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Inheritance Treatment
Polydactyly is the occurrence of extra Polydactyly occurs because of a glitch in At the heart of polydactyly lies a fundamental
fingers or toes1,2,4 at birth. Polydactyly DNA. However, a direct link to a specific change to the structure of a person’s DNA. This
is separated into three groups: preaxial, (mutated or deficient) protein has not been change causes a shift in the production of a
signal5 protein as a fetus or the “design for the
postaxial and central1,5. located4. This is most likely due to the fact that
body”, so to speak.
the expression of polydactyly occurs only in
fetal stages – in the womb. This is where However the specific location of the
An example of preaxial malformation of the hands/feet occurs5. troublesome gene has not been established
polydactyly – when the definitively. According to one study, preaxial
extra digit is on the side Research is still being done to learn more polydactyly could be traced to chromosome 7,
of the hand that has the about the complicated patterns of development specifically q365. However, only 11 out of the
thumb or the side of the in fetuses, and without a specific chromosome 12 being studied fit into this category, leaving
foot that has the big toe. or gene to pair with polydactyly (see “At the room for improvement.
Genetic Level”), finding a specific deficient
Postaxial polydactyly (which accounts for 80%
protein seems unlikely. of cases1) has been found to be an autosomal
dominant trait1, meaning that the gene that
causes polydactyly is not on the X or Y
An example of postaxial polydactyly
chromosome, and that a polydactyly allele
– when the extra digit is on the side
overrides a non-polydactyly allele.
of the pinky toe or little finger.
Central polydactyly is not as well understood as
the previous two types.