, pertaining sleep and 4-point with established cut-offs; Insomnia; breast
sleep latency, continuity Likert scale 7 subscales cancer; transplant
frequency and parameters and items patients, chronic pain;
severity of sleep graded severity fibromyalgia; TMD
disturbances, use of and frequency of
sleep medications, common sleep
daytime disturbances and
consequences, behaviors
overall/global sleep
quality

* ISI ⫽ Insomnia severity index; MOS ⫽ Medical Outcomes Study; PSD ⫽ Pittsburgh Sleep Diary; PSQI ⫽ Pittsburgh Sleep Quality Index; TMD ⫽ temporomandibular disorder.
Smith and Wegener

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