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Gait & Posture 55 (2017) 62–67

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Gait & Posture


journal homepage: www.elsevier.com/locate/gaitpost

Full length article

Falls in people with Parkinson’s disease: A prospective comparison of MARK


community and home-based falls

Robyn M. Lamonta, , Meg E. Morrisb,c, Hylton B. Menzb, Jennifer L. McGinleyd, Sandra G. Brauera
a
School of Health and Rehabilitation Sciences, University of Queensland, St Lucia, 4072, Australia
b
School of Allied Health, La Trobe University, Melbourne, 3086, Australia
c
Northpark Private Hospital Healthscope, Melbourne, Australia
d
Melbourne School of Health Sciences, The University of Melbourne, 3010, Melbourne, Australia

A R T I C L E I N F O A B S T R A C T

Keywords: Background: Falls are common and debilitating in people with Parkinson’s disease (PD) and restrict participation
Parkinson’s disease in daily activities. Understanding circumstances of falls in the community and at home may assist clinicians to
Fall target therapy more effectively.
Community Objective: To compare the characteristics of community and home fallers and the circumstances that contribute
to falls in people living with PD.
Methods: People with mild-moderately severe PD (n = 196) used a daily falls diary and telephone hotline to
report prospectively the occurrence, location and circumstances of falls over 14 months.
Results: 62% of people with PD fell, with most falling at least once in the community. Compared to people who
fell at home, the community-only fallers had shorter durations of PD (p = 0.012), less severe disease
(p = 0.008) and reported fewer falls in the year prior to the study (p = 0.003). Most falls occurred while
people were ambulant, during postural transitions and when medication was working well. Community-based
falls were frequently attributed to environmental factors such as challenging terrains (p < 0.001), high
attention demands (p = 0.029), busy or cluttered areas (p < 0.001) and tasks requiring speed (p = 0.020).
Physical loads were more often present in home than community-based falls (p = 0.027).
Conclusion: Falls that occur in the community typically affect people with earlier PD and less severe disease than
home-based falls. Individuals experiencing community-based falls may benefit from physiotherapy to manage
challenging environments and high attention demands.

1. Introduction between intrinsic factors such as balance impairments and extrinsic


factors including environmental demands and hazards [7]. Some
Falls are common and challenging for people with Parkinson’s intrinsic factors appear to predispose people to falling in particular
disease (PD) with many experiencing frequent falls [1]. Falls can have contexts [8]. For example, people with PD who fall outdoors have a
devastating consequences including restriction or avoidance of physical propensity for falls triggered by tripping, slipping, loss of balance or
activities [2,3] and reduced health-related quality of life [4]. Identify- loss of concentration [8]. In contrast, recurrent fallers are more inclined
ing individuals who are at risk of falling, and preventing or minimising to fall at home, in falls they attribute to muscles giving way, dizziness or
falls is a priority in comprehensive patient care. A “fall type approach” loss of balance [8].
to rehabilitation has been advocated for managing falls in people with After experiencing a fall, some people with PD restrict their physical
PD [5], whereby falls circumstances directly inform tailored interven- activities to avoid harm [2,9]. Falls that occur away from home can
tion. A targeted approach to fall prevention would be assisted by result in embarrassment and psychological distress [10]. If people fall
understanding fall types and their predisposing risk factors. in the community, they may restrict their activities to the close
Historically it was thought that falls in people with PD were surrounds of their home, which may reduce independence. It is there-
primarily caused by intrinsic factors [2,6]. Fall events are however fore important to identify characteristics of people with PD who fall in
now recognised as multifactorial and the result of an interaction the community and their potential contributing factors.


Corresponding author.
E-mail addresses: r.lamont@uq.edu.au (R.M. Lamont), M.Morris@latrobe.edu.au (M.E. Morris), H.Menz@latrobe.edu.au (H.B. Menz), mcginley@unimelb.edu.au (J.L. McGinley),
s.brauer@uq.edu.au (S.G. Brauer).

http://dx.doi.org/10.1016/j.gaitpost.2017.04.005
Received 7 November 2016; Received in revised form 27 February 2017; Accepted 2 April 2017
0966-6362/ © 2017 Elsevier B.V. All rights reserved.
R.M. Lamont et al. Gait & Posture 55 (2017) 62–67

Table 1
Factors that may have contributed to falls.

Factor Description

Ambulant At the time of the fall they were walking, including initiating or terminating walking.
Indoor The fall occurred inside a building.
Freezing At the time of the fall they reported experiencing freezing of gait.
Intrinsic only The fall was related to intrinsic or personal factors only (e.g. dizziness or hypotension).
Distance At the time of the fall they had been walking a long distance, which may have contributed directly to the fall or to fatigue which may
have been related to the fall.
Temporal At the time of the fall they were walking quickly, felt pressured to rush, or they were crossing a road.
Ambience At the time of the fall the lighting was dull, very bright, that the level of lighting had changed or that the weather was inclement,
causing reduced visibility (rain or fog) or making it difficult to move (wind).
Terrain At the time of the fall they were walking on a ramp, stairs, a curb, a slope, a hill or a rough, slippery, sticky (i.e. high friction) or soft
surface, or that they had walked from one surface to another.
Anticipated external physical load At the time of the fall the individual was carrying something, pushing or pulling a door open or closed.
Unanticipated external physical load They were knocked, pulled or jolted off balance by an external force just prior to the fall.
Attention At the time of the fall they were somehow distracted from the postural task and/or required to share their attention between the
postural task and another activity (e.g. walking while finding their way).
Postural Transition At the time of the fall they were initiating or terminating walking, changing speed or direction, sitting down or standing up, reaching
up or down or changing the position of their head to look left, right, up or down.
Density The participant stated that at the time of the fall they were walking in an environment that was or could be presumed to be busy (e.g.
walking on a train, in a grocery store or to their seat in a theatre).
Unable to determine environmental cause No specific environmental factors were present at the time of the fall, however was not sufficient to rule out the presence of
environmental factors (e.g. feet froze and I fell).
Inevitable fall It is likely that under the same circumstances a healthy, young person would have been unable to recover from the perturbation and
would have fallen.

The first aim of this study was to compare the characteristics of after a fall. A fall was defined as “an unexpected event in which the
people with PD who fell only in their community, to those who fell only participant comes to rest on the ground, floor or lower level” [16]. The
at home, as well as those who fell at both locations. It was hypothesised hotline operator recorded details about the fall, including the time and
that people who fall only in the community would have shorter disease location of the fall, a description of what caused the fall, the effective-
duration and less severe symptoms than people who fell at home only, ness of medication, whether freezing had occurred at the time of the fall
or in both locations. Second, we examined the personal and environ- and whether an injury occurred. Falls were also recorded on a calendar
mental factors that contributed to falls in each location, and predicted that was returned to researchers monthly. Falls reported on the
that these would differ. calendar, but not on the falls hotline were followed up by telephone
and where possible, details of the fall were added.
2. Methods
2.3. Data analysis
We conducted a secondary analysis of prospective falls data
collected as part of a large randomised controlled trial (RCT) assessing A community-based fall was a fall that occurred anywhere other
a fall prevention intervention in the PD population [11]. The protocol than the participants’ own home or garden. Falls that occurred at the
for the RCT data collection has been published previously [11,12]. The participant’s own home, including their garden or garage were classi-
study was approved by the Southern Health (Approval # 060035) and fied as home-based falls. Participants were categorised as those who
The University of Melbourne Health Sciences (Approval # 0828579) reported only community-based falls, only home-based falls or both
Human Research Ethics Committees. home and community-based falls. Individuals who reported more than
one fall in the 14-month trial period were classified as frequent, very-
2.1. Participants frequent fallers or extremely-frequent fallers based on the number of
falls reported [17,18].
A total of 210 people with idiopathic PD were recruited through The falls description was analysed to identify factors or circum-
movement disorders clinics, private neurologists, physiotherapists and stances that may have contributed to the fall. Each fall was reviewed to
local newspaper advertising in Victoria, Australia. Participants were determine whether it occurred while ambulant, while indoors or
required to have a confirmed diagnosis of idiopathic Parkinson’s outdoors, while freezing of gait (FOG) was occurring and based on
disease, be willing and able to provide written informed consent and the environmental challenges that may have contributed to the fall.
be able to walk independently with/without gait aids. People who had Descriptions of falls that indicated the fall occurred due to an intrinsic
deep brain stimulation, scored less than 24 on the Mini Mental State event alone, were classified as “intrinsic only”. Falls were classified as
Examination (MMSE) [13] and those on major tranquilisers were “inevitable” if it was considered that the fall would have occurred in a
excluded. young, healthy person. Environmental challenges were classified using
the environmental dimensions framework [19] which has previously
2.2. Procedure been used to describe the contribution of specific environmental
challenges to mobility disability in older adults [20].
Participants attended an assessment session at which a question- This framework describes eight environmental challenges that are
naire was used to collect demographic data including age and disease detailed in Table 1. It has not previously been applied to the analysis of
duration. Severity of PD symptoms was rated using the Unified falls, and was used here with one modification. The “external physical
Parkinson Disease Rating scale (UPDRS) [14] and the modified Hoehn load” domain was separated into anticipated and unanticipated physi-
and Yahr scale (mHY) [15]. The MMSE provided information about the cal loads based on whether anticipatory or reactive postural adjust-
participants’ cognitive status. ments would have been required to prevent a fall.
During the intervention (8 weeks) and 12-month follow-up periods Content analysis was initially performed independently by two of
participants were asked to phone a free fall hotline as soon as possible the investigators (RL and SB) who then met to identify and discuss

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discrepancies in their analyses. Consensus was reached by discussion. 146 community and 728 home-based falls identified (Table 3).
Multiple factors could contribute to each fall. In the example below, Almost three quarters (n = 90; 74%) of fallers reported recurrent
the fall was attributed to density, anticipated physical load, attention falls (Fig. 1). Seven participants fell extremely frequently (> 60 falls)
demands, postural transition and terrain characteristics. and accounted for 1046 (57%) of the falls that were reported. These
extremely-frequent fallers accounted for almost 75% of falls for which
“She was at a friend’s birthday party and there were a lot of people location was unknown and less than one-third of these falls could be
around. She had picked up a heavy bowl in the kitchen and was saying classified based on location. (Fig. 1). Approximately one-third of falls
goodbye to people. She had turned around and had not seen the step for which location was known resulted in injury (277, 31.7%). There
and missed the step and fell forward.” was no difference in the frequency of injuries between community and
home-based falls (p = 0.576).
Statistical analyses were performed using IBM SPSS Version 18.0
(IBM Corp). Continuous data were assessed for normality using the
3.1. Characteristics of fallers
Kolmogorov-Smirnov statistic and confirmed visually with histograms
and normality plots. The characteristics of the sample were described
The majority (55%) of fallers experienced community-based falls,
using means and standard deviations for continuous, parametric data,
with 18 reporting only community falls and 49 who fell in both
medians and ranges for continuous non-parametric data and frequen-
locations. Forty-nine people only fell at home. Six fallers (5%) did not
cies and proportions for categorical variables. Between group differ-
record a fall location and therefore could not be allocated to a group.
ences were tested using one-way ANOVA’s for parametric data, Kruskal-
The community-only fallers experienced the fewest falls, followed
Wallis tests for non-parametric data and Chi-squared test for categorical
by the home-only then the home and community fallers (Table 2). The
data. Post-hoc comparisons were made using the Tukey HSD test and
community-only fallers reported a similar number of community-based
Mann-Whitney U test. The significance level was set at α = 0.05.
falls as the home and community fallers. The home and community
To avoid over reporting repeated falls circumstances that may have
fallers reported a higher number of home-based falls than the home-
occurred in very-frequent fallers (> 60 falls), falls circumstances were
only fallers. Fewer community-only fallers fell recurrently compared to
also analysed with very-frequent fallers excluded.
the home-only fallers (p = 0.001) and home and community fallers
(p < 0.001).
3. Results The groups did not differ in age, gender distribution or MMSE score
(Table 2). Group differences were found for disease duration, modified
The characteristics of the 196 participants are presented in Table 2. HY stage, UPDRS-ADL and motor subsection scores and falls history.
In total, 62% of participants fell 1835 times during the 14-month The community-only fallers had lower UPDRS-ADL and UPDRS-motor
recording period (Table 3). Location was reported for 48% of falls, with subsection scores than the home-only fallers (p = 0.015 and p = 0.034

Table 2
Participant characteristics.

All Participants Home-only Community- only Home & Community p-value Group Single Recurrent p-value
(n = 196) Fallers Fallers (n = 18) Fallers (n = 49) differences Fallers Fallers
(n = 49) (p < 0.05) (n = 32) (n = 89)

BASELINE CHARACTERISTICS
Age (years)* 67.4 (9.5) 68.1 (10.2) 65.1 (11.6) 68.2 (9.1) 0.481 68.1 (11.1) 67.8 (9.6) 0.887
Male gender† 129 (66) 24 (49) 13 (72) 32 (65) 0.126 18 (56) 55 (61) 0.630
Disease duration 5.0 (0–30) 5.0 (1–28) 4.0 (1–12) 7.0 (1–30) 0.015 1,3; 2,3 4 (0.5–14) 6 (0.5–30) 0.002
(years)¥
Modified 2.6 (0.8) 2.6 (0.8) 2.2 (0.5) 2.8 (0.8) 0.010 2,3 2.2 (0.6) 2.8 (0.8) 0.002
Hoehn & Yahr
Stage*
Stage 1.0† 21 (10.7) 2 (4.1) 1 (5.6) 3 (6.1) 3 (9.4) 4 (4.4)
Stage 1.5† 12 (6.1) 4 (8.2) 1 (6.0) 1 (2.0) 2 (6.3) 4 (4.4)

Stage 2.0 53 (27.0) 11 (22.4) 8 (47.1) 7 (14.0) 14 (43.8) 15 (16.7)
Stage 2.5† 33 (16.8) 11 (22.4) 6 (35.3) 6 (12.0) 8 (25.0) 15 (16.7)
Stage 3.0† 55 (28.1) 13 (26.5) 2 (11.8) 22 (44.0) 5 (15.6) 34 (37.8)
Stage 4.0† 21 (10.7) 8 (16.3) 0 10 (20.0) 0 18 (20.0)
UPDRS − ADL 11.4 (6.0) 13.4 (5.4) 8.9 (3.1) 14.0 (6.6) 0.005 1,2; 2,3 9.2 (4.0) 13.9 (6.1) < 0.001
*
(score)
UPDRS − Motor 15.0 (5.9) 16.6 (5.8) 12.6 (3.5) 17.1 (6.0) 0.016 1,2; 2,3 14.1 (3.8) 16.9 (6.1) 0.004
(score)*
MMSE (score)¥ 29 (7) 29 (24–30) 29 (26–30) 29 (24–30) 0.508 29 (25–30) 29 (24–30) 0.348
Falls history (yes)† 107 (54.6) 31 (63.3) 9 (50) 41 (83.7) 16 (50.0) 68 (75.6) 0.007
12-month falls history 1 (0–300) 1 (0–300) 1 (0–6) 4 (0–100) 0.003 1,3; 2,3 1 (0–4) 3 (0–300) < 0.001
(number) ¥

REPORTED FALLS
Fall number¥ 1 (0–329) 3 (1–75) 1 (1–3) 7 (2–329) < 0.001 1,2: 1,3; 2,3 1 (1–1) 5 (2–329) < 0.001
Recurrent fallers† 88 (44.9) 35 (71.4) 4 (22.2) 49 (100) < 0.001 1,2: 1,3; 2,3 – –
Community-based 0 (0–15) – 1 (1–3) 1 (1–15) 0.074Ω 0 (0–1) 1 (0–15) 0.012
falls¥
Home −based falls¥ 0.5 (0–102) 2 (1–27) – 4 (1–102) 0.001π 0 (0–1) 3 (0–102) < 0.001

* Mean (SD), p-value from ANOVA and Tukey HSD test.



Frequency (%), p-value from Chi-square test.
¥
Median (range), p-value from Kruskal-Wallis and Mann-Whitney U test (α = 0.05). Group 1 = Home-only fallers. Group 2 = Community-only fallers; Group 3 = Home and
Community fallers.
Ω
=Only groups 2 & 3 were compared.
π
Only groups 1 & 3 were compared.

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Table 3
Frequency of fallers and falls.

All Community-based Home-based Fall location unknown

Number of fallers (% of all participants) 122 (62.2) 67 (34.2) 98 (50.0) 58 (29.5)


Number of falls (% of all falls) 1835 (100) 146 (8.0) 728 (39.6) 961 (52.4)
Mean (SD) number of falls per person 15.0 (43.2) 1.2 (2.1) 6.2 (13.6) 8.0 (34.8)
Median (Range) number of falls per person 3 (1–329) 1 (0–15) 2 (0–102) 0 (0–284)

Fig. 1. Number of fallers grouped by fall frequency (black) and proportion of falls for which location was reported, grouped by fall frequency.

respectively) and the home and community fallers (p = 0.004 and based falls (p = 0.029). Similarly, density and temporal demands were
p = 0.014). Mean mHY stage was also lower in the community-only present in 10% or less of falls but more often in community than home-
fallers compared to the home and community fallers (p = 0.008). based falls (p < 0.001 and p = 0.020). Postural transitions, such as
Participants who reported both home and community falls had moving between sitting and standing, frequently contributed to both
significantly longer duration of PD, and reported significantly more community and home-based falls with no difference between groups
falls in the year prior to the study than the community-only (p = 0.012 (p = 0.170). Anticipated physical loads, such as opening a door were
and p = 0.003 respectively) and home-only fallers (p = 0.022 and more frequently present during home-based compared to community-
p = 0.010 respectively). based falls (p = 0.027). Unanticipated physical loads and ambience
Compared to recurrent fallers, single fallers had a shorter disease contributed to a similar proportion of home and community-based falls
duration (p = 0.002), less advanced mHY stage (p = 0.002), lower (p > 0.117).
UPDRS-ADL (p < 0.001) and UPDRS-motor subsection (p = 0.004) The factors related to falls circumstance differed little between
scores and fewer falls in the year prior to their baseline assessment single and recurrent fallers. Recurrent fallers were more likely to report
(p < 0.001). falls related to freezing of gait (p = 0.006). Single fallers were far more
likely to report that negotiating complex terrain (p = 0.006) contrib-
3.2. Circumstances of falls uted to the fall. When extremely-frequent fallers were excluded from
the analysis there was no difference between the proportion of home
The causes of 576 falls (31.4%) were described by participants. and community-based falls related to freezing of gait (p = 0.368) or
During the independent content analysis, the two reviewers agreed on attention demands (p = 0.759).
4767 potential contributing factors (92%). Consensus was reached by
discussion for the other 8%. 4. Discussion
Compared to home-based falls, community-based falls were more
likely to occur while ambulating and when outdoors (p < 0.001) This is the first prospective study to compare the characteristics of
(Fig. 2A). Community-based falls were also less frequently attributed to and factors associated with community and home-based falls in people
freezing than home-based falls (p = 0.015). In the majority of falls with PD. The 17% community-fall rate is comparable to the annual 12%
antiparkinsonian medication was reported to be working well (> 60%) rate previously reported [21]. The current study is the first to
with no difference between community-based and home-based falls demonstrate the high proportion of fallers who experienced commu-
(Fig. 2B). nity-based falls and that the injury rate associated with community-
Fall descriptions were further analysed to identify the environmen- based falls was similar to home-based falls.
tal challenges present at the time of the fall (Fig. 2C). In 44% of the Research in older adults has shown that those who fall outdoors are
community and 32% of the home-based falls, multiple environmental more physically active, with less impaired walking and balance than
dimensions contributed. Terrain was the environmental dimension that those who fall only indoors [22]. Older adults with walking and balance
most often contributed to community-based falls, and significantly deficits may reduce their outdoor activities to reduce their risk of falling
fewer home-based falls (p < 0.001). Attention demands contributed to again [22]. It was therefore hypothesised that people who fell only in
approximately one third of falls, more often community than home- the community would have shorter disease duration and less severe

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Fig. 2. Proportion of community (black) and home-based (grey) falls attributed to a) circumstances; b) medication effect; c) environmental challenges. P-value * 0.025–0.05, **
0.001–0.025, *** < 0.001.

symptoms than people who fell at home. The group who fell only in the difficulties for people with PD. Recent consensus has suggested that
community did have the least advanced disease and least severe motor researchers and clinicians should work to identify fall types and to
impairment and disability. Somewhat surprisingly however, the group better understand the people who experience these different falls [5].
with the most advanced disease, most severe motor symptoms, greatest Future falls prevention strategies that directly target risk factors
disability and most frequent falls in the past fell in both locations. This associated with the specific fall type and location may prove more
suggests that either some people with PD do not sufficiently modify effective. Whether interventions aimed at improving gait with con-
their community-based activity to prevent falling, or individuals may current attention demands [26] could effectively reduce falls associated
be at such high risk of falling that community-based falls occur with with attention demands, or a “slow-down and concentrate” approach
low levels of community activity. Future research utilising new [10] is more appropriate remains to be examined.
technologies to continuously monitor physical activity is needed to In this study, FOG was reported to contribute to more home-based
further explore the interaction between volume of ambulatory activity falls than community-based falls. Tasks such as managing doorways and
and falls. negotiating small spaces are known triggers of FOG [27,28] and
When fall circumstances were examined, environmental challenges arguably more likely to occur when walking at home. Episodes of
such as postural transitions, attention demands, anticipated physical freezing are also more likely to occur during the “off” phase of the
loads and terrain characteristics were frequently associated with falls in medication cycle [28], when people with PD may be less likely to spend
both locations. Previous research has concluded that falls in people time in the community. Not surprisingly, FOG was more frequently
with PD are most commonly due to intrinsic causes [2]. The results of reported to contribute to falls in recurrent fallers than single fallers.
this study suggest that although an intrinsic factor may be the primary Indeed, when the participants who fell extremely frequently were
reason for a person being unable to regain their balance, without the removed from this analysis, there was no significant difference in the
contribution of an environmental trigger many falls may not have proportion of community and home-based falls attributed to freezing.
occurred. Exploring the environmental factors that contribute to falls is Further investigation of the characteristics of fallers and the complex
important in understanding the type of fall that occurred and planning relationship between falls, activity and FOG is warranted.
a targeted prevention strategy. Most falls in this study occurred while medication was working
Environmental challenges that were identified to contribute to well, a finding also reported in previous prospective studies [2]. Recent
community-based falls differed to those of home-based falls. This studies have demonstrated that high-intensity exercise interventions
reflects in part the different demands on the sensorimotor system in can effectively reduce the rate of falls in people with mild and moderate
the home and community environments [19]. It may also suggest that PD [9,29]. Furthermore, a lower intensity, but task- and context-
different symptoms of PD predispose some people to experiencing specific exercise program, incorporating indoor and outdoor training
home-based falls, and others community-based falls. For example, and targeting the spectrum of balance systems, has been shown to
difficulty maintaining gait and postural stability with concurrent reduce the number and severity of injurious falls, and improve balance
attention demands [23,24] and negotiating obstacles [3,25] are known confidence in people with PD [30]. The impact of targeted training

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