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  • List of Immunoglobulins

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    Yagnik Bandyopadhyay
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    The document lists the main immunoglobulins found in the human body: IgA, which is found in high concentrations in breast milk and mucous membranes; IgM, which is the first to respond to antigens as a pentamer and is produced in the spleen; IgD, which helps activate B-cells; IgE, which mediates allergic reactions through mast cells; and IgG, which is the most abundant in serum and helps with opsonization, agglutination, and complement activation.

    Descrizione originale:

    Its about the various types of immunoglobins which acts as antibody in our body

    Titolo originale

    Immunoglobins

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    The document lists the main immunoglobulins found in the human body: IgA, which is found in high concentrations in breast milk and mucous membranes; IgM, which is the first to respond to antigens as a pentamer and is produced in the spleen; IgD, which helps activate B-cells; IgE, which mediates allergic reactions through mast cells; and IgG, which is the most abundant in serum and helps with opsonization, agglutination, and complement activation.

    Copyright:

    © All Rights Reserved
    Scarica in formato PDF, TXT o leggi online su Scribd
    Segnala contenuti inappropriati
    6 visualizzazioni2 pagine

    List of Immunoglobulins

    Caricato da

    Yagnik Bandyopadhyay
    The document lists the main immunoglobulins found in the human body: IgA, which is found in high concentrations in breast milk and mucous membranes; IgM, which is the first to respond to antigens as a pentamer and is produced in the spleen; IgD, which helps activate B-cells; IgE, which mediates allergic reactions through mast cells; and IgG, which is the most abundant in serum and helps with opsonization, agglutination, and complement activation.

    Copyright:

    © All Rights Reserved
    Scarica in formato PDF, TXT o leggi online su Scribd
    Segnala contenuti inappropriati
    di 2

    List of Immunoglobulins

    IgA
    -Dimer.
    -present in breast milk in highest amount.
    (IgG and IgM are also present in colostrum)
    -in later life, present in tears, and in mucous membranes - in much higher
    concentration than all the others combined.

    IgM
    -Pentamer. ' J-chain' links the 5 units.
    -first to be synthesized in body in response to an antigen.
    -phylogenetically most ancient.
    -also the first to be expressed in fetus (20 weeks).
    -largest immunoglobulin.
    -produced in spleen.
    All monomers:

    IgD
    -can coexist with IgM on surface of B-cells.
    -acts as an activator of B-cells.
    -present in chondricthyes, hence, phylogenetically as ancient as IgM.

    IgE
    -mediate in allergic reactions.
    -stimulate mast cells for histamine release.
    -present only in mammals, hence, phylogenetically, neoteric.
    -immunity against parasitic worms (fasciola hepatica an so on) and some
    protozoans (Plasmodium falciparum for instance.)

    IgG
    -smallest immunoglobulin.
    -passed from mother to fetus.
    -accounts for 75% of all immunoglobulins present in human serum, by far most
    abundant.
    -the typical immunoglobulin: opsonization, agglutination, activation of complement
    system and wrath of god.

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