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General objectives:

1. Define the normal structure of the hematopoietic system.

2. Define the normal structure of the lymphatic system.

3. Define the normal structure of the reticuloendothelial system.

4. Understand the steps of hematopoiesis, blood cell differentiation.

5. To recognize disorders affecting the hematopoietic &

lymphoreticular systems.

6. Understand hemoglobin structure, function & metabolism.

7. To recognize disorders of hemoglobin.

8. Blood components including red blood cell, white blood cell &

9. Define the plasma and its components.

10.Define the components & the normal mechanisms of the hemostatic


11.To recognize the disorders of the hemostatic system.

12.To recognize oncogens, oncogenesis & understand the molecular

basis of malignancy.

13.To know hematologic proliferative, clonal & neoplastic disorders.

14.Define blood parasites & other microbial related blood diseases.

15.To understand the mechanism of action, indication & adverse

effects of drugs used in the treatment of the hematologic disorders.

16.To recognize other & new therapeutic techniques (e.g. chelating

therapy, gene therapy, BM & stem cell transplantation……..).

17.Understand blood transfusion & blood component therapy.

18.To recognize types, indication & complications of blood transfusion.

Specific objectives:
1. Knowledge about General hematology:

1.1. Understand initial approach to the patient describing:

1.1.1. History & physical examination.

1.2. Describe the anatomical & histological structure of:

1.2.1. The Bone marrow including; Types of bone marrow. Bone marrow stroma. The hematopoietic microenvironment. Bone marrow cells & vessels. Hematopoietic growth factors.

1.2.2. Lymphatic system including Primary lymphoid organs. Secondary lymphoid organs. Lymph vessels & cells of the immune system.

1.3. Examination and morphology of;

1.3.1. The peripheral blood.

1.3.2. The bone marrow.

1.4. Describe Immune-hematology of certain circumstances


1.4.1. Immune-hematology of the newborn.

1.4.2. Immune-hematology & pregnancy.

1.4.3. Geriatric Immune-hematology.

2. Knowledge about Molecular & cellular immunohematology:

2.1. Discuss Genetic principles & molecular biology of


2.2. Discuss Cytogenetics & gene rearrangement.

2.3. Discuss Cell cycle regulation describing:

2.3.1. The cell cycle.

2.3.2. Signal transduction pathways.

2.3.3. Apoptosis.

2.3.4. Hematopoietic stem cell, progenitors & cytokines.

3. Knowledge about therapeutic principles:

3.1. Describe Antineoplastic drugs.

3.2. Principles of antithrombotic therapy.

3.3. Principles of stem cell transplantation.

3.4. Principles of immune cell therapy.

3.5. Principles of therapeutic apheresis.

3.6. Principles of gene therapy.

4. Knowledge about Erythrocyte:

4.1. discuss Red blood cell including:

4.1.1. Erythropoiesis.

4.1.2. Reticulocytes, reticulocytosis & reticulocytopenia.

4.2. Describe composition of the erythrocyte including:

4.2.1. Red cell membrane.

4.2.2. Morphology of the erythron.

4.2.3. Describe Hemoglobin including; Hemoglobin structure. Molecular basis & steps of hemoglobin

synthesis. Types of normal & abnormal hemoglobin. Function of hemoglobin.

4.2.4. Discuss Red cell metabolism.

4.2.5. Discuss destruction of erythrocyte.

4.3. Discuss Folate, cobalamin (Vit. B12) & iron metabolism.

4.4. Discuss clinical manifestation & classification of erythrocyte

disorders including:

4.4.1. Discuss congenital red cell disorders including: Aplastic anemia & pure red cell aplasia. Congenital dyserythropoietic anemia. Disorders of red cell membrane abnormalities

including; Hereditary spherocytosis. Hereditary elliptocytosis. Other related disorders (e.g.

stomatocytosis, pyropoikilocytosis……). Erythrocytes enzymopathies including; G6PD deficiency. Pyruvate kinase deficiency. Other related disorders (e.g. aldolase

deficiency……..). Hemoglobinopathies including: Quantitative hemoglobinopahties

(thalassemia). Qualitative hemoglobinopathies including

(sickle cell anemia, unstable hemoglobin, congenital

4.4.2. Discuss acquired causes of anemia including: Iron deficiency anemia. Anemia of chronic disease & endocrinal

disorders. Megaloblastic anemia. Acquired hemolytic anemia including; Immune hemolytic anemia (autoimmune

hemolytic anemia & alloimmune hemolytic anemia). Anemia due to other causes (e.g. anemia

due to physical, chemical drugs or microbial

4.4.3. Discuss Hereditary & acquired sideroblastic anemia.

4.4.4. Discuss Anemia of acute blood loss.

4.4.5. Discuss Hypersplenism & hyposplenism.

4.4.6. Discuss Porphyria.

4.4.7. Discuss Iron overload, Hemosidrosis &

4.4.8. Discuss Primary & secondary polycythemia.

5. Knowledge about Granulocytes:

5.1. Discuss Granulopoiesis.

5.2. Discuss Morphology of neutrophils, eosinophils & basophils.

5.3. Discuss Composition, distribution & fate of neutrophils,

eosinophils & basophils.

5.4. Discuss Quantitative granulocyte disorders descriping:

5.4.1. Neutrophilia, leukomoid reaction, left shift &

leukoerythroblastic reaction & neutropenia.

5.4.2. Eosinophilia & eosinopenia.

5.4.3. Basophilia.

5.5. Discuss Qualitative disorders of neutrophils discriping:

5.5.1. Leukocyte adhesion defect.

5.5.2. Chemotaxis defect.

5.5.3. Granule function defect.

5.5.4. Phagocytic killing defect.

5.6. Discuss Eosinophil disorders.

5.7. Discuss Basophil & mast cell disorders.

6. Knowledge about Monocytes and macrophages:

6.1. Discuss Morphology, function, distribution & fate of

monocytes & macrophages.

6.2. Discuss Monocytosis & monocytopenia.

6.3. Describe inflammatory & malignant histocytosis.

6.4. Describe Lipid storage disease.

7. Knowledge about Lymphocytes & plasma cells:

7.1. Discuss Lymphopoiesis & lymphocyte maturation.

7.2. Discuss Morphology & composition of lymphocytes & plasma


7.3. Discuss Function of B-lymphocytes & role of plasma cell in

immunoglobulin production.
7.4. Discuss Function of T-lymphocytes.

7.5. Discuss Function of natural killer cell.

7.6. Discuss Lymphocytosis & lymphocytopenia.

7.7. Discuss Mononucleosis syndromes, describing atypical &

reactive lymphocytosis.

7.8. Discuss Immundefeiency diseases.

8. Knowledge about Malignant hematology:

8.1. Discuss Protooncogens, oncogens molecular basis of

malignant disorders.

8.2. Discuss Clonal myloid disorders including:

8.2.1. Myelodysplastic syndrome.

8.2.2. Acute myeloid leukemia.

8.2.3. Discuss Myeloproliferative disorders including; Chronic myeloid leukemia. Idiopathic myelofibrosis. Polycythemia rubra vera. Essential thrombocythemia.

8.3. Discuss Colonal lymphoid disorders including:

8.3.1. Acute lymphoblastic leukemia.

8.3.2. Chronic lymphoproliferative disorders including; Chronic lymphocytic leukemia. other related disorders as; prolymphocytic leukemia. Hairy cell leukemia & others …… Discuss Lymphoma including: Describing Non-hodgkin lymphoma with

defining; B-cell lymphoma as; Follicular lymphoma. Mantel cell lymphoma &
others ….. T-cell lymphoma as; Sezary syndrome. Mycosis fungoids & others

….. Describing Hodgkin lymphoma. Discuss Plasma cell dyscresia including; Multiple myeloma. Monoclonal gamopathies. Heavy chain disease. Primary amyloidoses. Macroglobinemia.

9. Knowledge about Hemostasis & thrombosis:

9.1. Discuss Megakaryopoiesis & thrombopoiesis.

9.2. Discuss Platelet structure, morphology, biochemistry &


9.3. Discuss Normal hemostasis & its pathways & the control

9.4. Discuss Coagulation factors & coagulation factor inhibitors.

9.5. Discuss Vascular & endothelial cell role in hemostasis &

vascular purpura.

9.6. Discuss Thrombocytopenia & thrombocytosis.

9.7. Discuss Congenital & acquired qualitative platelets disorders.

9.8. Discuss Congenital coagulation factor deficiency describing

hemophilia, von willibrand disease.

9.9. Discuss acquired hemostatic disorders including:

9.9.1. Hemostatic dysfunction related to liver disease & liver


9.9.2. Disseminated intravascular coagulopathy.

9.9.3. Thrombotic thrombocytopenic purpura.

9.9.4. Venous & atherothrombosis.

9.9.5. Antiphospholipid synderome.

9.10. Discuss Thrombophilia.

10.Knowledge about Transfusion medicine:

10.1. Discuss Erythrocyte antigen & antibodies.

10.2. Discuss human leukocyte antigen & antibodies.

10.3. Discuss Blood procurement & screening tests.

10.4. Discuss Preservation & clinical use of erythrocytes & whole


10.5. Discuss Indication & complication of blood transfusion.

10.6. Discuss Blood component therapy.

10.7. Discuss Blood less medicine & autologous blood transfusion.

10.8. Discuss Hemaphrases & plasmaphareses.

10.9. Discuss preservation & clinical use of platelets.

10.10. Discuss preparation & clinical usage of fresh frozen


10.11. Discuss preparation & clinical usage of cryoprecipitate

& cryosupernatant.

The student will be taught by the use of various learning methods and
activities. These include lectures, demonstrations, laboratory exercises,
Internet applications, individualized projects, self-paced worksheets,
prepared blood slides, Kodachrome slides and other resource-based
learning activities. Resources are also available in the student laboratory,
.campus library, and hospital libraries as well as at the clinical sites