Aprroach to the adult patient with erythroderma

Medical history

History f clinical Exposure to

evidence of medications,
characteristic pre chemicals  Complete physical
existing skin lesions (table 10.3) examination
 Histologic examination
(multiple skin biopsies,
Search for lymph node biopsy if obvious
additional clinila and/or lymphadenopathy
manifestations of Discontinue  Laboratory evaluation (e.g.
primary dermatosis offending agent flow cytmetry)

Confirmation via Improvement

histologic within 2-6
idiopathic Paraneplastic Cutaneus T-cell Rare causes, e.g.
examination and weeks (exvept
lymphoma hypereosinophilic
laboratory DRESS/DIHS)
syndrome,
evaluation (may
autoimmune
include patch  Reconsider other connective tissue
testing) drugs disease
 Continue t re-
evaluate fr
Primary dermatosis
cutaneous T-cell
e.g. psoriasis rubra
lymphoma Erythrodermis
pilaris, pemphigus
 Check for risk Solid organ, Seizary syndrome mycosis fungoides
foliaceus Drug induced Lymphoma
factors for HIV usually end stage (MF)